Characterization of a novel small molecule that potentiates β-lactam activity against gram-positive and gram-negative pathogens

Antimicrobial Agents and Chemotherapy

Volumn 59, Issue 4, 2015, Pages 1876-1885

  Nair, Dhanalakshmi R ^a   Monteiro, João M ^b   Memmi, Guido ^a   Thanassi, Jane ^c   Pucci, Michael ^d   Schwartzman, Joseph ^a   Pinho, Mariana G ^b   Cheung, Ambrose L ^a  

^a DARTMOUTH MEDICAL SCHOOL   (United States)

^b INSTITUTO DE TECNOLOGIA QUÍMICA E BIOLÓGICA   (Portugal)

^c Achillion Pharmaceuticals ^*  (United States)

^d Drug Product Development   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMPICILLIN; ANTIINFECTIVE AGENT; CEFALOTIN; CEFOXITIN; CEFTRIAXONE; CHLORAMPHENICOL; CIPROFLOXACIN; DNAC 1; DYE; IMIPENEM; LEVOFLOXACIN; NORFLOXACIN; OXACILLIN; PENICILLIN BINDING PROTEIN; PENICILLIN BINDING PROTEIN 2; PENICILLIN BINDING PROTEIN 4; TETRACYCLINE; UNCLASSIFIED DRUG; VANCOMYCIN; BETA LACTAM; DNACINS; MOLECULAR LIBRARY; QUINONE DERIVATIVE;

ACINETOBACTER BAUMANNII; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BACTERIAL CELL WALL; BACTERIAL LOAD; BACTERICIDAL ACTIVITY; CONTROLLED STUDY; CYTOSOL; CYTOTOXICITY; DRUG EFFECT; DRUG POTENTIATION; ENTEROBACTER AEROGENES; ENTEROCOCCUS FAECALIS; ENTEROCOCCUS FAECIUM; ESCHERICHIA COLI; FEMALE; FLUORESCENCE MICROSCOPY; GROWTH INHIBITION; HOST CELL; HUMAN; HUMAN CELL; KLEBSIELLA OXYTOCA; KLEBSIELLA PNEUMONIAE; MACROMOLECULE; MEMBRANE PERMEABILITY; MEMBRANE POTENTIAL; MEMBRANE STRUCTURE; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; MINIMUM INHIBITORY CONCENTRATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN SYNTHESIS; PSEUDOMONAS AERUGINOSA; SINGLE DRUG DOSE; SKIN ABSCESS; TRANSMISSION ELECTRON MICROSCOPY; VANCOMYCIN RESISTANT ENTEROCOCCUS; ANIMAL; BACTERIAL COUNT; BACTERIAL INFECTION; BAGG ALBINO MOUSE; CELL LINE; CELL WALL; CHEMISTRY; DRUG EFFECTS; DRUG SCREENING; GRAM NEGATIVE BACTERIUM; GRAM POSITIVE BACTERIUM; METABOLISM; MICROBIOLOGY; MOLECULAR LIBRARY;

ANIMALS; ANTI-BACTERIAL AGENTS; BACTERIAL INFECTIONS; BETA-LACTAMS; CELL LINE; CELL WALL; COLONY COUNT, MICROBIAL; CYTOSOL; DRUG EVALUATION, PRECLINICAL; DRUG SYNERGISM; GRAM-NEGATIVE BACTERIA; GRAM-POSITIVE BACTERIA; MICE, INBRED BALB C; PENICILLIN-BINDING PROTEINS; QUINONES; SMALL MOLECULE LIBRARIES;

EID: 84928919905     PISSN: 00664804     EISSN: 10986596     Source Type: Journal    
DOI: 10.1128/AAC.04164-14     Document Type: Article

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