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Volumn 211, Issue 9, 2015, Pages 1408-1417

Effect of influenza A(H5N1) vaccine prepandemic priming on CD4+ T-cell responses

Author keywords

Avian influenza; CD4+ T cells; H5N1; Influenza; Influenza vaccine; Pandemic influenza

Indexed keywords

EPITOPE; HEMAGGLUTININ; INFLUENZA A/INDONESIA/5/05(H5N1) VACCINE; INFLUENZA A/THAILAND/4(SP-528)/04(H5N1); INFLUENZA A/VIETNAM/1203/2004 VACCINE; INFLUENZA VACCINE; NEUTRALIZING ANTIBODY; NUCLEOPROTEIN; UNCLASSIFIED DRUG;

EID: 84928911808     PISSN: 00221899     EISSN: 15376613     Source Type: Journal    
DOI: 10.1093/infdis/jiu616     Document Type: Article
Times cited : (42)

References (50)
  • 1
    • 84928914013 scopus 로고    scopus 로고
    • Cumulative number of confirmed human cases for avian influenza A (H5N1) reported to WHO, 2003-2014 Accessed 19 June 2014
    • Cumulative number of confirmed human cases for avian influenza A (H5N1) reported to WHO, 2003-2014. http://www.who.int/influenza/human-animal-interface/EN-GIP-20140124CumulativeNumberH5N1 cases.pdf?ua=1. Accessed 19 June 2014.
  • 2
    • 42649132198 scopus 로고    scopus 로고
    • Probable limited person-to-person transmission of highly pathogenic avian influenza A (H5N1) virus in China
    • Wang H, Feng Z, Shu Y, et al. Probable limited person-to-person transmission of highly pathogenic avian influenza A (H5N1) virus in China. Lancet 2008; 371:1427-34.
    • (2008) Lancet , vol.371 , pp. 1427-1434
    • Wang, H.1    Feng, Z.2    Shu, Y.3
  • 3
    • 34848819983 scopus 로고    scopus 로고
    • Detecting human-to-human transmission of avian influenza A (H5N1)
    • Yang Y, Halloran ME, Sugimoto JD, Longini IM Jr. Detecting human-to-human transmission of avian influenza A (H5N1). Emerg Infect Dis 2007; 13:1348-53.
    • (2007) Emerg Infect Dis , vol.13 , pp. 1348-1353
    • Yang, Y.1    Halloran, M.E.2    Sugimoto, J.D.3    Longini, I.M.4
  • 4
    • 19944432232 scopus 로고    scopus 로고
    • Probable person-to-person transmission of avian influenza A (H5N1)
    • Ungchusak K, Auewarakul P, Dowell SF, et al. Probable person-to-person transmission of avian influenza A (H5N1). N Engl J Med 2005; 352:333-40.
    • (2005) N Engl J Med , vol.352 , pp. 333-340
    • Ungchusak, K.1    Auewarakul, P.2    Dowell, S.F.3
  • 5
    • 84862618108 scopus 로고    scopus 로고
    • Airborne transmission of influenza A/H5N1 virus between ferrets
    • Herfst S, Schrauwen EJ, Linster M, et al. Airborne transmission of influenza A/H5N1 virus between ferrets. Science 2012; 336:1534-41.
    • (2012) Science , vol.336 , pp. 1534-1541
    • Herfst, S.1    Schrauwen, E.J.2    Linster, M.3
  • 6
    • 84861394598 scopus 로고    scopus 로고
    • Experimental adaptation of an influenza H5 HA confers respiratory droplet transmission to a reassor-tant H5 HA/H1N1 virus in ferrets
    • Imai M, Watanabe T, Hatta M, et al. Experimental adaptation of an influenza H5 HA confers respiratory droplet transmission to a reassor-tant H5 HA/H1N1 virus in ferrets. Nature 2012; 486:420-8.
    • (2012) Nature , vol.486 , pp. 420-428
    • Imai, M.1    Watanabe, T.2    Hatta, M.3
  • 7
    • 84862610867 scopus 로고    scopus 로고
    • The potential for respiratory droplet-transmissible A/H5N1 influenza virus to evolve in a mammalian host
    • Russell CA, Fonville JM, Brown AE, et al. The potential for respiratory droplet-transmissible A/H5N1 influenza virus to evolve in a mammalian host. Science 2012; 336:1541-7.
    • (2012) Science , vol.336 , pp. 1541-1547
    • Russell, C.A.1    Fonville, J.M.2    Brown, A.E.3
  • 8
    • 33645399959 scopus 로고    scopus 로고
    • Safety and immunogenicity of an inactivated subvirion influenza A (H5N1) vaccine
    • Treanor JJ, Campbell JD, Zangwill KM, Rowe T, Wolff M. Safety and immunogenicity of an inactivated subvirion influenza A (H5N1) vaccine. N Engl J Med 2006; 354:1343-51.
    • (2006) N Engl J Med , vol.354 , pp. 1343-1351
    • Treanor, J.J.1    Campbell, J.D.2    Zangwill, K.M.3    Rowe, T.4    Wolff, M.5
  • 9
    • 0035825607 scopus 로고    scopus 로고
    • Safety and immunogenic-ity of a recombinant hemagglutinin vaccine for H5 influenza in humans
    • Treanor JJ, Wilkinson BE, Masseoud F, et al. Safety and immunogenic-ity of a recombinant hemagglutinin vaccine for H5 influenza in humans. Vaccine 2001; 19:1732-7.
    • (2001) Vaccine , vol.19 , pp. 1732-1737
    • Treanor, J.J.1    Wilkinson, B.E.2    Masseoud, F.3
  • 10
    • 40549088240 scopus 로고    scopus 로고
    • Effects of adjuvants on the safety and immunogenicity of an avian influenza H5N1 vaccine in adults
    • Bernstein DI, Edwards KM, Dekker CL, et al. Effects of adjuvants on the safety and immunogenicity of an avian influenza H5N1 vaccine in adults. J Infect Dis 2008; 197:667-75.
    • (2008) J Infect Dis , vol.197 , pp. 667-675
    • Bernstein, D.I.1    Edwards, K.M.2    Dekker, C.L.3
  • 11
    • 84856564196 scopus 로고    scopus 로고
    • Safety and immunogenicity of an MF59((R))-adjuvanted A/H5N1 pre-pandemic influenza vaccine in adults and the elderly
    • Vesikari T, Forsten A, Herbinger KH, et al. Safety and immunogenicity of an MF59((R))-adjuvanted A/H5N1 pre-pandemic influenza vaccine in adults and the elderly. Vaccine 2012; 30:1388-96.
    • (2012) Vaccine , vol.30 , pp. 1388-1396
    • Vesikari, T.1    Forsten, A.2    Herbinger, K.H.3
  • 12
    • 77957701029 scopus 로고    scopus 로고
    • Immunogenicity and safety of MF59-adjuvanted H5N1 influenza vaccine from infancy to adolescence
    • Vesikari T, Karvonen A, Tilman S, et al. Immunogenicity and safety of MF59-adjuvanted H5N1 influenza vaccine from infancy to adolescence. Pediatrics 2010; 126:e762-70.
    • (2010) Pediatrics , vol.126 , pp. e762-e770
    • Vesikari, T.1    Karvonen, A.2    Tilman, S.3
  • 13
    • 67650566442 scopus 로고    scopus 로고
    • Immunogenicity and adverse events of avian influenza A H5N1 vaccine in healthy adults: Multiple-treatments meta-analysis
    • Manzoli L, Salanti G, De Vito C, Boccia A, Ioannidis JP, Villari P. Immunogenicity and adverse events of avian influenza A H5N1 vaccine in healthy adults: multiple-treatments meta-analysis. Lancet Infect Dis 2009; 9:482-92.
    • (2009) Lancet Infect Dis , vol.9 , pp. 482-492
    • Manzoli, L.1    Salanti, G.2    De Vito, C.3    Boccia, A.4    Ioannidis, J.P.5    Villari, P.6
  • 14
    • 0035897889 scopus 로고    scopus 로고
    • Safety and antigenicity of non-adjuvanted and MF59-adjuvanted influenza A/Duck/Singapore/97 (H5N3) vaccine: A randomised trial of two potential vaccines against H5N1 influenza
    • Nicholson KG, Colegate AE, Podda A, et al. Safety and antigenicity of non-adjuvanted and MF59-adjuvanted influenza A/Duck/Singapore/97 (H5N3) vaccine: a randomised trial of two potential vaccines against H5N1 influenza. Lancet 2001; 357:1937-43.
    • (2001) Lancet , vol.357 , pp. 1937-1943
    • Nicholson, K.G.1    Colegate, A.E.2    Podda, A.3
  • 15
    • 77952327363 scopus 로고    scopus 로고
    • Vaccinate before the next pandemic?
    • Stohr K. Vaccinate before the next pandemic? Nature 2010; 465:161.
    • (2010) Nature , vol.465 , pp. 161
    • Stohr, K.1
  • 16
    • 84864571656 scopus 로고    scopus 로고
    • Influenza virus surveillance, vaccine strain selection, and manufacture
    • Stohr K, Bucher D, Colgate T, Wood J. Influenza virus surveillance, vaccine strain selection, and manufacture. Methods Mol Biol 2012; 865:147-62.
    • (2012) Methods Mol Biol , vol.865 , pp. 147-162
    • Stohr, K.1    Bucher, D.2    Colgate, T.3    Wood, J.4
  • 17
    • 50949099930 scopus 로고    scopus 로고
    • Immune responses of healthy subjects to a single dose of intramuscular inactivated influenza A/Vietnam/1203/2004 (H5N1) vaccine after priming with an antigenic variant
    • Goji NA, Nolan C, Hill H, et al. Immune responses of healthy subjects to a single dose of intramuscular inactivated influenza A/Vietnam/1203/2004 (H5N1) vaccine after priming with an antigenic variant. J Infect Dis 2008; 198:635-41.
    • (2008) J Infect Dis , vol.198 , pp. 635-641
    • Goji, N.A.1    Nolan, C.2    Hill, H.3
  • 18
    • 79751471067 scopus 로고    scopus 로고
    • Safety and immunogenicity of influenza A H5 subunit vaccines: Effect of vaccine schedule and antigenic variant
    • Belshe RB, Frey SE, Graham I, et al. Safety and immunogenicity of influenza A H5 subunit vaccines: effect of vaccine schedule and antigenic variant. J Infect Dis 2011; 203:666-73.
    • (2011) J Infect Dis , vol.203 , pp. 666-673
    • Belshe, R.B.1    Frey, S.E.2    Graham, I.3
  • 19
    • 84901753162 scopus 로고    scopus 로고
    • A Live Attenuated Influenza A(H5N1) Vaccine Induces Long-Term Immunity in the Absence of a Primary Antibody Response
    • Talaat KR, Luke CJ, Khurana S, et al. A Live Attenuated Influenza A(H5N1) Vaccine Induces Long-Term Immunity in the Absence of a Primary Antibody Response. J Infect Dis 2014; 209:1860-9.
    • (2014) J Infect Dis , vol.209 , pp. 1860-1869
    • Talaat, K.R.1    Luke, C.J.2    Khurana, S.3
  • 20
    • 53749098101 scopus 로고    scopus 로고
    • Antigenically distinct MF59-adjuvanted vaccine to boost immunity to H5N1
    • Stephenson I, Nicholson KG, Hoschler K, et al. Antigenically distinct MF59-adjuvanted vaccine to boost immunity to H5N1. N Engl J Med 2008; 359:1631-3.
    • (2008) N Engl J Med , vol.359 , pp. 1631-1633
    • Stephenson, I.1    Nicholson, K.G.2    Hoschler, K.3
  • 21
    • 84899698087 scopus 로고    scopus 로고
    • Heterologous prime-boost vaccination with MF59-adjuvanted H5 vaccines promotes antibody affinity maturation towards the hemagglutinin HA1 domain and broad H5N1 cross-clade neutralization
    • Khurana S, Coyle EM, Dimitrova M, et al. Heterologous prime-boost vaccination with MF59-adjuvanted H5 vaccines promotes antibody affinity maturation towards the hemagglutinin HA1 domain and broad H5N1 cross-clade neutralization. PLoS One 2014; 9:e95496.
    • (2014) PLoS One , vol.9 , pp. e95496
    • Khurana, S.1    Coyle, E.M.2    Dimitrova, M.3
  • 22
    • 66049086576 scopus 로고    scopus 로고
    • Fast rise of broadly cross-reactive antibodies after boosting long-lived human memory B cells primed by an MF59 adjuvanted prepandemic vaccine
    • Galli G, Hancock K, Hoschler K, et al. Fast rise of broadly cross-reactive antibodies after boosting long-lived human memory B cells primed by an MF59 adjuvanted prepandemic vaccine. Proc Natl Acad Sci USA 2009; 106:7962-7.
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 7962-7967
    • Galli, G.1    Hancock, K.2    Hoschler, K.3
  • 23
    • 73949109146 scopus 로고    scopus 로고
    • B cell responses to H5 influenza HA in human subjects vaccinated with a drifted variant
    • Baer J, Santiago F, Yang H, et al. B cell responses to H5 influenza HA in human subjects vaccinated with a drifted variant. Vaccine 2010; 28:907-15.
    • (2010) Vaccine , vol.28 , pp. 907-915
    • Baer, J.1    Santiago, F.2    Yang, H.3
  • 24
    • 79952675131 scopus 로고    scopus 로고
    • Follicular helper CD4 T cells (TFH)
    • Crotty S. Follicular helper CD4 T cells (TFH). Annu Rev Immunol 2011; 29:621-63.
    • (2011) Annu Rev Immunol , vol.29 , pp. 621-663
    • Crotty, S.1
  • 25
    • 79956079578 scopus 로고    scopus 로고
    • Germinal center B and follicular helper T cells: Siblings, cousins or just good friends?
    • Nutt SL, Tarlinton DM. Germinal center B and follicular helper T cells: siblings, cousins or just good friends? Nat Immunol 2011; 12:472-7.
    • (2011) Nat Immunol , vol.12 , pp. 472-477
    • Nutt, S.L.1    Tarlinton, D.M.2
  • 26
    • 84873674970 scopus 로고    scopus 로고
    • T-cell subsets in the germinal center
    • Ramiscal RR, Vinuesa CG. T-cell subsets in the germinal center. Immunol Rev 2013; 252:146-55.
    • (2013) Immunol Rev , vol.252 , pp. 146-155
    • Ramiscal, R.R.1    Vinuesa, C.G.2
  • 27
    • 84864303294 scopus 로고    scopus 로고
    • The origins, function, and regulation of T follicular helper cells
    • Ma CS, Deenick EK, Batten M, Tangye SG. The origins, function, and regulation of T follicular helper cells. J Exp Med 2012; 209: 1241-53.
    • (2012) J Exp Med , vol.209 , pp. 1241-1253
    • Ma, C.S.1    Deenick, E.K.2    Batten, M.3    Tangye, S.G.4
  • 28
    • 84871767448 scopus 로고    scopus 로고
    • CD4 T-cell expansion predicts neutralizing antibody responses to monovalent inactivated pandemic H1N1 influenza vaccine
    • Nayak JL, Fitzgerald TF, Richards KA, Yang H, Treanor JJ, Sant AJ. CD4 T-cell expansion predicts neutralizing antibody responses to monovalent inactivated pandemic H1N1 influenza vaccine. J Infect Dis 2013; 207:297-305.
    • (2013) J Infect Dis , vol.207 , pp. 297-305
    • Nayak, J.L.1    Fitzgerald, T.F.2    Richards, K.A.3    Yang, H.4    Treanor, J.J.5    Sant, A.J.6
  • 29
    • 62649105609 scopus 로고    scopus 로고
    • Adjuvanted H5N1 vaccine induces early CD4+ T cell response that predicts long-term persistence of protective antibody levels
    • Galli G, Medini D, Borgogni E, et al. Adjuvanted H5N1 vaccine induces early CD4+ T cell response that predicts long-term persistence of protective antibody levels. Proc Natl Acad Sci USA 2009; 106:3877-82.
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 3877-3882
    • Galli, G.1    Medini, D.2    Borgogni, E.3
  • 30
    • 84862852859 scopus 로고    scopus 로고
    • T-Helper 1 cells elicited by H5N1 vaccination predict seroprotection
    • Pedersen GK, Madhun AS, Breakwell L, et al. T-Helper 1 Cells Elicited by H5N1 Vaccination Predict Seroprotection. J Infect Dis 2012; 206:158-66.
    • (2012) J Infect Dis , vol.206 , pp. 158-166
    • Pedersen, G.K.1    Madhun, A.S.2    Breakwell, L.3
  • 31
    • 84875129611 scopus 로고    scopus 로고
    • Induction of ICOS-+CXCR3+CXCR5+ TH cells correlates with antibody responses to influenza vaccination
    • Bentebibel SE, Lopez S, Obermoser G, et al. Induction of ICOS-+CXCR3+CXCR5+ TH cells correlates with antibody responses to influenza vaccination. Sci Transl Med 2013; 5:176ra32.
    • (2013) Sci Transl Med , vol.5 , pp. 176ra32
    • Bentebibel, S.E.1    Lopez, S.2    Obermoser, G.3
  • 32
    • 84883334148 scopus 로고    scopus 로고
    • Human circulating influenza-CD4+ ICOS1+IL-21+ T cells expand after vaccination, exert helper function, and predict antibody responses
    • Spensieri F, Borgogni E, Zedda L, et al. Human circulating influenza-CD4+ ICOS1+IL-21+ T cells expand after vaccination, exert helper function, and predict antibody responses. Proc Natl Acad Sci USA 2013; 110:14330-5.
    • (2013) Proc Natl Acad Sci USA , vol.110 , pp. 14330-14335
    • Spensieri, F.1    Borgogni, E.2    Zedda, L.3
  • 33
    • 84880648571 scopus 로고    scopus 로고
    • Cutting edge: Heterosubtypic influenza infection antagonizes elicitation of immunological reactivity to hemag-glutinin
    • Nayak JL, Alam S, Sant AJ. Cutting edge: Heterosubtypic influenza infection antagonizes elicitation of immunological reactivity to hemag-glutinin. J Immunol 2013; 191:1001-5.
    • (2013) J Immunol , vol.191 , pp. 1001-1005
    • Nayak, J.L.1    Alam, S.2    Sant, A.J.3
  • 34
    • 84890888709 scopus 로고    scopus 로고
    • CD4 T cell help is limiting and selective during the primary B cell response to influenza virus infection
    • Alam S, Knowlden ZA, Sangster MY, Sant AJ. CD4 T cell help is limiting and selective during the primary B cell response to influenza virus infection. J Virol 2014; 88:314-24.
    • (2014) J Virol , vol.88 , pp. 314-324
    • Alam, S.1    Knowlden, Z.A.2    Sangster, M.Y.3    Sant, A.J.4
  • 35
    • 84855857028 scopus 로고    scopus 로고
    • Infection with seasonal influenza virus elicits CD4 T cells specific for genetically conserved epitopes that can be rapidly mobilized for protective immunity to pandemic H1N1 influenza virus
    • Alam S, Sant AJ. Infection with seasonal influenza virus elicits CD4 T cells specific for genetically conserved epitopes that can be rapidly mobilized for protective immunity to pandemic H1N1 influenza virus. J Virol 2011; 85:13310-21.
    • (2011) J Virol , vol.85 , pp. 13310-13321
    • Alam, S.1    Sant, A.J.2
  • 36
    • 78149483541 scopus 로고    scopus 로고
    • Cutting edge: CD4 T cells generated from encounter with seasonal influenza viruses and vaccines have broad protein specificity and can directly recognize naturally generated epitopes derived from the live pandemic H1N1 virus
    • Richards KA, Topham D, Chaves FA, Sant AJ. Cutting edge: CD4 T cells generated from encounter with seasonal influenza viruses and vaccines have broad protein specificity and can directly recognize naturally generated epitopes derived from the live pandemic H1N1 virus. J Immunol 2010; 185:4998-5002.
    • (2010) J Immunol , vol.185 , pp. 4998-5002
    • Richards, K.A.1    Topham, D.2    Chaves, F.A.3    Sant, A.J.4
  • 37
    • 0033041241 scopus 로고    scopus 로고
    • Detection of antibody to avian influenza A (H5N1) virus in human serum by using a combination of serologic assays
    • Rowe T, Abernathy RA, Hu-Primmer J, et al. Detection of antibody to avian influenza A (H5N1) virus in human serum by using a combination of serologic assays. J Clin Microbiol 1999; 37:937-43.
    • (1999) J Clin Microbiol , vol.37 , pp. 937-943
    • Rowe, T.1    Abernathy, R.A.2    Hu-Primmer, J.3
  • 38
    • 44649180474 scopus 로고    scopus 로고
    • Selective CD4+ T cell help for antibody responses to a large viral pathogen: Deterministic linkage of specificities
    • Sette A, Moutaftsi M, Moyron-Quiroz J, et al. Selective CD4+ T cell help for antibody responses to a large viral pathogen: deterministic linkage of specificities. Immunity 2008; 28:847-58.
    • (2008) Immunity , vol.28 , pp. 847-858
    • Sette, A.1    Moutaftsi, M.2    Moyron-Quiroz, J.3
  • 39
    • 84859717525 scopus 로고    scopus 로고
    • Germinal center selection and the development of memory B and plasma cells
    • Shlomchik MJ, Weisel F. Germinal center selection and the development of memory B and plasma cells. Immunol Rev 2012; 247:52-63.
    • (2012) Immunol Rev , vol.247 , pp. 52-63
    • Shlomchik, M.J.1    Weisel, F.2
  • 41
    • 40749139110 scopus 로고    scopus 로고
    • Healthy human subjects have CD4+ T cells directed against H5N1 influenza virus
    • Roti M, Yang J, Berger D, Huston L, James EA, Kwok WW. Healthy human subjects have CD4+ T cells directed against H5N1 influenza virus. J Immunol 2008; 180:1758-68.
    • (2008) J Immunol , vol.180 , pp. 1758-1768
    • Roti, M.1    Yang, J.2    Berger, D.3    Huston, L.4    James, E.A.5    Kwok, W.W.6
  • 42
    • 0033564710 scopus 로고    scopus 로고
    • Human CD8+ and CD4+ T lymphocyte memory to influenza A viruses of swine and avian species
    • Jameson J, Cruz J, Terajima M, Ennis FA. Human CD8+ and CD4+ T lymphocyte memory to influenza A viruses of swine and avian species. J Immunol 1999; 162:7578-83.
    • (1999) J Immunol , vol.162 , pp. 7578-7583
    • Jameson, J.1    Cruz, J.2    Terajima, M.3    Ennis, F.A.4
  • 43
    • 67449090726 scopus 로고    scopus 로고
    • Infection of HLA-DR1 transgenic mice with a human isolate of influenza a virus (H1N1) primes a diverse CD4 T-cell repertoire that includes CD4 T cells with heterosubtypic cross-reactivity to avian (H5N1) influenza virus
    • Richards KA, Chaves FA, Sant AJ. Infection of HLA-DR1 transgenic mice with a human isolate of influenza a virus (H1N1) primes a diverse CD4 T-cell repertoire that includes CD4 T cells with heterosubtypic cross-reactivity to avian (H5N1) influenza virus. J Virol 2009; 83:6566-77.
    • (2009) J Virol , vol.83 , pp. 6566-6577
    • Richards, K.A.1    Chaves, F.A.2    Sant, A.J.3
  • 44
    • 77954240468 scopus 로고    scopus 로고
    • In vitro responsesto avian influenza H5 by human CD4 T cells
    • Cusick MF, Wang S, Eckels DD. In vitro responsesto avian influenza H5 by human CD4 T cells. J Immunol 2009; 183:6432-41.
    • (2009) J Immunol , vol.183 , pp. 6432-6441
    • Cusick, M.F.1    Wang, S.2    Eckels, D.D.3
  • 45
    • 55849125109 scopus 로고    scopus 로고
    • Memory T cells established by seasonal human influenza A infection cross-react with avian influenza A (H5N1) in healthy individuals
    • Lee LY, Ha do LA, Simmons C, et al. Memory T cells established by seasonal human influenza A infection cross-react with avian influenza A (H5N1) in healthy individuals. J Clin Invest 2008; 118:3478-90.
    • (2008) J Clin Invest , vol.118 , pp. 3478-3490
    • Lee, L.Y.1    Ha Do, L.A.2    Simmons, C.3
  • 46
    • 84871135645 scopus 로고    scopus 로고
    • A randomized clinical trial of an inactivated avian influenza A (H7N7) vaccine
    • Couch RB, Patel SM, Wade-Bowers CL, Nino D. A randomized clinical trial of an inactivated avian influenza A (H7N7) vaccine. PLoS One 2012; 7:e49704.
    • (2012) PLoS One , vol.7 , pp. e49704
    • Couch, R.B.1    Patel, S.M.2    Wade-Bowers, C.L.3    Nino, D.4
  • 47
    • 61349200100 scopus 로고    scopus 로고
    • A phase i clinical trial of a PER.C6 cell grown influenza H7 virus vaccine
    • Cox RJ, Madhun AS, Hauge S, et al. A phase I clinical trial of a PER.C6 cell grown influenza H7 virus vaccine. Vaccine 2009; 27:1889-97.
    • (2009) Vaccine , vol.27 , pp. 1889-1897
    • Cox, R.J.1    Madhun, A.S.2    Hauge, S.3
  • 48
    • 84862776631 scopus 로고    scopus 로고
    • Preexisting influenza-specific CD4(+) T cells correlate with disease protection against influenza challenge in humans
    • Wilkinson TM, Li CK, Chui CS, et al. Preexisting influenza-specific CD4(+) T cells correlate with disease protection against influenza challenge in humans. Nat Med 2012; 18:274-80.
    • (2012) Nat Med , vol.18 , pp. 274-280
    • Wilkinson, T.M.1    Li, C.K.2    Chui, C.S.3


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