Acute traumatic coagulopathy: Whole blood thrombelastography measures the tip of the iceberg

Journal of Trauma and Acute Care Surgery

Volumn 78, Issue 5, 2015, Pages 955-961

  Campbell, James Eric ^a   Aden, James Keith ^b   Cap, Andrew Peter ^b  

^a WILFORD HALL MEDICAL CENTER   (United States)

^b US ARMY INSTITUTE OF SURGICAL RESEARCH   (United States)

Author keywords

acidemia; Erythrocyte; red blood cells; thrombelastography; tissue factor

Indexed keywords

BUFFER; SODIUM CHLORIDE; BIOLOGICAL MARKER;

ACIDEMIA; ACUTE TRAUMATIC COAGULOPATHY; ARTICLE; BLOOD CLOTTING DISORDER; BLOOD CLOTTING PARAMETERS; BLOOD SAMPLING; CENTRIFUGE; CLOT STRENGTH; ERYTHROCYTE; HEMATOCRIT; HUMAN; MALE; NORMAL HUMAN; PH; PRIORITY JOURNAL; SHEAR ELASTIC MODULUS STRENGTH; THROMBOCYTE POOR PLASMA; THROMBOCYTE RICH PLASMA; THROMBOELASTOGRAPHY; WHOLE BLOOD THROMBELASTOGRAPHY; YOUNG MODULUS; ADULT; BLOOD; BLOOD CLOTTING; BLOOD COAGULATION DISORDERS; BLOOD DONOR; COMPLICATION; INJURY SCALE; PREDICTIVE VALUE; PROCEDURES; WOUNDS AND INJURIES;

ADULT; BIOLOGICAL MARKERS; BLOOD COAGULATION; BLOOD COAGULATION DISORDERS; BLOOD DONORS; HEALTHY VOLUNTEERS; HUMANS; MALE; PREDICTIVE VALUE OF TESTS; THROMBELASTOGRAPHY; TRAUMA SEVERITY INDICES; WOUNDS AND INJURIES;

EID: 84928902139     PISSN: 21630755     EISSN: 21630763     Source Type: Journal    
DOI: 10.1097/TA.0000000000000586     Document Type: Article

References (36)

1. Heron M. Deaths: leading causes for 2009. Natl Vital Stat Rep. 2012; 61(7):1-96.
2. Sauaia A, Moore FA, Moore EE, Moser KS, Brennan R, Read RA, Pons PT. Epidemiology of trauma deaths: a reassessment. J Trauma. 1995;38(2):185-193.
3. Blackbourne LH, Czarnik J, Mabry R, Eastridge B, Baer D, Butler F, Pruitt B Jr. Decreasing killed in action and died of wounds rates in combat wounded. J Trauma. 2010;69:S1YS4.
4. Eastridge BJ, Hardin M, Cantrell J, Oetjen-Gerdes L, Zubko T, Mallak C, Wade CE, Simmons J, Mace J, Mabry R, et al. Died of wounds on the battlefield: causation and implications for improving combat casualty care. J Trauma. 2011;71(1 Suppl):S4YS8.
5. Brohi K, Singh J, Heron M, Coats T. Acute traumatic coagulopathy. J Trauma. 2003;54(6):1127-1130.
6. Frith D, Goslings JC, Gaarder C, Maegele M, Cohen MJ, Allard S, Johansson PI, Stanworth S, Thiemermann C, Brohi K. Definition and drivers of acute traumatic coagulopathy: clinical and experimental investigations. J Thromb Haemost. 2010;8(9):1919-1925.
7. Brohi K, Cohen MJ, Ganter MT, Matthay MA, Mackersie RC, Pittet JF. Acute traumatic coagulopathy: initiated by hypoperfusionVmodulated through the protein C pathway? Ann Surg. 2007;245(5):812-818.
8. Cheddie S, Muckart DJJ, Hardcastle TC. Base deficit as an early marker of coagulopathy in trauma. S Afr J Surg. 2013;51(3):88-90.
9. Lee TH,McCullyBH,Underwood SJ, CottonBA,CohenMJ, SchreiberMA. Correlation of conventional thrombelastography and rapid thrombelastography in trauma. Am J Surg. 2013;205(5):521-527.
10. Harr JN, Moore EE, Wohlauer MV, Droz N, Fragoso M, Banerjee A, Silliman CC. The acute coagulopathy of trauma is due to impaired initial thrombin generation but not clot formation or clot strength. J Surg Res. 2011;170(2):319-324.
11. da Luz LT, Nascimento B, Rizoli S. Thrombelastography (TEG (R)): practical considerations on its clinical use in trauma resuscitation. Scand J Trauma Resusc Emerg Med. 2013;21:29.
12. Bochsen L, Johansson PI, Kristensen AT, Daugaard G, Ostrowski SR. The influence of platelets, plasma and red blood cells on functional haemostatic assays. Blood Coagul Fibrinolysis. 2011;22(3):167-175.
13. Ramaker A, Meyer P, van der Meer J, Struys M, Lisman T, van OeverenW, Hendriks HG. Effects of acidosis, alkalosis, hyperthermia and hypothermia on haemostasis: results of point of care testing with the thromboelastography analyser. Blood Coagul Fibrinolysis. 2009;20(6):436-439.
14. Engstrom M, Schott U, Romner B, Reinstrup P. Acidosis impairs the coagulation: a thromboelastographic study. J Trauma. 2006;61(3): 624-628.
15. Drucker WR, Chadwick CJ, Gann DS. Transcapillary refill in hemorrhage and shock. Arch Surg. 1981;116(10):1344-1353.
16. Thorson CM, Van Haren RM, Ryan ML, Pereira R, Olloqui J, Guarch GA, Barrera JM, Busko AM, Livingstone AS, Proctor KG. Admission hematocrit and transfusion requirements after trauma. J Am Coll Surg. 2013;216(1):65-73.
17. Dunham CM, Siegel JH, Weireter L, Fabian M, Goodarzi S, Guadalupi P, Gettings L, Linberg SE, Vary TC. Oxygen debt and metabolic acidemia as quantitative predictors of mortality and the severity of the ischemic insult in hemorrhagic-shock. Crit Care Med. 1991;19(2):231-243.
18. Meng ZH, Wolberg AS, Monroe DM, Hoffman M. The effect of temperature and pH on the activity of factor VIIa: implications for the efficacy of high-dose factor VIIa in hypothermic and acidotic patients. J Trauma. 2003;55(5):886-891.
19. Lipowsky HH, Usami S, Chien S. In vivo measurements of ''apparent viscosity'' and microvessel hematocrit in the mesentery of the cat. Microvasc Res. 1980;19(3):297-319.
20. Puyana JC, Soller BR, Parikh B, Heard SO. Directly measured tissue pH is an earlier indicator of splanchnic acidosis than tonometric parameters during hemorrhagic shock in swine. Crit Care Med. 2000;28(7):2557-2562.
21. Surgenor DM. Transport of oxygen and carbon dioxide. In: Bishop C, Surgenor DM, eds. The Red Blood Cell. New York, NY: Academic Press; 1964.
22. Sun L, Strelow H, Mies G, Veltkamp R. Oxygen therapy improves energy metabolism in focal cerebral ischemia. Brain Res. 2011;1415:103-108.
23. Ganter MT, Hofer CK. Coagulation monitoring: current techniques and clinical use of viscoelastic point-of-care coagulation devices. Anesth Analg. 2008;106(5):1366-1375.
24. Johansson PI, Stissing T, Bochsen L, Ostrowski SR. Thrombelastography and tromboelastometry in assessing coagulopathy in trauma. Scand J Trauma Resusc Emerg Med. 2009;17:45.
25. Levrat A, Gros A, Rugeri L, Inaba K, Floccard B, Negrier C, David JS. Evaluation of rotation thrombelastography for the diagnosis of hyperfibrinolysis in trauma patients. Br J Anaesth. 2008;100(6):792-797.
26. Carroll RC, Craft RM, Langdon RJ, Clanton CR, Snider CC,Wellons DD, Dakin PA, Lawson CM, Enderson BL, Kurek SJ. Early evaluation of acute traumatic coagulopathy by thrombelastography. Transl Res. 2009; 154(1):34-39.
27. Hagemo JS. Prehospital detection of traumatic coagulopathy. Transfusion. 2013;53:48SY51S.
28. DukeWW. The relation of blood platelets to hemorrhagic diseaseVdescription of a method for determining the bleeding time and coagulation time and report of three cases of hemorrhagic disease relieved by transfusion. JAMA. 1910;55:1185-1192.
29. Cadroy Y, Hanson SR. Effects of red-blood-cell concentration on hemostasis and thrombus formation in a primate model. Blood. 1990;75(11): 2185-2193.
30. Wohlauer MV, Moore EE, Droz NM, Harr J, Gonzalez E, Fragoso M, Silliman CC. Hemodilution is not critical in the pathogenesis of the acute coagulopathy of trauma. J Surg Res. 2012;173(1):26-30.
31. Mann KG. Thrombin generation in hemorrhage control and vascular occlusion. Circulation. 2011;124(2):225-235.
32. Rourke C, Curry N, Khan S, Taylor R, Raza I, Davenport R, Stanworth S, Brohi K. Fibrinogen levels during trauma hemorrhage, response to replacement therapy, and association with patient outcomes. J Thromb Haemost. 2012;10(7):1342-1351.
33. Plotkin AJ, Wade CE, Jenkins DH, Smith KA, Noe JC, Park MS, Perkins JG, Holcomb JB. A reduction in clot formation rate and strength assessed by thrombelastography is indicative of transfusion requirements in patients with penetrating injuries. J Trauma. 2008;64(2):S64YS68.
34. Kaufmann CR, Dwyer KM, Crews JD, Dols SJ, Trask AL. Usefulness of thrombelastography in assessment of trauma patient coagulation. J Trauma. 1997;42(4):716-722.
35. Schreiber MA, Differding J, Thorborg P, Mayberry JC, Mullins RJ. Hypercoagulability is most prevalent early after injury and in female patients. J Trauma. 2005;58(3):475-480.
36. Rugeri L, Levrat A, David JS, Delecroix E, Floccard B, Gros A, Allaouchiche B, Negrier C. Diagnosis of early coagulation abnormalities in trauma patients by rotation thrombelastography. J Thromb Haemost. 2007;5(2):289-295.