Effects of acidosis, alkalosis, hyperthermia and hypothermia on haemostasis: Results of point of care testing with the thromboelastography analyser

Blood Coagulation and Fibrinolysis

Volumn 20, Issue 6, 2009, Pages 436-439

  Ramaker, Albert J D W R ^a   Meyer, Peter ^a   Van Der Meer, Jan ^a   Struys, Michel M R F ^a   Lisman, Ton ^a   Van Oeveren, Wim ^a   Hendriks, Herman G D ^a  

^a UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

Author keywords

Coagulation; pH; Temperature; Thromboelastography

Indexed keywords

ACIDIFICATION; ACIDOSIS; ADULT; ALKALOSIS; ARTICLE; BLOOD CLOTTING; BLOOD SAMPLING; CONTROLLED STUDY; FEMALE; HEMOSTASIS; HUMAN; HYPERTHERMIA; HYPOTHERMIA; MALE; PARTIAL THROMBOPLASTIN TIME; PH MEASUREMENT; POINT OF CARE TESTING; PRIORITY JOURNAL; PROTHROMBIN TIME; TEMPERATURE SENSITIVITY; THROMBOELASTOGRAPHY;

ACIDOSIS; ADULT; ALKALOSIS; CALCIUM; FEMALE; FEVER; FIBRINOGEN; HEMOSTASIS; HUMANS; HYDROGEN-ION CONCENTRATION; HYPOTHERMIA; MALE; MIDDLE AGED; MONITORING, INTRAOPERATIVE; PLATELET COUNT; POINT-OF-CARE SYSTEMS; TEMPERATURE; THROMBELASTOGRAPHY;

EID: 69549138772     PISSN: 09575235     EISSN: None     Source Type: Journal    
DOI: 10.1097/MBC.0b013e32832dc327     Document Type: Article

References (14)

1. Shander A. Financial and clinical outcomes associated with surgical bleeding complications. Surgery 2007; 142:20-25.
2. Cosgriff N, Moore EE, Sauaia A, Kenny-Moynihan M, Burch JM, Galloway B. Predicting life-threatening coagulopathy in the massively transfused trauma patient: hypothermia and acidoses revisited. J Trauma 1997; 42:857-861. (Pubitemid 27258316)
3. Engström M, Schött U, Romner B, Reinstrup P. Acidosis impairs the coagulation: a Thromboelastographic Study. J Trauma 2006; 61:624-628. (Pubitemid 44400945)
4. Martini WZ, Holcomb JB. Acidosis and coagulopathy: the differential effects on fibrinogen synthesis and breakdown in pigs. Ann Surg 2007; 246:831-835.
5. Rohrer MJ, Natale AM. Effect of hypothermia on the coagulation cascade. Crit Care Med 1992; 20:1402-1405.
6. Watts DD, Trask A, Soeken K, Perdue P, Dols S, Kaufmann C. Hypothermic coagulopathy in trauma: effect of varying levels of hypothermia on enzyme speed, platelet function, and fibrinolytic activity. J Trauma 1998; 44:846-854. (Pubitemid 28233032)
7. Hartert H. Blutgerinnungsstudien mit der Thrombelastographie, einem neuen Untersuchungsverfahren [Thrombelastography, a new method for physical analysis of blood coagulation]. Klinische Wochenschrift 1948; 26:577-583.
8. Luddington RJ. Thrombelastography/thromboelastometry. Clin Lab Haem 2005; 27:81-90.
9. Kang YG, Martin DJ, Marquez J, Lewis JH, Bontempo FA, Shaw BW Jr, et al. Intraoperative changes in blood coagulation and thrombelastographic monitoring in liver transplantation. Anesth Analg 1985; 64:888-896. (Pubitemid 15015038)
10. Dirkmann D, Hanke AA, Görlinger K, Peters J. Hypothermia and acidosis synergistically impair coagulation in human whole blood. Anesth Analg 2008; 106:1627-1632.
11. Dunn EL, Moore EE, Breslich DJ, Galloway WB. Acidosis induced coagulopathy. Surg Forum 1979; 30:471-473.
12. Wolberg AS, Meng ZH, Monroe DM, Hoffman M. A systematic evaluation of the effect of temperature on coagulation enzyme activity and platelet function. J Trauma 2004; 56:1221-1228. (Pubitemid 38901832)
13. Xavier RG, White AE, Fox SC, Wilcox RG, Heptinstall S. Enhanced platelet aggregation and activation under conditions of hypothermia. Thromb Haemost 2007; 98:1266-1275. (Pubitemid 350252857)
14. James MFM, Roche AM. Dose-response relationship between plasma ionized calcium concentration and thrombelastography. J Cardiothorac Vasc Anesth 2004; 18:581-586.