Dietary iron supplementation: A proinflammatory attack on the intestine?

Gut

Volumn 64, Issue 5, 2015, Pages 696-697

  Weiss, Guenter ^a  

^a INNSBRUCK MEDICAL UNIVERSITY   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

CALGRANULIN; HEPCIDIN; IRON INTAKE;

BACTERIAL FLORA; CLINICAL DECISION MAKING; CLOSTRIDIA; DIARRHEA; DISEASE ASSOCIATION; ENTERITIS; ESCHERICHIA COLI; HUMAN; IMMUNE RESPONSE; INCIDENCE; INFLAMMATORY BOWEL DISEASE; INTESTINE FLORA; IRON DEFICIENCY ANEMIA; IRON FORTIFICATION; IRON THERAPY; KENYA; MICRONUTRIENT POWDER; NONHUMAN; NOTE; OUTCOME ASSESSMENT; POWDER; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL (TOPIC); RISK BENEFIT ANALYSIS; SENSITIVITY AND SPECIFICITY; SHIGELLA; SPECIES COMPOSITION; SUPPLEMENTATION; TROPICS; ADVERSE EFFECTS; CHEMICALLY INDUCED; DIET SUPPLEMENTATION; DRUG EFFECTS; ENTEROCOLITIS; INTESTINE; IRON INTAKE; MICROBIOLOGY; MICROFLORA;

ENTEROCOLITIS; FOOD, FORTIFIED; HUMANS; INTESTINES; IRON, DIETARY; MICROBIOTA;

EID: 84928892195     PISSN: 00175749     EISSN: 14683288     Source Type: Journal    
DOI: 10.1136/gutjnl-2014-308147     Document Type: Note

References (10)

1. Hershko C, Camaschella C. How I treat unexplained refractory iron deficiency anemia. Blood 2014;123:326-33.
2. Sazawal S, Black RE, Ramsan M, et al. Effects of routine prophylactic supplementation with iron and folic acid on admission to hospital and mortality in preschool children in a high malaria transmission setting: community-based, randomised, placebo-controlled trial. Lancet 2006;367:133-43.
3. Nairz M, Haschka D, Demetz E, et al. Iron at the interface of immunity and infection. Front Pharmacol 2014;5:152.
4. Jaeggi T, Kortman GA, Moretti D, et al. Iron fortification adversely affects the gut microbiome, increases pathogen abundance and induces intestinal inflammation in Kenyan infants. Gut 2015;64:731-42.
5. Gwamaka M, Kurtis JD, Sorensen BE, et al. Iron deficiency protects against severe Plasmodium falciparum malaria and death in young children. Clin Infect Dis 2012;54:1137-44.
6. Pasricha SR, Atkinson SH, Armitage AE, et al. Expression of the iron hormone hepcidin distinguishes different types of anemia in African children. Sci Transl Med 2014;6:235re3.
7. Theurl I, Aigner E, Theurl M, et al. Regulation of iron homeostasis in anemia of chronic disease and iron deficiency anemia: diagnostic and therapeutic implications. Blood 2009;113:5277-86.
8. Koskenkorva-Frank TS, Weiss G, Koppenol WH, et al. The complex interplay of iron metabolism, reactive oxygen species, and reactive nitrogen species: insights into the potential of various iron therapies to induce oxidative and nitrosative stress. Free Radic Biol Med 2013;65:1174-94.
9. Werner T, Wagner SJ, Martinez I, et al. Depletion of luminal iron alters the gut microbiota and prevents Crohn's disease-like ileitis. Gut 2011;60:325-33.
10. Deriu E, Liu JZ, Pezeshki M, et al. Probiotic bacteria reduce salmonella typhimurium intestinal colonization by competing for iron. Cell Host Microbe 2013;14:26-37.