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Volumn 4, Issue 2, 2007, Pages 78-91

Treatment with biologic therapies and the risk of cancer in patients with IBD

Author keywords

[No Author keywords available]

Indexed keywords

ADALIMUMAB; ANTIBIOTIC AGENT; AZATHIOPRINE; CERTOLIZUMAB PEGOL; ETANERCEPT; GLUCOCORTICOID; IMMUNOMODULATING AGENT; IMMUNOSUPPRESSIVE AGENT; INFLIXIMAB; MERCAPTOPURINE; METHOTREXATE; METRONIDAZOLE; NARCOTIC ANALGESIC AGENT; NATALIZUMAB; ONERCEPT; PLACEBO; PREDNISONE; STEROID; TACROLIMUS; THALIDOMIDE; TUMOR NECROSIS FACTOR; TUMOR NECROSIS FACTOR ALPHA ANTIBODY; ANTIINFLAMMATORY AGENT; IMMUNOLOGIC FACTOR; MONOCLONAL ANTIBODY; TUMOR NECROSIS FACTOR ALPHA;

EID: 33847731814     PISSN: 17434378     EISSN: 17434386     Source Type: Journal    
DOI: 10.1038/ncpgasthep0695     Document Type: Review
Times cited : (53)

References (77)
  • 1
    • 0031781603 scopus 로고    scopus 로고
    • Inflammatory bowel disease: Etiology and pathogenesis
    • Fiocchi C (1998) Inflammatory bowel disease: Etiology and pathogenesis. Gastroenterology 115: 182-205
    • (1998) Gastroenterology , vol.115 , pp. 182-205
    • Fiocchi, C.1
  • 2
    • 15544382565 scopus 로고    scopus 로고
    • Immunity, inflammation, and allergy in the gut
    • MacDonald TT and Monteleone G (2005) Immunity, inflammation, and allergy in the gut. Science 307: 1920-1925
    • (2005) Science , vol.307 , pp. 1920-1925
    • MacDonald, T.T.1    Monteleone, G.2
  • 3
    • 0027361432 scopus 로고
    • Construction and initial characterization of a mouse-human chimeric anti-TNF antibody
    • Knight DM et al. (1993) Construction and initial characterization of a mouse-human chimeric anti-TNF antibody. Mol Immunol 30: 1443-1453
    • (1993) Mol Immunol , vol.30 , pp. 1443-1453
    • Knight, D.M.1
  • 4
    • 0038305753 scopus 로고    scopus 로고
    • Crohn's disease: Step up or top down therapy
    • Hanauer SB (2003). Crohn's disease: Step up or top down therapy. Best Pract Res Clin Gastroenterol 17:131-137
    • (2003) Best Pract Res Clin Gastroenterol , vol.17 , pp. 131-137
    • Hanauer, S.B.1
  • 5
    • 31344455134 scopus 로고    scopus 로고
    • Top-down versus step-up approaches to chronic inflammatory bowel disease: Presumed innocent or presumed guilty
    • [Editorial]
    • Hanauer SB (2005) Top-down versus step-up approaches to chronic inflammatory bowel disease: Presumed innocent or presumed guilty. [Editorial] Nat Clin Pract Gastroenterol Hepatol 2: 493
    • (2005) Nat Clin Pract Gastroenterol Hepatol , vol.2 , pp. 493
    • Hanauer, S.B.1
  • 6
    • 1342289293 scopus 로고    scopus 로고
    • Closing fistulas in Crohn's disease - Should the accent be on maintenance or safety?
    • Fiocchi C (2004) Closing fistulas in Crohn's disease - should the accent be on maintenance or safety? N Engl J Med 350: 934-936
    • (2004) N Engl J Med , vol.350 , pp. 934-936
    • Fiocchi, C.1
  • 7
    • 0027131566 scopus 로고
    • Intestinal cancer risk and mortality in patients with Crohn's disease
    • Munkholm P et al. (1993) Intestinal cancer risk and mortality in patients with Crohn's disease. Gastroenterology 105: 1716-1723
    • (1993) Gastroenterology , vol.105 , pp. 1716-1723
    • Munkholm, P.1
  • 8
    • 0029050742 scopus 로고
    • Treatment of Crohn's disease with anti-tumor necrosis factor chimeric monoclonal antibody (cA2)
    • van Dullemen HM et al. (1995) Treatment of Crohn's disease with anti-tumor necrosis factor chimeric monoclonal antibody (cA2). Gastroenterology 109: 129-135
    • (1995) Gastroenterology , vol.109 , pp. 129-135
    • van Dullemen, H.M.1
  • 9
    • 0030954732 scopus 로고    scopus 로고
    • A short-term study of chimeric monoclonal antibody cA2 to tumor necrosis factor alpha for Crohn's disease
    • Targan SR et al. (1997) A short-term study of chimeric monoclonal antibody cA2 to tumor necrosis factor alpha for Crohn's disease. N Engl J Med 337: 1029-1035
    • (1997) N Engl J Med , vol.337 , pp. 1029-1035
    • Targan, S.R.1
  • 10
    • 0032833517 scopus 로고    scopus 로고
    • Efficacy and safety of retreatment with anti-tumor necrosis factor antibody (infliximab) to maintain remission in Crohn's disease
    • Rutgeerts P et al. (1999) Efficacy and safety of retreatment with anti-tumor necrosis factor antibody (infliximab) to maintain remission in Crohn's disease. Gastroenterology 117: 761-769
    • (1999) Gastroenterology , vol.117 , pp. 761-769
    • Rutgeerts, P.1
  • 11
    • 0033529049 scopus 로고    scopus 로고
    • Infliximab for the treatment of fistulas in patients with Crohn's disease
    • Present DH et al. (1999) Infliximab for the treatment of fistulas in patients with Crohn's disease. N Engl J Med 340: 1398-1405
    • (1999) N Engl J Med , vol.340 , pp. 1398-1405
    • Present, D.H.1
  • 12
    • 0037018761 scopus 로고    scopus 로고
    • Maintenance infliximab for Crohn's disease: The ACCENT I randomised trial
    • Hanauer SB et al. (2002) Maintenance infliximab for Crohn's disease: The ACCENT I randomised trial. Lancet 359: 1541-1549
    • (2002) Lancet , vol.359 , pp. 1541-1549
    • Hanauer, S.B.1
  • 13
    • 10744224387 scopus 로고    scopus 로고
    • Comparison of scheduled and episodic treatment strategies of infliximab in Crohn's disease
    • Rutgeerts P et al. (2004) Comparison of scheduled and episodic treatment strategies of infliximab in Crohn's disease. Gastroenterology 126: 402-413
    • (2004) Gastroenterology , vol.126 , pp. 402-413
    • Rutgeerts, P.1
  • 14
    • 10744221312 scopus 로고    scopus 로고
    • Infliximab maintenance therapy for fistulizing Crohn's disease
    • Sands BE et al. (2004) Infliximab maintenance therapy for fistulizing Crohn's disease. N Engl J Med 350: 876-885
    • (2004) N Engl J Med , vol.350 , pp. 876-885
    • Sands, B.E.1
  • 15
    • 0037345583 scopus 로고    scopus 로고
    • Immunomodulators and "on demand" therapy with infliximab in Crohn's disease: Clinical experience with 400 infusions
    • Kinney T et al. (2003) Immunomodulators and "on demand" therapy with infliximab in Crohn's disease: Clinical experience with 400 infusions. Am J Gastroenterol 98: 608-612
    • (2003) Am J Gastroenterol , vol.98 , pp. 608-612
    • Kinney, T.1
  • 16
    • 0347991877 scopus 로고    scopus 로고
    • The safety profile of infliximab in patients with Crohn's disease: The Mayo Clinic experience in 500 patients
    • Colombel JF et al. (2004) The safety profile of infliximab in patients with Crohn's disease: The Mayo Clinic experience in 500 patients. Gastroenterology 126: 19-31
    • (2004) Gastroenterology , vol.126 , pp. 19-31
    • Colombel, J.F.1
  • 17
    • 2442696315 scopus 로고    scopus 로고
    • Infliximab in inflammatory bowel disease: Clinical outcome in a population-based cohort from Stockholm County
    • Ljung et al. (2004) Infliximab in inflammatory bowel disease: Clinical outcome in a population-based cohort from Stockholm County. Gut 53: 849-853
    • (2004) Gut , vol.53 , pp. 849-853
    • Ljung1
  • 18
    • 2442668848 scopus 로고    scopus 로고
    • Balancing the risks and benefits of infliximab in the treatment of inflammatory bowel disease
    • Sandborn WJ and Loftus EV (2004) Balancing the risks and benefits of infliximab in the treatment of inflammatory bowel disease. Gut 53: 780-782
    • (2004) Gut , vol.53 , pp. 780-782
    • Sandborn, W.J.1    Loftus, E.V.2
  • 19
    • 30944442404 scopus 로고    scopus 로고
    • Infliximab and newly diagnosed neoplasia in Crohn's disease: A multicentre matched pair study
    • Biancone L et al. (2006) Infliximab and newly diagnosed neoplasia in Crohn's disease: A multicentre matched pair study. Gut 55: 228-233
    • (2006) Gut , vol.55 , pp. 228-233
    • Biancone, L.1
  • 20
    • 26444478543 scopus 로고    scopus 로고
    • Infliximab in the treatment of Crohn's disease: Predictors of response in an Italian multicentric open study
    • Orlando A et al. (2005) Infliximab in the treatment of Crohn's disease: predictors of response in an Italian multicentric open study. Dig Liver Dis 37: 577-583
    • (2005) Dig Liver Dis , vol.37 , pp. 577-583
    • Orlando, A.1
  • 21
    • 0028135110 scopus 로고
    • Crohn's disease and cancer: A population-based cohort study
    • Persson PG et al. (1994) Crohn's disease and cancer: A population-based cohort study. Gastroenterology 107: 1675-1679
    • (1994) Gastroenterology , vol.107 , pp. 1675-1679
    • Persson, P.G.1
  • 22
    • 0032738644 scopus 로고    scopus 로고
    • The relationship between infliximab treatment and lymphoma in Crohn's disease
    • Bickston SJ et al. (1999) The relationship between infliximab treatment and lymphoma in Crohn's disease. Gastroenterology 117: 1433-1437
    • (1999) Gastroenterology , vol.117 , pp. 1433-1437
    • Bickston, S.J.1
  • 23
    • 0344064951 scopus 로고    scopus 로고
    • Acute leukemia after infliximab therapy
    • Alcain G et al. (2003) Acute leukemia after infliximab therapy. Am J Gastroenterol 98: 2577
    • (2003) Am J Gastroenterol , vol.98 , pp. 2577
    • Alcain, G.1
  • 24
    • 3543106775 scopus 로고    scopus 로고
    • Epstein-Barr virus-associated lymphoma in Crohn's disease
    • Losco A et al. (2004) Epstein-Barr virus-associated lymphoma in Crohn's disease. Inflamm Bowel Dis 10: 425-429
    • (2004) Inflamm Bowel Dis , vol.10 , pp. 425-429
    • Losco, A.1
  • 25
    • 17644366511 scopus 로고    scopus 로고
    • Biologics in inflammatory disease: Infliximab associated risk of lymphoma development
    • Bucher C et al. (2005) Biologics in inflammatory disease: Infliximab associated risk of lymphoma development. Gut 54: 732-733
    • (2005) Gut , vol.54 , pp. 732-733
    • Bucher, C.1
  • 26
    • 22744450192 scopus 로고    scopus 로고
    • Crohn's colitis presenting with node-negative colon cancer and liver metastasis after therapy with infliximab: Report of two cases
    • Nicholson T et al. (2005) Crohn's colitis presenting with node-negative colon cancer and liver metastasis after therapy with infliximab: Report of two cases. Dis Colon Rectum 48: 1651-1655
    • (2005) Dis Colon Rectum , vol.48 , pp. 1651-1655
    • Nicholson, T.1
  • 27
    • 13244270133 scopus 로고    scopus 로고
    • Eruptive tufted angiomas in a patient with Crohn's disease
    • Al-Za'abi AM et al. (2005) Eruptive tufted angiomas in a patient with Crohn's disease. J Clin Pathol 58: 214-216
    • (2005) J Clin Pathol , vol.58 , pp. 214-216
    • Al-Za'abi, A.M.1
  • 28
    • 33947396933 scopus 로고    scopus 로고
    • Carcinoma arising in enterocutan fistulae of Crohn's disease patients: Description of two cases
    • Zagoni T et al. (2005) Carcinoma arising in enterocutan fistulae of Crohn's disease patients: Description of two cases. Int J Colorectal Dis 21: 461-464
    • (2005) Int J Colorectal Dis , vol.21 , pp. 461-464
    • Zagoni, T.1
  • 29
    • 33750530178 scopus 로고    scopus 로고
    • Colon cancer after infliximab therapy for Crohn's disease in a young patient transplanted for primary sclerosing cholangitis
    • Peyrin-Biroulet L et al. (2006) Colon cancer after infliximab therapy for Crohn's disease in a young patient transplanted for primary sclerosing cholangitis. Gut 101: 2664-2665
    • (2006) Gut , vol.101 , pp. 2664-2665
    • Peyrin-Biroulet, L.1
  • 30
    • 33644977514 scopus 로고    scopus 로고
    • A 71-year old woman with Crohns' disease and altered mental status
    • Podolsky DK et al. (2006) A 71-year old woman with Crohns' disease and altered mental status. N Engl J Med 354: 1178-1184
    • (2006) N Engl J Med , vol.354 , pp. 1178-1184
    • Podolsky, D.K.1
  • 31
    • 0034764110 scopus 로고    scopus 로고
    • Inflammatory bowel disease is not associated with an increased risk of lymphoma
    • Lewis JD et al. (2001). Inflammatory bowel disease is not associated with an increased risk of lymphoma. Gastroenterology 121: 1080-1087
    • (2001) Gastroenterology , vol.121 , pp. 1080-1087
    • Lewis, J.D.1
  • 32
    • 0034754283 scopus 로고    scopus 로고
    • Lymphoma risk in inflammatory bowel disease: Influences of referral bias and therapy
    • Loftus VE and Sandborn W (2001) Lymphoma risk in inflammatory bowel disease: Influences of referral bias and therapy. Gastroenterology 121: 1239-1242
    • (2001) Gastroenterology , vol.121 , pp. 1239-1242
    • Loftus, V.E.1    Sandborn, W.2
  • 33
    • 0036900501 scopus 로고    scopus 로고
    • Tumor necrosis factor antagonist therapy and lymphoma development: Twenty-six cases reported to the Food and Drug Administration
    • Brown SL et al. (2002) Tumor necrosis factor antagonist therapy and lymphoma development: Twenty-six cases reported to the Food and Drug Administration. Arthritis Rheum 46: 3151-3158
    • (2002) Arthritis Rheum , vol.46 , pp. 3151-3158
    • Brown, S.L.1
  • 34
    • 33750349656 scopus 로고    scopus 로고
    • Safety of infliximab: Primum non nocere. The safety profile of infliximab in patients with Crohn's disease: The Mayo Clinic experience in 500 patients
    • Parsi MA and Lashner BA (2004) Safety of infliximab: Primum non nocere. The safety profile of infliximab in patients with Crohn's disease: The Mayo Clinic experience in 500 patients. Inflamm Bowel Dis 10: 486-487
    • (2004) Inflamm Bowel Dis , vol.10 , pp. 486-487
    • Parsi, M.A.1    Lashner, B.A.2
  • 35
    • 33644892470 scopus 로고    scopus 로고
    • Review article: Infliximab therapy for inflammatory bowel disease - Seven years on
    • Rutgeerts P et al. (2006) Review article: Infliximab therapy for inflammatory bowel disease - seven years on. Aliment Pharmacol Ther 23: 451-463
    • (2006) Aliment Pharmacol Ther , vol.23 , pp. 451-463
    • Rutgeerts, P.1
  • 36
    • 33645651405 scopus 로고    scopus 로고
    • Drug insight: Antagonists of tumor-necrosis factor-α in the treatment of inflammatory bowel disease
    • Chang JT and Lichtenstein GR (2006) Drug insight: Antagonists of tumor-necrosis factor-α in the treatment of inflammatory bowel disease. Nat Clin Pract Gastroenterol Hepatol 3: 220-228
    • (2006) Nat Clin Pract Gastroenterol Hepatol , vol.3 , pp. 220-228
    • Chang, J.T.1    Lichtenstein, G.R.2
  • 37
    • 33947387687 scopus 로고    scopus 로고
    • Periodic Safety Update Report (PSUR 11) Infliximab
    • Periodic Safety Update Report (PSUR 11) (2005) Infliximab
    • (2005)
  • 38
    • 33646147141 scopus 로고    scopus 로고
    • Serious infections and mortality in association with therapies for Crohn's disease: TREAT Registry
    • Lichtenstein GR et al. (2006) Serious infections and mortality in association with therapies for Crohn's disease: TREAT Registry. Clin Gastroenterol Hepatol 4: 621-630
    • (2006) Clin Gastroenterol Hepatol , vol.4 , pp. 621-630
    • Lichtenstein, G.R.1
  • 39
    • 33746345358 scopus 로고    scopus 로고
    • Risk and benefits of infliximab for the treatment of Crohn's disease
    • Siegel CA et al. (2006) Risk and benefits of infliximab for the treatment of Crohn's disease. Clin Gastroenterol Hepatol 4: 1017-1024
    • (2006) Clin Gastroenterol Hepatol , vol.4 , pp. 1017-1024
    • Siegel, C.A.1
  • 40
    • 33947408497 scopus 로고    scopus 로고
    • Centocor [http://www.centocor.com/index.jsp]
  • 41
    • 0003059415 scopus 로고    scopus 로고
    • Infliximab for patients with refractory ulcerative colitis
    • Chey WY et al. (2001) Infliximab for patients with refractory ulcerative colitis. Inflamm Bowel Dis 7 (Suppl): S30-S33
    • (2001) Inflamm Bowel Dis , vol.7 , Issue.SUPPL.
    • Chey, W.Y.1
  • 42
    • 0034777502 scopus 로고    scopus 로고
    • Infliximab in the treatment of severe, steroid-refractory ulcerative colitis: A pilot study
    • Sands BE et al. (2001) Infliximab in the treatment of severe, steroid-refractory ulcerative colitis: A pilot study. Inflamm Bowel Dis 7: 83-88
    • (2001) Inflamm Bowel Dis , vol.7 , pp. 83-88
    • Sands, B.E.1
  • 43
    • 0035905514 scopus 로고    scopus 로고
    • Infliximab in severe steroid-refractory ulcerative colitis: A pilot study
    • Kaser A et al. (2001) Infliximab in severe steroid-refractory ulcerative colitis: A pilot study. Wien Klin Wochenschr 113: 930-933
    • (2001) Wien Klin Wochenschr , vol.113 , pp. 930-933
    • Kaser, A.1
  • 44
    • 0036743233 scopus 로고    scopus 로고
    • Anti-tumour necrosis factor alpha (infliximab) in the treatment of severe ulcerative colitis: Result of an open study on 13 patients
    • Kohn A et al. (2002) Anti-tumour necrosis factor alpha (infliximab) in the treatment of severe ulcerative colitis: Result of an open study on 13 patients. Dig Liver Dis 34: 626-630
    • (2002) Dig Liver Dis , vol.34 , pp. 626-630
    • Kohn, A.1
  • 45
    • 0036741262 scopus 로고    scopus 로고
    • Infliximab for treatment of steroid-refractory ulcerative colitis
    • Actis GC et al. (2002) Infliximab for treatment of steroid-refractory ulcerative colitis. Dig Liver Dis 34: 631-634
    • (2002) Dig Liver Dis , vol.34 , pp. 631-634
    • Actis, G.C.1
  • 46
    • 0038460945 scopus 로고    scopus 로고
    • Infliximab in moderately severe glucorticoid resistant ulcerative colitis: A randomised controlled trial
    • Probert CSJ et al. (2003) Infliximab in moderately severe glucorticoid resistant ulcerative colitis: A randomised controlled trial. Gut 52: 998-1002
    • (2003) Gut , vol.52 , pp. 998-1002
    • Probert, C.S.J.1
  • 47
    • 8444238193 scopus 로고    scopus 로고
    • Infliximab for acute, not steroid-refractory ulcerative colitis: A randomized pilot study
    • Ochsenkuhn T et al. (2004) Infliximab for acute, not steroid-refractory ulcerative colitis: A randomized pilot study. Eur J Gastroenterol Hepatol 16: 1167-1171
    • (2004) Eur J Gastroenterol Hepatol , vol.16 , pp. 1167-1171
    • Ochsenkuhn, T.1
  • 48
    • 20444479336 scopus 로고    scopus 로고
    • Infliximab as rescue therapy in severe to moderately severe ulcerative colitis: A randomized, placebo-controlled study
    • Järnerot G et al. (2005) Infliximab as rescue therapy in severe to moderately severe ulcerative colitis: A randomized, placebo-controlled study. Gastroenterology 128: 1805-1811
    • (2005) Gastroenterology , vol.128 , pp. 1805-1811
    • Järnerot, G.1
  • 49
    • 28844473957 scopus 로고    scopus 로고
    • Infliximab for induction and maintenance therapy for ulcerative colitis
    • Rutgeerts P et al. (2005) Infliximab for induction and maintenance therapy for ulcerative colitis. N Engl J Med 353: 2462-2476
    • (2005) N Engl J Med , vol.353 , pp. 2462-2476
    • Rutgeerts, P.1
  • 50
    • 0036792705 scopus 로고    scopus 로고
    • Efficacy of anti-tumor necrosis factor therapy in patients with ulcerative colitis
    • Su C et al. (2002) Efficacy of anti-tumor necrosis factor therapy in patients with ulcerative colitis. Am J Gastroenterol 97: 2577-2584
    • (2002) Am J Gastroenterol , vol.97 , pp. 2577-2584
    • Su, C.1
  • 51
    • 0013401756 scopus 로고    scopus 로고
    • National Cancer Institute. SEER Incidence Crude Rates, 11 Registries, 1993-2001 (accessed 28 November)
    • National Cancer Institute. Surveillance, Epidemiology, and End Results Database (SEER) program. SEER Incidence Crude Rates, 11 Registries, 1993-2001 [http://seer.cancer.gov/] (accessed 28 November 2006)
    • (2006) Surveillance, Epidemiology, and End Results Database (SEER) Program
  • 52
    • 33644984507 scopus 로고    scopus 로고
    • Expression and regulation of tumour necrosis factor alpha in normal and malignant ovarian epithelium
    • Szlosarek PW et al. (2006) Expression and regulation of tumour necrosis factor alpha in normal and malignant ovarian epithelium. Mol Cancer Ther 5: 382-390
    • (2006) Mol Cancer Ther , vol.5 , pp. 382-390
    • Szlosarek, P.W.1
  • 53
    • 14644405678 scopus 로고    scopus 로고
    • Regression of inflammatory myofibroblastic tumour of the gastrointestinal tract under infliximab treatment
    • Germanidis G et al. (2005) Regression of inflammatory myofibroblastic tumour of the gastrointestinal tract under infliximab treatment. Dig Dis Sci 50: 262-265
    • (2005) Dig Dis Sci , vol.50 , pp. 262-265
    • Germanidis, G.1
  • 54
    • 12144268598 scopus 로고    scopus 로고
    • A pilot study on safety and pharmacokinetics of infliximab for the cancer anorexia/weight loss syndrome in non-small-cell lung cancer patients
    • Jatoi A et al. (2004) A pilot study on safety and pharmacokinetics of infliximab for the cancer anorexia/weight loss syndrome in non-small-cell lung cancer patients. Support Care Cancer 12: 859-863
    • (2004) Support Care Cancer , vol.12 , pp. 859-863
    • Jatoi, A.1
  • 55
    • 3242756749 scopus 로고    scopus 로고
    • Tumor necrosis factor-alpha blockade for the treatment for the treatment of acute GVHD
    • Couriel D et al. (2004) Tumor necrosis factor-alpha blockade for the treatment for the treatment of acute GVHD. Blood 104: 649-654
    • (2004) Blood , vol.104 , pp. 649-654
    • Couriel, D.1
  • 56
    • 0031043778 scopus 로고    scopus 로고
    • Randomised controlled trial of CDP571 antibody to tumour necrosis factor-alpha in Crohn's disease
    • Stack WA et al. (1997) Randomised controlled trial of CDP571 antibody to tumour necrosis factor-alpha in Crohn's disease. Lancet 349: 521-524
    • (1997) Lancet , vol.349 , pp. 521-524
    • Stack, W.A.1
  • 57
    • 0035053968 scopus 로고    scopus 로고
    • An engineered human antibody to TNF (CDP571) for active Crohn's disease: A randomized double-blind placebo-controlled trial
    • Sandborn WJ et al. (2001) An engineered human antibody to TNF (CDP571) for active Crohn's disease: A randomized double-blind placebo-controlled trial. Gastroenterology 120: 1330-1338
    • (2001) Gastroenterology , vol.120 , pp. 1330-1338
    • Sandborn, W.J.1
  • 58
    • 4644325814 scopus 로고    scopus 로고
    • CDP571, a humanised monoclonal antibody to tumour necrosis factor alpha, for moderate to severe Crohn's disease: A randomised, double-blind, placebo-controlled trial
    • Sandborn WJ et al. (2004) CDP571, a humanised monoclonal antibody to tumour necrosis factor alpha, for moderate to severe Crohn's disease: A randomised, double-blind, placebo-controlled trial. Gut 53: 1485-1493
    • (2004) Gut , vol.53 , pp. 1485-1493
    • Sandborn, W.J.1
  • 59
    • 20044382590 scopus 로고    scopus 로고
    • A randomized, double-blind, placebo-controlled trial of CDP571, a humanized monoclonal antibody to tumour necrosis factor-alpha, in patients with corticosteroid-dependent Crohn's disease
    • Feagan BG et al. (2005) A randomized, double-blind, placebo-controlled trial of CDP571, a humanized monoclonal antibody to tumour necrosis factor-alpha, in patients with corticosteroid-dependent Crohn's disease. Aliment Pharmacol Ther 21: 373-384
    • (2005) Aliment Pharmacol Ther , vol.21 , pp. 373-384
    • Feagan, B.G.1
  • 60
    • 33644999128 scopus 로고    scopus 로고
    • CDP571, a humanized monoclonal antibody to tumour necrosis factor-alpha, for steroid-dependent Crohn's disease: A randomized, double-blind, placebo-controlled trial
    • Feagan BG et al. (2006) CDP571, a humanized monoclonal antibody to tumour necrosis factor-alpha, for steroid-dependent Crohn's disease: A randomized, double-blind, placebo-controlled trial. Aliment Pharmacol Ther 23: 617-628
    • (2006) Aliment Pharmacol Ther , vol.23 , pp. 617-628
    • Feagan, B.G.1
  • 61
    • 0034827790 scopus 로고    scopus 로고
    • Etanercept in the treatment of active refractory Crohn's disease: A single-center pilot study
    • D'Haens G et al. (2001) Etanercept in the treatment of active refractory Crohn's disease: A single-center pilot study. Am J Gastroenterol 96: 2564-2568
    • (2001) Am J Gastroenterol , vol.96 , pp. 2564-2568
    • D'Haens, G.1
  • 62
    • 0034754477 scopus 로고    scopus 로고
    • Etanercept for active Crohn's disease: A randomized, double-blind placebo-controlled trial
    • Sandborn WJ et al. (2001) Etanercept for active Crohn's disease: A randomized, double-blind placebo-controlled trial. Gastroenterology 121: 1089-1094
    • (2001) Gastroenterology , vol.121 , pp. 1089-1094
    • Sandborn, W.J.1
  • 63
    • 0037315157 scopus 로고    scopus 로고
    • Treatment of active Crohn's disease with onercept (recombinant human soluble p55 tumour necrosis factor receptor): Results of a randomized, open-label, pilot study
    • Rutgeerts P et al. (2003) Treatment of active Crohn's disease with onercept (recombinant human soluble p55 tumour necrosis factor receptor): Results of a randomized, open-label, pilot study. Aliment Pharmacol Ther 17: 185-192
    • (2003) Aliment Pharmacol Ther , vol.17 , pp. 185-192
    • Rutgeerts, P.1
  • 64
    • 33745608448 scopus 로고    scopus 로고
    • Onercept for moderate-severe Crohn's disease: A randomized, double-blind, placebo-controlled trial
    • Rutgeerts P et al. (2006) Onercept for moderate-severe Crohn's disease: a randomized, double-blind, placebo-controlled trial. Clin Gastroenterol Hepatol 4: 888-893
    • (2006) Clin Gastroenterol Hepatol , vol.4 , pp. 888-893
    • Rutgeerts, P.1
  • 65
    • 7044226437 scopus 로고    scopus 로고
    • An open-label study of the human anti-TNF monoclonal antibody adalimumab in subjects with prior loss of response or intolerance to infliximab for Crohn's disease
    • Sandborn WJ et al. (2004) An open-label study of the human anti-TNF monoclonal antibody adalimumab in subjects with prior loss of response or intolerance to infliximab for Crohn's disease. Am J Gastroenterol 99: 1984-1989
    • (2004) Am J Gastroenterol , vol.99 , pp. 1984-1989
    • Sandborn, W.J.1
  • 66
    • 3543075236 scopus 로고    scopus 로고
    • A pilot study of adalimumab in infliximab-allergic patients
    • Youdim A et al. (2004) A pilot study of adalimumab in infliximab-allergic patients. Inflamm Bowel Dis 10: 333-338
    • (2004) Inflamm Bowel Dis , vol.10 , pp. 333-338
    • Youdim, A.1
  • 67
    • 13744255984 scopus 로고    scopus 로고
    • Safety and efficacy of adalimumab (D2E7) in Crohn's disease patients with an attenuated response to infliximab
    • Papadakis KA et al. (2005) Safety and efficacy of adalimumab (D2E7) in Crohn's disease patients with an attenuated response to infliximab. Am J Gastroenterol 100: 75-79
    • (2005) Am J Gastroenterol , vol.100 , pp. 75-79
    • Papadakis, K.A.1
  • 68
    • 32044451548 scopus 로고    scopus 로고
    • Human anti-tumor necrosis factor monoclonal antibody (adalimumab) in Crohn's disease: The CLASSIC-1 trial
    • Hanauer S et al. (2006) Human anti-tumor necrosis factor monoclonal antibody (adalimumab) in Crohn's disease: The CLASSIC-1 trial. Gastroenterology 130: 323-333
    • (2006) Gastroenterology , vol.130 , pp. 323-333
    • Hanauer, S.1
  • 69
    • 11144318616 scopus 로고    scopus 로고
    • Intravenous CDP870, a PEGylated Fab'fragment of a humanized anti-tumor necrosis factor antibody, in patients with moderate-to severe Crohn's disease: An exploratory study
    • Winter TA et al. (2004) Intravenous CDP870, a PEGylated Fab'fragment of a humanized anti-tumor necrosis factor antibody, in patients with moderate-to severe Crohn's disease: An exploratory study. Aliment Pharmacol Ther 20: 1337-1346
    • (2004) Aliment Pharmacol Ther , vol.20 , pp. 1337-1346
    • Winter, T.A.1
  • 70
    • 24144483087 scopus 로고    scopus 로고
    • A randomized, placebo-controlled trial of certulizumab pegol (CDP870) for treatment of Crohns' disease
    • Schreiber S et al. (2005) A randomized, placebo-controlled trial of certulizumab pegol (CDP870) for treatment of Crohns' disease. Gastroenterology 129: 807-818
    • (2005) Gastroenterology , vol.129 , pp. 807-818
    • Schreiber, S.1
  • 71
    • 14044252848 scopus 로고    scopus 로고
    • Adalimumab induces apoptosis of human monocytes: A comparative study with infliximab and etanercept
    • Shen C et al. (2005) Adalimumab induces apoptosis of human monocytes: A comparative study with infliximab and etanercept. Aliment Pharmacol Ther 21: 251-258
    • (2005) Aliment Pharmacol Ther , vol.21 , pp. 251-258
    • Shen, C.1
  • 72
    • 7044264854 scopus 로고    scopus 로고
    • A comprehensive review and evaluation of the side effects of the tumor necrosis factor alpha blockers etanercept, infliximab and adalimumab
    • Scheinfeld N et al. (2004) A comprehensive review and evaluation of the side effects of the tumor necrosis factor alpha blockers etanercept, infliximab and adalimumab. J Dermatol Treat 15: 280-294
    • (2004) J Dermatol Treat , vol.15 , pp. 280-294
    • Scheinfeld, N.1
  • 73
    • 10044264157 scopus 로고    scopus 로고
    • Efficacy and safety of tumor necrosis factor antagonists in Crohn's disease: Overview of randomized clinical studies
    • Hanauer S (2004) Efficacy and safety of tumor necrosis factor antagonists in Crohn's disease: Overview of randomized clinical studies. Rev Gastroenterol Disord 4 (Suppl): S18-S24
    • (2004) Rev Gastroenterol Disord , vol.4 , Issue.SUPPL.
    • Hanauer, S.1
  • 74
    • 33646696885 scopus 로고    scopus 로고
    • Anti-TNF antibody therapy in rheumatoid arthritis and the risk of serious infections and malignancies: Systematic review and meta-analysis of rare harmful effects in randomized controlled trials
    • Bongartz T et al. (2006) Anti-TNF antibody therapy in rheumatoid arthritis and the risk of serious infections and malignancies: systematic review and meta-analysis of rare harmful effects in randomized controlled trials. JAMA 295: 2275-2285
    • (2006) JAMA , vol.295 , pp. 2275-2285
    • Bongartz, T.1
  • 75
    • 0034903450 scopus 로고    scopus 로고
    • A randomized placebo-controlled trial of a humanized monoclonal antibody to α4 integrin in active Crohn's disease
    • Gordon FH et al. (2001) A randomized placebo-controlled trial of a humanized monoclonal antibody to α4 integrin in active Crohn's disease. Gastroenterology 121: 268-274
    • (2001) Gastroenterology , vol.121 , pp. 268-274
    • Gordon, F.H.1
  • 76
    • 0037413468 scopus 로고    scopus 로고
    • Natalizumab for active Crohn's disease
    • Ghosh S et al. (2003) Natalizumab for active Crohn's disease. N Engl J Med 348: 24-32
    • (2003) N Engl J Med , vol.348 , pp. 24-32
    • Ghosh, S.1
  • 77
    • 27644441529 scopus 로고    scopus 로고
    • Natalizumab induction and maintenance therapy for Crohn's disease
    • Sandborn WJ et al. (2005) Natalizumab induction and maintenance therapy for Crohn's disease. N Engl J Med 353: 1912-1925
    • (2005) N Engl J Med , vol.353 , pp. 1912-1925
    • Sandborn, W.J.1


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