Protective effect of apigenin on Freund's complete adjuvant-induced arthritis in rats via inhibiting P2X7/NF-κB pathway

Chemico-Biological Interactions

Volumn 236, Issue , 2015, Pages 41-46

  Chang, Xiayun ^a   He, He ^a   Zhu, Lingpeng ^a   Gao, Jin ^a   Wei, Tingting ^a   Ma, Zhanqian ^a   Yan, Tianhua ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Apigenin; Arthritis; Inflammation; P2X7 NF B

Indexed keywords

APIGENIN; DICLOFENAC; FREUND ADJUVANT; I KAPPA B ALPHA; I KAPPA B KINASE ALPHA; I KAPPA B KINASE BETA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; INTERLEUKIN 6; PURINERGIC P2X7 RECEPTOR; TRANSCRIPTION FACTOR RELA; TUMOR NECROSIS FACTOR ALPHA; CYTOKINE; PROTECTIVE AGENT;

ADJUVANT ARTHRITIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; HISTOPATHOLOGY; JOINT DESTRUCTION; NONHUMAN; PAW EDEMA; RAT; ANIMAL; ARTHRITIS, EXPERIMENTAL; BLOOD; DRUG EFFECTS; JOINT; METABOLISM; PATHOLOGY; SIGNAL TRANSDUCTION; SPRAGUE DAWLEY RAT;

RATTUS;

ANIMALS; APIGENIN; ARTHRITIS, EXPERIMENTAL; CYTOKINES; FREUND'S ADJUVANT; JOINTS; NF-KAPPA B; PROTECTIVE AGENTS; RATS, SPRAGUE-DAWLEY; RECEPTORS, PURINERGIC P2X7; SIGNAL TRANSDUCTION;

EID: 84928883724     PISSN: 00092797     EISSN: 18727786     Source Type: Journal    
DOI: 10.1016/j.cbi.2015.04.021     Document Type: Article

References (31)

1. E.H. Choy, and G.S. Panayi Cytokine pathways and joint inflammation in rheumatoid arthritis New Engl. J. Med. 344 2001 907 916
2. S.E. Sweeney, and G.S. Firestein Rheumatoid arthritis: regulation of synovial inflammation Int. J. Biochem. Cell Biol. 36 2004 372 378
3. Z. Wang, Z. Chen, and S. Yang Berberine ameliorates collagen-induced arthritis in rats associated with anti-inflammatory and anti-angiogenic effects Inflammation 37 2014 1789 1798
4. M.L. Cotrina, and M. Nedergaard Physiological and pathological functions of P2X7 receptor in the spinal cord Purinergic Signal. 5 2009 223 232
5. Korcok Extracellular nucleotides act through P2X7 receptors to activate NF-κB in osteoclasts J. Bone Miner. Res. 19 2004 642 651
6. Mu. Hui, and Ru.-Bing. Yao Sinomenine decreases MyD88 expression and improves inflammation-induced joint damage progression and symptoms in rat adjuvant-induced arthritis Inflammation 36 2013 1136 1144
7. T. Sun, W.G. Song, Z.J. Fu, Z.H. Liu, Y.M. Liu, and S.L. Yao Alleviation of neuropathic pain by intrathecal injection of antisense oligonucleotides to p65 subunit of NF-κB Br. J. Anaesth. 97 2006 553 558
8. J.F. Lima-Garcia, R.C. Dutra, K. da Silva, E.M. Motta, M.M. Campos, and J.B. Calixto The precursor of resolvin D series and aspirintriggered resolvin D1 display anti-hyperalgesic properties in adjuvant-induced arthritis in rats Br. J. Pharmacol. 164 2011 278 293
9. S. Bandyopadhyay, J.M. Lion, and Mentaverrir Attenuation of osteoclastogenesis and osteoclast function by apigenin Biochem. Pharmacol. 72 2006 184 197
10. M. Xue, Z.Z. Jiang, T. Wu, J. Li, L. Zhang, and Y. Zhao Anti-inflammatory effects and hepatotoxicity of Tripterygium-loaded solid lipid nanoparticles on adjuvant induced arthritis in rats Phytomedicine 19 2012 998 1006
11. F. Shi Anti-arthritic activity of luteolin in Freund's complete adjuvant-induced arthritis in rats by suppressing P2X4 pathway Chem. Biol. Interact. 2014 10.1016/j.cbi.2014.10.031
12. S. Gay, R.E. Gay, and W.J. Koopman Molecular and cellular mechanisms of joint destruction in rheumatoid arthritis: two cellular mechanisms explain joint destruction Ann. Rheum. Dis. 52 1993 S39 S47
13. Y.A. Lee, J.Y. Kim, S.J. Hong, S.H. Lee, M.C. Yoo, and K.S. Kim Synovial proliferation differentially affects hypoxia in the joint cavities of rheumatoid arthritis and osteoarthritis patients Clin. Rheumatol. 26 2007 2023 2029
14. M.D. Yi Xin Wang Therapeutic effects of p75 tumor necrosis factor receptor monoclonal antibody on a rat model of traumatic arthritis J. Surg. Res. 186 2014 234 239
15. M.S. Fu, B.J. Zhu, and D.W. Luo Apigenin prevents TNF-α induced apoptosis of primary rat retinal ganglion cells Cell Mol. Biol. (Noisy-le-grand) 60 2014 37 42
16. J. Chen, H. Wu, and Q. Wang Ginsenoside metabolite compound k alleviates adjuvant-induced arthritis by suppressing T cell activation Inflammation 37 2014 1608 1615
17. Guo Effect of Bizhongxiao decoction and its dismantled formulae on IL-1 and TNF levels in collagen-induced arthritis in rat synovial joints Theor. Biol. Med. Model. 9 2012 47
18. E.M. Gravallese, and S.R. Goldring Cellular mechanism and the role of cytokines in bone erosions in rheumatoid arthritis Arthritis Rheum. 43 2000 2143221511
19. Mijung. Yeom Phosphatidylserine inhibits inflammatory responses in interleukin-1β-stimulated fibroblast-like synoviocytes and alleviates carrageenan-induced arthritis in rat Nutr. Res. 33 2013 242 250
20. M. Feldmann, F.M. Brennan, and B.M. Foxwell The role of TNF-alpha and IL-1 in the rheumatoid arthritis Curr. Dir. Autoimmun. 3 2001 188 199
21. M. Rajan, C. Anne, and W. John The significance of determination of tumor necrosis factor in patients with chronic infection Ann. Rheum. Dis. 52 1993 232
22. I.B. McInnes Targeting the P2X7 receptor in rheumatoid arthritis: biological rationale for P2X7 antagonism Clin. Exp. Rheumatol. 32 2014 878 882
23. J. Zhang, X. Li, Y. Gao, G. Guo, C. Xu, G. Li, S. Liu, A. Huang, G. Tu, H. Peng, S. Qiu, B. Fan, Q. Zhu, S. Yu, C. Zheng, and S. Liang Effects of puerarin on the inflammatory role of burn-related procedural pain mediated by P2X(7) receptors Burns 39 2013 610 618
24. S. Liang, C. Xu, G. Li, and Y. Gao P2X receptors and modulation of pain transmission: focus on effects of drugs and compounds used in traditional Chinese medicine Neurochem. Int. 57 2010 705 712
25. J.A. Gallagher, and K.A. Buckley Expression and function of P2 receptors in bone J. Musculoskelet. Neuronal Interact. 2 2002 432 439
26. A.K. Rosenthal, and C.M. Gohr The progressive ankylosis gene product ANK regulates extracellular ATP levels in primary articular chondrocytes Arthritis Res. Ther. 15 2013 R154
27. W.J. Boyle, W.S. Simonet, and D.L. Lacey Osteoclast differentiation and activation Nature 423 2003 337 342
28. L. Penolazzi, E. Bianchini, and E. Lambertini N-Arylpiperazine modified analogues of the P2X7 receptor KN-62 antagonist are potent inducers of apoptosis of human primary osteoclasts J. Biomed. Sci. 12 2005 1013 1020
29. H.Z. Ke, and H. Qi Deletion of the P2X7 nucleotide receptor reveals its regulatory roles in bone formation and resorption Mol. Endocrinol. 17 2003 1356 1367
30. C. He, X. Chen, and C. Zhao Eleutheroside E ameliorates arthritis severity in collagen-induced arthritis mice model by suppressing inflammatory cytokine release Inflammation 37 2014 1533 1543
31. A. Israël Signal transduction: a regulator branches out Nature 423 2003 596 597