Osteoblast ablation burns out functional stem cells

Blood

Volumn 125, Issue 17, 2015, Pages 2590-2591

  Zhao, Meng ^a   Li, Linheng ^a,b  

^a STOWERS INSTITUTE FOR MEDICAL RESEARCH   (United States)

^b UNIVERSITY OF KANSAS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA2 INTEGRIN; CD150 ANTIGEN; CD48 ANTIGEN; COLLAGEN TYPE 1;

ARTICLE; BONE MARROW; BONE MARROW TRANSPLANTATION; CELL CYCLE; CELL DIFFERENTIATION; CELL PROLIFERATION; CHRONIC MYELOID LEUKEMIA; ENGRAFTMENT; HEMATOPOIESIS; HEMATOPOIETIC STEM CELL; LEUKEMIA CELL; LEUKEMOGENESIS; MICROENVIRONMENT; OSTEOBLAST; PRIORITY JOURNAL; SELF CONCEPT; STEM CELL; STROMA CELL; TRABECULAR BONE; ANIMAL; CANCER STEM CELL; CYTOLOGY; PATHOLOGY;

ANIMALS; HEMATOPOIETIC STEM CELLS; LEUKEMIA, MYELOGENOUS, CHRONIC, BCR-ABL POSITIVE; NEOPLASTIC STEM CELLS; OSTEOBLASTS;

EID: 84928882883     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2015-03-633651     Document Type: Article

References (10)

1. Bowers M, Zhang B, Ho Y, Agarwal P, Chen C-C, Bhatia R. Osteoblast ablation reduces normal long-term hematopoietic stem cell self-renewal but accelerates leukemia development. Blood. 2015;125(17):2678-2688.
2. Zhang J, Niu C, Ye L, et al. Identification of the haematopoietic stem cell niche and control of the niche size. Nature. 2003;425(6960):836-841.
3. Calvi LM, Adams GB, Weibrecht KW, et al. Osteoblastic cells regulate the haematopoietic stem cell niche. Nature. 2003;425(6960):841-846.
4. Kiel MJ, Yilmaz OH, Iwashita T, Yilmaz OH, Terhorst C, Morrison SJ. SLAM family receptors distinguish hematopoietic stem and progenitor cells and reveal endothelial niches for stem cells. Cell. 2005;121(7): 1109-1121.
5. Kunisaki Y, Bruns I, Scheiermann C, et al. Arteriolar niches maintain haematopoietic stem cell quiescence. Nature. 2013;502(7473):637-643.
6. Sugiyama T, Kohara H, Noda M, Nagasawa T. Maintenance of the hematopoietic stem cell pool by CXCL12-CXCR4 chemokine signaling in bone marrow stromal cell niches. Immunity. 2006;25(6):977-988.
7. Ding L, Saunders TL, Enikolopov G, Morrison SJ. Endothelial and perivascular cells maintain haematopoietic stem cells. Nature. 2012;481(7382):457-462.
8. Wilson A, Laurenti E, Oser G, et al. Hematopoietic stem cells reversibly switch from dormancy to self-renewal during homeostasis and repair. Cell. 2008;135(6):1118-1129.
9. Guezguez B, Campbell CJ, Boyd AL, et al. Regional localization within the bone marrow influences the functional capacity of human HSCs. Cell Stem Cell. 2013;13(2):175-189.
10. Li L, Clevers H. Coexistence of quiescent and active adult stem cells in mammals. Science. 2010;327(5965):542-545.