Tendon basic science: Development, repair, regeneration, and healing

Journal of Orthopaedic Research

Volumn 33, Issue 6, 2015, Pages 780-784

  Andarawis Puri, Nelly ^a   Flatow, Evan L ^a   Soslowsky, Louis J ^b  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

New Frontiers; tendinopathy; tendon conference; tendon injury

Indexed keywords

BONE MORPHOGENETIC PROTEIN 2; FIBROBLAST GROWTH FACTOR; TRANSCRIPTION FACTOR OSTERIX; TRANSCRIPTION FACTOR RUNX2; TRANSCRIPTION FACTOR SOX9; TRANSFORMING GROWTH FACTOR BETA; VASCULOTROPIN;

CELL PROLIFERATION; CONFERENCE PAPER; CYTOLOGY; EXTRACELLULAR MATRIX; HEALING IMPAIRMENT; HUMAN; INFLAMMATORY CELL; MECHANOTRANSDUCTION; MEDICAL SOCIETY; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; TENDINITIS; TENDON INJURY; TENDON RECONSTRUCTION; TENDON RUPTURE; THROMBOCYTE RICH PLASMA; TISSUE REGENERATION; ANIMAL; PATHOPHYSIOLOGY; PHYSIOLOGY; TENDON; WOUND HEALING;

ANIMALS; HUMANS; TENDINOPATHY; TENDON INJURIES; TENDONS; WOUND HEALING;

EID: 84928828121     PISSN: 07360266     EISSN: 1554527X     Source Type: Journal    
DOI: 10.1002/jor.22869     Document Type: Conference Paper

References (64)

1. McCormick A, Charlton J, Fleming D,. 1995. Assessing health needs in primary care. Morbidity study from general practice provides another source of information. BMJ 310: 1534.
2. Magnusson SP, Langberg H, Kjaer M,. 2010. The pathogenesis of tendinopathy: balancing the response to loading. Nat Rev Rheumatol 6: 262-268.
3. Sun HB, Andarawis-Puri N, Li Y, et al. 2010. Cycle-dependent matrix remodeling gene expression response in fatigue-loaded rat patellar tendons. J Orthop Res 28: 1380-1386.
4. Zhang J, Pan T, Liu Y, et al. 2010. Mouse treadmill running enhances tendons by expanding the pool of tendon stem cells (TSCs) and TSC-related cellular production of collagen. J Orthop Res 28: 1178-1183.
5. Szczodry M, Zhang J, Lim C, et al. 2009. Treadmill running exercise results in the presence of numerous myofibroblasts in mouse patellar tendons. J Orthop Res 27: 1373-1378.
6. Zhang J, Wang JH,. 2013. The effects of mechanical loading on tendons-an in vivo and in vitro model study. PLoS ONE 8: e71740.
7. Kjaer M,. 2004. Role of extracellular matrix in adaptation of tendon and skeletal muscle to mechanical loading. Physiol Rev 84: 649-698.
8. Ristolainen L, Kettunen JA, Waller B, et al. 2014. Training-related risk factors in the etiology of overuse injuries in endurance sports. J Sports Med Phys Fitness 54: 78-87.
9. Lundgreen K, Lian OB, Scott A, et al. 2014. Rotator cuff tear degeneration and cell apoptosis in smokers versus nonsmokers. Arthroscopy 30: 936-941.
10. Gumina S, Candela V, Passaretti D, et al. 2014. The association between body fat and rotator cuff tear: the influence on rotator cuff tear sizes. J Shoulder Elbow Surg 23: 1669-1674.
11. Beason DP, Tucker JJ, Lee CS, et al. 2014. Rat rotator cuff tendon-to-bone healing properties are adversely affected by hypercholesterolemia. J Shoulder Elbow Surg 23: 867-872.
12. Tashjian RZ,. Epidemiology, natural history, and indications for treatment of rotator cuff tears. Clin Sports Med. 31: 589-604.
13. Yu TY, Pang JH, Wu KP, et al. 2013. Aging is associated with increased activities of matrix metalloproteinase-2 and -9 in tenocytes. BMC Musculoskelet Disord 14: 2.
14. Magnusson SP, Hansen M, Langberg H, et al. 2007. The adaptability of tendon to loading differs in men and women. Int J Exp Pathol 88: 237-240.
15. Legerlotz K, Jones ER, Screen HR, et al. 2012. Increased expression of IL-6 family members in tendon pathology. Rheumatology (Oxford) 51: 1161-1165.
16. Gaida JE, Bagge J, Purdam C, et al. 2012. Evidence of the TNF-alpha system in the human Achilles tendon: expression of TNF-alpha and TNF receptor at both protein and mRNA levels in the tenocytes. Cells Tissues Organs 196: 339-352.
17. Rees JD, Stride M, Scott A,. 2014. Tendons-time to revisit inflammation. Br J Sports Med 48: 1553-1557.
18. Dakin SG, Dudhia J, Smith RK,. 2014. Resolving an inflammatory concept: the importance of inflammation and resolution in tendinopathy. Vet Immunol Immunopathol 158: 121-127.
19. Connizzo BK, Yannascoli SM, Tucker JJ, et al. 2014. The detrimental effects of systemic Ibuprofen delivery on tendon healing are time-dependent. Clin Orthop Relat Res 472: 2433-2439.
20. Jelinsky SA, Rodeo SA, Li J, et al. 2011. Regulation of gene expression in human tendinopathy. BMC Musculoskelet Disord 12: 86.
21. Riley G,. 2008. Tendinopathy-from basic science to treatment. Nat Clin Pract Rheumatol 4: 82-89.
22. Fung DT, Wang VM, Andarawis-Puri N, et al. 2010. Early response to tendon fatigue damage accumulation in a novel in vivo model. J Biomech 43: 274-279.
23. Soslowsky LJ, Thomopoulos S, Tun S, et al. 2000. Neer Award 1999. Overuse activity injures the supraspinatus tendon in an animal model: a histologic and biomechanical study. J Shoulder Elbow Surg 9: 79-84.
24. Bell R, Taub P, Cagle P, et al. 2014. Development of a mouse model of supraspinatus tendon insertion site healing. J Orthop Res 33: 25-32.
25. Bishop J, Klepps S, Lo IK, et al. 2006. Cuff integrity after arthroscopic versus open rotator cuff repair: a prospective study. J Shoulder Elbow Surg 15: 290-299.
26. Galatz LM, Ball CM, Teefey SA, et al. 2004. The outcome and repair integrity of completely arthroscopically repaired large and massive rotator cuff tears. J Bone Joint Surg Am 86-A: 219-224.
27. Montgomery SR, Petrigliano FA, Gamradt SC,. 2012. Failed rotator cuff surgery, evaluation and decision making. Clin Sports Med 31: 693-712.
28. Robertson CM, Chen CT, Shindle MK, et al. 2012. Failed healing of rotator cuff repair correlates with altered collagenase and gelatinase in supraspinatus and subscapularis tendons. Am J Sports Med 40: 1993-2001.
29. Muller SA, Todorov A, Heisterbach PE, et al. 2013. Tendon healing: an overview of physiology, biology, and pathology of tendon healing and systematic review of state of the art in tendon bioengineering. Knee Surg Sports Traumatol Arthrosc [published online September 21, 2013].
30. Dolkart O, Chechik O, Zarfati Y, et al. 2014. A single dose of platelet-rich plasma improves the organization and strength of a surgically repaired rotator cuff tendon in rats. Arch Orthop Trauma Surg 134: 1271-1277.
31. Kollitz KM, Parsons EM, Weaver MS, et al. 2014. Platelet-rich plasma for zone II flexor tendon repair. Hand (NY) 9: 217-224.
32. Manning CN, Kim HM, Sakiyama-Elbert S, et al. 2011. Sustained delivery of transforming growth factor beta three enhances tendon-to-bone healing in a rat model. J Orthop Res 29: 1099-1105.
33. Kim HM, Galatz LM, Das R, et al. 2011. The role of transforming growth factor beta isoforms in tendon-to-bone healing. Connect Tissue Res 52: 87-98.
34. Selek O, Buluç L, Muezzinoʇlu B, et al. 2014. Mesenchymal stem cell application improves tendon healing via anti-apoptotic effect (Animal study). Acta Orthop Traumatol Turc 48: 187-195.
35. Pietschmann MF, Frankewycz B, Schmitz P, et al. 2013. Comparison of tenocytes and mesenchymal stem cells seeded on biodegradable scaffolds in a full-size tendon defect model. J Mater Sci Mater Med 24: 211-220.
36. Kraus TM, Imhoff FB, Wexel G, et al. 2014. Stem cells and basic fibroblast growth factor failed to improve tendon healing: an in vivo study using lentiviral gene transfer in a rat model. J Bone Joint Surg Am 96: 761-769.
37. Bedi A, Fox AJ, Kovacevic D, et al. 2010. Doxycycline-mediated inhibition of matrix metalloproteinases improves healing after rotator cuff repair. Am J Sports Med 38: 308-317.
38. Kessler MW, Barr J, Greenwald R, et al. 2014. Enhancement of Achilles tendon repair mediated by matrix metalloproteinase inhibition via systemic administration of doxycycline. J Orthop Res 32: 500-506.
39. Pasternak B, Fellenius M, Aspenberg P,. 2006. Doxycycline impairs tendon repair in rats. Acta Orthop Belg 72: 756-760.
40. Kim JG, Kim HJ, Kim SE, et al. 2014. Enhancement of tendon-bone healing with the use of bone morphogenetic protein-2 inserted into the suture anchor hole in a rabbit patellar tendon model. Cytotherapy 16: 857-867.
41. Thomopoulos S, Kim HM, Silva MJ, et al. 2013. Effect of bone morphogenetic protein 2 on tendon-to-bone healing in a canine flexor tendon model. J Orthop Res 30: 1702-1709.
42. Longo UG, Franceschi F, Ruzzini L, et al. 2008. Histopathology of the supraspinatus tendon in rotator cuff tears. Am J Sports Med 36: 533-538.
43. Clegg PD, Strassburg S, Smith RK,. 2007. Cell phenotypic variation in normal and damaged tendons. Int J Exp Pathol 88: 227-235.
44. Li F, Li B, Wang QM, et al. 2008. Cell shape regulates collagen type I expression in human tendon fibroblasts. Cell Motil Cytoskeleton 65: 332-341.
45. Waggett AD, Benjamin M, Ralphs JR,. 2006. Connexin 32 and 43 gap junctions differentially modulate tenocyte response to cyclic mechanical load. Eur J Cell Biol 85: 1145-1154.
46. Wall ME, Otey C, Qi J, et al. 2007. Connexin 43 is localized with actin in tenocytes. Cell Motil Cytoskeleton 64: 121-130.
47. Zhang J, Wang JH,. 2010. Characterization of differential properties of rabbit tendon stem cells and tenocytes. BMC Musculoskelet Disord 11: 10.
48. Zhou Z, Akinbiyi T, Xu L, et al. Tendon-derived stem/progenitor cell aging: defective self-renewal and altered fate. Aging Cell. 9: 911-915.
49. Checa S, Rausch MK, Petersen A, et al. 2015. The emergence of extracellular matrix mechanics and cell traction forces as important regulators of cellular self-organization. Biomech Model Mechanobiol 14: 1-13.
50. Hynes RO,. 2014. Stretching the boundaries of extracellular matrix research. Nat Rev Mol Cell Biol 15: 761-763.
51. Birk DE, Lande MA,. 1981. Corneal and scleral collagen fiber formation in vitro. Biochim Biophys Acta 670: 362-369.
52. Birk DE, Trelstad RL,. 1984. Extracellular compartments in matrix morphogenesis: collagen fibril, bundle, and lamellar formation by corneal fibroblasts. J Cell Biol 99: 2024-2033.
53. Kalson NS, Starborg T, Lu Y, et al. 2013. Nonmuscle myosin II powered transport of newly formed collagen fibrils at the plasma membrane. Proc Natl Acad Sci USA 110: E4743-E4752.
54. Starborg T, Kalson NS, Lu Y, et al. 2013. Using transmission electron microscopy and 3View to determine collagen fibril size and three-dimensional organization. Nat Protoc 8: 1433-1448.
55. Schweitzer R, Zelzer E, Volk T,. 2010. Connecting muscles to tendons: tendons and musculoskeletal development in flies and vertebrates. Development 137: 2807-2817.
56. Evanko SP, Vogel KG,. 1993. Proteoglycan synthesis in fetal tendon is differentially regulated by cyclic compression in vitro. Arch Biochem Biophys 307: 153-164.
57. Killian ML, Cavinatto L, Galatz LM, et al. 2012. The role of mechanobiology in tendon healing. J Shoulder Elbow Surg 21: 228-237.
58. Arnoczky SP, Tian T, Lavagnino M, et al. 2002. Activation of stress-activated protein kinases (SAPK) in tendon cells following cyclic strain: the effects of strain frequency, strain magnitude, and cytosolic calcium. J Orthop Res 20: 947-952.
59. Langberg H, Rosendal L, Kjaer M,. 2001. Training-induced changes in peritendinous type I collagen turnover determined by microdialysis in humans. J Physiol 534: 297-302.
60. Archambault JM, Hart DA, Herzog W,. 2001. Response of rabbit Achilles tendon to chronic repetitive loading. Connect Tissue Res 42: 13-23.
61. Gardner K, Arnoczky SP, Caballero O, et al. 2008. The effect of stress-deprivation and cyclic loading on the TIMP/MMP ratio in tendon cells: an in vitro experimental study. Disabil Rehabil 30: 1523-1529.
62. Arnoczky SP, et al. 2008. Loss of homeostatic strain alters mechanostat "set point" of tendon cells in vitro. Clin Orthop Relat Res 466: 1583-1591.
63. Abate M, Silbernagel KG, Siljeholm C, et al. 2009. Pathogenesis of tendinopathies: inflammation or degeneration?. Arthritis Res Ther 11: 235.
64. Riley GP, Curry V, DeGroot J, et al. 2002. Matrix metalloproteinase activities and their relationship with collagen remodelling in tendon pathology. Matrix Biol 21: 185-195.