The detrimental effects of systemic ibuprofen delivery on tendon healing are time-dependent

Clinical Orthopaedics and Related Research

Volumn 472, Issue 8, 2014, Pages 2433-2439

  Connizzo, Brianne K ^a   Yannascoli, Sarah M ^a   Tucker, Jennica J ^a   Caro, Adam C ^a   Riggin, Corinne N ^a   Mauck, Robert L ^a   Soslowsky, Louis J ^a   Steinberg, David R ^b   Bernstein, Joseph ^b  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

IBUPROFEN;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; CELL DENSITY; CELL SHAPE; CONFERENCE PAPER; CONTROLLED STUDY; HISTOLOGY; JOINT STIFFNESS; MALE; NONHUMAN; POSTOPERATIVE PERIOD; PRIORITY JOURNAL; RAT; ROTATOR CUFF INJURY; SUPRASPINATUS MUSCLE; SYSTEMIC THERAPY; TENDON RECONSTRUCTION; THERAPY DELAY; TREATMENT DURATION; WOUND HEALING;

ADMINISTRATION, ORAL; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; BIOMECHANICAL PHENOMENA; DISEASE MODELS, ANIMAL; DRUG ADMINISTRATION SCHEDULE; ELASTIC MODULUS; IBUPROFEN; MALE; RATS; RATS, SPRAGUE-DAWLEY; TENDON INJURIES; TENDONS; TENOTOMY; TIME FACTORS; WOUND HEALING;

EID: 84904128814     PISSN: 0009921X     EISSN: 15281132     Source Type: Journal    
DOI: 10.1007/s11999-013-3258-2     Document Type: Conference Paper

References (34)

1. Almekinders LC, Baynes AJ, Bracey LW. An in vitro investigation into the effects of repetitive motion and nonsteroidal antiinflammatory medication on human tendon fibroblasts. Am J Sports Med. 1995;23:119-123.
2. Altman RD, Latta LL, Keer R, Renfree K, Hornicek FJ, Banovac K. Effect of nonsteroidal antiinflammatory drugs on fracture healing: a laboratory study in rats. J Orthop Trauma. 1995;9:392-400.
3. Beason DP, Connizzo BK, Dourte LM, Mauck RL, Soslowsky LJ, Steinberg DR, Bernstein J. Fiber-aligned polymer scaffolds for rotator cuff repair in a rat model. J Shoulder Elbow Surg. 2012;21:245-250.
4. Cohen DB, Kawamura S, Ehteshami JR, Rodeo SA. Indomethacin and celecoxib impair rotator cuff tendon-to-bone healing. Am J Sports Med. 2006;34:362-369. (Pubitemid 43260571)
5. Dimmen S, Engebretsen L, Nordsletten L, Madsen JE. Negative effects of parecoxib and indomethacin on tendon healing: an experimental study in rats. Knee Surg Sports Traumatol Arthrosc. 2009;17:835-839.
6. Dimmen S, Nordsletten L, Engebretsen L, Steen H, Madsen JE. The effect of parecoxib and indometacin on tendon-to-bone healing in a bone tunnel: an experimental study in rats. J Bone Joint Surg Br. 2009;91:259-263.
7. Edelstein L, Thomas SJ, Soslowsky LJ. Rotator cuff tears: what have we learned from animal models? J Musculoskelet Neuronal Interact. 2011;11:150-162.
8. Ferry ST, Dahners LE, Afshari HM, Weinhold PS. The effects of common anti-inflammatory drugs on the healing rat patellar tendon. Am J Sports Med. 2007;35:1326-1333. (Pubitemid 47086271)
9. Feucht CL, Patel DR. Analgesics and anti-inflammatory medications in sports: use and abuse. Pediatr Clin North Am. 2010;57:751-774.
10. Gerstenfeld LC, Al-Ghawas M, Alkhiary YM, Cullinane DM, Krall EA, Fitch JL, Webb EG, Thiede MA, Einhorn TA. Selective and nonselective cyclooxygenase-2 inhibitors and experimental fracture-healing: reversibility of effects after short-term treatment. J Bone Joint Surg Am. 2007;89:114-125. (Pubitemid 46059150)
11. Gerstenfeld LC, Thiede M, Seibert K, Mielke C, Phippard D, Svagr B, Cullinane D, Einhorn TA. Differential inhibition of fracture healing by non-selective and cyclooxygenase-2 selective non-steroidal anti-inflammatory drugs. J Orthop Res. 2003;21:670-675. (Pubitemid 36763489)
12. Gimbel JA, Van Kleunen JP, Lake SP, Williams GR, Soslowsky LJ. The role of repair tension on tendon to bone healing in an animal model of chronic rotator cuff tears. J Biomech. 2007;40:561-568. (Pubitemid 46107452)
13. Gimbel JA, Van Kleunen JP, Mehta S, Perry SM, Williams GR, Soslowsky LJ. Supraspinatus tendon organizational and mechanical properties in a chronic rotator cuff tear animal model. J Biomech. 2004;37:739-749. (Pubitemid 38445036)
14. Gimbel JA, Van Kleunen JP, Williams GR, Thomopoulos S, Soslowsky LJ. Long durations of immobilization in the rat result in enhanced mechanical properties of the healing supraspinatus tendon insertion site. J Biomech Eng. 2007;129:400-404. (Pubitemid 47066853)
15. Holmes N, Cronholm PF, Duffy AJ 3rd, Webner D. Nonsteroidal anti-inflammatory drug use in collegiate football players. Clin J Sport Med. 2013;23:283-286.
16. Hsu JE, Reuther KE, Sarver JJ, Lee CS, Thomas SJ, Glaser DL, Soslowsky LJ. Restoration of anterior-posterior rotator cuff force balance improves shoulder function in a rat model of chronic massive tears. J Orthop Res. 2011;29:1028-1033.
17. Kulick MI, Smith S, Hadler K. Oral ibuprofen: evaluation of its effect on peritendinous adhesions and the breaking strength of a tenorrhaphy. J Hand Surg Am. 1986;11:110-120. (Pubitemid 16187934)
18. Lin TW, Cardenas L, Soslowsky LJ. Biomechanics of tendon injury and repair. J Biomech. 2004;37:865-877. (Pubitemid 38521208)
19. Lindholm TS, Törnkvist H. Inhibitory effect on bone formation and calcification exerted by the anti-inflammatory drug ibuprofen: an experimental study on adult rat with fracture. Scand J Rheumatol. 1981;10:38-42. (Pubitemid 11114040)
20. Pedowitz RA, Yamaguchi K, Ahmad CS, Burks RT, Flatow EL, Green A, Iannotti JP, Miller BS, Tashjian RZ, Watters WC 3rd, Weber K, Turkelson CM, Wies JL, Anderson S, St Andre J, Boyer K, Raymond L, Sluka P, McGowan R. Optimizing the management of rotator cuff problems. J Am Acad Orthop Surg. 2011;19:368-379.
21. Peltz CD, Dourte LM, Kuntz AF, Sarver JJ, Kim SY, Williams GR, Soslowsky LJ. The effect of postoperative passive motion on rotator cuff healing in a rat model. J Bone Joint Surg Am. 2009;91:2421-2429.
22. Rainsford KD. Ibuprofen: A Critical Bibliographic Review. London, UK: Taylor & Francis; 2003.
23. Reddy GK, Stehno-Bittel L, Enwemeka CS. Matrix remodeling in healing rabbit Achilles tendon. Wound Repair Regen. 1999;7:518-527. (Pubitemid 30027575)
24. Shah A, Jung D. Dose-dependent pharmacokinetics of ibuprofen in the rat. Drug Metab Dispos. 1987;15:151-154. (Pubitemid 17056755)
25. Simon AM, O'Connor JP. Dose and time-dependent effects of cyclooxygenase-2 inhibition on fracture-healing. J Bone Joint Surg Am. 2007;89:500-511. (Pubitemid 46365350)
26. Tan V, Nourbakhsh A, Capo J, Cottrell JA, Meyenhofer M, O'Connor JP. Effects of nonsteroidal anti-inflammatory drugs on flexor tendon adhesion. J Hand Surg Am. 2010;35:941-947.
27. Thomopoulos S, Hattersley G, Rosen V, Mertens M, Galatz LM, Williams GR, Soslowsky LJ. The localized expression of extracellular matrix components in healing tendon insertion sites: an in situ hybridization study. J Orthop Res. 2002;20:454-463. (Pubitemid 34461003)
28. Thomopoulos S, Williams GR, Gimbel JA, Favata M, Soslowsky LJ. Variation of biomechanical, structural, and compositional properties along the tendon to bone insertion site. J Orthop Res. 2003;21:413-419. (Pubitemid 36546807)
29. Thomopoulos S, Williams GR, Soslowsky LJ. Tendon to bone healing: differences in biomechanical, structural, and compositional properties due to a range of activity levels. J Biomech Eng. 2003;125:106-113. (Pubitemid 36297232)
30. Tsai WC, Hsu CC, Chang HN, Lin YC, Lin MS, Pang JH. Ibuprofen upregulates expressions of matrix metalloproteinase-1, -8, -9, and -13 without affecting expressions of Types I and III collagen in tendon cells. J Orthop Res. 2010;28:487-491.
31. Tsai WC, Hsu CC, Chen CP, Chen MJ, Lin MS, Pang JH. Ibuprofen inhibition of tendon cell migration and down-regulation of paxillin expression. J Orthop Res. 2006;24:551-558. (Pubitemid 43773018)
32. Tsai WC, Hsu CC, Chou SW, Chung CY, Chen J, Pang JH. Effects of celecoxib on migration, proliferation and collagen expression of tendon cells. Connect Tissue Res. 2007;48:46-51. (Pubitemid 46371978)
33. Virchenko O, Skoglund B, Aspenberg P. Parecoxib impairs early tendon repair but improves later remodeling. Am J Sports Med. 2004;32:1743-1747. (Pubitemid 39390526)
34. Woo SL, Debski RE, Zeminski J, Abramowitch SD, Saw SS, Fenwick JA. Injury and repair of ligaments and tendons. Annu Rev Biomed Eng. 2000;2:83-118.