Failed healing of rotator cuff repair correlates with altered collagenase and gelatinase in supraspinatus and subscapularis tendons

American Journal of Sports Medicine

Volumn 40, Issue 9, 2012, Pages 1993-2001

  Robertson, Catherine M ^a   Chen, Christopher T ^a,b   Shindle, Michael K ^a   Cordasco, Frank A ^a   Rodeo, Scott A ^a   Warren, Russell F ^a  

^a HOSPITAL FOR SPECIAL SURGERY   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

cytokines; inflammation; matrix metalloproteinase; rotator cuff tear; synovitis; ultrasound

Indexed keywords

BIOLOGICAL MARKER; COLLAGENASE; GELATINASE;

AGED; ARTHROSCOPY; ARTICLE; CASE CONTROL STUDY; ECHOGRAPHY; FEMALE; GENETICS; HUMAN; INJURY; MALE; MIDDLE AGED; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; ROTATOR CUFF; TENDON; TREATMENT FAILURE; WOUND HEALING;

AGED; ARTHROSCOPY; BIOLOGICAL MARKERS; CASE-CONTROL STUDIES; COLLAGENASES; FEMALE; GELATINASES; HUMANS; MALE; MIDDLE AGED; ROTATOR CUFF; TENDONS; TREATMENT FAILURE; WOUND HEALING;

EID: 84866025743     PISSN: 03635465     EISSN: 15523365     Source Type: Journal    
DOI: 10.1177/0363546512456519     Document Type: Article

References (36)

1. Arnoczky SP, Lavagnino M, Egerbacher M, Caballero O, Gardner K. Matrix metalloproteinase inhibitors prevent a decrease in the mechanical properties of stress-deprived tendons: an in vitro experimental study. Am J Sports Med. 2007 ; 35 (5). 763-769
2. Arnoczky SP, Tian T, Lavagnino M, Gardner K. Ex vivo static tensile loading inhibits MMP-1 expression in rat tail tendon cells through a cytoskeletally based mechanotransduction mechanism. J Orthop Res. 2004 ; 22 (2). 328-333
3. Bedi A, Fox AJ, Kovacevic D, Deng XH, Warren RF, Rodeo SA. Doxycycline-mediated inhibition of matrix metalloproteinases improves healing after rotator cuff repair. Am J Sports Med. 2010 ; 38 (2). 308-317
4. Boileau P, Brassart N, Watkinson DJ, Carles M, Hatzidakis AM, Krishnan SG. Arthroscopic repair of full-thickness tears of the supraspinatus: does the tendon really heal?. J Bone Joint Surg Am. 2005 ; 87 (6). 1229-1240
5. Choi HR, Kondo S, Hirose K, Ishiguro N, Hasegawa Y, Iwata H. Expression and enzymatic activity of MMP-2 during healing process of the acute supraspinatus tendon tear in rabbits. J Orthop Res. 2002 ; 20 (5). 927-933
6. Cofield RH. Rotator cuff disease of the shoulder. J Bone Joint Surg Am. 1985 ; 67 (6). 974-979
7. Cofield RH, Parvizi J, Hoffmeyer PJ, Lanzer WL, Ilstrup DM, Rowland CM. Surgical repair of chronic rotator cuff tears: a prospective long-term study. J Bone Joint Surg Am. 2001 ; 83 (1). 71-77
8. Cordasco FA, Backer M, Craig EV, Klein D, Warren RF. The partial-thickness rotator cuff tear: is acromioplasty without repair sufficient?. Am J Sports Med. 2002 ; 30 (2). 257-260
9. Dodson CC, Kitay A, Verma NN, et al. The long-term outcome of recurrent defects after rotator cuff repair. Am J Sports Med. 2010 ; 38 (1). 35-39
10. Galatz LM, Ball CM, Teefey SA, Middleton WD, Yamaguchi K. The outcome and repair integrity of completely arthroscopically repaired large and massive rotator cuff tears. J Bone Joint Surg Am. 2004 ; 86 (2). 219-224
11. Galatz LM, Sandell LJ, Rothermich SY, et al. Characteristics of the rat supraspinatus tendon during tendon-to-bone healing after acute injury. J Orthop Res. 2006 ; 24 (3). 541-550
12. Gotoh M, Hamada K, Yamakawa H, et al. Perforation of rotator cuff increases interleukin 1beta production in the synovium of glenohumeral joint in rotator cuff diseases. J Rheumatol. 2000 ; 27 (12). 2886-2892
13. Gotoh M, Hamada K, Yamakawa H, Tomonaga A, Inoue A, Fukuda H. Significance of granulation tissue in torn supraspinatus insertions: an immunohistochemical study with antibodies against interleukin-1 beta, cathepsin D, and matrix metalloprotease-1. J Orthop Res. 1997 ; 15 (1). 33-39
14. Gulotta LV, Rodeo SA. Growth factors for rotator cuff repair. Clin Sports Med. 2009 ; 28 (1). 13-23
15. Ishii H, Brunet JA, Welsh RP, Uhthoff HK. "Bursal reactions" in rotator cuff tearing, the impingement syndrome, and calcifying tendinitis. J Shoulder Elbow Surg. 1997 ; 6 (2). 131-136
16. Kamath G, Galatz LM, Keener JD, Teefey S, Middleton W, Yamaguchi K. Tendon integrity and functional outcome after arthroscopic repair of high-grade partial-thickness supraspinatus tears. J Bone Joint Surg Am. 2009 ; 91 (5). 1055-1062
17. Khan KM, Visentini PJ, Kiss ZS, et al. Correlation of ultrasound and magnetic resonance imaging with clinical outcome after patellar tenotomy: prospective and retrospective studies. Victorian Institute of Sport Tendon Study Group. Clin J Sport Med. 1999 ; 9 (3). 129-137
18. Koshima H, Kondo S, Mishima S, et al. Expression of interleukin-1beta, cyclooxygenase-2, and prostaglandin E2 in a rotator cuff tear in rabbits. J Orthop Res. 2007 ; 25 (1). 92-97
19. Kumagai J, Sarkar K, Uhthoff HK. The collagen types in the attachment zone of rotator cuff tendons in the elderly: an immunohistochemical study. J Rheumatol. 1994 ; 21 (11). 2096-2100
20. Lafosse L, Brozska R, Toussaint B, Gobezie R. The outcome and structural integrity of arthroscopic rotator cuff repair with use of the double-row suture anchor technique. J Bone Joint Surg Am. 2007 ; 89 (7). 1533-1541
21. Lakemeier S, Braun J, Efe T, et al. Expression of matrix metalloproteinases 1, 3, and 9 in differing extents of tendon retraction in the torn rotator cuff. Knee Surg Sports Traumatol Arthrosc. 2011 ; 19 (10). 1760-1765
22. Lo IK, Marchuk LL, Hollinshead R, Hart DA, Frank CB. Matrix metalloproteinase and tissue inhibitor of matrix metalloproteinase mRNA levels are specifically altered in torn rotator cuff tendons. Am J Sports Med. 2004 ; 32 (5). 1223-1229
23. Maffulli N, Longo UG, Franceschi F, Rabitti C, Denaro V. Movin and Bonar scores assess the same characteristics of tendon histology. Clin Orthop Relat Res. 2008 ; 466 (7). 1605-1611
24. Nho SJ, Yadav H, Shindle MK, Macgillivray JD. Rotator cuff degeneration: etiology and pathogenesis. Am J Sports Med. 2008 ; 36 (5). 987-993
25. Osawa T, Shinozaki T, Takagishi K. Multivariate analysis of biochemical markers in synovial fluid from the shoulder joint for diagnosis of rotator cuff tears. Rheumatol Int. 2005 ; 25 (6). 436-441
26. Pearle AD, Scanzello CR, George S, et al. Elevated high-sensitivity C-reactive protein levels are associated with local inflammatory findings in patients with osteoarthritis. Osteoarthritis Cartilage. 2007 ; 15 (5). 516-523
27. Perry SM, McIlhenny SE, Hoffman MC, Soslowsky LJ. Inflammatory and angiogenic mRNA levels are altered in a supraspinatus tendon overuse animal model. J Shoulder Elbow Surg. 2005 ; 14: 79S - 83S
28. Pickering JG, Boughner DR. Quantitative assessment of the age of fibrotic lesions using polarized light microscopy and digital image analysis. Am J Pathol. 1991 ; 138 (5). 1225-1231
29. Riley G. Tendinopathy: from basic science to treatment. Nat Clin Pract Rheumatol. 2008 ; 4 (2). 82-89
30. Rodeo SA, Delos D, Williams RJ, Adler RS, Pearle A, Warren RF. The effect of platelet-rich fibrin matrix on rotator cuff tendon healing: a prospective, randomized clinical study. Am J Sports Med. 2012 ; 40: 1234-1241
31. Shindle MK, Chen CC, Robertson C, et al. Full-thickness supraspinatus tears are associated with more synovial inflammation and tissue degeneration than partial-thickness tears. J Shoulder Elbow Surg. 2011 ; 20 (6). 917-927
32. Soslowsky LJ, Carpenter JE, Bucchieri JS, Flatow EL. Biomechanics of the rotator cuff. Orthop Clin North Am. 1997 ; 28 (1). 17-30
33. Sugaya H, Maeda K, Matsuki K, Moriishi J. Functional and structural outcome after arthroscopic full-thickness rotator cuff repair: single-row versus dual-row fixation. Arthroscopy. 2005 ; 21 (11). 1307-1316
34. Thain LM, Adler RS. Sonography of the rotator cuff and biceps tendon: technique, normal anatomy, and pathology. J Clin Ultrasound. 1999 ; 27 (8). 446-458
35. Tsuzaki M, Guyton G, Garrett W, et al. IL-1 beta induces COX2, MMP-1, -3 and -13, ADAMTS-4, IL-1 beta and IL-6 in human tendon cells. J Orthop Res. 2003 ; 21 (2). 256-264
36. Wei AS, Callaci JJ, Juknelis D, et al. The effect of corticosteroid on collagen expression in injured rotator cuff tendon. J Bone Joint Surg Am. 2006 ; 88 (6). 1331-1338