BMP2 response pattern in human lung fibroblasts predicts outcome in lung adenocarcinomas

BMC Medical Genomics

Volumn 8, Issue 1, 2015, Pages

  Rajski, Michal ^a,d   Saaf, Annika ^b   Buess, Martin ^a,c  

^a UNIVERSITY OF BASEL   (Switzerland)

^b UNIVERSITY OF CHICAGO   (United States)

^c Department of Clinical and Biological Sciences   (Switzerland)

^d UNIVERSITY OF ZURICH   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

BONE MORPHOGENETIC PROTEIN 2; BONE MORPHOGENETIC PROTEIN 4; GLYCOPROTEIN; GREMLIN; NOGGIN; OSTEOGENIC PROTEIN 1; UNCLASSIFIED DRUG; BMP2 PROTEIN, HUMAN; BMP4 PROTEIN, HUMAN; BMP7 PROTEIN, HUMAN; CARRIER PROTEIN; GREM1 PROTEIN, HUMAN; NOGGIN PROTEIN; SIGNAL PEPTIDE;

ARTICLE; BREAST CANCER CELL LINE; CANCER PROGNOSIS; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE FREE SURVIVAL; EX VIVO STUDY; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; LUNG ADENOCARCINOMA; LUNG FIBROBLAST; OVERALL SURVIVAL; PRIORITY JOURNAL; REGULATOR GENE; STROMA CELL; ADENOCARCINOMA; BIOLOGY; DNA MICROARRAY; FIBROBLAST; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENETIC DATABASE; HUMAN GENOME; LUNG; LUNG TUMOR; METABOLISM; PROGNOSIS; TUMOR CELL LINE;

ADENOCARCINOMA; BONE MORPHOGENETIC PROTEIN 2; BONE MORPHOGENETIC PROTEIN 4; BONE MORPHOGENETIC PROTEIN 7; CARRIER PROTEINS; CELL LINE, TUMOR; COMPUTATIONAL BIOLOGY; DATABASES, GENETIC; FIBROBLASTS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENE EXPRESSION REGULATION, NEOPLASTIC; GENOME, HUMAN; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; LUNG; LUNG NEOPLASMS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PROGNOSIS;

EID: 84928822372     PISSN: None     EISSN: 17558794     Source Type: Journal    
DOI: 10.1186/s12920-015-0090-4     Document Type: Article

References (29)

1. Bragdon B, Moseychuk O, Saldanha S, King D, Julian J, Nohe A. Bone morphogenetic proteins: a critical review. Cell Signal. 2011;23(4):609-20.
2. Langenfeld EM, Calvano SE, Abou-Nukta F, Lowry SF, Amenta P, Langenfeld J. The mature bone morphogenetic protein-2 is aberrantly expressed in non-small cell lung carcinomas and stimulates tumor growth of A549 cells. Carcinogenesis. 2003;24(9):1445-54.
3. Langenfeld E, Kong Y, Langenfeld J. Bone morphogenetic protein 2 stimulation of tumor growth involves the activation of Smad-1/5. Oncogene. 2005;25(5):685-92.
4. Sharpe P, Ferguson M. Mesenchymal influences on epithelial differentiation in developing systems. J Cell Sci.1988;1988(Supplement 10):195-230.
5. Sonnenschein C, Soto AM. An updated review of environmental estrogen and androgen mimics and antagonists. J Steroid Biochem Mol Biol. 1998;65(1):143-50.
6. Zhang J, Niu C, Ye L, Huang H, He X, Tong W-G, et al. Identification of the haematopoietic stem cell niche and control of the niche size. Nature. 2003;425(6960):836-41.
7. Pietras K, Östman A. Hallmarks of cancer: interactions with the tumor stroma. Exp Cell Res. 2010;316(8):1324-31.
8. Singh A, Morris RJ. The Yin and Yang of bone morphogenetic proteins in cancer. Cytokine Growth Factor Rev. 2010;21(4):299-313.
9. Hubble J, Demeter J, Jin H, Mao M, Nitzberg M, Reddy T, et al. Implementation of genepattern within the stanford microarray database. Nucleic Acids Res. 2009;37 suppl 1:D898-901.
10. Eisen MB, Spellman PT, Brown PO, Botstein D. Cluster analysis and display of genome-wide expression patterns. Proc Natl Acad Sci U S A. 1998;95(25):14863-8.
11. Tusher VG, Tibshirani R, Chu G. Significance analysis of microarrays applied to the ionizing radiation response. Proc Natl Acad Sci U S A. 2001;98(9):5116-21.
12. Troyanskaya O, Cantor M, Sherlock G, Brown P, Hastie T, Tibshirani R, et al. Missing value estimation methods for DNA microarrays. Bioinformatics. 2001;17(6):520-5.
13. Garber ME, Troyanskaya OG, Schluens K, Petersen S, Thaesler Z, Pacyna-Gengelbach M, et al. Diversity of gene expression in adenocarcinoma of the lung. Proc Natl Acad Sci U S A. 2001;98(24):13784-9.
14. Lee E-S, Son D-S, Kim S-H, Lee J, Jo J, Han J, et al. Prediction of recurrence-free survival in postoperative nonâ€"small cell lung cancer patients by using an integrated model of clinical information and gene expression. Clin Cancer Res. 2008;14(22):7397-404.
15. Bhattacharjee A, Richards WG, Staunton J, Li C, Monti S, Vasa P, et al. Classification of human lung carcinomas by mRNA expression profiling reveals distinct adenocarcinoma subclasses. Proc Natl Acad Sci. 2001;98(24):13790-5.
16. Boyle EI, Weng S, Gollub J, Jin H, Botstein D, Cherry JM, et al. GO::TermFinder-open source software for accessing Gene Ontology information and finding significantly enriched Gene Ontology terms associated with a list of genes. Bioinformatics. 2004;20(18):3710-5.
17. Calvi L, Adams G, Weibrecht K, Weber J, Olson D, Knight M, et al. Osteoblastic cells regulate the haematopoietic stem cell niche. Nature. 2003;425(6960):841-6.
18. Chiquet-Ehrismann R, Mackie EJ, Pearson CA, Sakakura T. Tenascin: an extracellular matrix protein involved in tissue interactions during fetal development and oncogenesis. Cell. 1986;47(1):131-9.
19. Malanchi I. Santamaria-Martínez A, Susanto E, Peng H, Lehr H-A, Delaloye J-F, Huelsken J: Interactions between cancer stem cells and their niche govern metastatic colonization. Nature. 2011;481(7379):85-9.
20. Chang HY, Sneddon JB, Alizadeh AA, Sood R, West RB, Montgomery K, et al. Gene expression signature of fibroblast serum response predicts human cancer progression: similarities between tumors and wounds. PLoS Biol. 2004;2(2), E7.
21. Buess M, Nuyten DS, Hastie T, Nielsen T, Pesich R, Brown PO. Characterization of heterotypic interaction effects in vitro to deconvolute global gene expression profiles in cancer. Genome Biol. 2007;8(9):R191.
22. Nuyten DS, Kreike B, Hart AA, Chi JT, Sneddon JB, Wessels LF, et al. Predicting a local recurrence after breast-conserving therapy by gene expression profiling. Breast Cancer Res. 2006;8(5):R62.
23. Masters JR. Epithelial-mesenchymal interaction during lung development: the effect of mesenchymal mass. Dev Biol. 1976;51(1):98-108.
24. Sr B. Henderson R, Winnier G, Oikawa T, Hogan B: Evidence from normal expression and targeted misexpression that bone morphogenetic protein (Bmp-4) plays a role in mouse embryonic lung morphogenesis. Development. 1996;122(6):1693-702.
25. Weaver M, Yingling JM, Dunn NR, Bellusci S, Hogan B. Bmp signaling regulates proximal-distal differentiation of endoderm in mouse lung development. Development. 1999;126(18):4005-15.
26. Malanchi I, Santamaria-Martínez A, Susanto E, Peng H, Lehr H-A, Delaloye J-F, et al. Interactions between cancer stem cells and their niche govern metastatic colonization. Nature. 2012;481(7379):85-9.
27. Choi YJ, Kim ST, Park KH, Oh SC, Seo JH, Shin SW, et al. The serum bone morphogenetic protein-2 level in non-small-cell lung cancer patients. Med Oncol. 2012;29(2):582-8.
28. Fei Z-H, Yao C-Y, Yang X-L, Huang X-E, Ma S-L. Serum BMP-2 up-regulation as an indicator of poor survival in advanced non-small cell lung cancer patients. Asian Pac J Cancer Prev. 2013;14:5293-9.
29. Ye X, Niu X, Tang N, Xu Y, Li Z, Yu Y, et al. Adenovirus mediated knockdown of bone morphogenetic protein 2 inhibits human lung cancer growth and invasion in vitro and in vivo. Int J Immunopathol Pharmacol. 2011;25(4):967-76.