Compartmentalized accumulation of cAMP near complexes of multidrug resistance protein 4 (MRP4) and cystic fibrosis transmembrane conductance regulator (CFTR) contributes to drug-induced diarrhea

Journal of Biological Chemistry

Volumn 290, Issue 18, 2015, Pages 11246-11257

  Moon, Changsuk ^a,b   Zhang, Weiqiang ^b   Ren, Aixia ^b,c   Arora, Kavisha ^a,b   Sinha, Chandrima ^b   Yarlagadda, Sunitha ^a,b   Woodrooffe, Koryse ^a   Schuetz, John D ^c   Valasani, Koteswara Rao ^d   De Jonge, Hugo R ^e   Shanmukhappa, Shiva Kumar ^a   Shata, Mohamed Tarek M ^f   Buddington, Randal K ^g   Parthasarathi, Kaushik ^b   Naren, Anjaparavanda P ^a,b  

^a CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

^b UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

^c ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

^d UNIVERSITY OF KANSAS   (United States)

^e ERASMUS MEDICAL CENTER   (Netherlands)

^f UNIVERSITY OF CINCINNATI MEDICAL CENTER   (United States)

^g UNIVERSITY OF MEMPHIS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PATIENT TREATMENT; PHYSIOLOGY; PROTEINS; SCAFFOLDS (BIOLOGY);

ADVERSE SIDE EFFECTS; COMPLEX FORMATIONS; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATORS; FOOD AND DRUG ADMINISTRATION; HIV INFECTION; MACROMOLECULAR COMPLEXES; MULTIDRUG RESISTANCE; SCAFFOLDING PROTEINS;

DRUG INTERACTIONS;

CYCLIC AMP; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; IRINOTECAN; MULTIDRUG RESISTANCE PROTEIN 4; PDZK1 SCAFFOLD PROTEIN; SCAFFOLD PROTEIN; UNCLASSIFIED DRUG; ZIDOVUDINE; ABCC4 PROTEIN, MOUSE; CAMPTOTHECIN; MULTIDRUG RESISTANCE PROTEIN;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; C57BL 6 MOUSE; COMPLEX FORMATION; CONTROLLED STUDY; DIARRHEA; DRUG INHIBITION; DRUG PROTEIN BINDING; HUMAN; HUMAN CELL; IN VITRO STUDY; INTESTINE FLUID; MOLECULAR MECHANICS; MOUSE; NONHUMAN; NUCLEOTIDE TRANSPORT; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; SECRETION (PROCESS); ANALOGS AND DERIVATIVES; ANIMAL; CHEMICAL STRUCTURE; CHEMICALLY INDUCED; CHEMISTRY; DEFICIENCY; DRUG APPROVAL; DRUG EFFECTS; FOOD AND DRUG ADMINISTRATION; HT 29 CELL LINE; INTRACELLULAR SPACE; METABOLISM; PROTEIN CONFORMATION; UNITED STATES;

ANIMALS; CAMPTOTHECIN; CYCLIC AMP; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; DIARRHEA; DRUG APPROVAL; HT29 CELLS; HUMANS; INTRACELLULAR SPACE; MICE; MODELS, MOLECULAR; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; PROTEIN CONFORMATION; UNITED STATES; UNITED STATES FOOD AND DRUG ADMINISTRATION;

EID: 84928820076     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.605410     Document Type: Article

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