Primary prevention of psychosis through interventions in the symptomatic prodromal phase, a pragmatic Norwegian ultra high risk study

BMC Psychiatry

Volumn 15, Issue 1, 2015, Pages

  Joa, Inge ^a,b   Gisselgård, Jens ^a   Brønnick, Kolbjørn ^a,b   McGlashan, Thomas ^c   Johannessen, Jan Olav ^a,b  

^a STAVANGER UNIVERSITY HOSPITAL   (Norway)

^b UNIVERSITY OF STAVANGER   (Norway)

^c YALE UNIVERSITY   (United States)

Author keywords

Early detection; Prodromal; Psychosis; Schizophrenia; Ultra high risk

Indexed keywords

ADOLESCENT; ADULT; AGED; ARTICLE; BIPOLAR I DISORDER; BIPOLAR II DISORDER; BRIEF PSYCHOTIC DISORDER; COGNITIVE THERAPY; DELUSION; DICHOTIC LISTENING; FUNCTIONAL MAGNETIC RESONANCE IMAGING; FUNCTIONAL NEUROIMAGING; HALLUCINATION; HEALTH CARE SYSTEM; HIGH RISK POPULATION; HUMAN; MAJOR DEPRESSION; MENTAL HEALTH SERVICE; NORWAY; PRIMARY PREVENTION; PRODROMAL SYMPTOM; PSYCHOSIS; RESTING STATE NETWORK; RISK ASSESSMENT; SCHIZOAFFECTIVE PSYCHOSIS; SCHIZOPHRENIA; SCHIZOPHRENIFORM DISORDER; SOCIAL INTERACTION; THINKING IMPAIRMENT; WORKING MEMORY; BRAIN; CLINICAL PROTOCOL; DIET THERAPY; EARLY DIAGNOSIS; FEMALE; MALE; MIDDLE AGED; MULTIMODALITY CANCER THERAPY; NUCLEAR MAGNETIC RESONANCE IMAGING; PATHOPHYSIOLOGY; PHYSIOLOGY; PROCEDURES; PSYCHOTHERAPY; PSYCHOTIC DISORDERS; RISK FACTOR; TIME; YOUNG ADULT;

OMEGA 3 FATTY ACID;

ADOLESCENT; ADULT; AGED; BRAIN; CLINICAL PROTOCOLS; COMBINED MODALITY THERAPY; EARLY DIAGNOSIS; FATTY ACIDS, OMEGA-3; FEMALE; FUNCTIONAL NEUROIMAGING; HUMANS; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; PRIMARY PREVENTION; PRODROMAL SYMPTOMS; PSYCHOTHERAPY; PSYCHOTIC DISORDERS; RISK FACTORS; TIME FACTORS; YOUNG ADULT;

EID: 84928805257     PISSN: None     EISSN: 1471244X     Source Type: Journal    
DOI: 10.1186/s12888-015-0470-5     Document Type: Article

References (62)

1. Melle I, Larsen TK, Haahr U, Friis S, Johannessen JO, Opjordsmoen S, et al. Reducing the duration of untreated first-episode psychosis: effects on clinical presentation. Arch Gen Psychiatry. 2004;61(2):143-50.
2. Johannessen JO, McGlashan TH, Larsen TK, Horneland M, Joa I, Mardal S, et al. Early detection strategies for untreated first-episode psychosis. Schizophr Res. 2001;51(1):39-46.
3. Hegelstad WT, Larsen TK, Auestad B, Evensen J, Haahr U, Joa I, et al. Long-term follow-up of the TIPS early detection in psychosis study: effects on 10-year outcome. Am J Psychiatry. 2012;169(4):374-80.
4. Thompson PM, Stein JL, Medland SE, Hibar DP, Vasquez AA, Renteria ME, et al. The ENIGMA Consortium: large-scale collaborative analyses of neuroimaging and genetic data. Brain Imaging Behav. 2014;8(2):153-82.
5. Reay R, Mitford E, McCabe K, Paxton R, Turkington D. Incidence and diagnostic diversity in first-episode psychosis. Acta Psychiatr Scand. 2010;121(4):315-9.
6. Melle I, Johannesen JO, Friis S, Haahr U, Joa I, Larsen TK, et al. Early detection of the first episode of schizophrenia and suicidal behavior. Am J Psychiatry. 2006;163(5):800-4.
7. Larsen TK, Melle I, Auestad B, Haahr U, Joa I, Johannessen JO, et al. Early detection of psychosis: positive effects on 5-year outcome. Psychol Med. 2011;41(7):1461-9.
8. Melle I, Larsen TK, Haahr U, Friis S, Johannesen JO, Opjordsmoen S, et al. Prevention of negative symptom psychopathologies in first-episode schizophrenia: two-year effects of reducing the duration of untreated psychosis. Arch Gen Psychiatry. 2008;65(6):634-40.
9. Fusar-Poli P, Bonoldi I, Yung AR, Borgwardt S, Kempton MJ, Valmaggia L, et al. Predicting psychosis: meta-analysis of transition outcomes in individuals at high clinical risk. Arch Gen Psychiatry. 2012;69(3):220-9.
10. Yung AR, McGorry PD. The prodromal phase of first-episode psychosis: past and current conceptualizations. Schizophr Bull. 1996;22(2):353-70.
11. Miller TJ, McGlashan TH, Rosen JL, Cadenhead K, Cannon T, Ventura J, et al. Prodromal assessment with the structured interview for prodromal syndromes and the scale of prodromal symptoms: predictive validity, interrater reliability, and training to reliability. Schizophr Bull. 2003;29(4):703-15.
12. McFarlane WR, Cook WL, Downing D, Verdi MB, Woodberry KA, Ruff A. Portland identification and early referral: a community-based system for identifying and treating youths at high risk of psychosis. Psychiatr Serv. 2010;61(5):512-5.
13. Yung AR, Phillips LJ, McGorry PD, McFarlane CA, Francey S, Harrigan S, et al. Prediction of psychosis. A step towards indicated prevention of schizophrenia. Br J Psychiatry Suppl. 1998;172(33):14-20.
14. Miller TJ, McGlashan TH, Rosen JL, Somjee L, Markovich PJ, Stein K, et al. Prospective diagnosis of the initial prodrome for schizophrenia based on the Structured Interview for Prodromal Syndromes: preliminary evidence of interrater reliability and predictive validity. Am J Psychiatry. 2002;159(5):863-5.
15. Klosterkotter J, Hellmich M, Steinmeyer EM, Schultze-Lutter F. Diagnosing schizophrenia in the initial prodromal phase. Arch Gen Psychiatry. 2001;58(2):158-64.
16. Mason O, Startup M, Halpin S, Schall U, Conrad A, Carr V. Risk factors for transition to first episode psychosis among individuals with 'at-risk mental states'. Schizophr Res. 2004;71(2-3):227-37.
17. Yung AR, Yuen HP, McGorry PD, Phillips LJ, Kelly D, Dell'Olio M, et al. Mapping the onset of psychosis: the comprehensive assessment of at-risk mental states. Aust N Z J Psychiatry. 2005;39(11-12):964-71.
18. Cannon TD, Cadenhead K, Cornblatt B, Woods SW, Addington J, Walker E, et al. Prediction of psychosis in youth at high clinical risk: a multisite longitudinal study in North America. Arch Gen Psychiatry. 2008;65(1):28-37.
19. Addington J, Cornblatt BA, Cadenhead KS, Cannon TD, McGlashan TH, Perkins DO, et al. At clinical high risk for psychosis: outcome for nonconverters. Am J Psychiatry. 2011;168(8):800-5.
20. Yung AR, Yuen HP, Berger G, Francey S, Hung TC, Nelson B, et al. Declining transition rate in ultra high risk (prodromal) services: dilution or reduction of risk? Schizophr Bull. 2007;33(3):673-81.
21. Yung AR, Phillips LJ, Nelson B, Francey SM, PanYuen H, Simmons MB, et al. Randomized controlled trial of interventions for young people at ultra high risk for psychosis: 6-month analysis. J Clin Psychiatry. 2011;72(4):430-40.
22. Simon AE, Velthorst E, Nieman DH, Linszen D, Umbricht D, de Haan L. Ultra high-risk state for psychosis and non-transition: a systematic review. Schizophr Res. 2011;132(1):8-17.
23. Stafford MR, Jackson H, Mayo-Wilson E, Morrison AP, Kendall T. Early interventions to prevent psychosis: systematic review and meta-analysis. BMJ. 2013;346:f185.
24. Morrison AP, French P, Walford L, Lewis SW, Kilcommons A, Green J, et al. Cognitive therapy for the prevention of psychosis in people at ultra-high risk: randomised controlled trial. Br J Psychiatry. 2004;185:291-7.
25. Addington J, Epstein I, Liu L, French P, Boydell KM, Zipursky RB. A randomized controlled trial of cognitive behavioral therapy for individuals at clinical high risk of psychosis. Schizophr Res. 2011;125(1):54-61.
26. Morrison AP, Turkington D, Wardle M, Spencer H, Barratt S, Dudley R, et al. A preliminary exploration of predictors of outcome and cognitive mechanisms of change in cognitive behaviour therapy for psychosis in people not taking antipsychotic medication. Behav Res Ther. 2012;50(2):163-7.
27. van der Gaag M, Nieman DH, Rietdijk J, Dragt S, Ising HK, Klaassen RM, et al. Cognitive behavioral therapy for subjects at ultrahigh risk for developing psychosis: a randomized controlled clinical trial. Schizophr Bull. 2012;38(6):1180-8.
28. Phillips LJ, Nelson B, Yuen HP, Francey SM, Simmons M, Stanford C, et al. Randomized controlled trial of interventions for young people at ultra-high risk of psychosis: study design and baseline characteristics. Aust N Z J Psychiatry. 2009;43(9):818-29.
29. McGorry PD, Yung AR, Phillips LJ, Yuen HP, Francey S, Cosgrave EM, et al. Randomized controlled trial of interventions designed to reduce the risk of progression to first-episode psychosis in a clinical sample with subthreshold symptoms. Arch Gen Psychiatry. 2002;59(10):921-8.
30. McGlashan TH, Zipursky RB, Perkins D, Addington J, Miller T, Woods SW, et al. Randomized, double-blind trial of olanzapine versus placebo in patients prodromally symptomatic for psychosis. Am J Psychiatry. 2006;163(5):790-9.
31. Bechdolf A, Wagner M, Ruhrmann S, Harrigan S, Putzfeld V, Pukrop R, et al. Preventing progression to first-episode psychosis in early initial prodromal states. Br J Psychiatry. 2012;200(1):22-9.
32. Nordentoft M, Thorup A, Petersen L, Ohlenschlaeger J, Melau M, Christensen TO, et al. Transition rates from schizotypal disorder to psychotic disorder for first-contact patients included in the OPUS trial. A randomized clinical trial of integrated treatment and standard treatment. Schizophr Res. 2006;83(1):29-40.
33. Amminger GP, Schafer MR, Papageorgiou K, Klier CM, Cotton SM, Harrigan SM, et al. Long-chain omega-3 fatty acids for indicated prevention of psychotic disorders: a randomized, placebo-controlled trial. Arch Gen Psychiatry. 2010;67(2):146-54.
34. Ruhrmann S, Bechdolf A, Kuhn KU, Wagner M, Schultze-Lutter F, Janssen B, et al. Acute effects of treatment for prodromal symptoms for people putatively in a late initial prodromal state of psychosis. Br J Psychiatry Suppl. 2007;51:s88-95.
35. McFarlane E, Dodge RA, Burrell L, Crowne S, Cheng TL, Duggan AK. The importance of early parenting in at-risk families and children's social-emotional adaptation to school. Acad Pediatr. 2010;10(5):330-7.
36. Fusar-Poli P, Deste G, Smieskova R, Barlati S, Yung AR, Howes O, et al. Cognitive functioning in prodromal psychosis: a meta-analysis. Arch Gen Psychiatry. 2012;69(6):562-71.
37. Giuliano AJ, Li H, Mesholam-Gately RI, Sorenson SM, Woodberry KA, Seidman LJ. Neurocognition in the psychosis risk syndrome: a quantitative and qualitative review. Curr Pharm Des. 2012;18(4):399-415.
38. Seidman LJ, Giuliano AJ, Meyer EC, Addington J, Cadenhead KS, Cannon TD, et al. Neuropsychology of the prodrome to psychosis in the NAPLS consortium: relationship to family history and conversion to psychosis. Arch Gen Psychiatry. 2010;67(6):578-88.
39. Woodberry KA, Giuliano AJ, Seidman LJ. Premorbid IQ in schizophrenia: a meta-analytic review. Am J Psychiatry. 2008;165(5):579-87.
40. Lin A, Wood SJ, Nelson B, Brewer WJ, Spiliotacopoulos D, Bruxner A, et al. Neurocognitive predictors of functional outcome two to 13 years after identification as ultra-high risk for psychosis. Schizophr Res. 2011;132(1):1-7.
41. McGuire P, Howes OD, Stone J, Fusar-Poli P. Functional neuroimaging in schizophrenia: diagnosis and drug discovery. Trends Pharmacol Sci. 2008;29(2):91-8.
42. Phillips LJ, Velakoulis D, Pantelis C, Wood S, Yuen HP, Yung AR, et al. Non-reduction in hippocampal volume is associated with higher risk of psychosis. Schizophr Res. 2002;58(2-3):145-58.
43. Velakoulis D, Wood SJ, Wong MT, McGorry PD, Yung A, Phillips L, et al. Hippocampal and amygdala volumes according to psychosis stage and diagnosis: a magnetic resonance imaging study of chronic schizophrenia, first-episode psychosis, and ultra-high-risk individuals. Arch Gen Psychiatry. 2006;63(2):139-49.
44. Yucel M, Wood SJ, Phillips LJ, Stuart GW, Smith DJ, Yung A, et al. Morphology of the anterior cingulate cortex in young men at ultra-high risk of developing a psychotic illness. Br J Psychiatry. 2003;182:518-24.
45. Mechelli A, Riecher-Rossler A, Meisenzahl EM, Tognin S, Wood SJ, Borgwardt SJ, et al. Neuroanatomical abnormalities that predate the onset of psychosis: a multicenter study. Arch Gen Psychiatry. 2011;68(5):489-95.
46. Fusar-Poli P, Radua J, McGuire P, Borgwardt S. Neuroanatomical maps of psychosis onset: voxel-wise meta-analysis of antipsychotic-naive VBM studies. Schizophr Bull. 2012;38(6):1297-307.
47. Joa I, Johannessen JO, Auestad B, Friis S, McGlashan T, Melle I, et al. The key to reducing duration of untreated first psychosis: information campaigns. Schizophr Bull. 2008;34(3):466-72.
48. Loewy RL, Pearson R, Vinogradov S, Bearden CE, Cannon TD. Psychosis risk screening with the Prodromal Questionnaire-brief version (PQ-B). Schizophr Res. 2011;129(1):42-6.
49. Morrison AP, Stewart SL, French P, Bentall RP, Birchwood M, Byrne R, et al. Early detection and intervention evaluation for people at high-risk of psychosis-2 (EDIE-2): trial rationale, design and baseline characteristics. Early Interv Psychiatry. 2011;5(1):24-32.
50. O'Brien MP, Zinberg JL, Ho L, Rudd A, Kopelowicz A, Daley M, et al. Family problem solving interactions and 6-month symptomatic and functional outcomes in youth at ultra-high risk for psychosis and with recent onset psychotic symptoms: a longitudinal study. Schizophr Res. 2009;107(2-3):198-205.
51. Miklowitz DJ, O'Brien M, Schlosser DA, Zinberg JL, De Silva S, George EL, et al. Clinician's treatment manual for family-Focused Therapy for Prodromal Youth (FFT-PY). 2010.
52. First MSR, Gibbon M, Williams J. Structured clinical interview for DSM-IV Axis I Disorders-Patient Edition (SCID I/P, Version 2.0). New York: New York State Psychiatric Institute, Biometrics Research Dept; 1995.
53. Kay SR, Fiszbein A, Opler LA. The positive and negative syndrome scale (PANSS) for schizophrenia. Schizophr Bull. 1987;13(2):261-76.
54. Schlagenhauf F, Wustenberg T, Schmack K, Dinges M, Wrase J, Koslowski M, et al. Switching schizophrenia patients from typical neuroleptics to olanzapine: effects on BOLD response during attention and working memory. Eur Neuropsychopharmacol. 2008;18(8):589-99.
55. Schlagenhauf F, Dinges M, Beck A, Wustenberg T, Friedel E, Dembler T, et al. Switching schizophrenia patients from typical neuroleptics to aripiprazole: effects on working memory dependent functional activation. Schizophr Res. 2010;118(1-3):189-200.
56. Deserno L, Sterzer P, Wustenberg T, Heinz A, Schlagenhauf F. Reduced prefrontal-parietal effective connectivity and working memory deficits in schizophrenia. J Neurosci. 2012;32(1):12-20.
57. Hugdahl K, Andersson L. The "forced-attention paradigm" in dichotic listening to CV-syllables: a comparison between adults and children. Cortex. 1986;22(3):417-32.
58. Hugdahl K, Rund BR, Lund A, Asbjornsen A, Egeland J, Landro NI, et al. Attentional and executive dysfunctions in schizophrenia and depression: evidence from dichotic listening performance. Biol Psychiatry. 2003;53(7):609-16.
59. Kompus K, Specht K, Ersland L, Juvodden HT, van Wageningen H, Hugdahl K, et al. A forced-attention dichotic listening fMRI study on 113 subjects. Brain Lang. 2012;121(3):240-7.
60. Hiscock M, Stewart C. The effect of asymmetrically focused attention upon subsequent ear differences in dichotic listening. Neuropsychologia. 1984;22(3):337-51.
61. Westerhausen R, Woerner W, Kreuder F, Schweiger E, Hugdahl K, Wittling W. The role of the corpus callosum in dichotic listening: a combined morphological and diffusion tensor imaging study. Neuropsychology. 2006;20(3):272-9.
62. van den Noort M, Specht K, Rimol LM, Ersland L, Hugdahl K. A new verbal reports fMRI dichotic listening paradigm for studies of hemispheric asymmetry. Neuroimage. 2008;40(2):902-11.