Using light to shape chemical gradients for parallel and automated analysis of chemotaxis

Molecular Systems Biology

Volumn 11, Issue 4, 2015, Pages 1-13

  Collins, Sean R ^a,b   Yang, Hee Won ^a   Bonger, Kimberly M ^a,c   Guignet, Emmanuel G ^a,d   Wandless, Thomas J ^a   Meyer, Tobias ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c RADBOUD UNIVERSITY NIJMEGEN   (Netherlands)

^d Bio Rad Laboratories   (Switzerland)

Author keywords

chemokinesis; chemotaxis; Galphai; gradients; uncaging

Indexed keywords

ADENOSINE TRIPHOSPHATE; CHEMOATTRACTANT; GUANINE NUCLEOTIDE BINDING PROTEIN ALPHA SUBUNIT; GUANINE NUCLEOTIDE BINDING PROTEIN BETA SUBUNIT; SMALL INTERFERING RNA; CHEMOTACTIC FACTOR; FLUORESCEIN DERIVATIVE; FLUORESCENT DYE; FORMYLMETHIONYLLEUCYLPHENYLALANINE; INHIBITORY GUANINE NUCLEOTIDE BINDING PROTEIN; TUMOR PROTEIN;

ARTICLE; CELL FUNCTION; CELL MIGRATION; CELL MOTILITY; CELL MOTION; CHEMOTAXIS; CONTROLLED STUDY; FLUORESCENCE MICROSCOPY; HUMAN; HUMAN CELL; LIGHT; NEUTROPHIL CHEMOTAXIS; PRIORITY JOURNAL; ACUTE MYELOBLASTIC LEUKEMIA; CYTOLOGY; DOSE RESPONSE; DRUG EFFECTS; EQUIPMENT DESIGN; IMAGE PROCESSING; NEUTROPHIL; PATHOLOGY; PHOTOCHEMISTRY; PHYSIOLOGY; PROCEDURES; TIME LAPSE IMAGING; TUMOR CELL LINE; ULTRAVIOLET RADIATION;

EUKARYOTA;

ADENOSINE TRIPHOSPHATE; CELL LINE, TUMOR; CHEMOTACTIC FACTORS; CHEMOTAXIS; DOSE-RESPONSE RELATIONSHIP, DRUG; EQUIPMENT DESIGN; FLUORESCEINS; FLUORESCENT DYES; GTP-BINDING PROTEIN ALPHA SUBUNITS, GI-GO; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; LEUKEMIA, MYELOID, ACUTE; MICROSCOPY, FLUORESCENCE; N-FORMYLMETHIONINE LEUCYL-PHENYLALANINE; NEOPLASM PROTEINS; NEUTROPHILS; PHOTOCHEMISTRY; RNA, SMALL INTERFERING; TIME-LAPSE IMAGING; ULTRAVIOLET RAYS;

EID: 84928788720     PISSN: None     EISSN: 17444292     Source Type: Journal    
DOI: 10.15252/msb.20156027     Document Type: Article

References (33)

1. Ashe HL, Briscoe J, (2006) The interpretation of morphogen gradients. Development 133: 385-394
2. Bravo-Cordero JJ, Magalhaes MAO, Eddy RJ, Hodgson L, Condeelis J, (2013) Functions of cofilin in cell locomotion and invasion. Nat Rev Mol Cell Biol 14: 405-415
3. Charest PG, Firtel RA, (2007) Big roles for small GTPases in the control of directed cell movement. Biochem J 401: 377-390
4. Chen Y, Corriden R, Inoue Y, Yip L, Hashiguchi N, Zinkernagel A, Nizet V, Insel PA, Junger WG, (2006) ATP release guides neutrophil chemotaxis via P2Y2 and A3 receptors. Science 314: 1792-1795
5. Cook DR, Rossman KL, Der CJ, (2014) Rho guanine nucleotide exchange factors: regulators of Rho GTPase activity in development and disease. Oncogene 33: 4021-4035
6. Derivery E, Gautreau A, (2010) Generation of branched actin networks: assembly and regulation of the N-WASP and WAVE molecular machines. BioEssays 32: 119-131
7. Friedl P, Weigelin B, (2008) Interstitial leukocyte migration and immune function. Nat Immunol 9: 960-969
8. Guignet EG, Meyer T, (2008) Suspended-drop electroporation for high-throughput delivery of biomolecules into cells. Nat Methods 5: 393-395
9. Hawkins PT, Stephens LR, Suire S, Wilson M, (2010) PI3K signaling in neutrophils. Curr Top Microbiol Immunol 346: 183-202
10. Hayakawa K, Tatsumi H, Sokabe M, (2011) Actin filaments function as a tension sensor by tension-dependent binding of cofilin to the filament. J Cell Biol 195: 721-727
11. Heit B, Robbins SM, Downey CM, Guan Z, Colarusso P, Miller BJ, Jirik FR, Kubes P, (2008) PTEN functions to "prioritize" chemotactic cues and prevent "distraction" in migrating neutrophils. Nat Immunol 9: 743-752
12. Heit B, Tavener S, Raharjo E, Kubes P, (2002) An intracellular signaling hierarchy determines direction of migration in opposing chemotactic gradients. J Cell Biol 159: 91-102
13. Iglesias PA, Devreotes PN, (2008) Navigating through models of chemotaxis. Curr Opin Cell Biol 20: 35-40
14. Isfort K, Ebert F, Bornhorst J, Sargin S, Kardakaris R, Pasparakis M, Baehler M, Schwerdtle T, Schwab A, Hanley PJ, (2011) Real-time imaging reveals that P2Y2 and P2Y12 receptor agonists are not chemoattractants and macrophage chemotaxis to C5a is PI3K- and p38 MAPK-independent. J Biol Chem 286: 44776-44787
15. Kamakura S, Nomura M, Hayase J, Iwakiri Y, Nishikimi A, Takayanagi R, Fukui Y, Sumimoto H, (2013) The cell polarity protein minsc regulates neutrophil chemotaxis via a noncanonical G protein signaling pathway. Dev Cell 26: 292-302
16. Kaplan JH, Forbush B, Hoffman JF, (1978) Rapid photolytic release of adenosine 5′-triphosphate from a protected analogue: utilization by the Na:K pump of human red blood cell ghosts. Biochemistry 17: 1929-1935
17. Kölsch V, Charest PG, Firtel RA, (2008) The regulation of cell motility and chemotaxis by phospholipid signaling. J Cell Sci 121: 551-559
18. Meshki J, Tuluc F, Bredetean O, Garcia A, Kunapuli SP, (2006) Signaling pathways downstream of P2 receptors in human neutrophils. Purinergic Signal 2: 537-544
19. Mouneimne G, Soon L, DesMarais V, Sidani M, Song X, Yip S-C, Ghosh M, Eddy R, Backer JM, Condeelis J, (2004) Phospholipase C and cofilin are required for carcinoma cell directionality in response to EGF stimulation. J Cell Biol 166: 697-708
20. Neptune ER, Bourne HR, (1997) Receptors induce chemotaxis by releasing the betagamma subunit of Gi, not by activating Gq or Gs. Proc Natl Acad Sci USA 94: 14489-14494
21. Pirrung MC, Drabik SJ, Ahamed J, Ali H, (2000) Caged chemotactic peptides. Bioconjug Chem 11: 679-681
22. Pujic Z, Mortimer D, Feldner J, Goodhill GJ, (2009) Assays for eukaryotic cell chemotaxis. Comb Chem High Throughput Screen 12: 580-588
23. Renkawitz J, Sixt M, (2010) Mechanisms of force generation and force transmission during interstitial leukocyte migration. EMBO Rep 11: 744-750
24. Segall JE, (1993) Polarization of yeast cells in spatial gradients of alpha mating factor. Proc Natl Acad Sci USA 90: 8332-8336
25. Servant G, Weiner OD, Neptune ER, Sedat JW, Bourne HR, (1999) Dynamics of a chemoattractant receptor in living neutrophils during chemotaxis. Mol Biol Cell 10: 1163-1178
26. Stradal TE, Scita G, (2006) Protein complexes regulating Arp2/3-mediated actin assembly. Curr Opin Cell Biol 18: 4-10
27. Swaney KF, Huang C-H, Devreotes PN, (2010) Eukaryotic chemotaxis: a network of signaling pathways controls motility, directional sensing, and polarity. Annu Rev Biophys 39: 265-289
28. Tamura M, Gu J, Matsumoto K, Aota S, Parsons R, Yamada KM, (1998) Inhibition of cell migration, spreading, and focal adhesions by tumor suppressor PTEN. Science 280: 1614-1617
29. Tojima T, Hines JH, Henley JR, Kamiguchi H, (2011) Second messengers and membrane trafficking direct and organize growth cone steering. Nat Rev Neurosci 12: 191-203
30. Tucker KA, Lilly MB, Heck L, Rado TA, (1987) Characterization of a new human diploid myeloid leukemia cell line (PLB-985) with granulocytic and monocytic differentiating capacity. Blood 70: 372-378
31. Vladimirov N, Sourjik V, (2009) Chemotaxis: how bacteria use memory. Biol Chem 390: 1097-1104
32. Ye RD, (2010) Editorial: biased agonism in chemoattractant receptor signaling. J Leukoc Biol 87: 959-961
33. Zigmond SH, Foxman EF, Segall JE, (2001) Chemotaxis assays for eukaryotic cells. Curr Protoc Cell Biol 00:12.1: 12.1.1-12.1.29