Src-family protein tyrosine kinase phosphorylates WNK4 and modulates its inhibitory effect on KCNJ1 (ROMK)

Proceedings of the National Academy of Sciences of the United States of America

Volumn 112, Issue 14, 2015, Pages 4495-4500

  Lin, Dao Hong ^a   Yue, Peng ^a   Yarborough, Orlando ^b   Scholl, Ute I ^b   Giebisch, Gerhard ^b   Lifton, Richard P ^b   Rinehart, Jesse ^b,c   Wang, Wen Hui ^a  

^a NEW YORK MEDICAL COLLEGE   (United States)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c YALE UNIVERSITY   (United States)

Author keywords

Hyperkalemia; Hypokalemia; PTP 1D; SGK1; Volume depletion

Indexed keywords

POTASSIUM CHANNEL; POTASSIUM CHANNEL KCNJ1; PROTEIN KINASE WNK4; PROTEIN TYROSINE KINASE; PROTEIN TYROSINE KINASE SRC; PROTEIN TYROSINE PHOSPHATASE; PROTEIN TYROSINE PHOSPHATASE 1D; UNCLASSIFIED DRUG; IMMEDIATE EARLY PROTEIN; INWARDLY RECTIFYING POTASSIUM CHANNEL; KCNJ1 PROTEIN, HUMAN; KCNJ1 PROTEIN, MOUSE; PRKWNK4 PROTEIN, MOUSE; PROTEIN SERINE THREONINE KINASE; SERUM-GLUCOCORTICOID REGULATED KINASE; TITANIUM; TITANIUM DIOXIDE; TYROSINE; WNK4 PROTEIN, HUMAN;

ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME BINDING; ENZYME INHIBITION; HEK293 CELL LINE; IMMUNOPRECIPITATION; MASS SPECTROMETRY; POTASSIUM CURRENT; PRIORITY JOURNAL; PROTEIN MOTIF; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; WESTERN BLOTTING; ANIMAL; BINDING SITE; CHEMISTRY; ELECTROPHYSIOLOGY; HUMAN; HYPERKALEMIA; HYPOKALEMIA; LIQUID CHROMATOGRAPHY; METABOLISM; MOUSE; MUTATION; NEPHRON; PHOSPHORYLATION; RAT; TANDEM MASS SPECTROMETRY;

ANIMALS; BINDING SITES; CHROMATOGRAPHY, LIQUID; ELECTROPHYSIOLOGY; HEK293 CELLS; HUMANS; HYPERKALEMIA; HYPOKALEMIA; IMMEDIATE-EARLY PROTEINS; MICE; MUTATION; NEPHRONS; PHOSPHORYLATION; POTASSIUM CHANNELS, INWARDLY RECTIFYING; PROTEIN-SERINE-THREONINE KINASES; RATS; SRC-FAMILY KINASES; TANDEM MASS SPECTROMETRY; TITANIUM; TYROSINE;

EID: 84928778487     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1503437112     Document Type: Article

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