Salacia reticulata (Kothala himbutu) revisited; a missed opportunity to treat diabetes and obesity?

Nutrition Journal

Volumn 14, Issue 1, 2015, Pages

  Medagama, Arjuna B ^a  

^a UNIVERSITY OF PERADENIYA   (Sri Lanka)

Author keywords

[No Author keywords available]

Indexed keywords

ADIPONECTIN; ALPHA GLUCOSIDASE; ANTIDIABETIC AGENT; ANTIOBESITY AGENT; GLUCOSE; HEMOGLOBIN A1C; HORMONE SENSITIVE LIPASE; MALTOSE; MESSENGER RNA; PLANT EXTRACT; SALACIA RETICULATA EXTRACT; SUCROSE; TRIACYLGLYCEROL LIPASE; UNCLASSIFIED DRUG; VITAMIN D; CHOLESTEROL ESTERASE; GLUCOSE BLOOD LEVEL; GLYCOSYLATED HEMOGLOBIN; HEMOGLOBIN A1C PROTEIN, HUMAN; INSULIN;

ANTI OBESITY ACTIVITY; ANTIDIABETIC ACTIVITY; BODY MASS; DOWN REGULATION; DRUG ACTIVITY; DRUG EFFECT; DRUG EFFICACY; DRUG SAFETY; DYSPEPSIA; ENZYME INHIBITION; GENE EXPRESSION REGULATION; GLUCOSE BLOOD LEVEL; GLUCOSE METABOLISM; HEMOGLOBIN BLOOD LEVEL; HUMAN; HYPERGLYCEMIA; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; LIPOGENESIS; LIPOLYSIS; LOOSE FECES; MESENTERIC FAT; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OBESITY; REVIEW; SALACIA; SALACIA RETICULATA; TREATMENT DURATION; TRIACYLGLYCEROL LIPASE BLOOD LEVEL; UPREGULATION; WEIGHT REDUCTION; ADIPOCYTE; ANIMAL; BLOOD; BODY WEIGHT; DIET THERAPY; DRUG EFFECTS; GENETICS; METABOLISM; MOUSE; TREATMENT OUTCOME;

ADIPOCYTES; ADIPONECTIN; ALPHA-GLUCOSIDASES; ANIMALS; BLOOD GLUCOSE; BODY WEIGHT; DIABETES MELLITUS, TYPE 2; HEMOGLOBIN A, GLYCOSYLATED; HUMANS; INSULIN; INSULIN RESISTANCE; LIPOGENESIS; LIPOLYSIS; MICE; OBESITY; PLANT EXTRACTS; RNA, MESSENGER; SALACIA; STEROL ESTERASE; TREATMENT OUTCOME;

EID: 84928744477     PISSN: None     EISSN: 14752891     Source Type: Journal    
DOI: 10.1186/s12937-015-0013-4     Document Type: Review

References (36)

1. World Health Organization. WHO Diabetes fact sheet No 312; available at http://www.who.int/mediacentre/factsheets. 2013 October.
2. Wild S, Roglic G, Green A, Sicree R, King H. Global prevalence of diabetes: estimates for the year 2000 and projections for 2030. Diabetes Care. 2004;27(5):1047-53.
3. Cramer JA. A systematic review of adherence with medications for diabetes. Diabetes Care. 2004;27(5):1218-24.
4. Ranasinghe P, Jayawardana R, Galappaththy P, Constantine GR, de Vas GN, Katulanda P. Efficacy and safety of 'true' cinnamon (Cinnamomum zeylanicum) as a pharmaceutical agent in diabetes: a systematic review and meta-analysis. Diabet Med. 2012;29(12):1480-92.
5. Medagama AB, Bandara R. The use of Complementary and Alternative Medicines (CAMs) in the treatment of diabetes mellitus: is continued use safe and effective? Nutr J. 2014;13(1):102.
6. Chang CL, Lin Y, Bartolome AP, Chen YC, Chiu SC, Yang WC. Herbal therapies for type 2 diabetes mellitus: chemistry, biology, and potential application of selected plants and compounds. Evid Based Complement Altern Med. 2013;2013:378657.
7. Vuksan VSJ, Koo VY, Francis JL. American ginseng (Panax quinquefolius L) reduces postprandial glycemia in nondiabetic subjects and subjects with type 2 diabetes mellitus. Arch Intern Med. 2000;160(7):1009-13.
8. Millstein RA. Measuring outcomes in adult weight loss studies that include diet and physical activity: a systematic review. J Nutr Metab. 2014;2014:421423.
9. Folsom AR, Kaye SA, Sellers TA, Hong CP, Cerhan JR, Potter JD, et al. Body fat distribution and 5-year risk of death in older women. JAMA. 1993;269(4):483-7.
10. Ho S. C. CYM, Woo J. L. F., Leung S. S. F., Lam T. H., Janus E. D. Association between simple anthropometric indices and cardiovascular risk factors. Int J Obes. 2001;25(11):1689-97
11. Ching SM, Zakaria ZA, Paimin F, Jalalian M. Complementary alternative medicine use among patients with type 2 diabetes mellitus in the primary care setting: a cross-sectional study in Malaysia. BMC Complement Altern Med. 2013;13:148.
12. Anurakumara KKIUSS. Salacia reticulata Wight: A review of botany, phyochemistry and pharmacology. Tropical Agricultural Research and Extension. 2010;13(2):41-5.
13. Matsuda HYM, Morikawa T, Tanabe G, Muraoka O. Antidiabetogenic constituents from Salacia species. J Trad Med. 2005;22(1):145-53.
14. Li Y, Huang TH, Yamahara J. Salacia root, a unique Ayurvedic medicine, meets multiple targets in diabetes and obesity. Life Sci. 2008;82(21-22):1045-9.
15. Yoshikawa MMT, Yashiro K, Matsuda H. Katalanol a potent alpha glucosidase inhibitor with thiosugar sulfonium silphate structure from antidiabetic Ayurvedic medicine Salacia reticulata. Chem Pharm Bull. 1998;46(8):1339-40.
16. Yoshikawa MNN, Shimoda H, Takada M. Polyphenol constituents from Salacia species: quantitative analysis of mangiferin with alpha glucosidase and aldose reductase inhibitory activities. Yakugaku Zasshi. 2001;121:5371-8.
17. Hiromi OEOS. Hypoglycaemic effect of 13-Memebered ring thiocyclitol a novel alpha-glucosidase inhibitor from Kothala himbutu (salacia reticulata). Biosci Biotechnol Biochem. 2008;72(7):1962-4.
18. Derosa GMP. α-Glucosidase inhibitors and their use in clinical practice. Arch Med Sci. 2012;8(5):899-906.
19. Shimoda HKS, Kawahara Y. Effects of an aqueous extract of Salacia reticulata, a useful plant in Sri Lanka, on postprandial hyperglycaemia in rats and humans. J Jpn Soc Nutr Food Sci. 1998;51:279-89.
20. Yoshikawa MMT, Matsuda H, Tanabe G, Muraoka O. Absolute Stereostructure of Potent-Glucosidase Inhibitor, Salacinol, with Unique Thiosugar Sulfonium Sulfate Inner Salt Structure from Salacia reticulata. Bioorg Med Chem. 2002;10:1547-54.
21. Huang TH, Yang Q, Harada M, Uberai J, Radford J, Li GQ, et al. Salacia oblonga root improves cardiac lipid metabolism in Zucker diabetic fatty rats: modulation of cardiac PPAR-alpha-mediated transcription of fatty acid metabolic genes. Toxicol Appl Pharmacol. 2006;210(1-2):78-85.
22. Yoshikawa M, Shimoda H, Nishida N, Takada M, Matsuda H. Salacia reticulata and its polyphenolic constituents with lipase inhibitory and lipolytic activities have mild antiobesity effects in rats. J Nutr. 2002;132:1819-24.
23. Matsuzawa Y, Funahashi T, Kihara S, Shimomura I. Adiponectin and metabolic syndrome. Arterioscler Thromb Vasc Biol. 2004;24(1):29-33.
24. Shimada T, Nakayama Y, Harasawa Y, Matsui H, Kobayashi H, Sai Y, et al. Salacia reticulata has therapeutic effects on obesity. J Nat Med. 2014;68(4):668-76.
25. Shimada T, Nagai E, Harasawa Y, Watanabe M, Negishi K, Akase T, et al. Salacia reticulata inhibits differentiation of 3 T3-L1 adipocytes. J Ethnopharmacol. 2011;136(1):67-74.
26. Akase T, Shimada T, Harasawa Y, Akase T, Ikeya Y, Nagai E, et al. Preventive Effects of Salacia reticulata on Obesity and Metabolic Disorders in TSOD Mice. Evid Based Complement Altern Med. 2011;2011:484590.
27. Yamauchi T, Kamon J, Minokoshi Y, Ito Y, Waki H, Uchida S, et al. Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase. Nat Med. 2002;8(11):1288-95.
28. Kajimoto OKS, Shimoda H, Kawahara Y, Hirata H, Takahashi T. Effects of a diet containing Salacia reticulata on mild type 2 diabetes in humans. A placebo controlled, cross over trial. Journal of the Japanes society of. Nutr Food Sci. 2000;53(5):199-205.
29. Jayawardena MH, de Alwis NM, Hettigoda V, Fernando DJ. A double blind randomised placebo controlled cross over study of a herbal preparation containing Salacia reticulata in the treatment of type 2 diabetes. J Ethnopharmacol. 2005;97(2):215-8.
30. Shivaprasad HN, Bhanumathy M, Sushma G, Midhun T, Raveendra KR, Sushma KR, et al. Salacia reticulata improves serum lipid profiles and glycemic control in patients with prediabetes and mild to moderate hyperlipidemia: a double-blind, placebo-controlled, randomized trial. J Med Food. 2013;16(6):564-8.
31. Ofner M, Tomaschitz A, Wonisch M, Litscher G. Complementary treatment of obesity and overweight with salacia reticulata and vitamin d. Int J Vitam Nutr Res. 2013;83(4):216-23.
32. Serasinghe SSP, Yamazaki H, Nishiguchi K, Hombhanje F, Nakanishi S. Oral hypoglycemic effect of Salacia reticulata in the Streptozotocin induced diabetic rat. Phytother Res. 1990;4(5):205-6.
33. Kumara NKVMRPR, Pathirana C. Hypoglycemic activity of the root and stem of salacia reticulata var. B-diandra in alloxan diabetic rats. Pharm Biol. 2005;43(3):219-25.
34. Iizuka S, Suzuki W, Tabuchi M, Nagata M, Imamura S, Kobayashi Y, et al. Diabetic complications in a new animal model (TSOD mouse) of spontaneous NIDDM with obesity. Exp Anim. 2005;54(1):71-83.
35. Hirayama I, Yi Z, Izumi S, Arai I, Suzuki W, Nagamachi Y, et al. Genetic analysis of obese diabetes in the TSOD mouse. Diabetes. 1999;48(5):1183-91.
36. Fysekidis M, Cosson E, Banu I, Duteil R, Cyrille C, Valensi P. Increased glycemic variability and decrease of the postprandial glucose contribution to HbA1c in obese subjects across the glycemic continuum from normal glycemia to first time diagnosed diabetes. Metab Clin Exp. 2014;63(12):1553-61.