Pulmonary alveolar proteinosis and macrophage transplantation

New England Journal of Medicine

Volumn 372, Issue 18, 2015, Pages 1762-1764

  Doerschuk, Claire M ^a  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR RECEPTOR; LUNG SURFACTANT; CD34 ANTIGEN;

ARTICLE; CELL THERAPY; CELL TRANSPLANTATION; CELLULAR DISTRIBUTION; GENETIC ENGINEERING; HOMEOSTASIS; HUMAN; IMMUNE RESPONSE; INTRACELLULAR SIGNALING; LUNG ALVEOLUS MACROPHAGE; LUNG ALVEOLUS PROTEINOSIS; MACROPHAGE FUNCTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; ANIMAL; DISEASE MODEL; GENE THERAPY; KNOCKOUT MOUSE; MOUSE; PULMONARY ALVEOLAR PROTEINOSIS; TRANSPLANTATION;

ANIMALS; ANTIGENS, CD34; DISEASE MODELS, ANIMAL; GENETIC THERAPY; HUMANS; MACROPHAGES, ALVEOLAR; MICE; MICE, KNOCKOUT; PULMONARY ALVEOLAR PROTEINOSIS; RECEPTORS, GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR;

EID: 84928731601     PISSN: 00284793     EISSN: 15334406     Source Type: Journal    
DOI: 10.1056/NEJMcibr1413035     Document Type: Article

References (5)

1. Kleff V, Sorg UR, Bury C, et al. Gene therapy of beta(c)-deficient pulmonary alveolar proteinosis (beta(c)-PAP): studies in a murine in vivo model. Mol Ther 2008;16:757-64.
2. Willinger T, Rongvaux A, Takizawa H, et al. Human IL-3/GM-CSF knock-in mice support human alveolar macrophage development and human immune responses in the lung. Proc Natl Acad Sci U S A 2011;108:2390-5.
3. Happle C, Lachmann N, Škuljec J, et al. Pulmonary transplantation of macrophage progenitors as effective and long-lasting therapy for hereditary pulmonary alveolar proteinosis. Sci Transl Med 2014;6:ra113.
4. Suzuki T, Arumugam P, Sakagami T, et al. Pulmonary macrophage transplantation therapy. Nature 2014;514:450-4.
5. Lachmann N, Happle C, Ackermann M, et al. Gene correction of human induced pluripotent stem cells repairs the cellular phenotype in pulmonary alveolar proteinosis. Am J Respir Crit Care Med 2014;189:167-82.