Particulate air pollution induces arrhythmia via oxidative stress and calcium calmodulin kinase II activation

Toxicology and Applied Pharmacology

Volumn 259, Issue 1, 2012, Pages 66-73

  Kim, Jin Bae ^a   Kim, Changsoo ^b   Choi, Eunmi ^b   Park, Sanghoon ^b   Park, Hyelim ^b   Pak, Hui Nam ^b   Lee, Moon Hyoung ^b   Shin, Dong Chun ^b   Hwang, Ki Chul ^b   Joung, Boyoung ^b  

^a Kyung Hee University Hospital   (South Korea)

^b Yonsei University College of Medicine   (South Korea)

Author keywords

Ca 2+ calmodulin dependent protein kinase II; Oxidative stress; Particulate matter; Ventricular fibrillation; Ventricular tachycardia

Indexed keywords

ACETYLCYSTEINE; CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE II; KN 92; N [2 [[N [3 (4 CHLOROPHENYL) 2 PROPENYL] N METHYLAMINO]METHYL]PHENYL] N (2 HYDROXYETHYL) 4 METHOXYBENZENESULFONAMIDE; NIFEDIPINE; PROTEIN SERINE THREONINE KINASE INHIBITOR; REACTIVE OXYGEN METABOLITE; RYANODINE; THAPSIGARGIN; UNCLASSIFIED DRUG;

AIR POLLUTION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARRHYTHMOGENESIS; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; ENZYME ACTIVATION; ENZYME INHIBITION; EXHAUST GAS; HEART ARRHYTHMIA; HEART DEPOLARIZATION; HEART MUSCLE CELL; HEART MUSCLE POTENTIAL; HEART REPOLARIZATION; HEART VENTRICLE EXTRASYSTOLE; HEART VENTRICLE FIBRILLATION; HEART VENTRICLE TACHYCARDIA; IN VITRO STUDY; IN VIVO STUDY; ISOLATED HEART; MALE; NEWBORN; NONHUMAN; OXIDATIVE STRESS; PARTICULATE MATTER; QT INTERVAL; RAT;

ACETYLCYSTEINE; ACTION POTENTIALS; AIR POLLUTANTS; ANIMALS; ANIMALS, NEWBORN; APOPTOSIS; ARRHYTHMIAS, CARDIAC; CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASE TYPE 2; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME ACTIVATION; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; MALE; MYOCYTES, CARDIAC; OXIDATIVE STRESS; PARTICULATE MATTER; RATS; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES; VEHICLE EMISSIONS; VENTRICULAR PREMATURE COMPLEXES; VOLTAGE-SENSITIVE DYE IMAGING;

RATTUS;

EID: 84857111710     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2011.12.007     Document Type: Article

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