Esters of the marine-derived triterpene sipholenol a reverse P-GP-mediated drug resistance

Marine Drugs

Volumn 13, Issue 4, 2015, Pages 2267-2286

  Zhang, Yongchao ^a   Zhang, Yun Kai ^b   Wang, Yi Jun ^b   Vispute, Saurabh G ^b   Jain, Sandeep ^c   Chen, Yangmin ^d   Li, Jessalyn ^b,f   Youssef, Diaa T A ^e   El Sayed, Khalid A ^c   Chen, Zhe Sheng ^b  

^a ZHENGZHOU UNIVERSITY   (China)

^b ST JOHN'S UNIVERSITY   (United States)

^c UNIVERSITY OF LOUISIANA AT MONROE   (United States)

^d RUTGERS UNIVERSITY   (United States)

^e KING ABDULAZIZ UNIVERSITY   (Saudi Arabia)

^f Great Neck South High School   (United States)

Author keywords

ABC transporter; BCRP ABCG2; Marine natural products; MRP1 ABCC1; Multidrug resistance; P gp ABCB1; Sipholenol A

Indexed keywords

ADENOSINE TRIPHOSPHATASE; BREAST CANCER RESISTANCE PROTEIN; CISPLATIN; DOXORUBICIN; GLYCOPROTEIN P INHIBITOR; MITOXANTRONE; MULTIDRUG RESISTANCE ASSOCIATED PROTEIN 1; MULTIDRUG RESISTANCE PROTEIN; PACLITAXEL; SIPHOLENOL A 4 O ACETATE; SIPHOLENOL A 4 O ISONICOTINATE; TRITERPENE DERIVATIVE; UNCLASSIFIED DRUG; VERAPAMIL; VINCRISTINE; ABCB1 PROTEIN, HUMAN; ACETIC ACID DERIVATIVE; ANTINEOPLASTIC AGENT; ISONICOTINIC ACID; RECOMBINANT PROTEIN; SIPHOLENOL A; TRITERPENE;

ABCC1 GENE; ABCG2 GENE; ARTICLE; CALLYSPONGIA; CALLYSPONGIA SIPHONELLA; CANCER RESISTANCE; CELL SURVIVAL; CELL VIABILITY; COMPUTER MODEL; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY TEST; DRUG ACCUMULATION; DRUG EFFECT; DRUG IDENTIFICATION; DRUG MECHANISM; DRUG POTENTIATION; DRUG PROTEIN BINDING; DRUG SCREENING; DRUG STRUCTURE; DRUG TRANSPORT; ENZYME ACTIVITY; ENZYME SUBSTRATE; GENE; GENE EXPRESSION; HEK293 CELL LINE; HUMAN; HUMAN CELL; IC50; MOLECULAR DOCKING; MULTIDRUG RESISTANCE; PROTEIN EXPRESSION; WESTERN BLOTTING; ABSORPTION; AGONISTS; ANIMAL; BINDING SITE; CHEMISTRY; COLONIC NEOPLASMS; CONFORMATION; DRUG EFFECTS; DRUG RESISTANCE; ESTERIFICATION; GENETICS; METABOLISM; TUMOR CELL LINE;

ABSORPTION, PHYSIOLOGICAL; ACETATES; ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; BINDING SITES; CALLYSPONGIA; CELL LINE, TUMOR; CELL SURVIVAL; COLONIC NEOPLASMS; DRUG RESISTANCE, MULTIPLE; DRUG RESISTANCE, NEOPLASM; DRUG SYNERGISM; ESTERIFICATION; HEK293 CELLS; HUMANS; ISONICOTINIC ACIDS; MOLECULAR CONFORMATION; MOLECULAR DOCKING SIMULATION; P-GLYCOPROTEINS; PACLITAXEL; RECOMBINANT PROTEINS; TRITERPENES;

EID: 84928713356     PISSN: None     EISSN: 16603397     Source Type: Journal    
DOI: 10.3390/md13042267     Document Type: Article

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