Optimization, pharmacophore modeling and 3D-QSAR studies of sipholanes as breast cancer migration and proliferation inhibitors

European Journal of Medicinal Chemistry

Volumn 73, Issue , 2014, Pages 310-324

  Foudah, Ahmed I ^a   Sallam, Asmaa A ^a   Akl, Mohamed R ^a   El Sayed, Khalid A ^a  

^a UNIVERSITY OF LOUISIANA AT MONROE   (United States)

Author keywords

3D QSAR; Antimigratory; Antiproliferative; Breast cancer; Brk; Pharmacophore modeling; Sipholane

Indexed keywords

4 BETA O 2' FUROYLSIPHOLENOL A; 4 BETA O 3' (TRIFLUOROMETHYL)BENZOYLSIPHOLENOL A; 4 BETA O 3' CHLOROBENZOYLSIPHOLENOL A; 4 BETA O 3' FLUORO 5' (TRIFLUOROMETHYL)BENZOYLSIPHOLENOL A; 4 BETA O 3' FLUOROBENZOYLSIPHOLENOL A; 4 BETA O 3' NITROBENZOYLSIPHOLENOL A; 4 BETA O 4' (TRIFLUOROMETHYL)BENZOYLSIPHOLENOL A; 4 BETA O 4' FLUORO 5' (TRIFLUOROMETHYL)BENZOYLSIPHOLENOL A; 4 BETA O 4' NITROBENZOYLSIPHOLENOL A; 4 BETA O 4', 5' DICHLOROBENZOYLSIPHOLENOL A; 4 BETA O 5' (TRIFLUOROMETHYL)BENZOYLSIPHOLENOL A; 4 BETA O 5' FLUOROBENZOYLSIPHOLENOL A; 4 BETA O 5' METHOXYBENZOYLSIPHOLENOL A; 4 BETA O 5' NITRO 2' FUROYLSIPHOLENOL A; 4 BETA O 5' NITROBENZOYLSIPHOLENOL A; ANTINEOPLASTIC AGENT; SIPHOLENOL A; TRITERPENE DERIVATIVE; UNCLASSIFIED DRUG;

ANTIMIGRATORY ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; ARTICLE; BREAST CANCER; BREAST CELL; CANCER CELL CULTURE; CARBON NUCLEAR MAGNETIC RESONANCE; CONTROLLED STUDY; CYTOTOXICITY; DRUG ACTIVITY; ELECTROSPRAY MASS SPECTROMETRY; ENZYME PHOSPHORYLATION; HETERONUCLEAR MULTIPLE BOND CORRELATION; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; MTT ASSAY; PHARMACOPHORE; PROTON NUCLEAR MAGNETIC RESONANCE; QUANTITATIVE STRUCTURE ACTIVITY RELATION; THREE DIMENSIONAL QUANTITATIVE STRUCTURE ACTIVITY RELATION; WESTERN BLOTTING;

3D-QSAR; ANTIMIGRATORY; ANTIPROLIFERATIVE; BREAST CANCER; BRK; PHARMACOPHORE MODELING; SIPHOLANE;

ANTINEOPLASTIC AGENTS; BLOTTING, WESTERN; BREAST NEOPLASMS; CELL LINE, TUMOR; CELL MOVEMENT; CELL PROLIFERATION; CELL SURVIVAL; DRUG DESIGN; EPITHELIAL CELLS; FEMALE; HUMANS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; NEOPLASM PROTEINS; PHOSPHORYLATION; PROTEIN-TYROSINE KINASES; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; TRITERPENES;

EID: 85047686702     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2013.11.039     Document Type: Article

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