-
1
-
-
33751106653
-
New approaches to molecular cancer therapeutics
-
I. Collins, and P. Workman New approaches to molecular cancer therapeutics Nat Chem Biol 2 2006 689 700
-
(2006)
Nat Chem Biol
, vol.2
, pp. 689-700
-
-
Collins, I.1
Workman, P.2
-
2
-
-
33644806404
-
Genomics and the second golden era of cancer drug development
-
P. Workman Genomics and the second golden era of cancer drug development Mol Biosyst 1 2005 17 26
-
(2005)
Mol Biosyst
, vol.1
, pp. 17-26
-
-
Workman, P.1
-
3
-
-
84880752991
-
A systematic approach to the development of novel therapeutics for lung cancer using genomic analyses
-
Y. Daigo, A. Takano, K. Teramoto, S. Chung, and Y. Nakamura A systematic approach to the development of novel therapeutics for lung cancer using genomic analyses Clin Pharmacol Ther 94 2013 218 223
-
(2013)
Clin Pharmacol Ther
, vol.94
, pp. 218-223
-
-
Daigo, Y.1
Takano, A.2
Teramoto, K.3
Chung, S.4
Nakamura, Y.5
-
4
-
-
77649234756
-
How to improve R&D productivity: The pharmaceutical industry's grand challenge
-
S.M. Paul, D.S. Mytelka, and C.T. Dunwiddie How to improve R&D productivity: the pharmaceutical industry's grand challenge Nat Rev Drug Discov 9 2010 203 214
-
(2010)
Nat Rev Drug Discov
, vol.9
, pp. 203-214
-
-
Paul, S.M.1
Mytelka, D.S.2
Dunwiddie, C.T.3
-
5
-
-
79953249834
-
High drug attrition rates-where are we going wrong?
-
L. Hutchinson, and R. Kirk High drug attrition rates-where are we going wrong? Nat Rev Clin Oncol 8 2011 189 190
-
(2011)
Nat Rev Clin Oncol
, vol.8
, pp. 189-190
-
-
Hutchinson, L.1
Kirk, R.2
-
6
-
-
84859441677
-
Drug development and clinical trials-the path to an approved cancer drug
-
E.H. Rubin, and D.G. Gilliland Drug development and clinical trials-the path to an approved cancer drug Nat Rev Clin Oncol 9 2012 215 222
-
(2012)
Nat Rev Clin Oncol
, vol.9
, pp. 215-222
-
-
Rubin, E.H.1
Gilliland, D.G.2
-
7
-
-
84875937242
-
Genotyping and genomic profiling of non-small-cell lung cancer: Implications for current and future therapies
-
T. Li, H.J. Kung, P.C. Mack, and D.R. Gandara Genotyping and genomic profiling of non-small-cell lung cancer: implications for current and future therapies J Clin Oncol 31 2013 1039 1049
-
(2013)
J Clin Oncol
, vol.31
, pp. 1039-1049
-
-
Li, T.1
Kung, H.J.2
Mack, P.C.3
Gandara, D.R.4
-
8
-
-
84865456673
-
Algorithm for codevelopment of new drug-predictive biomarker combinations: Accounting for inter- and intrapatient tumor heterogeneity
-
D.R. Gandara, T. Li, and P.N. Lara Jr. Algorithm for codevelopment of new drug-predictive biomarker combinations: accounting for inter- and intrapatient tumor heterogeneity Clin Lung Cancer 13 2012 321 325
-
(2012)
Clin Lung Cancer
, vol.13
, pp. 321-325
-
-
Gandara, D.R.1
Li, T.2
Lara, Jr.P.N.3
-
9
-
-
79960100831
-
Reengineering translational science: The time is right
-
F.S. Collins Reengineering translational science: the time is right Sci Transl Med 3 2011 90cm17
-
(2011)
Sci Transl Med
, vol.3
, pp. 90cm17
-
-
Collins, F.S.1
-
11
-
-
84891829967
-
Acquired resistance to targeted therapies against oncogene-driven non-small-cell lung cancer: Approach to subtyping progressive disease and clinical implications
-
D.R. Gandara, T. Li, and P.N. Lara Acquired resistance to targeted therapies against oncogene-driven non-small-cell lung cancer: approach to subtyping progressive disease and clinical implications Clin Lung Cancer 15 2014 1 6
-
(2014)
Clin Lung Cancer
, vol.15
, pp. 1-6
-
-
Gandara, D.R.1
Li, T.2
Lara, P.N.3
-
12
-
-
84903275106
-
Oncogenic drivers, targeted therapies, and acquired resistance in non-small-cell lung cancer
-
A. Gower, Y. Wang, and G. Giaccone Oncogenic drivers, targeted therapies, and acquired resistance in non-small-cell lung cancer J Mol Med (Berl) 92 2014 697 707
-
(2014)
J Mol Med (Berl)
, vol.92
, pp. 697-707
-
-
Gower, A.1
Wang, Y.2
Giaccone, G.3
-
13
-
-
79953316881
-
Evolutionary dynamics of intratumor heterogeneity
-
Y. Iwasa, and F. Michor Evolutionary dynamics of intratumor heterogeneity PLoS One 6 2011 e17866
-
(2011)
PLoS One
, vol.6
, pp. e17866
-
-
Iwasa, Y.1
Michor, F.2
-
14
-
-
79957936388
-
How genetically engineered mouse tumor models provide insights into human cancers
-
K. Politi, and W. Pao How genetically engineered mouse tumor models provide insights into human cancers J Clin Oncol 29 2011 2273 2281
-
(2011)
J Clin Oncol
, vol.29
, pp. 2273-2281
-
-
Politi, K.1
Pao, W.2
-
15
-
-
33749363890
-
Mouse modeling in oncologic preclinical and translational research
-
B.S. Carver, and P.P. Pandolfi Mouse modeling in oncologic preclinical and translational research Clin Cancer Res 12 2006 5305 5311
-
(2006)
Clin Cancer Res
, vol.12
, pp. 5305-5311
-
-
Carver, B.S.1
Pandolfi, P.P.2
-
16
-
-
33748331308
-
The mighty mouse: Genetically engineered mouse models in cancer drug development
-
N.E. Sharpless, and R.A. Depinho The mighty mouse: genetically engineered mouse models in cancer drug development Nat Rev Drug Discov 5 2006 741 754
-
(2006)
Nat Rev Drug Discov
, vol.5
, pp. 741-754
-
-
Sharpless, N.E.1
Depinho, R.A.2
-
17
-
-
41049089483
-
Development of new mouse lung tumor models expressing EGFR T790M mutants associated with clinical resistance to kinase inhibitors
-
L. Regales, M.N. Balak, and Y. Gong Development of new mouse lung tumor models expressing EGFR T790M mutants associated with clinical resistance to kinase inhibitors PLoS One 2 2007 e810
-
(2007)
PLoS One
, vol.2
, pp. e810
-
-
Regales, L.1
Balak, M.N.2
Gong, Y.3
-
18
-
-
84869234735
-
Temporal molecular and biological assessment of an erlotinib-resistant lung adenocarcinoma model reveals markers of tumor progression and treatment response
-
Z. Weaver, S. Difilippantonio, and J. Carretero Temporal molecular and biological assessment of an erlotinib-resistant lung adenocarcinoma model reveals markers of tumor progression and treatment response Cancer Res 72 2012 5921 5933
-
(2012)
Cancer Res
, vol.72
, pp. 5921-5933
-
-
Weaver, Z.1
Difilippantonio, S.2
Carretero, J.3
-
19
-
-
84861719757
-
Patient-derived tumour xenografts as models for oncology drug development
-
J.J. Tentler, A.C. Tan, and C.D. Weekes Patient-derived tumour xenografts as models for oncology drug development Nat Rev Clin Oncol 9 2012 338 350
-
(2012)
Nat Rev Clin Oncol
, vol.9
, pp. 338-350
-
-
Tentler, J.J.1
Tan, A.C.2
Weekes, C.D.3
-
20
-
-
33846630040
-
Humanized mice in translational biomedical research
-
L.D. Shultz, F. Ishikawa, and D.L. Greiner Humanized mice in translational biomedical research Nat Rev Immunol 7 2007 118 130
-
(2007)
Nat Rev Immunol
, vol.7
, pp. 118-130
-
-
Shultz, L.D.1
Ishikawa, F.2
Greiner, D.L.3
-
21
-
-
33749337828
-
The use of targeted mouse models for preclinical testing of novel cancer therapeutics
-
K.P. Olive, and D.A. Tuveson The use of targeted mouse models for preclinical testing of novel cancer therapeutics Clin Cancer Res 12 2006 5277 5287
-
(2006)
Clin Cancer Res
, vol.12
, pp. 5277-5287
-
-
Olive, K.P.1
Tuveson, D.A.2
-
22
-
-
80051588648
-
A pilot clinical study of treatment guided by personalized tumorgrafts in patients with advanced cancer
-
M. Hidalgo, E. Bruckheimer, and N.V. Rajeshkumar A pilot clinical study of treatment guided by personalized tumorgrafts in patients with advanced cancer Mol Cancer Ther 10 2011 1311 1316
-
(2011)
Mol Cancer Ther
, vol.10
, pp. 1311-1316
-
-
Hidalgo, M.1
Bruckheimer, E.2
Rajeshkumar, N.V.3
-
23
-
-
78751471036
-
The ability to form primary tumor xenografts is predictive of increased risk of disease recurrence in early-stage non-small-cell lung cancer
-
T. John, D. Kohler, and M. Pintilie The ability to form primary tumor xenografts is predictive of increased risk of disease recurrence in early-stage non-small-cell lung cancer Clin Cancer Res 17 2011 134 141
-
(2011)
Clin Cancer Res
, vol.17
, pp. 134-141
-
-
John, T.1
Kohler, D.2
Pintilie, M.3
-
24
-
-
84941034401
-
Mouse Tumor Biology (MTB): A database of mouse models for human cancer
-
C.J. Bult, D.M. Krupke, and D.A. Begley Mouse Tumor Biology (MTB): a database of mouse models for human cancer Nucleic Acids Res 43 Database issue 2015 D818 D824
-
(2015)
Nucleic Acids Res
, vol.43
, Issue.DATABASE ISSUE
, pp. D818-D824
-
-
Bult, C.J.1
Krupke, D.M.2
Begley, D.A.3
-
25
-
-
78650512312
-
Association of epidermal growth factor receptor activating mutations with low ERCC1 gene expression in non-small-cell lung cancer
-
D.R. Gandara, P. Grimminger, and P.C. Mack Association of epidermal growth factor receptor activating mutations with low ERCC1 gene expression in non-small-cell lung cancer J Thorac Oncol 5 2010 1933 1938
-
(2010)
J Thorac Oncol
, vol.5
, pp. 1933-1938
-
-
Gandara, D.R.1
Grimminger, P.2
Mack, P.C.3
-
26
-
-
84892859492
-
KRAS mutations in non-small-cell lung cancer and colorectal cancer: Implications for EGFR-targeted therapies
-
M.K. Maus, P.P. Grimminger, and P.C. Mack KRAS mutations in non-small-cell lung cancer and colorectal cancer: implications for EGFR-targeted therapies Lung Cancer 83 2014 163 167
-
(2014)
Lung Cancer
, vol.83
, pp. 163-167
-
-
Maus, M.K.1
Grimminger, P.P.2
Mack, P.C.3
|