Chloride intracellular channel 1 (CLIC1) is activated and functions as an oncogene in pancreatic cancer

Medical Oncology

Volumn 32, Issue 6, 2015, Pages

  Lu, Jianhua ^a,b   Dong, Qian ^a,b   Zhang, Bingtai ^c   Wang, Xuefeng ^a,b   Ye, Bin ^d   Zhang, Fei ^a,b   Song, Xiaoling ^a,b   Gao, Guofeng ^c   Mu, Jiasheng ^a,b   Wang, Zheng ^a,b   Ma, Fei ^a   Gu, Jun ^a,b  

^a XINHUA HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^c SHANXI MEDICAL UNIVERSITY   (China)

^d LISHUI CENTRAL HOSPITAL   (China)

Author keywords

Cell proliferation; Chloride intracellular channel 1; Pancreatic cancer; RNA interference

Indexed keywords

AGAR; LENTIVIRUS VECTOR; MESSENGER RNA; OLIGONUCLEOTIDE; PROTEIN; SMALL INTERFERING RNA; CHLORIDE CHANNEL; CLIC1 PROTEIN, HUMAN;

ADULT; AGAR MEDIUM; ANCHORAGE INDEPENDENT GROWTH; ARTICLE; CANCER PATIENT; CANCER PROGNOSIS; CANCER SURVIVAL; CANCER TISSUE; CELL MIGRATION; CELL PROLIFERATION; CHLORIDE INTRACELLULAR CHANNEL 1 GENE; CONTROLLED STUDY; DRUG TARGETING; FEMALE; GENE ACTIVATION; GENE FUNCTION; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; OLIGONUCLEOTIDE THERAPY; ONCOGENE; OVERALL SURVIVAL; PANCREAS CANCER; PANCREATIC CANCER CELL LINE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RNA INTERFERENCE; VIRAL GENE DELIVERY SYSTEM; CELL MOTION; GENETICS; MIDDLE AGED; PANCREAS TUMOR; PHYSIOLOGY; TUMOR CELL LINE;

CELL LINE, TUMOR; CELL MOVEMENT; CELL PROLIFERATION; CHLORIDE CHANNELS; FEMALE; HUMANS; MALE; MIDDLE AGED; ONCOGENES; PANCREATIC NEOPLASMS; RNA INTERFERENCE; RNA, SMALL INTERFERING;

EID: 84928691092     PISSN: 13570560     EISSN: 1559131X     Source Type: Journal    
DOI: 10.1007/s12032-015-0616-9     Document Type: Article

References (28)

1. Biankin AV, Waddell N, Kassahn KS, Gingras MC, Muthuswamy LB, Johns AL, et al. Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes. Nature. 2012;491(7424):399–405.
2. Chen Q, Yang L, Xiao Y, Zhu J, Li Z. Circulating microRNA-182 in plasma and its potential diagnostic and prognostic value for pancreatic cancer. Med Oncol. 2014;31(11):225.
3. Logsdon CD, Simeone DM, Binkley C, Arumugam T, Greenson JK, Giordano TJ, et al. Molecular profiling of pancreatic adenocarcinoma and chronic pancreatitis identifies multiple genes differentially regulated in pancreatic cancer. Cancer Res. 2003;63(10):2649–57.
4. Viale A, Pettazzoni P, Lyssiotis CA, Ying H, Sanchez N, Marchesini M, et al. Oncogene ablation-resistant pancreatic cancer cells depend on mitochondrial function. Nature. 2014;514(7524):628–32.
5. Rosenfeldt MT, O’Prey J, Morton JP, Nixon C, MacKay G, Mrowinska A, et al. p53 status determines the role of autophagy in pancreatic tumour development. Nature. 2013;504(7479):296–300.
6. Zhou L, Li J, Zhao YP, Guo JC, Cui QC, Zhou WX, et al. Prognostic significance of epidermal growth factor-like domain 7 in pancreatic cancer. Hepatobiliary Pancreat Dis Int. 2014;13(5):523–8.
7. Perez-Mancera PA, Rust AG, van der Weyden L, Kristiansen G, Li A, Sarver AL, et al. The deubiquitinase USP9X suppresses pancreatic ductal adenocarcinoma. Nature. 2012;486(7402):266–70.
8. Li M, Zhang Z, Li X, Ye J, Wu X, Tan Z, et al. Whole-exome and targeted gene sequencing of gallbladder carcinoma identifies recurrent mutations in the ErbB pathway. Nat Genet. 2014;4(8):872–6.
9. Averaimo S, Milton RH, Duchen MR, Mazzanti M. Chloride intracellular channel 1 (CLIC1): sensor and effector during oxidative stress. FEBS Lett. 2010;584:2076–84.
10. Wang W, Xu X, Wang W, Shao W, Li L, Yin W, et al. The expression and clinical significance of CLIC1 and HSP27 in lung adenocarcinoma. Tumour Biol. 2011;32(10):1199–208.
11. Tian Y, Guan Y, Jia Y, Meng Q, Yang J. Chloride intracellular channel 1 regulates prostate cancer cell proliferation and migration through the MAPK/ERK pathway. Cancer Biother Radiopharm. 2014;29(8):339–44.
12. Ding Q, Li M, Wu X, Zhang L, Wu W, Ding Q, et al. CLIC1 overexpression is associated with poor prognosis in gallbladder cancer. Tumour Biol. 2015;36(1):193–8.
13. Wang P, Zhang C, Yu P, Tang B, Liu T, Cui H, et al. Regulation of colon cancer cell migration and invasion by CLIC1-mediated RVD. Mol Cell Biochem. 2012;365(1–2):313–21.
14. Ma PF, Chen JQ, Wang Z, Liu JL, Li BP. Function of chloride intracellular channel 1 in gastric cancer cells. World J Gastroenterol. 2012;18(24):3070–80.
15. Petrova DT, Asif AR, Armstrong VW, Dimova I, Toshev S, Yaramov N, et al. Expression of chloride intracellular channel protein 1 (CLIC1) and tumor protein D52 (TPD52) as potential biomarkers for colorectal cancer. Clin Biochem. 2008;41(14–15):1224–36.
16. Li M, Shen J, Wu X, Zhang B, Zhang R, Weng H, et al. Downregulated expression of hepatoma-derived growth factor (HDGF) reduces gallbladder cancer cell proliferation and invasion. Med Oncol. 2013;30(2):587.
17. Bruenderman EH, Martin RC II. High-risk population in sporadic pancreatic adenocarcinoma: guidelines for screening. J Surg Res. 2015;194(1):212–9.
18. Xia X, Wu W, Huang C, Cen G, Jiang T, Cao J, et al. SMAD4 and its role in pancreatic cancer. Tumour Biol. 2015;36(1):111–9.
19. Ren H, Chu Z, Mao L. Antibodies targeting hepatoma-derived growth factor as a novel strategy in treating lung cancer. Mol Cancer Ther. 2009;8(5):1106–12.
20. Skaper SD. Ion channels on microglia: therapeutic targets for neuroprotection. CNS Neurol Disord Drug Targets. 2011;10(1):44–56.
21. Littler DR, Harrop SJ, Fairlie WD, Brown LJ, Pankhurst GJ, Pankhurst S, et al. The intracellular chloride ion channel protein CLIC1 undergoes a redox-controlled structural transition. J Biol Chem. 2004;279(10):9298–305.
22. Tung JJ, Kitajewski J. Chloride intracellular channel 1 functions in endothelial cell growth and migration. J Angiogenes Res. 2010;2:23.
23. Singh H, Ashley RH. Redox regulation of CLIC1 by cysteine residues associated with the putative channel pore. Biophys J. 2006;90(5):1628–38.
24. Tulk BM, Kapadia S, Edwards JC. CLIC1 inserts from the aqueous phase into phospholipid membranes, where it functions as an anion channel. Am J Physiol Cell Physiol. 2002;282(5):C1103–12.
25. Gurski LA, Knowles LM, Basse PH, Maranchie JK, Watkins SC, Pilch J. Relocation of CLIC1 promotes tumor cell invasion and colonization of fibrin. Mol Cancer Res. 2014;13(2):273–80.
26. Wang L, He S, Tu Y, Ji P, Zong J, Zhang J, et al. Elevated expression of chloride intracellular channel 1 is correlated with poor prognosis in human gliomas. J Exp Clin Cancer Res. 2012;31:44.
27. Peretti M, Angelini M, Savalli N, Florio T, Yuspa SH, Mazzanti M. Chloride channels in cancer: focus on chloride intracellular channel 1 and 4 (CLIC1 AND CLIC4) proteins in tumor development and as novel therapeutic targets. Biochim Biophys Acta. 2014. doi:10.1016/j.bbamem.2014.12.012.
28. Zhang S, Wang XM, Yin ZY, Zhao WX, Zhou JY, Zhao BX, et al. Chloride intracellular channel 1 is overexpression in hepatic tumor and correlates with a poor prognosis. APMIS. 2013;121(11):1047–53.