Disassembling bacterial extracellular matrix with DNase-coated nanoparticles to enhance antibiotic delivery in biofilm infections

Journal of Controlled Release

Volumn 209, Issue , 2015, Pages 150-158

  Baelo, Aida ^a   Levato, Riccardo ^a,b   Julián, Esther ^c   Crespo, Anna ^a   Astola, José ^a   Gavaldà, Joan ^d   Engel, Elisabeth ^a,b,e   Mateos Timoneda, Miguel Angel ^a,b   Torrents, Eduard ^a  

^a INSTITUTE FOR BIOENGINEERING OF CATALONIA IBEC   (Spain)

^b BIOMATERIALES Y NANOMEDICINA CIBER BBN   (Spain)

^c UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

^d HOSPITAL UNIVERSITARI VALL D HEBRON   (Spain)

^e UNIVERSITAT POLITÈCNICA DE CATALUNYA   (Spain)

Author keywords

Biofilm; Ciprofloxacin; DNase I; Nanoparticles; Pseudomonas aeruginosa

Indexed keywords

AMINO ACIDS; ANTIBIOTICS; BACTERIA; CONTROLLED DRUG DELIVERY; GREEN MANUFACTURING; NANOPARTICLES; PULMONARY DISEASES; TARGETED DRUG DELIVERY;

CHRONIC OBSTRUCTIVE PULMONARY DISEASE; CIPROFLOXACIN; DNASE I; DRUG DELIVERY DEVICES; EXTRACELLULAR MATRICES; NANOPARTICLE FORMULATION; POLY LACTIC-CO-GLYCOLIC ACID; PSEUDOMONAS AERUGINOSA;

BIOFILMS;

CIPROFLOXACIN; DEOXYRIBONUCLEASE I; DNA; NANOPARTICLE; POLYGLACTIN; POLYLYSINE; SOLVENT; ANTIINFECTIVE AGENT; DRUG CARRIER; LACTIC ACID; POLYGLYCOLIC ACID; POLYLACTIC ACID-POLYGLYCOLIC ACID COPOLYMER;

ANTIBACTERIAL ACTIVITY; ARTICLE; BACTERIAL GROWTH; BACTERIAL STRAIN; BIOFILM; CELL DENSITY; CONTROLLED DRUG RELEASE; CONTROLLED STUDY; CYTOTOXICITY; DRUG DELIVERY SYSTEM; DRUG FORMULATION; EXTRACELLULAR MATRIX; MACROPHAGE; MINIMUM INHIBITORY CONCENTRATION; NANOENCAPSULATION; NANOFABRICATION; NONHUMAN; PRIORITY JOURNAL; PSEUDOMONAS AERUGINOSA; PSEUDOMONAS INFECTION; ANIMAL; BACTERIAL INFECTIONS; CELL LINE; CHEMISTRY; DRUG EFFECTS; DRUG RELEASE; GROWTH, DEVELOPMENT AND AGING; MICROBIAL SENSITIVITY TEST; MOUSE; STAPHYLOCOCCUS AUREUS;

ANIMALS; ANTI-BACTERIAL AGENTS; BACTERIAL INFECTIONS; BIOFILMS; CELL LINE; CIPROFLOXACIN; DEOXYRIBONUCLEASE I; DNA; DRUG CARRIERS; DRUG LIBERATION; EXTRACELLULAR MATRIX; LACTIC ACID; MICE; MICROBIAL SENSITIVITY TESTS; NANOPARTICLES; POLYGLYCOLIC ACID; POLYLYSINE; PSEUDOMONAS AERUGINOSA; STAPHYLOCOCCUS AUREUS;

EID: 84928659963     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2015.04.028     Document Type: Article

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