Plasma and urine metabolic profiles are reflective of altered beta-oxidation in non-diabetic obese subjects and patients with type 2 diabetes mellitus

Diabetology and Metabolic Syndrome

Volumn 6, Issue 1, 2014, Pages

  Villarreal Pérez, Jesús Zacarías ^a   Villarreal Martínez, Jesús Zacarías ^a   Lavalle González, Fernando Javier ^a   Torres Sepúlveda, María Del Rosario ^b   Ruiz Herrera, Consuelo ^b   Cerda Flores, Ricardo Martín ^b   Castillo García, Erik Rubén ^b   Rodríguez Sánchez, Irám Pablo ^b   De Villarreal, Laura Elia Martínez ^b  

^a HOSPITAL UNIVERSITARIO DR JOSÉ ELEUTERIO GONZÁLEZ   (Mexico)

^b UNIVERSIDAD AUTÓNOMA DE NUEVO LEÓN   (Mexico)

Author keywords

Acetylcarnitine; Air plethysmography; Beta oxidation defect; Butyrylcarnitine; Non diabetic obese; T2DM

Indexed keywords

3 HYDROXYBUTYRIC ACID; ACYLCARNITINE; ALANINE; ALANINE AMINOTRANSFERASE; ALBUMIN; ALKALINE PHOSPHATASE; ARGININE; ASPARTATE AMINOTRANSFERASE; BILIRUBIN; BUTYRYLCARNITINE; CHOLESTEROL; CITRIC ACID; FATTY ACID; GLOBULIN; GLUCOSE; GLYCINE; INSULIN; LEUCINE; METHIONINE; ORNITHINE; PHENYLALANINE; PROTEIN; TYROSINE; UNCLASSIFIED DRUG; VALINE;

ADULT; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALBUMIN BLOOD LEVEL; ALKALINE PHOSPHATASE BLOOD LEVEL; AMINO ACID BLOOD LEVEL; ANTHROPOMETRIC PARAMETERS; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BILIRUBIN BLOOD LEVEL; CHOLESTEROL BLOOD LEVEL; CLINICAL ARTICLE; CONTROLLED STUDY; FATTY ACID BLOOD LEVEL; FATTY ACID OXIDATION; FEMALE; GLOBULIN BLOOD LEVEL; GLUCOSE BLOOD LEVEL; HUMAN; INSULIN BLOOD LEVEL; LIMIT OF QUANTITATION; MALE; MASS FRAGMENTOGRAPHY; MASS SPECTROMETRY; NON INSULIN DEPENDENT DIABETES MELLITUS; OBESITY; PATHOGENESIS; PLETHYSMOGRAPHY; PRIORITY JOURNAL; PROGENY; PROTEIN BLOOD LEVEL; URINALYSIS; URINARY EXCRETION;

EID: 84928600933     PISSN: None     EISSN: 17585996     Source Type: Journal    
DOI: 10.1186/1758-5996-6-129     Document Type: Article

References (33)

1. Galgani J, Diaz E: Obesity and fatty acids in the etiology of insulin resistance. Rev Med Chil 2000, 128:1354-1360.
2. Aguilar-Salinas CA, Mehta R, Rojas R, Gomez-Perez FJ, Olaiz G, Rull JA: Management of the metabolic syndrome as a strategy for preventing the macrovascular complications of type 2 diabetes: controversial issues. Curr Diabetes Rev 2005, 1:145-158.
3. Hu FB: Sedentary lifestyle and risk of obesity and type 2 diabetes. Lipids 2003, 38:103-108.
4. Encuesta Nacional de Salud y Nutrición: Encuesta Nacional de Salud y Nutrición. 2006.
5. Maassen JA, Romijn JA, Heine RJ: Fatty acid-induced mitochondrial uncoupling in adipocytes as a key protective factor against insulin resistance and beta cell dysfunction: A new concept in the pathogenesis of obesity-Associated type 2 diabetes mellitus. Diabetologia 2007, 50:2036-2041.
6. Koves TR, Ussher JR, Noland RC, Slentz D, Mosedale M, Ilkayeva O, Bain J, Stevens R, Dyck JR, Newgard CB, Lopaschuk GD, Muoio DM: Mitochondrial overload and incomplete fatty acid oxidation contribute to skeletal muscle insulin resistance. Cell Metab 2008, 7:45-56.
7. Lieber CS, Savolainen M: Ethanol and lipids. Alcohol Clin Exp Res 1984, 8:409-423.
8. Brands M, Verhoeven AJ, Serlie MJ: Role of mitochondrial function in insulin resistance. Adv Exp Med Biol 2012, 942:215-234.
9. Hesselink MK C, Mensink M, Schrauwen P: Lipotoxicity and mitochondrial dysfunction in type 2 diabetes. Immunol Endoc Metab Agents Med Chem 2007, 7:3-17.
10. Goodpaster BH, Wolf D: Skeletal muscle lipid accumulation in obesity, insulin resistance, and type 2 diabetes. Pediatr Diabetes 2004, 5:219-226.
11. Zytkovicz TH, Fitzgerald EF, Marsden D, Larson CA, Shih VE, Johnson DM, Strauss AW, Comeau AM, Eaton RB, Grady GF: Tandem mass spectrometric analysis for amino, organic, and fatty acid disorders in newborn dried blood spots: A two-year summary from the New England Newborn Screening Program. Clin Chem 2001, 47:1945-1955.
12. Spiekerkoetter U: Mitochondrial fatty acid oxidation disorders: clinical presentation of long-chain fatty acid oxidation defects before and after newborn screening. J Inherit Metab Dis 2010, 33:527-532.
13. Adams SH, Hoppel CL, Lok KH, Zhao L, Wong SW, Minkler PE, Hwang DH, Newman JW, Garvey WT: Plasma acylcarnitine profiles suggest incomplete long-chain fatty acid beta-oxidation and altered tricarboxylic acid cycle activity in type 2 diabetic African-American women. J Nutr 2009, 139:1073-1081.
14. Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC: Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 1985, 28:412-419.
15. Harris EH: Elevated liver function tests in type 2 diabetes. Clin Diabetes 2005, 23:115-119.
16. Begriche K, Massart J, Robin MA, Bonnet F, Fromenty B: Mitochondrial adaptations and dysfunctions in nonalcoholic fatty liver disease. Hepatology 2013, 58:1497-1507.
17. Suhre K, Meisinger C, Döring A, Altmaier E, Belcredi P, Gieger C, Chang D, Milburn MV, Gall WE, Weinberger KM, Mewes HW, HrabédeAngelis M, Wichmann HE, Kronenberg F, Adamski J, Illig T: Metabolic footprint of diabetes: A multiplatform metabolomics study in an epidemiological setting. PLoS One 2010, 5:e13953.
18. Mihalik SJ, Goodpaster BH, Kelley DE, Chace DH, Vockley J, Toledo FG, DeLany JP: Increased levels of plasma acylcarnitines in obesity and type 2 diabetes and identification of a marker of glucolipotoxicity. Obesity (Silver Spring) 2010, 18:1695-1700.
19. Bene J, Marton M, Mohas M, Bagosi Z, Bujtor Z, Oroszlan T, Gasztonyi B, Wittmann I, Melegh B: Similarities in serum acylcarnitine patterns in type 1 and type 2 diabetes mellitus and in metabolic syndrome. Ann Nutr Metab 2013, 62:80-85.
20. Fiehn O, Garvey WT, Newman JW, Lok KH, Hoppel CL, Adams SH: Plasma metabolomic profiles reflective of glucose homeostasis in non-diabetic and type 2 diabetic obese African-American women. PLoS One 2010, 5:e15234.
21. Schooneman MG, Vaz FM, Houten SM, Soeters MR: Acylcarnitines: reflecting or inflicting insulin resistance? Diabetes 2013, 62:1-8.
22. Zhao X, Fritsche J, Wang J, Chen J, Rittig K, Schmitt-Kopplin P, Fritsche A, Haring HU, Schleicher ED, Xu G, Lehmann R: Metabonomic fingerprints of fasting plasma and spot urine reveal human pre-diabetic metabolic traits. Metab 2010, 6:362-374.
23. Wörtz P, Mäkinen VP, Soininen P, Kangas AJ, Tukiainen T, Kettunen J, Savolainen MJ, Tammelin T, Viikari JS, Rönnemaa T, Kähönen M, Lehtimäki T, Ripatti S, Raitakari OT, Järvelin MR, Ala-Korpela M: Metabolic signatures of insulin resistance in 7, 098 young adults. Diabetes 2012, 61:1372-1380.
24. Vannini P, Marchesini G, Forlani G, Angiolini A, Ciavarella A, Zoli M, Pisi E: Branched-chain amino acids and alanine as indices of the metabolic control in type 1 (insulin-dependent) and type 2 (non-insulin-dependent) diabetic patients. Diabetologia 1982, 22:217-219.
25. Ruderman NB: Muscle amino acid metabolism and gluconeogenesis. Annu Rev Med 1975, 26:245-258.
26. Layman DK, Walker DA: Potential importance of leucine in treatment of obesity and the metabolic syndrome. J Nutr 2006, 136:319S-323S.
27. Huffman KM, Shah SH, Stevens RD, Bain JR, Muehlbauer M, Slentz CA, Tanner CJ, Kuchibhatla M, Houmard JA, Newgard CB, Kraus WE: Relationships between circulating metabolic intermediates and insulin action in overweight to obese, inactive men and women. Diabetes Care 2009, 32:1678-1683.
28. Wang TJ, Larson MG, Vasan RS, Cheng S, Rhee EP, McCabe E, Lewis GD, Fox CS, Jacques PF, Fernandez C, O'Donnell CJ, Carr SA, Mootha VK, Florez JC, Souza A, Melander O, Clish CB, Gerszten RE: Metabolite profiles and the risk of developing diabetes. Nat Med 2011, 17:448-453.
29. Adams SH: Emerging perspectives on essential amino acid metabolism in obesity and the insulin-resistant state. Adv Nutr 2011, 2:445-456.
30. Quiroga AD, Lehner R: Liver triacylglycerol lipases. Biochim Biophys Acta 1821, 2012:762-769.
31. Gregersen N, Kolvraa S, Mortensen PB, Rasmussen K: C6-C10-dicarboxylic aciduria: biochemical considerations in relation to diagnosis of beta-oxidation defects. Scand J Clin Lab Invest Suppl 1982, 161:15-27.
32. Mortensen PB: C6-C10-dicarboxylic aciduria in starved, fat-fed and diabetic rats receiving decanoic acid or medium-chain triacylglycerol. An in vivo measure of the rate of beta-oxidation of fatty acids. Biochim Biophys Acta 1981, 664:349-355.
33. Mortensen PB, Gregersen N: The biological origin of ketotic dicarboxylic aciduria. II. In vivo and in vitro investigations of the beta-oxidation of C8-C16-dicarboxylic acids in unstarved, starved and diabetic rats. Biochim Biophys Acta 1982, 710:477-484.