Elevated liver enzymes following polytraumatic injury

Journal of Rehabilitation Research and Development

Volumn 51, Issue 6, 2014, Pages 869-874

  Fox, Aaron ^a   Sanderlin, James B ^b   McNamee, Shane ^b   Bajaj, Jasmohan S ^c   Carne, William ^b   Cifu, David X ^b  

^a Departments of Primary Care   (United States)

^b Departments of Rehabilitation Sciences Physical Medicine and Rehabilitation and Neurosciences   (United States)

^c VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Blast injuries; Brain injury; Drug induced liver inju ries; Liver enzyme elevations; Liver function tests; Polytraumatic injury; Rehabilitation; TBI; Trauma severity indices; Veteran

Indexed keywords

AMINO ACIDS; BRAIN; ENZYMES; HEALTH RISKS;

BLAST INJURIES; BRAIN INJURY; DRUG-INDUCED LIVER INJU-RIES; LIVER ENZYMES; LIVER FUNCTIONS; POLYTRAUMATIC INJURY; SEVERITY INDEX; TBI; VETERAN;

PATIENT REHABILITATION;

ALANINE AMINOTRANSFERASE;

DISEASE SEVERITY; ELECTRONIC MEDICAL RECORD; FEMALE; HUMAN; HYPERTRANSAMINASEMIA; MAJOR CLINICAL STUDY; MALE; NUTRITION; PILOT STUDY; POLYTRAUMA REHABILITATION CENTER; PRIORITY JOURNAL; PUBLIC HEALTH; REHABILITATION CENTER; RETROSPECTIVE STUDY; REVIEW; TRAUMATIC BRAIN INJURY; BLOOD; BRAIN INJURIES; ENZYMOLOGY; FOLLOW UP; INJURY SCALE; LIVER; LIVER FUNCTION TEST; MULTIPLE TRAUMA; PHYSIOLOGIC MONITORING; SOLDIER; TIME;

ALANINE TRANSAMINASE; BRAIN INJURIES; FEMALE; FOLLOW-UP STUDIES; HUMANS; LIVER; LIVER FUNCTION TESTS; MALE; MILITARY PERSONNEL; MONITORING, PHYSIOLOGIC; MULTIPLE TRAUMA; RETROSPECTIVE STUDIES; TIME FACTORS; TRAUMA SEVERITY INDICES;

EID: 84928593987     PISSN: 07487711     EISSN: 19381352     Source Type: Journal    
DOI: 10.1682/JRRD.2013.10.0233     Document Type: Review

References (11)

1. Cifu DX, Taylor BC, Carne WF, Bidelspach D, Sayer NA, Scholten J, Campbell EH. Traumatic brain injury, posttraumatic stress disorder, and pain diagnoses in OIF/OEF/OND Veterans. J Rehabil Res Dev. 2013;50(9):1169–76. [PMID:24458958] http://dx.doi.org/10.1682/JRRD.2013.01.0006
2. Kalisky Z, Morrison DP, Meyers CA, Von Laufen A. Medi-cal problems encountered during rehabilitation of patients with head injury. Arch Phys Med Rehabil. 1985;66(1):25–29. [PMID:3917661]
3. Goessling W, Friedman LS. Increased liver chemistry in an asymptomatic patient. Clin Gastroenterol Hepatol. 2005; 3(9):852–58. [PMID:16234021]  http://dx.doi.org/10.1016/S1542-3565(05)00416-7
4. Ioannou GN, Boyko EJ, Lee SP. The prevalence and pre-dictors of elevated serum aminotransferase activity in the United States in 1999–2002. Am J Gastroenterol. 2006; 101(1):76–82. [PMID:16405537]  http://dx.doi.org/10.1111/j.1572-0241.2005.00341.x
5. Department of Defense and Department of Veterans Affairs. Traumatic Brain Injury Task Force [Internet]. Atlanta (GA): Centers for Disease Control and Prevention; 2008. Available from: http://www.cdc.gov/nchs/data/icd/ Sep08TBI.pdf
6. Ruhl CE, Everhart JE. Upper limits of normal for alanine aminotransferase activity in the United States population. Hepatology. 2012;55(2):447–54. [PMID:21987480]  http://dx.doi.org/10.1002/hep.24725
7. Armstrong GL, Wasley A, Simard EP, McQuillan GM, Kuhnert WL, Alter MJ. The prevalence of hepatitis C virus infection in the United States, 1999 through 2002. Ann Intern Med. 2006;144(10):705–14. [PMID:16702586] http://dx.doi.org/10.7326/0003-4819-144-10-200605160-00004
8. Sanfilippo F, Veenith T, Santonocito C, Vrettou CS, Matta BF. Liver function test abnormalities after traumatic brain injury: Is hepato-biliary ultrasound a sensitive diagnostic tool? Br J Anaesth. 2014;112(2):298–303. [PMID:24067331]  http://dx.doi.org/10.1093/bja/aet305
9. Thomson SJ, Cowan ML, Johnston I, Musa S, Grounds M, Rahman TM. ‘Liver function tests’ on the intensive care unit: A prospective, observational study. Intensive Care Med. 2009;35(8):1406–11. [PMID:19513695]  http://dx.doi.org/10.1007/s00134-009-1511-7
10. Navarro VJ, Senior JR. Drug-related hepatotoxicity. N Engl J Med. 2006;354(7):731–39. [PMID:16481640] http://dx.doi.org/10.1056/NEJMra052270
11. Dutta A, Saha C, Johnson CS, Chalasani N. Variability in the upper limit of normal for serum alanine aminotransfer-ase levels: A statewide study. Hepatology. 2009;50(6) 1957–62. [PMID:19787805]  http://dx.doi.org/10.1002/hep.23200