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Volumn 33, Issue 21, 2015, Pages 2399-2405

Advances and challenges in mucosal adjuvant technology

Author keywords

Adjuvants; Immune response; Mucosal vaccines; Nanoparticles

Indexed keywords

ARCHAEOSOME; CHOLERA TOXIN; CHOLERA VACCINE; CYTOKINE; DRUG CARRIER; ENTEROTOXIN; FLT3 LIGAND; IMMUNOLOGICAL ADJUVANT; IMMUNOSTIMULATING AGENT; LIPOSOME; MAST CELL ACTIVATOR; MUCOSAL VACCINE; NANOPARTICLE; PATTERN RECOGNITION RECEPTOR; UNCLASSIFIED DRUG; VACCINE;

EID: 84928581450     PISSN: 0264410X     EISSN: 18732518     Source Type: Journal    
DOI: 10.1016/j.vaccine.2015.03.096     Document Type: Review
Times cited : (58)

References (69)
  • 1
    • 79751482268 scopus 로고    scopus 로고
    • A mucosal gateway for vaccines
    • McGhee J.R. A mucosal gateway for vaccines. Nat Biotechnol 2011, 29(2):136-138.
    • (2011) Nat Biotechnol , vol.29 , Issue.2 , pp. 136-138
    • McGhee, J.R.1
  • 3
    • 79251475565 scopus 로고    scopus 로고
    • Enhancing oral vaccine potency by targeting intestinal M cells
    • Azizi A., Kumar A., Diaz-Mitoma F., Mestecky J. Enhancing oral vaccine potency by targeting intestinal M cells. PLoS Pathog 2010, 6(11):e1001147.
    • (2010) PLoS Pathog , vol.6 , Issue.11 , pp. e1001147
    • Azizi, A.1    Kumar, A.2    Diaz-Mitoma, F.3    Mestecky, J.4
  • 4
    • 77952581247 scopus 로고    scopus 로고
    • Mucosal HIV vaccines: a holy grail or a dud?
    • Azizi A., Ghunaim H., Diaz-Mitoma F., Mestecky J. Mucosal HIV vaccines: a holy grail or a dud?. Vaccine 2010, 28(May (24)):4015-4026.
    • (2010) Vaccine , vol.28 , Issue.MAY 24 , pp. 4015-4026
    • Azizi, A.1    Ghunaim, H.2    Diaz-Mitoma, F.3    Mestecky, J.4
  • 5
    • 79960738803 scopus 로고    scopus 로고
    • An immunological comparison between lipidated and non-lipidated multivalent HIV-1 peptides representing Gp120 and Gag hypervariable regions
    • Ghunaim H., Kumar A., Torres J., Diaz-Mitoma F., Azizi A. An immunological comparison between lipidated and non-lipidated multivalent HIV-1 peptides representing Gp120 and Gag hypervariable regions. Vaccine 2011, 29(Aug (35)):5950-5958.
    • (2011) Vaccine , vol.29 , Issue.AUG 35 , pp. 5950-5958
    • Ghunaim, H.1    Kumar, A.2    Torres, J.3    Diaz-Mitoma, F.4    Azizi, A.5
  • 7
    • 84891692114 scopus 로고    scopus 로고
    • Novel adjuvants & delivery vehicles for vaccines development: a road ahead
    • Mohan T., Verma P., Rao D.N. Novel adjuvants & delivery vehicles for vaccines development: a road ahead. Indian J Med Res 2013, 138(Nov (5)):779-795.
    • (2013) Indian J Med Res , vol.138 , Issue.NOV 5 , pp. 779-795
    • Mohan, T.1    Verma, P.2    Rao, D.N.3
  • 9
    • 0038325751 scopus 로고    scopus 로고
    • Mucosal immunisation and adjuvants: a brief overview of recent advances and challenges
    • Holmgren J., Czerkinsky C., Eriksson K., Mharandi A. Mucosal immunisation and adjuvants: a brief overview of recent advances and challenges. Vaccine 2003, 21(Jun (Suppl 2)):S89-S95.
    • (2003) Vaccine , vol.21 , Issue.JUN SUPPL. 2 , pp. S89-S95
    • Holmgren, J.1    Czerkinsky, C.2    Eriksson, K.3    Mharandi, A.4
  • 10
    • 65449133249 scopus 로고    scopus 로고
    • Cholera toxin and Escherichia coli heat-labile enterotoxin, but not their nontoxic counterparts, improve the antigen-presenting cell function of human B lymphocytes
    • Negri D.R., Pinto D., Vendetti S., et al. Cholera toxin and Escherichia coli heat-labile enterotoxin, but not their nontoxic counterparts, improve the antigen-presenting cell function of human B lymphocytes. Infect Immun 2009, 77(5):1924-1935.
    • (2009) Infect Immun , vol.77 , Issue.5 , pp. 1924-1935
    • Negri, D.R.1    Pinto, D.2    Vendetti, S.3
  • 11
    • 44849126376 scopus 로고    scopus 로고
    • Cholera toxin, E. coli heat-labile toxin, and non-toxic derivatives induce dendritic cell migration into the follicle-associated epithelium of Peyer's patches
    • Anosova N.G., Chabot S., Shreedhar V., Borawski J.A., Dickinson B.L., Neutra M.R. Cholera toxin, E. coli heat-labile toxin, and non-toxic derivatives induce dendritic cell migration into the follicle-associated epithelium of Peyer's patches. Mucosal Immunol 2008, 1(1):59-67.
    • (2008) Mucosal Immunol , vol.1 , Issue.1 , pp. 59-67
    • Anosova, N.G.1    Chabot, S.2    Shreedhar, V.3    Borawski, J.A.4    Dickinson, B.L.5    Neutra, M.R.6
  • 12
    • 0035925592 scopus 로고    scopus 로고
    • Mucosal vaccines: non toxic derivatives of LT and CT as mucosal adjuvants
    • Pizza M., Giuliani M.M., Fontana M.R., et al. Mucosal vaccines: non toxic derivatives of LT and CT as mucosal adjuvants. Vaccine 2001, 19(Mar (17-19)):2534-2541.
    • (2001) Vaccine , vol.19 , Issue.MAR 17 19 , pp. 2534-2541
    • Pizza, M.1    Giuliani, M.M.2    Fontana, M.R.3
  • 13
    • 84877795556 scopus 로고    scopus 로고
    • A double mutant heat-labile toxin from Escherichia coli, LT(R192G/L211A), is an effective mucosal adjuvant for vaccination against Helicobacter pylori infection
    • Sjokvist O.L., Flach C.F., Clements J., Holmgren J., Raghavan S. A double mutant heat-labile toxin from Escherichia coli, LT(R192G/L211A), is an effective mucosal adjuvant for vaccination against Helicobacter pylori infection. Infect Immun 2013, 81(5):1532-1540.
    • (2013) Infect Immun , vol.81 , Issue.5 , pp. 1532-1540
    • Sjokvist, O.L.1    Flach, C.F.2    Clements, J.3    Holmgren, J.4    Raghavan, S.5
  • 14
    • 1342268100 scopus 로고    scopus 로고
    • Use of the inactivated intranasal influenza vaccine and the risk of Bell's palsy in Switzerland
    • Mutsch M., Zhou W., Rhodes P., et al. Use of the inactivated intranasal influenza vaccine and the risk of Bell's palsy in Switzerland. N Engl J Med 2004, 350(Feb (9)):896-903.
    • (2004) N Engl J Med , vol.350 , Issue.FEB 9 , pp. 896-903
    • Mutsch, M.1    Zhou, W.2    Rhodes, P.3
  • 15
    • 70349621646 scopus 로고    scopus 로고
    • Transient facial nerve paralysis (Bell's palsy) following intranasal delivery of a genetically detoxified mutant of Escherichia coli heat labile toxin
    • Lewis D.J., Huo Z., Barnett S., et al. Transient facial nerve paralysis (Bell's palsy) following intranasal delivery of a genetically detoxified mutant of Escherichia coli heat labile toxin. PLoS ONE 2009, 4(9):e6999.
    • (2009) PLoS ONE , vol.4 , Issue.9 , pp. e6999
    • Lewis, D.J.1    Huo, Z.2    Barnett, S.3
  • 16
    • 0034327167 scopus 로고    scopus 로고
    • Cutting edge: the mucosal adjuvant cholera toxin redirects vaccine proteins into olfactory tissues
    • van Ginkel F.W., Jackson R.J., Yuki Y., McGhee J.R. Cutting edge: the mucosal adjuvant cholera toxin redirects vaccine proteins into olfactory tissues. J Immunol 2000, 165(Nov (9)):4778-4782.
    • (2000) J Immunol , vol.165 , Issue.NOV 9 , pp. 4778-4782
    • van Ginkel, F.W.1    Jackson, R.J.2    Yuki, Y.3    McGhee, J.R.4
  • 17
    • 25444525685 scopus 로고    scopus 로고
    • Enterotoxin-based mucosal adjuvants alter antigen trafficking and induce inflammatory responses in the nasal tract
    • van Ginkel F.W., Jackson R.J., Yoshino N., et al. Enterotoxin-based mucosal adjuvants alter antigen trafficking and induce inflammatory responses in the nasal tract. Infect Immun 2005, 73(10):6892-6902.
    • (2005) Infect Immun , vol.73 , Issue.10 , pp. 6892-6902
    • van Ginkel, F.W.1    Jackson, R.J.2    Yoshino, N.3
  • 18
  • 19
    • 48449101169 scopus 로고    scopus 로고
    • Neonatal immune response and serum bactericidal activity induced by a meningococcal conjugate vaccine is enhanced by LT-K63 and CpG2006
    • Brynjolfsson S.F., Bjarnarson S.P., Mori E., Del G.G., Jonsdottir I. Neonatal immune response and serum bactericidal activity induced by a meningococcal conjugate vaccine is enhanced by LT-K63 and CpG2006. Vaccine 2008, 26(Aug (35)):4557-4562.
    • (2008) Vaccine , vol.26 , Issue.AUG 35 , pp. 4557-4562
    • Brynjolfsson, S.F.1    Bjarnarson, S.P.2    Mori, E.3    Del, G.G.4    Jonsdottir, I.5
  • 20
    • 80455128989 scopus 로고    scopus 로고
    • Use of inactivated Escherichia coli enterotoxins to enhance respiratory mucosal adjuvanticity during vaccination in swine
    • Barrette R.W., Szczepanek S.M., Rood D., et al. Use of inactivated Escherichia coli enterotoxins to enhance respiratory mucosal adjuvanticity during vaccination in swine. Clin Vaccine Immunol 2011, 18(11):1996-1998.
    • (2011) Clin Vaccine Immunol , vol.18 , Issue.11 , pp. 1996-1998
    • Barrette, R.W.1    Szczepanek, S.M.2    Rood, D.3
  • 21
    • 84896733087 scopus 로고    scopus 로고
    • Subcomponent vaccine based on CTA1-DD adjuvant with incorporated UreB class II peptides stimulates protective Helicobacter pylori immunity
    • Nedrud J.G., Bagheri N., Schon K., et al. Subcomponent vaccine based on CTA1-DD adjuvant with incorporated UreB class II peptides stimulates protective Helicobacter pylori immunity. PLoS ONE 2013, 8(12):e83321.
    • (2013) PLoS ONE , vol.8 , Issue.12 , pp. e83321
    • Nedrud, J.G.1    Bagheri, N.2    Schon, K.3
  • 22
    • 79955643457 scopus 로고    scopus 로고
    • A novel non-toxic combined CTA1-DD and ISCOMS adjuvant vector for effective mucosal immunization against influenza virus
    • Eliasson D.G., Helgeby A., Schon K., et al. A novel non-toxic combined CTA1-DD and ISCOMS adjuvant vector for effective mucosal immunization against influenza virus. Vaccine 2011, 29(May (23)):3951-3961.
    • (2011) Vaccine , vol.29 , Issue.MAY 23 , pp. 3951-3961
    • Eliasson, D.G.1    Helgeby, A.2    Schon, K.3
  • 23
    • 84906658091 scopus 로고    scopus 로고
    • Unleashing the potential of NOD- and Toll-like agonists as vaccine adjuvants
    • Maisonneuve C., Bertholet S., Philpott D.J., De G.E. Unleashing the potential of NOD- and Toll-like agonists as vaccine adjuvants. Proc Natl Acad Sci USA 2014, 111(Aug (34)):12294-12299.
    • (2014) Proc Natl Acad Sci USA , vol.111 , Issue.AUG 34 , pp. 12294-12299
    • Maisonneuve, C.1    Bertholet, S.2    Philpott, D.J.3    De, G.E.4
  • 24
    • 84882783980 scopus 로고    scopus 로고
    • Mucosal vaccine adjuvants update
    • Rhee J.H., Lee S.E., Kim S.Y. Mucosal vaccine adjuvants update. Clin Exp Vaccine Res 2012, 1(Jul (1)):50-63.
    • (2012) Clin Exp Vaccine Res , vol.1 , Issue.JUL 1 , pp. 50-63
    • Rhee, J.H.1    Lee, S.E.2    Kim, S.Y.3
  • 26
    • 84918564833 scopus 로고    scopus 로고
    • Toll-like receptor signaling pathways
    • Kawasaki T., Kawai T. Toll-like receptor signaling pathways. Front Immunol 2014, 5:461.
    • (2014) Front Immunol , vol.5 , pp. 461
    • Kawasaki, T.1    Kawai, T.2
  • 27
    • 84925246830 scopus 로고    scopus 로고
    • TLR-dependent human mucosal epithelial cell responses to microbial pathogens
    • McClure R., Massari P. TLR-dependent human mucosal epithelial cell responses to microbial pathogens. Front Immunol 2014, 5:386.
    • (2014) Front Immunol , vol.5 , pp. 386
    • McClure, R.1    Massari, P.2
  • 28
    • 77951019151 scopus 로고    scopus 로고
    • Induction of cytokines and chemokines by Toll-like receptor signaling: strategies for control of inflammation
    • Zeytun A., Chaudhary A., Pardington P., Cary R., Gupta G. Induction of cytokines and chemokines by Toll-like receptor signaling: strategies for control of inflammation. Crit Rev Immunol 2010, 30(1):53-67.
    • (2010) Crit Rev Immunol , vol.30 , Issue.1 , pp. 53-67
    • Zeytun, A.1    Chaudhary, A.2    Pardington, P.3    Cary, R.4    Gupta, G.5
  • 29
    • 70449535617 scopus 로고    scopus 로고
    • The role of Toll-like receptor 4 in eliciting acquired immune responses against nontypeable Haemophilus influenzae following intranasal immunization with outer membrane protein
    • Hirano T., Kodama S., Moriyama M., Kawano T., Suzuki M. The role of Toll-like receptor 4 in eliciting acquired immune responses against nontypeable Haemophilus influenzae following intranasal immunization with outer membrane protein. Int J Pediatr Otorhinolaryngol 2009, 73(12):1657-1665.
    • (2009) Int J Pediatr Otorhinolaryngol , vol.73 , Issue.12 , pp. 1657-1665
    • Hirano, T.1    Kodama, S.2    Moriyama, M.3    Kawano, T.4    Suzuki, M.5
  • 30
    • 84874062317 scopus 로고    scopus 로고
    • Intravaginal TLR agonists increase local vaccine-specific CD8 T cells and human papillomavirus-associated genital-tumor regression in mice
    • Domingos-Pereira S., Decrausaz L., Derre L., et al. Intravaginal TLR agonists increase local vaccine-specific CD8 T cells and human papillomavirus-associated genital-tumor regression in mice. Mucosal Immunol 2013, 6(Mar (2)):393-404.
    • (2013) Mucosal Immunol , vol.6 , Issue.MAR 2 , pp. 393-404
    • Domingos-Pereira, S.1    Decrausaz, L.2    Derre, L.3
  • 31
    • 84896903153 scopus 로고    scopus 로고
    • TLR7 and 9 agonists are highly effective mucosal adjuvants for norovirus virus-like particle vaccines
    • Hjelm B.E., Kilbourne J., Herbst-Kralovetz M.M. TLR7 and 9 agonists are highly effective mucosal adjuvants for norovirus virus-like particle vaccines. Hum Vaccin Immunother 2014, 10(2):410-416.
    • (2014) Hum Vaccin Immunother , vol.10 , Issue.2 , pp. 410-416
    • Hjelm, B.E.1    Kilbourne, J.2    Herbst-Kralovetz, M.M.3
  • 32
    • 84871269972 scopus 로고    scopus 로고
    • Evaluation of TLR agonists as potential mucosal adjuvants for HIV gp140 and tetanus toxoid in mice
    • Buffa V., Klein K., Fischetti L., Shattock R.J. Evaluation of TLR agonists as potential mucosal adjuvants for HIV gp140 and tetanus toxoid in mice. PLoS ONE 2012, 7(12):e50529.
    • (2012) PLoS ONE , vol.7 , Issue.12 , pp. e50529
    • Buffa, V.1    Klein, K.2    Fischetti, L.3    Shattock, R.J.4
  • 33
    • 0037073603 scopus 로고    scopus 로고
    • The use of Flt3 ligand as an adjuvant for hepatitis B vaccination of healthy adults
    • Evans T.G., Hasan M., Galibert L., Caron D. The use of Flt3 ligand as an adjuvant for hepatitis B vaccination of healthy adults. Vaccine 2002, 21(Dec (3-4)):322-329.
    • (2002) Vaccine , vol.21 , Issue.DEC 3 4 , pp. 322-329
    • Evans, T.G.1    Hasan, M.2    Galibert, L.3    Caron, D.4
  • 34
    • 79951849275 scopus 로고    scopus 로고
    • A combination of Flt3 ligand cDNA and CpG oligodeoxynucleotide as nasal adjuvant elicits protective secretory-IgA immunity to Streptococcus pneumoniae in aged mice
    • Fukuyama Y., King J.D., Kataoka K., et al. A combination of Flt3 ligand cDNA and CpG oligodeoxynucleotide as nasal adjuvant elicits protective secretory-IgA immunity to Streptococcus pneumoniae in aged mice. J Immunol 2011, 186(Feb (4)):2454-2461.
    • (2011) J Immunol , vol.186 , Issue.FEB 4 , pp. 2454-2461
    • Fukuyama, Y.1    King, J.D.2    Kataoka, K.3
  • 35
    • 78649396753 scopus 로고    scopus 로고
    • Interleukin-1 family cytokines as mucosal vaccine adjuvants for induction of protective immunity against influenza virus
    • Kayamuro H., Yoshioka Y., Abe Y., et al. Interleukin-1 family cytokines as mucosal vaccine adjuvants for induction of protective immunity against influenza virus. J Virol 2010, 84(Dec (24)):12703-12712.
    • (2010) J Virol , vol.84 , Issue.DEC 24 , pp. 12703-12712
    • Kayamuro, H.1    Yoshioka, Y.2    Abe, Y.3
  • 36
    • 0036140236 scopus 로고    scopus 로고
    • Cytokines as adjuvants for the induction of anti-human immunodeficiency virus peptide immunoglobulin G (IgG) and IgA antibodies in serum and mucosal secretions after nasal immunization
    • Bradney C.P., Sempowski G.D., Liao H.X., Haynes B.F., Staats H.F. Cytokines as adjuvants for the induction of anti-human immunodeficiency virus peptide immunoglobulin G (IgG) and IgA antibodies in serum and mucosal secretions after nasal immunization. J Virol 2002, 76(Jan (2)):517-524.
    • (2002) J Virol , vol.76 , Issue.JAN 2 , pp. 517-524
    • Bradney, C.P.1    Sempowski, G.D.2    Liao, H.X.3    Haynes, B.F.4    Staats, H.F.5
  • 37
    • 84901690099 scopus 로고    scopus 로고
    • Membrane-bound IL-12 and IL-23 serve as potent mucosal adjuvants when co-presented on whole inactivated influenza vaccines
    • Khan T., Heffron C.L., High K.P., Roberts P.C. Membrane-bound IL-12 and IL-23 serve as potent mucosal adjuvants when co-presented on whole inactivated influenza vaccines. Virol J 2014, 11:78.
    • (2014) Virol J , vol.11 , pp. 78
    • Khan, T.1    Heffron, C.L.2    High, K.P.3    Roberts, P.C.4
  • 38
    • 0038392603 scopus 로고    scopus 로고
    • Delivery of IL-12 intranasally leads to reduced IL-12-mediated toxicity
    • Huber V.C., Arulanandam B.P., Arnaboldi P.M., et al. Delivery of IL-12 intranasally leads to reduced IL-12-mediated toxicity. Int Immunopharmacol 2003, 3(6):801-809.
    • (2003) Int Immunopharmacol , vol.3 , Issue.6 , pp. 801-809
    • Huber, V.C.1    Arulanandam, B.P.2    Arnaboldi, P.M.3
  • 40
    • 0030766971 scopus 로고    scopus 로고
    • Effects of single-dose interleukin-12 exposure on interleukin-12-associated toxicity and interferon-gamma production
    • Leonard J.P., Sherman M.L., Fisher G.L., et al. Effects of single-dose interleukin-12 exposure on interleukin-12-associated toxicity and interferon-gamma production. Blood 1997, 90(Oct (7)):2541-2548.
    • (1997) Blood , vol.90 , Issue.OCT 7 , pp. 2541-2548
    • Leonard, J.P.1    Sherman, M.L.2    Fisher, G.L.3
  • 41
    • 0028824039 scopus 로고
    • IL-12 deaths: explanation and a puzzle
    • Cohen J. IL-12 deaths: explanation and a puzzle. Science 1995, 270(Nov (5238)):908.
    • (1995) Science , vol.270 , Issue.NOV 5238 , pp. 908
    • Cohen, J.1
  • 42
    • 17444419036 scopus 로고    scopus 로고
    • Interleukin-12 has no effect on vascular density, perfusion, hypoxia and proliferation of an implanted human squamous cell carcinoma xenograft tumour despite up-regulation of ICAM-1
    • van Herpen C.M., Bussink J., van der Kogel A.J., et al. Interleukin-12 has no effect on vascular density, perfusion, hypoxia and proliferation of an implanted human squamous cell carcinoma xenograft tumour despite up-regulation of ICAM-1. Anticancer Res 2005, 25(Mar (2A)):1015-1021.
    • (2005) Anticancer Res , vol.25 , Issue.MAR 2A , pp. 1015-1021
    • van Herpen, C.M.1    Bussink, J.2    van der Kogel, A.J.3
  • 43
    • 16344363217 scopus 로고    scopus 로고
    • Intratumoral recombinant human interleukin-12 administration in head and neck squamous cell carcinoma patients modifies locoregional lymph node architecture and induces natural killer cell infiltration in the primary tumor
    • van Herpen C.M., van der Laak J.A., de Vries I.J., et al. Intratumoral recombinant human interleukin-12 administration in head and neck squamous cell carcinoma patients modifies locoregional lymph node architecture and induces natural killer cell infiltration in the primary tumor. Clin Cancer Res 2005, 11(Mar (5)):1899-1909.
    • (2005) Clin Cancer Res , vol.11 , Issue.MAR 5 , pp. 1899-1909
    • van Herpen, C.M.1    van der Laak, J.A.2    de Vries, I.J.3
  • 44
    • 53449098507 scopus 로고    scopus 로고
    • Intratumoral rhIL-12 administration in head and neck squamous cell carcinoma patients induces B cell activation
    • van Herpen C.M., van der Voort R., van der Laak J.A., et al. Intratumoral rhIL-12 administration in head and neck squamous cell carcinoma patients induces B cell activation. Int J Cancer 2008, 123(Nov (10)):2354-2361.
    • (2008) Int J Cancer , vol.123 , Issue.NOV 10 , pp. 2354-2361
    • van Herpen, C.M.1    van der Voort, R.2    van der Laak, J.A.3
  • 45
    • 43249097624 scopus 로고    scopus 로고
    • Mast cell activators: a new class of highly effective vaccine adjuvants
    • McLachlan J.B., Shelburne C.P., Hart J.P., et al. Mast cell activators: a new class of highly effective vaccine adjuvants. Nat Med 2008, 14(5):536-541.
    • (2008) Nat Med , vol.14 , Issue.5 , pp. 536-541
    • McLachlan, J.B.1    Shelburne, C.P.2    Hart, J.P.3
  • 46
    • 79956312742 scopus 로고    scopus 로고
    • Intranasal immunization with recombinant HA and mast cell activator C48/80 elicits protective immunity against 2009 pandemic H1N1 influenza in mice
    • Meng S., Liu Z., Xu L., et al. Intranasal immunization with recombinant HA and mast cell activator C48/80 elicits protective immunity against 2009 pandemic H1N1 influenza in mice. PLoS ONE 2011, 6(5):e19863.
    • (2011) PLoS ONE , vol.6 , Issue.5 , pp. e19863
    • Meng, S.1    Liu, Z.2    Xu, L.3
  • 47
    • 84896298795 scopus 로고    scopus 로고
    • Intranasal immunization of mice with inactivated virus and mast cell activator C48/80 elicits protective immunity against influenza H1 but not H5
    • Xu L., Bao L., Li F., et al. Intranasal immunization of mice with inactivated virus and mast cell activator C48/80 elicits protective immunity against influenza H1 but not H5. Immunol Invest 2014, 43(3):224-235.
    • (2014) Immunol Invest , vol.43 , Issue.3 , pp. 224-235
    • Xu, L.1    Bao, L.2    Li, F.3
  • 49
    • 24944552040 scopus 로고    scopus 로고
    • Towards the preparative and large-scale precision manufacture of virus-like particles
    • Pattenden L.K., Middelberg A.P., Niebert M., Lipin D.I. Towards the preparative and large-scale precision manufacture of virus-like particles. Trends Biotechnol 2005, 23(10):523-529.
    • (2005) Trends Biotechnol , vol.23 , Issue.10 , pp. 523-529
    • Pattenden, L.K.1    Middelberg, A.P.2    Niebert, M.3    Lipin, D.I.4
  • 50
    • 84871650149 scopus 로고    scopus 로고
    • Construction and characterization of virus-like particles: a review
    • Zeltins A. Construction and characterization of virus-like particles: a review. Mol Biotechnol 2013, 53(1):92-107.
    • (2013) Mol Biotechnol , vol.53 , Issue.1 , pp. 92-107
    • Zeltins, A.1
  • 51
    • 65249098980 scopus 로고    scopus 로고
    • Immunodrugs: therapeutic VLP-based vaccines for chronic diseases
    • Jennings G.T., Bachmann M.F. Immunodrugs: therapeutic VLP-based vaccines for chronic diseases. Annu Rev Pharmacol Toxicol 2009, 49:303-326.
    • (2009) Annu Rev Pharmacol Toxicol , vol.49 , pp. 303-326
    • Jennings, G.T.1    Bachmann, M.F.2
  • 53
    • 79955098392 scopus 로고    scopus 로고
    • Enhanced mucosal immune responses to HIV virus-like particles containing a membrane-anchored adjuvant
    • Vassilieva E.V., Wang B.Z., Vzorov A.N., et al. Enhanced mucosal immune responses to HIV virus-like particles containing a membrane-anchored adjuvant. MBio 2011, 2(1):e00328-e410.
    • (2011) MBio , vol.2 , Issue.1 , pp. e00328-e410
    • Vassilieva, E.V.1    Wang, B.Z.2    Vzorov, A.N.3
  • 54
    • 84864546404 scopus 로고    scopus 로고
    • Enhanced influenza virus-like particle vaccines containing the extracellular domain of matrix protein 2 and a Toll-like receptor ligand
    • Wang B.Z., Gill H.S., Kang S.M., et al. Enhanced influenza virus-like particle vaccines containing the extracellular domain of matrix protein 2 and a Toll-like receptor ligand. Clin Vaccine Immunol 2012, 19(8):1119-1125.
    • (2012) Clin Vaccine Immunol , vol.19 , Issue.8 , pp. 1119-1125
    • Wang, B.Z.1    Gill, H.S.2    Kang, S.M.3
  • 55
    • 77953828852 scopus 로고    scopus 로고
    • Liposomes as delivery systems for nasal vaccination: strategies and outcomes
    • Heurtault B., Frisch B., Pons F. Liposomes as delivery systems for nasal vaccination: strategies and outcomes. Expert Opin Drug Deliv 2010, 7(7):829-844.
    • (2010) Expert Opin Drug Deliv , vol.7 , Issue.7 , pp. 829-844
    • Heurtault, B.1    Frisch, B.2    Pons, F.3
  • 57
    • 77951258835 scopus 로고    scopus 로고
    • CAF01 liposomes as a mucosal vaccine adjuvant: In vitro and in vivo investigations
    • Christensen D., Foged C., Rosenkrands I., et al. CAF01 liposomes as a mucosal vaccine adjuvant: In vitro and in vivo investigations. Int J Pharm 2010, 390(May (1)):19-24.
    • (2010) Int J Pharm , vol.390 , Issue.MAY 1 , pp. 19-24
    • Christensen, D.1    Foged, C.2    Rosenkrands, I.3
  • 58
    • 80955177124 scopus 로고    scopus 로고
    • Mucosal immunization with liposome-nucleic acid adjuvants generates effective humoral and cellular immunity
    • Henderson A., Propst K., Kedl R., Dow S. Mucosal immunization with liposome-nucleic acid adjuvants generates effective humoral and cellular immunity. Vaccine 2011, 29(Jul (32)):5304-5312.
    • (2011) Vaccine , vol.29 , Issue.JUL 32 , pp. 5304-5312
    • Henderson, A.1    Propst, K.2    Kedl, R.3    Dow, S.4
  • 59
    • 24644519461 scopus 로고    scopus 로고
    • Archaeosome immunostimulatory vaccine delivery system
    • Patel G.B., Chen W. Archaeosome immunostimulatory vaccine delivery system. Curr Drug Deliv 2005, 2(Oct (4)):407-421.
    • (2005) Curr Drug Deliv , vol.2 , Issue.OCT 4 , pp. 407-421
    • Patel, G.B.1    Chen, W.2
  • 60
    • 84926435038 scopus 로고    scopus 로고
    • Liposomes as vaccine delivery systems: a review of the recent advances
    • Schwendener R.A. Liposomes as vaccine delivery systems: a review of the recent advances. Ther Adv Vaccines 2014, 2(Nov (6)):159-182.
    • (2014) Ther Adv Vaccines , vol.2 , Issue.NOV 6 , pp. 159-182
    • Schwendener, R.A.1
  • 61
    • 79960336687 scopus 로고    scopus 로고
    • Archaeosomes with encapsulated antigens for oral vaccine delivery
    • Li Z., Zhang L., Sun W., Ding Q., Hou Y., Xu Y. Archaeosomes with encapsulated antigens for oral vaccine delivery. Vaccine 2011, 29(Jul (32)):5260-5266.
    • (2011) Vaccine , vol.29 , Issue.JUL 32 , pp. 5260-5266
    • Li, Z.1    Zhang, L.2    Sun, W.3    Ding, Q.4    Hou, Y.5    Xu, Y.6
  • 62
    • 78650827255 scopus 로고    scopus 로고
    • Intranasal immunization with an archaeal lipid mucosal vaccine adjuvant and delivery formulation protects against a respiratory pathogen challenge
    • Patel G.B., Zhou H., Ponce A., Harris G., Chen W. Intranasal immunization with an archaeal lipid mucosal vaccine adjuvant and delivery formulation protects against a respiratory pathogen challenge. PLoS ONE 2010, 5(12):e15574.
    • (2010) PLoS ONE , vol.5 , Issue.12 , pp. e15574
    • Patel, G.B.1    Zhou, H.2    Ponce, A.3    Harris, G.4    Chen, W.5
  • 63
    • 77953900226 scopus 로고    scopus 로고
    • Nanogel antigenic protein-delivery system for adjuvant-free intranasal vaccines
    • Nochi T., Yuki Y., Takahashi H., et al. Nanogel antigenic protein-delivery system for adjuvant-free intranasal vaccines. Nat Mater 2010, 9(7):572-578.
    • (2010) Nat Mater , vol.9 , Issue.7 , pp. 572-578
    • Nochi, T.1    Yuki, Y.2    Takahashi, H.3
  • 64
    • 84877822320 scopus 로고    scopus 로고
    • Nanogel-based PspA intranasal vaccine prevents invasive disease and nasal colonization by Streptococcus pneumoniae
    • Kong I.G., Sato A., Yuki Y., et al. Nanogel-based PspA intranasal vaccine prevents invasive disease and nasal colonization by Streptococcus pneumoniae. Infect Immun 2013, 81(5):1625-1634.
    • (2013) Infect Immun , vol.81 , Issue.5 , pp. 1625-1634
    • Kong, I.G.1    Sato, A.2    Yuki, Y.3
  • 65
    • 84868199473 scopus 로고    scopus 로고
    • Nanoemulsion W805EC improves immune responses upon intranasal delivery of an inactivated pandemic H1N1 influenza vaccine
    • Das S.C., Hatta M., Wilker P.R., et al. Nanoemulsion W805EC improves immune responses upon intranasal delivery of an inactivated pandemic H1N1 influenza vaccine. Vaccine 2012, 30(Nov (48)):6871-6877.
    • (2012) Vaccine , vol.30 , Issue.NOV 48 , pp. 6871-6877
    • Das, S.C.1    Hatta, M.2    Wilker, P.R.3
  • 66
    • 84927176976 scopus 로고    scopus 로고
    • A cationic nanoemulsion for the delivery of next-generation RNA vaccines
    • Brito L.A., Chan M., Shaw C.A., et al. A cationic nanoemulsion for the delivery of next-generation RNA vaccines. Mol Ther 2014, 22(12):2118-2129.
    • (2014) Mol Ther , vol.22 , Issue.12 , pp. 2118-2129
    • Brito, L.A.1    Chan, M.2    Shaw, C.A.3
  • 67
    • 84897510295 scopus 로고    scopus 로고
    • Distinct pathways of humoral and cellular immunity induced with the mucosal administration of a nanoemulsion adjuvant
    • Bielinska A.U., Makidon P.E., Janczak K.W., et al. Distinct pathways of humoral and cellular immunity induced with the mucosal administration of a nanoemulsion adjuvant. J Immunol 2014, 192(Mar (6)):2722-2733.
    • (2014) J Immunol , vol.192 , Issue.MAR 6 , pp. 2722-2733
    • Bielinska, A.U.1    Makidon, P.E.2    Janczak, K.W.3
  • 68
    • 84355161937 scopus 로고    scopus 로고
    • Safety and immunogenicity of a novel nanoemulsion mucosal adjuvant W805EC combined with approved seasonal influenza antigens
    • Stanberry L.R., Simon J.K., Johnson C., et al. Safety and immunogenicity of a novel nanoemulsion mucosal adjuvant W805EC combined with approved seasonal influenza antigens. Vaccine 2012, 30(Jan (2)):307-316.
    • (2012) Vaccine , vol.30 , Issue.JAN 2 , pp. 307-316
    • Stanberry, L.R.1    Simon, J.K.2    Johnson, C.3
  • 69
    • 84880861978 scopus 로고    scopus 로고
    • Delivery of immunogens to mucosal immune system using an oral inactivated cholera vaccine: a new approach for development of oral vaccines
    • Azizi A., Ghunaim H., Sirskyj D., Fallahi F., Le H.T., Kumar A. Delivery of immunogens to mucosal immune system using an oral inactivated cholera vaccine: a new approach for development of oral vaccines. Hum Vaccin Immunother 2013, 9(7):1445-1448.
    • (2013) Hum Vaccin Immunother , vol.9 , Issue.7 , pp. 1445-1448
    • Azizi, A.1    Ghunaim, H.2    Sirskyj, D.3    Fallahi, F.4    Le, H.T.5    Kumar, A.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.