메뉴 건너뛰기




Volumn 9, Issue 5, 2015, Pages 539-542

Is it time to target gut dysbiosis and immune dysfunction in the therapy of hepatic encephalopathy?

Author keywords

ammonia; cirrhosis; gut dysbiosis; hepatic encephalopathy; immune dysfunction; inflammation; microbiota

Indexed keywords

AMMONIA; INTERLEUKIN 10; INTERLEUKIN 8; RIFAXIMIN; TOLL LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR ALPHA;

EID: 84928580431     PISSN: 17474124     EISSN: 17474132     Source Type: Journal    
DOI: 10.1586/17474124.2015.1035257     Document Type: Review
Times cited : (28)

References (29)
  • 1
    • 77951485993 scopus 로고    scopus 로고
    • Clinical course of alcoholic liver cirrhosis: A Danish population-based cohort study
    • Jepsen P, Ott P, Andersen PK, et al. Clinical course of alcoholic liver cirrhosis: a Danish population-based cohort study. Hepatology 2010; 51(5): 1675-82
    • (2010) Hepatology , vol.51 , Issue.5 , pp. 1675-1682
    • Jepsen, P.1    Ott, P.2    Andersen, P.K.3
  • 2
    • 80052469447 scopus 로고    scopus 로고
    • The multi-dimensional burden of cirrhosis and hepatic encephalopathy on patients and caregivers
    • Bajaj JS, Wade JB, Gibson DP, et al. The multi-dimensional burden of cirrhosis and hepatic encephalopathy on patients and caregivers. Am J Gastroenterol 2011; 106(9): 1646-53
    • (2011) Am J Gastroenterol , vol.106 , Issue.9 , pp. 1646-1653
    • Bajaj, J.S.1    Wade, J.B.2    Gibson, D.P.3
  • 3
    • 84904749223 scopus 로고    scopus 로고
    • Hepatic encephalopathy in chronic liver disease: 2014 practice guideline by the american association for the study of liver diseases and the european association for the study of the liver
    • Vilstrup H, Amodio P, Bajaj J, et al. Hepatic encephalopathy in chronic liver disease: 2014 practice guideline by the american association for the study of liver diseases and the european association for the study of the liver. Hepatology 2014; 60(2): 715-35
    • (2014) Hepatology , vol.60 , Issue.2 , pp. 715-735
    • Vilstrup, H.1    Amodio, P.2    Bajaj, J.3
  • 4
    • 25144522285 scopus 로고    scopus 로고
    • Ammonia and hepatic encephalopathy: The more things change, the more they remain the same
    • Shawcross DL, Olde Damink SW, Butterworth -RF, et al. Ammonia and hepatic encephalopathy: the more things change, the more they remain the same. Metab Brain Dis 2005; 20(3): 169-79
    • (2005) Metab Brain Dis , vol.20 , Issue.3 , pp. 169-179
    • Shawcross, D.L.1    Olde Damink, S.W.2    Butterworth, R.F.3
  • 5
    • 37749006615 scopus 로고    scopus 로고
    • Arterial ammonia and clinical risk factors for encephalopathy and intracranial hypertension in acute liver failure
    • Bernal W, Hall C, Karvellas C, et al. Arterial ammonia and clinical risk factors for encephalopathy and intracranial hypertension in acute liver failure. Hepatology 2007; 46(6): 1844-52
    • (2007) Hepatology , vol.46 , Issue.6 , pp. 1844-1852
    • Bernal, W.1    Hall, C.2    Karvellas, C.3
  • 6
    • 33751093747 scopus 로고    scopus 로고
    • Myth: Interpretation of a single ammonia level in patients with chronic liver disease can confirm or rule out hepatic encephalopathy
    • Arora S, Martin CL, Herbert M. Myth: interpretation of a single ammonia level in patients with chronic liver disease can confirm or rule out hepatic encephalopathy. CJEM 2006; 8(6): 433-5
    • (2006) CJEM , vol.8 , Issue.6 , pp. 433-435
    • Arora, S.1    Martin, C.L.2    Herbert, M.3
  • 7
    • 79952695979 scopus 로고    scopus 로고
    • Infection and systemic inflammation, not ammonia are associated with Grade 3/4 hepatic encephalopathy, but not mortality in cirrhosis
    • Shawcross DL, Sharifi Y, Canavan JB, et al. Infection and systemic inflammation, not ammonia are associated with Grade 3/4 hepatic encephalopathy, but not mortality in cirrhosis. J Hepatol 2011; 54(4): 640-9
    • (2011) J Hepatol , vol.54 , Issue.4 , pp. 640-649
    • Shawcross, D.L.1    Sharifi, Y.2    Canavan, J.B.3
  • 8
    • 22544482372 scopus 로고    scopus 로고
    • Evaluation of plasma ammonia levels in patients with acute liver failure and chronic liver disease and its correlation with the severity of hepatic encephalopathy and clinical features of raised intracranial tension
    • Kundra A, Jain A, Banga A, et al. Evaluation of plasma ammonia levels in patients with acute liver failure and chronic liver disease and its correlation with the severity of hepatic encephalopathy and clinical features of raised intracranial tension. Clin Biochem 2005; 38(8): 696-9
    • (2005) Clin Biochem , vol.38 , Issue.8 , pp. 696-699
    • Kundra, A.1    Jain, A.2    Banga, A.3
  • 9
    • 1642491776 scopus 로고    scopus 로고
    • Systemic inflammatory response exacerbates the neuropsychological effects of induced hyperammonemia in cirrhosis
    • Shawcross D, Davies N, Williams R, et al. Systemic inflammatory response exacerbates the neuropsychological effects of induced hyperammonemia in cirrhosis. J Hepatol 2004; 40(2): 247-54
    • (2004) J Hepatol , vol.40 , Issue.2 , pp. 247-254
    • Shawcross, D.1    Davies, N.2    Williams, R.3
  • 10
    • 4644341574 scopus 로고    scopus 로고
    • Pathogenesis of intracranial hypertension in acute liver failure: Inflammation, ammonia and cerebral blood flow
    • Jalan R, Olde Damink SW, Hayes PC, et al. Pathogenesis of intracranial hypertension in acute liver failure: inflammation, ammonia and cerebral blood flow. J Hepatol 2004; 41(4): 613-20
    • (2004) J Hepatol , vol.41 , Issue.4 , pp. 613-620
    • Jalan, R.1    Olde Damink, S.W.2    Hayes, P.C.3
  • 11
    • 34250327519 scopus 로고    scopus 로고
    • Endotoxemia produces coma and brain swelling in bile duct ligated rats
    • Wright G, Davies N, Shawcross D, et al. Endotoxemia produces coma and brain swelling in bile duct ligated rats. Hepatology 2007; 45(6): 1517-26
    • (2007) Hepatology , vol.45 , Issue.6 , pp. 1517-1526
    • Wright, G.1    Davies, N.2    Shawcross, D.3
  • 12
    • 0035133561 scopus 로고    scopus 로고
    • Bacterial translocation of enteric organisms in patients with cirrhosis
    • Cirera I, Bauer TM, Navasa M, et al. Bacterial translocation of enteric organisms in patients with cirrhosis. J Hepatol 2001; 34(1): 32-7
    • (2001) J Hepatol , vol.34 , Issue.1 , pp. 32-37
    • Cirera, I.1    Bauer, T.M.2    Navasa, M.3
  • 13
    • 78651368325 scopus 로고    scopus 로고
    • Status of bacterial colonization Toll-like receptor expression and nuclear factor-kappa B activation in normal and diseased human livers
    • Singh R, Bullard J, Kalra M, et al. Status of bacterial colonization, Toll-like receptor expression and nuclear factor-kappa B activation in normal and diseased human livers. Clin Immunol 2011; 138(1): 41-9
    • (2011) Clin Immunol , vol.138 , Issue.1 , pp. 41-49
    • Singh, R.1    Bullard, J.2    Kalra, M.3
  • 14
    • 84898830272 scopus 로고    scopus 로고
    • Altered profile of human gut microbiome is associated with cirrhosis and its complications
    • Bajaj JS, Heuman DM, Hylemon PB, et al. Altered profile of human gut microbiome is associated with cirrhosis and its complications. J Hepatol 2014; 60(5): 940-7
    • (2014) J Hepatol , vol.60 , Issue.5 , pp. 940-947
    • Bajaj, J.S.1    Heuman, D.M.2    Hylemon, P.B.3
  • 15
    • 84907225684 scopus 로고    scopus 로고
    • Alterations of the human gut microbiome in liver cirrhosis
    • Qin N, Yang F, Li A, et al. Alterations of the human gut microbiome in liver cirrhosis. Nature 2014; 513(7516): 59-64
    • (2014) Nature , vol.513 , Issue.7516 , pp. 59-64
    • Qin, N.1    Yang, F.2    Li, A.3
  • 16
    • 84875670330 scopus 로고    scopus 로고
    • Modulation of the metabiome by rifaximin in patients with cirrhosis and minimal hepatic encephalopathy
    • Bajaj JS, Heuman DM, Sanyal AJ, et al. Modulation of the metabiome by rifaximin in patients with cirrhosis and minimal hepatic encephalopathy. PLoS One 2013; 8(4): e60042
    • (2013) PLoS One , vol.8 , Issue.4 , pp. e60042
    • Bajaj, J.S.1    Heuman, D.M.2    Sanyal, A.J.3
  • 17
    • 79953817132 scopus 로고    scopus 로고
    • Severity of the compensatory anti-inflammatory response determined by monocyte HLA-DR expression may assist outcome prediction in cirrhosis
    • Berry PA, Antoniades CG, Carey I, et al. Severity of the compensatory anti-inflammatory response determined by monocyte HLA-DR expression may assist outcome prediction in cirrhosis. Intensive Care Med 2011; 37(3): 453-60
    • (2011) Intensive Care Med , vol.37 , Issue.3 , pp. 453-460
    • Berry, P.A.1    Antoniades, C.G.2    Carey, I.3
  • 18
    • 84906220081 scopus 로고    scopus 로고
    • The severity of circulating neutrophil dysfunction in patients with cirrhosis is associated with 90-day and 1-year mortality
    • Taylor NJ, Manakkat Vijay GK, Abeles RD, et al. The severity of circulating neutrophil dysfunction in patients with cirrhosis is associated with 90-day and 1-year mortality. Aliment Pharmacol Ther 2014; 40(6): 705-15
    • (2014) Aliment Pharmacol Ther , vol.40 , Issue.6 , pp. 705-715
    • Taylor, N.J.1    Manakkat Vijay, G.K.2    Abeles, R.D.3
  • 19
    • 54449098017 scopus 로고    scopus 로고
    • Ammonia impairs neutrophil phagocytic function in liver disease
    • Shawcross D, Wright G, Stadlbauer V, et al. Ammonia impairs neutrophil phagocytic function in liver disease. Hepatology 2008; 48(4): 1202-12
    • (2008) Hepatology , vol.48 , Issue.4 , pp. 1202-1212
    • Shawcross, D.1    Wright, G.2    Stadlbauer, V.3
  • 20
    • 13144260678 scopus 로고    scopus 로고
    • Dispelling myths in the treatment of hepatic encephalopathy
    • Shawcross D, Jalan R. Dispelling myths in the treatment of hepatic encephalopathy. Lancet 2005; 365(9457): 431-3
    • (2005) Lancet , vol.365 , Issue.9457 , pp. 431-433
    • Shawcross, D.1    Jalan, R.2
  • 21
    • 33947392621 scopus 로고    scopus 로고
    • Lactulose improves cognitive functions and health-related quality of life in patients with cirrhosis who have minimal hepatic encephalopathy
    • Prasad S, Dhimna R, Duseja A, et al. Lactulose improves cognitive functions and health-related quality of life in patients with cirrhosis who have minimal hepatic encephalopathy. Hepatology 2007; 45: 549-59
    • (2007) Hepatology , vol.45 , pp. 549-559
    • Prasad, S.1    Dhimna, R.2    Duseja, A.3
  • 22
    • 2342487336 scopus 로고    scopus 로고
    • Non-absorbable disaccharides for hepatic encephalopathy: Systematic review of randomised trials
    • Als-Nielsen B, Gluud L, Gluud C. Non-absorbable disaccharides for hepatic encephalopathy: systematic review of randomised trials. Br Med J 2004; 328: 1046-50
    • (2004) Br Med J , vol.328 , pp. 1046-1050
    • Als-Nielsen, B.1    Gluud, L.2    Gluud, C.3
  • 23
    • 84896709238 scopus 로고    scopus 로고
    • Randomized double-blind controlled study of glycerol phenylbutyrate in hepatic encephalopathy
    • Rockey DC, Vierling JM, Mantry P, et al. Randomized, double-blind, controlled study of glycerol phenylbutyrate in hepatic encephalopathy. Hepatology 2014; 59(3): 1073-83
    • (2014) Hepatology , vol.59 , Issue.3 , pp. 1073-1083
    • Rockey, D.C.1    Vierling, J.M.2    Mantry, P.3
  • 24
    • 84902204300 scopus 로고    scopus 로고
    • Randomised clinical trial: L-ornithine-L-aspartate reduces significantly the increase of venous ammonia concentration after TIPSS
    • Bai M, He C, Yin Z, et al. Randomised clinical trial: L-ornithine-L-aspartate reduces significantly the increase of venous ammonia concentration after TIPSS. Aliment Pharmacol Ther 2014; 40(1): 63-71
    • (2014) Aliment Pharmacol Ther , vol.40 , Issue.1 , pp. 63-71
    • Bai, M.1    He, C.2    Yin, Z.3
  • 25
    • 84925153220 scopus 로고    scopus 로고
    • L-Ornithine phenylacetate reduces ammonia in pigs with acute liver failure through phenylacetylglycine formation: A novel ammonia-lowering pathway
    • Kristiansen RG, Rose CF, Fuskevag OM, et al. L-Ornithine phenylacetate reduces ammonia in pigs with acute liver failure through phenylacetylglycine formation: a novel ammonia-lowering pathway. Am J Physiol Gastrointest Liver Physiol 2014; 307(10): G1024-31
    • (2014) Am J Physiol Gastrointest Liver Physiol , vol.307 , Issue.10 , pp. G1024-31
    • Kristiansen, R.G.1    Rose, C.F.2    Fuskevag, O.M.3
  • 26
    • 2342580955 scopus 로고    scopus 로고
    • Synbiotic modulation of gut flora: Effect on minimal hepatic encephalopathy in patients with cirrhosis
    • Liu Q, Duan ZP, Ha DK, et al. Synbiotic modulation of gut flora: effect on minimal hepatic encephalopathy in patients with cirrhosis. Hepatology 2004; 39(5): 1441-9
    • (2004) Hepatology , vol.39 , Issue.5 , pp. 1441-1449
    • Liu, Q.1    Duan, Z.P.2    Ha, D.K.3
  • 27
    • 84899046306 scopus 로고    scopus 로고
    • Randomised clinical trial: Lactobacillus GG modulates gut microbiome, metabolome and endotoxemia in patients with cirrhosis
    • Bajaj JS, Heuman DM, Hylemon PB, et al. Randomised clinical trial: Lactobacillus GG modulates gut microbiome, metabolome and endotoxemia in patients with cirrhosis. Aliment Pharmacol Ther 2014; 39(10): 1113-25
    • (2014) Aliment Pharmacol Ther , vol.39 , Issue.10 , pp. 1113-1125
    • Bajaj, J.S.1    Heuman, D.M.2    Hylemon, P.B.3
  • 28
    • 84913553798 scopus 로고    scopus 로고
    • Probiotic VSL#3 reduces liver disease severity and hospitalization in patients with cirrhosis: A randomized, controlled trial
    • Dhiman RK, Rana B, Agrawal S, et al. Probiotic VSL#3 reduces liver disease severity and hospitalization in patients with cirrhosis: a randomized, controlled trial. Gastroenterology 2014; 147(6): 1327-37
    • (2014) Gastroenterology , vol.147 , Issue.6 , pp. 1327-1337
    • Dhiman, R.K.1    Rana, B.2    Agrawal, S.3
  • 29
    • 43049181923 scopus 로고    scopus 로고
    • Effect of probiotic treatment on deranged neutrophil function and cytokine responses in patients with compensated alcoholic cirrhosis
    • Stadlbauer V, Mookerjee R, Hodges S et al. Effect of probiotic treatment on deranged neutrophil function and cytokine responses in patients with compensated alcoholic cirrhosis. J Hepatol 2008; 48(6): 945-51
    • (2008) J Hepatol , vol.48 , Issue.6 , pp. 945-951
    • Stadlbauer, V.1    Mookerjee, R.2    Hodges, S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.