L-Ornithine phenylacetate reduces ammonia in pigs with acute liver failure through phenylacetylglycine formation: A novel ammonia-lowering pathway

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 307, Issue 10, 2014, Pages G1024-G1031

  Kristiansen, Rune Gangsøy ^a   Rose, Christopher F ^b   Fuskevåg, Ole Martin ^a   Mæhre, Hanne ^c   Revhaug, Arthur ^a   Jalan, Rajiv ^d   Ytrebø, Lars Marius ^a  

^a UNIVERSITY HOSPITAL OF NORTH NORWAY   (Norway)

^b CENTRE HOSPITALIER DE L UNIVERSITÉ DE MONTRÉAL   (Canada)

^c UNIVERSITY OF TROMSØ   (Norway)

^d UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Ammonia; Glycine; L ornithine phenylacetate; Phenylacetylglycine

Indexed keywords

ALANINE; AMMONIA; GLUTAMIC ACID; GLYCINE; GLYCINE DERIVATIVE; HIPPURIC ACID; ORNITHINE PHENYLACETATE; PHENYLACETYLGLYCINE; SERINE; UNCLASSIFIED DRUG; BIOLOGICAL MARKER; ORNITHINE;

ACUTE LIVER FAILURE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG MECHANISM; FEMALE; NONHUMAN; PORCINE MODEL; PRIORITY JOURNAL; SYSTEMIC CIRCULATION; URINARY EXCRETION; ANALOGS AND DERIVATIVES; ANIMAL; BLOOD; BRAIN; COMPLICATION; DISEASE MODEL; DRUG EFFECTS; HYPERAMMONEMIA; KIDNEY; LIVER FAILURE, ACUTE; METABOLISM; PIG; RANDOMIZATION; TIME; URINE;

AMMONIA; ANIMALS; BIOMARKERS; BRAIN; DISEASE MODELS, ANIMAL; FEMALE; GLYCINE; HYPERAMMONEMIA; KIDNEY; LIVER FAILURE, ACUTE; ORNITHINE; RANDOM ALLOCATION; SWINE; TIME FACTORS;

EID: 84925153220     PISSN: 01931857     EISSN: 15221547     Source Type: Journal    
DOI: 10.1152/ajpgi.00244.2014     Document Type: Article

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