A high mean arterial pressure target is associated with improved microcirculation in septic shock patients with previous hypertension: A prospective open label study

Critical Care

Volumn 19, Issue 1, 2015, Pages

  Xu, Jing Yuan ^a   Ma, Si Qing ^b   Pan, Chun ^a   He, Hong Li ^a   Cai, Shi Xia ^a   Hu, Shu Ling ^a   Liu, Ai Ran ^a   Liu, Ling ^a   Huang, Ying Zi ^a   Guo, Feng Mei ^a   Yang, Yi ^a   Qiu, Hai Bo ^a  

^a MEDICAL SCHOOL OF SOUTHEAST UNIVERSITY   (China)

^b Department of Dermatology   (China)

Author keywords

[No Author keywords available]

Indexed keywords

HEMOGLOBIN; LACTIC ACID; MORPHINE; NORADRENALIN; PROPOFOL; VASOCONSTRICTOR AGENT;

AGED; APACHE; ARTERIAL OXYGEN TENSION; ARTERIAL PH; ARTICLE; ARTIFICIAL VENTILATION; BLOOD FLOW; BLOOD PRESSURE MEASUREMENT; CAPILLARY DENSITY; CENTRAL VENOUS PRESSURE; CLINICAL ARTICLE; COMORBIDITY; DRUG DOSE TITRATION; FEMALE; FLUID RESUSCITATION; HEART OUTPUT; HEART RATE; HEART STROKE VOLUME; HEMODYNAMICS; HEMOGLOBIN BLOOD LEVEL; HUMAN; HYPERTENSION; INTENSIVE CARE UNIT; LACTATE BLOOD LEVEL; LENGTH OF STAY; MALE; MEAN ARTERIAL PRESSURE; MICROCIRCULATION; MORTALITY; OPEN STUDY; OXYGEN SATURATION; PHYSICAL EXAMINATION; PRIORITY JOURNAL; PROSPECTIVE STUDY; SEPTIC SHOCK; VENOUS OXYGEN TENSION; ARTERIAL PRESSURE; DRUG EFFECTS; FLUID THERAPY; MIDDLE AGED; MOUTH; PATHOPHYSIOLOGY; PROCEDURES; SHOCK, SEPTIC; VASCULARIZATION; VERY ELDERLY;

AGED; AGED, 80 AND OVER; ARTERIAL PRESSURE; FEMALE; FLUID THERAPY; HEMODYNAMICS; HUMANS; HYPERTENSION; INTENSIVE CARE UNITS; MALE; MICROCIRCULATION; MIDDLE AGED; MOUTH FLOOR; NOREPINEPHRINE; PROSPECTIVE STUDIES; RESPIRATION, ARTIFICIAL; SHOCK, SEPTIC; VASOCONSTRICTOR AGENTS;

EID: 84928575681     PISSN: 13648535     EISSN: 1466609X     Source Type: Journal    
DOI: 10.1186/s13054-015-0866-0     Document Type: Article

References (28)

1. Angus DC, van der Poll T. Severe sepsis and septic shock. N Engl J Med. 2013;369:840-51.
2. Rivers E, Nguyen B, Havstad S, Ressler J, Muzzin A, Knoblich B, et al. Early goal-directed therapy in the treatment of severe sepsis and septic shock. N Engl J Med. 2001;345:1368-77.
3. Yealy DM, Kellum JA, Huang DT, Barnato AE, Weissfeld LA, Pike F, et al. A randomized trial of protocol-based care for early septic shock. N Engl J Med. 2014;370:1683-93.
4. De Backer D, Creteur J, Preiser JC, Dubois MJ, Vincent JL. Microvascular blood flow is altered in patients with sepsis. Am J Respir Crit Care Med. 2002;166:98-104.
5. Hernandez G, Boerma EC, Dubin A, Bruhn A, Koopmans M, Edul VK, et al. Severe abnormalities in microvascular perfused vessel density are associated to organ dysfunctions and mortality and can be predicted by hyperlactatemia and norepinephrine requirements in septic shock patients. J Crit Care. 2013;28:538.e9-14.
6. Sakr Y, Dubois MJ, De Backer D, Creteur J, Vincent JL. Persistent microcirculatory alterations are associated with organ failure and death in patients with septic shock. Crit Care Med. 2004;32:1825-31.
7. Trzeciak S, McCoy JV, Phillip DR, Arnold RC, Rizzuto M, Abate NL, et al. Early increases in microcirculatory perfusion during protocol-directed resuscitation are associated with reduced multi-organ failure at 24 h in patients with sepsis. Intensive Care Med. 2008;34:2210-7.
8. De Backer D, Donadello K, Taccone FS, Ospina-Tascon G, Salgado D, Vincent JL. Microcirculatory alterations: potential mechanisms and implications for therapy. Ann Intensive Care. 2011;1:27.
9. Correa TD, Vuda M, Takala J, Djafarzadeh S, Silva E, Jakob SM. Increasing mean arterial blood pressure in sepsis: effects on fluid balance, vasopressor load and renal function. Crit Care. 2013;17:R21.
10. Badin J, Boulain T, Ehrmann S, Skarzynski M, Bretagnol A, Buret J, et al. Relation between mean arterial pressure and renal function in the early phase of shock: a prospective, explorative cohort study. Crit Care. 2011;15:R135.
11. Jhanji S, Stirling S, Patel N, Hinds CJ, Pearse RM. The effect of increasing doses of norepinephrine on tissue oxygenation and microvascular flow in patients with septic shock. Crit Care Med. 2009;37:1961-6.
12. Dubin A, Pozo MO, Casabella CA, Palizas Jr F, Murias G, Moseinco MC, et al. Increasing arterial blood pressure with norepinephrine does not improve microcirculatory blood flow: a prospective study. Crit Care. 2009;13:R92.
13. Thooft A, Favory R, Salgado DR, Taccone FS, Donadello K, De Backer D, et al. Effects of changes in arterial pressure on organ perfusion during septic shock. Crit Care. 2011;15:R222.
14. Beloncle F, Lerolle N, Radermacher P, Asfar P. Target blood pressure in sepsis: between a rock and a hard place. Crit Care. 2013;17:126.
15. Dellinger RP, Levy MM, Rhodes A, Annane D, Gerlach H, Opal SM, et al. Surviving sepsis campaign: international guidelines for management of severe sepsis and septic shock: 2012. Crit Care Med. 2013;41:580-637.
16. Asfar P, Meziani F, Hamel JF, Grelon F, Megarbane B, Anguel N, et al. High versus low blood-pressure target in patients with septic shock. N Engl J Med. 2014;370:1583-93.
17. Levy MM, Fink MP, Marshall JC, Abraham E, Angus D, Cook D, et al. SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference. Crit Care Med. 2003;2001:1250-6.
18. De Backer D, Hollenberg S, Boerma C, Goedhart P, Buchele G, Ospina-Tascon G, et al. How to evaluate the microcirculation: report of a round table conference. Crit Care. 2007;11:R101.
19. Sevransky JE, Nour S, Susla GM, Needham DM, Hollenberg S, Pronovost P. Hemodynamic goals in randomized clinical trials in patients with sepsis: a systematic review of the literature. Crit Care. 2007;11:R67.
20. Strandgaard S, Olesen J, Skinhoj E, Lassen NA. Autoregulation of brain circulation in severe arterial hypertension. Br Med J. 1973;1:507-10.
21. Monnet X, Jabot J, Maizel J, Richard C, Teboul JL. Norepinephrine increases cardiac preload and reduces preload dependency assessed by passive leg raising in septic shock patients. Crit Care Med. 2011;39:689-94.
22. Ospina-Tascon G, Neves AP, Occhipinti G, Donadello K, Buchele G, Simion D, et al. Effects of fluids on microvascular perfusion in patients with severe sepsis. Intensive Care Med. 2010;36:949-55.
23. Pottecher J, Deruddre S, Teboul JL, Georger JF, Laplace C, Benhamou D, et al. Both passive leg raising and intravascular volume expansion improve sublingual microcirculatory perfusion in severe sepsis and septic shock patients. Intensive Care Med. 2010;36:1867-74.
24. Hamzaoui O, Georger JF, Monnet X, Ksouri H, Maizel J, Richard C, et al. Early administration of norepinephrine increases cardiac preload and cardiac output in septic patients with life-threatening hypotension. Crit Care. 2010;14:R142.
25. Georger JF, Hamzaoui O, Chaari A, Maizel J, Richard C, Teboul JL. Restoring arterial pressure with norepinephrine improves muscle tissue oxygenation assessed by near-infrared spectroscopy in severely hypotensive septic patients. Intensive Care Med. 2010;36:1882-9.
26. Boerma EC, Ince C. The role of vasoactive agents in the resuscitation of microvascular perfusion and tissue oxygenation in critically ill patients. Intensive Care Med. 2010;36:2004-18.
27. Marque S, Cariou A, Chiche JD, Squara P. Comparison between Flotrac-Vigileo and Bioreactance, a totally noninvasive method for cardiac output monitoring. Crit Care. 2009;13:R73.
28. Squara P, Rotcajg D, Denjean D, Estagnasie P, Brusset A. Comparison of monitoring performance of bioreactance vs. pulse contour during lung recruitment maneuvers. Crit Care. 2009;13:R125.