메뉴 건너뛰기




Volumn 2015, Issue , 2015, Pages

Gastric carcinogenesis and underlying molecular mechanisms: Helicobacter pylori and novel targeted therapy

Author keywords

[No Author keywords available]

Indexed keywords

CAGA PROTEIN; CYTIDINE DEAMINASE; EPIDERMAL GROWTH FACTOR RECEPTOR 2; MICRORNA; BACTERIAL ANTIGEN; BACTERIAL PROTEIN; BACTERIAL SECRETION SYSTEM; CAGA PROTEIN, HELICOBACTER PYLORI; DNA; ERBB2 PROTEIN, HUMAN; RNA;

EID: 84928557918     PISSN: 23146133     EISSN: 23146141     Source Type: Journal    
DOI: 10.1155/2015/794378     Document Type: Review
Times cited : (34)

References (51)
  • 1
    • 48149107365 scopus 로고    scopus 로고
    • Effect of eradication of Helicobacter pylori on incidence of metachronous gastric carcinoma after endoscopic resection of early gastric cancer: An open-label, randomised controlled trial
    • K. Fukase, M. Kato, S. Kikuchi et al. , "Effect of eradication of Helicobacter pylori on incidence of metachronous gastric carcinoma after endoscopic resection of early gastric cancer: an open-label, randomised controlled trial, " The Lancet, vol. 372, no. 9636, pp. 392-397, 2008.
    • (2008) The Lancet , vol.372 , Issue.9636 , pp. 392-397
    • Fukase, K.1    Kato, M.2    Kikuchi, S.3
  • 2
    • 77950497468 scopus 로고    scopus 로고
    • Helicobacter pylori eradication therapy
    • H. Suzuki, T. Nishizawa, and T. Hibi, "Helicobacter pylori eradication therapy, " Future Microbiology, vol. 5, no. 4, pp. 639-648, 2010.
    • (2010) Future Microbiology , vol.5 , Issue.4 , pp. 639-648
    • Suzuki, H.1    Nishizawa, T.2    Hibi, T.3
  • 3
    • 62349119037 scopus 로고    scopus 로고
    • Early Helicobacter pylori eradication restores sonic hedgehog expression in the gastric mucosa of mongolian gerbils
    • T. Nishizawa, H. Suzuki, I. Nakagawa et al. , "Early Helicobacter pylori eradication restores sonic hedgehog expression in the gastric mucosa of mongolian gerbils, " Digestion, vol. 79, no. 2, pp. 99-108, 2009.
    • (2009) Digestion , vol.79 , Issue.2 , pp. 99-108
    • Nishizawa, T.1    Suzuki, H.2    Nakagawa, I.3
  • 4
    • 67349155510 scopus 로고    scopus 로고
    • Clinical prevention of gastric cancer by Helicobacter pylori eradication therapy: A systematic review
    • M. Ito, S. Takata, M. Tatsugami et al. , "Clinical prevention of gastric cancer by Helicobacter pylori eradication therapy: a systematic review, " Journal of Gastroenterology, vol. 44, no. 5, pp. 365-371, 2009.
    • (2009) Journal of Gastroenterology , vol.44 , Issue.5 , pp. 365-371
    • Ito, M.1    Takata, S.2    Tatsugami, M.3
  • 5
    • 67651091935 scopus 로고    scopus 로고
    • Meta-analysis: Can Helicobacter pylori eradication treatment reduce the risk for gastric cancer?
    • L. Fuccio, R. M. Zagari, L. H. Eusebi, L. Laterza, V. Cennamo, and L. Ceroni, "Meta-analysis: can Helicobacter pylori eradication treatment reduce the risk for gastric cancer?" Annals of Internal Medicine, vol. 151, no. 7, pp. 121-128, 2009.
    • (2009) Annals of Internal Medicine , vol.151 , Issue.7 , pp. 121-128
    • Fuccio, L.1    Zagari, R.M.2    Eusebi, L.H.3    Laterza, L.4    Cennamo, V.5    Ceroni, L.6
  • 6
    • 74349106695 scopus 로고    scopus 로고
    • Guidelines for the management of Helicobacter pylori infection in Japan: 2009 revised edition
    • M. Asaka, M. Kato, S.-I. Takahashi et al. , "Guidelines for the management of Helicobacter pylori infection in Japan: 2009 revised edition, " Helicobacter, vol. 15, no. 1, pp. 1-20, 2010.
    • (2010) Helicobacter , vol.15 , Issue.1 , pp. 1-20
    • Asaka, M.1    Kato, M.2    Takahashi, S.-I.3
  • 7
    • 84874888505 scopus 로고    scopus 로고
    • Molecular approaches and modern clinical strategies for the management of Helicobacter pylori infection in Japan
    • H. Suzuki, T. Nishizawa, H. Tsugawa, and T. Hibi, "Molecular approaches and modern clinical strategies for the management of Helicobacter pylori infection in Japan, " Keio Journal of Medicine, vol. 61, no. 4, pp. 109-119, 2012.
    • (2012) Keio Journal of Medicine , vol.61 , Issue.4 , pp. 109-119
    • Suzuki, H.1    Nishizawa, T.2    Tsugawa, H.3    Hibi, T.4
  • 8
    • 0026492780 scopus 로고
    • Helicobacter pyloriassociated ammonia production enhances neutrophil-dependent gastric mucosal cell injury
    • M. Suzuki, S. Miura, M. Suematsu et al. , "Helicobacter pyloriassociated ammonia production enhances neutrophil-dependent gastric mucosal cell injury, " The American Journal of Physiology: Gastrointestinal and Liver Physiology, vol. 263, no. 5, pp. G719-G725, 1992.
    • (1992) The American Journal of Physiology: Gastrointestinal and Liver Physiology , vol.263 , Issue.5 , pp. G719-G725
    • Suzuki, M.1    Miura, S.2    Suematsu, M.3
  • 10
    • 79952528125 scopus 로고    scopus 로고
    • CD44 variant regulates redox status in cancer cells by stabilizing the xCT subunit of system xc? and thereby promotes tumor growth
    • T. Ishimoto, O. Nagano, T. Yae et al. , "CD44 variant regulates redox status in cancer cells by stabilizing the xCT subunit of system xc? and thereby promotes tumor growth, " Cancer Cell, vol. 19, no. 3, pp. 387-400, 2011.
    • (2011) Cancer Cell , vol.19 , Issue.3 , pp. 387-400
    • Ishimoto, T.1    Nagano, O.2    Yae, T.3
  • 11
    • 84901236412 scopus 로고    scopus 로고
    • Activation of EGFR and ERBB2 by Helicobacter pylori results in survival of gastric epithelial cells withDNAdamage
    • R. Chaturvedi, M. Asim, M. B. Piazuelo et al. , "Activation of EGFR and ERBB2 by Helicobacter pylori results in survival of gastric epithelial cells withDNAdamage, " Gastroenterology, vol. 146, no. 7, pp. 1739. e14-1751. e14, 2014.
    • (2014) Gastroenterology , vol.146 , Issue.7 , pp. 1739e14-1751e14
    • Chaturvedi, R.1    Asim, M.2    Piazuelo, M.B.3
  • 12
    • 84869170531 scopus 로고    scopus 로고
    • Carcinoma of the stomach: A reviewof epidemiology, pathogenesis, molecular genetics and chemoprevention
    • S. Nagini, "Carcinoma of the stomach: a reviewof epidemiology, pathogenesis, molecular genetics and chemoprevention, " World Journal of Gastrointestinal Oncology, vol. 4, no. 7, pp. 156-169, 2012.
    • (2012) World Journal of Gastrointestinal Oncology , vol.4 , Issue.7 , pp. 156-169
    • Nagini, S.1
  • 13
    • 4544334936 scopus 로고    scopus 로고
    • Oncogenic mechanisms of the Helicobacter pylori CagA protein
    • M. Hatakeyama, "Oncogenic mechanisms of the Helicobacter pylori CagA protein, " Nature Reviews Cancer, vol. 4, no. 9, pp. 688-694, 2004.
    • (2004) Nature Reviews Cancer , vol.4 , Issue.9 , pp. 688-694
    • Hatakeyama, M.1
  • 14
    • 84896078858 scopus 로고    scopus 로고
    • Helicobacter pylori CagA and gastric cancer: A paradigm for hit-and-run carcinogenesis
    • M. Hatakeyama, "Helicobacter pylori CagA and gastric cancer: a paradigm for hit-and-run carcinogenesis, " Cell Host &Microbe, vol. 15, pp. 306-316, 2014.
    • (2014) Cell Host &Microbe , vol.15 , pp. 306-316
    • Hatakeyama, M.1
  • 15
    • 0037195107 scopus 로고    scopus 로고
    • Biological activity of the Helicobacter pylori virulence factor CagA is determined by variation in the tyrosine phosphorylation sites
    • H. Higashi, R. Tsutsumi, A. Fujita et al. , "Biological activity of the Helicobacter pylori virulence factor CagA is determined by variation in the tyrosine phosphorylation sites, " Proceedings of the National Academy of Sciences of the United States of America, vol. 99, no. 22, pp. 14428-14433, 2002.
    • (2002) Proceedings of the National Academy of Sciences of the United States of America , vol.99 , Issue.22 , pp. 14428-14433
    • Higashi, H.1    Tsutsumi, R.2    Fujita, A.3
  • 16
    • 84870999066 scopus 로고    scopus 로고
    • Reactive oxygen speciesinduced autophagic degradation of Helicobacter pylori CagA is specifically suppressed in cancer stem-like cells
    • H. Tsugawa, H. Suzuki, H. Saya et al. , "Reactive oxygen speciesinduced autophagic degradation of Helicobacter pylori CagA is specifically suppressed in cancer stem-like cells, " Cell Host and Microbe, vol. 12, no. 6, pp. 764-777, 2012.
    • (2012) Cell Host and Microbe , vol.12 , Issue.6 , pp. 764-777
    • Tsugawa, H.1    Suzuki, H.2    Saya, H.3
  • 17
    • 84897112342 scopus 로고    scopus 로고
    • Enhanced expression of activation-induced cytidine deaminase in human gastric mucosa infected by Helicobacter pylori and its decrease following eradication
    • N. Nagata, J. Akiyama, H. Marusawa et al. , "Enhanced expression of activation-induced cytidine deaminase in human gastric mucosa infected by Helicobacter pylori and its decrease following eradication, " Journal of Gastroenterology, vol. 49, no. 3, pp. 427-435, 2014.
    • (2014) Journal of Gastroenterology , vol.49 , Issue.3 , pp. 427-435
    • Nagata, N.1    Akiyama, J.2    Marusawa, H.3
  • 18
    • 34147180434 scopus 로고    scopus 로고
    • Helicobacter pylori infection triggers aberrant expression of activationinduced cytidine deaminase in gastric epithelium
    • Y. Matsumoto, H. Marusawa, K. Kinoshita et al. , "Helicobacter pylori infection triggers aberrant expression of activationinduced cytidine deaminase in gastric epithelium, " Nature Medicine, vol. 13, no. 4, pp. 470-476, 2007.
    • (2007) Nature Medicine , vol.13 , Issue.4 , pp. 470-476
    • Matsumoto, Y.1    Marusawa, H.2    Kinoshita, K.3
  • 19
    • 84904747964 scopus 로고    scopus 로고
    • Accumulation of somatic mutations in TP53 in gastric epithelium with Helicobacter pylori infection
    • T. Shimizu, H. Marusawa, Y. Matsumoto et al. , "Accumulation of somatic mutations in TP53 in gastric epithelium with Helicobacter pylori infection, " Gastroenterology, vol. 147, no. 2, pp. 407. e3-417. e3, 2014.
    • (2014) Gastroenterology , vol.147 , Issue.2 , pp. 407e3-417e3
    • Shimizu, T.1    Marusawa, H.2    Matsumoto, Y.3
  • 20
    • 84905253056 scopus 로고    scopus 로고
    • Targeted therapy for gastric cancer:molecular pathways and ongoing investigations
    • W. Yang, A. Raufi, and S. J. Klempner, "Targeted therapy for gastric cancer:molecular pathways and ongoing investigations, " Biochimica et Biophysica Acta, vol. 1846, no. 1, pp. 232-237, 2014.
    • (2014) Biochimica et Biophysica Acta , vol.1846 , Issue.1 , pp. 232-237
    • Yang, W.1    Raufi, A.2    Klempner, S.J.3
  • 21
    • 79953786463 scopus 로고    scopus 로고
    • Geneticmutationsof p53 and k-ras in gastric carcinomapatients fromHunan, China
    • H.-C. Chen, H.-J. Chen, M. A. Khanet al. , "Geneticmutationsof p53 and k-ras in gastric carcinomapatients fromHunan, China, " Tumor Biology, vol. 32, no. 2, pp. 367-373, 2011.
    • (2011) Tumor Biology , vol.32 , Issue.2 , pp. 367-373
    • Chen, H.-C.1    Chen, H.-J.2    Khan, M.A.3
  • 22
    • 0037050745 scopus 로고    scopus 로고
    • K-ras mutation in Helicobacter pylori-associated chronic gastritis in patients with and without gastric cancer
    • T. Hiyama, K. Haruma, Y. Kitadai et al. , "K-ras mutation in Helicobacter pylori-associated chronic gastritis in patients with and without gastric cancer, " International Journal of Cancer, vol. 97, no. 5, pp. 562-566, 2002.
    • (2002) International Journal of Cancer , vol.97 , Issue.5 , pp. 562-566
    • Hiyama, T.1    Haruma, K.2    Kitadai, Y.3
  • 23
    • 77956262693 scopus 로고    scopus 로고
    • Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastrooesophageal junction cancer (ToGA): A phase 3, open-label, randomised controlled trial
    • Y.-J. Bang, E. Van Cutsem, A. Feyereislova et al. , "Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastrooesophageal junction cancer (ToGA): a phase 3, open-label, randomised controlled trial, " The Lancet, vol. 376, no. 9742, pp. 687-697, 2010.
    • (2010) The Lancet , vol.376 , Issue.9742 , pp. 687-697
    • Bang, Y.-J.1    Van Cutsem, E.2    Feyereislova, A.3
  • 24
    • 84876951761 scopus 로고    scopus 로고
    • Capecitabine and cisplatin with or without cetuximab for patients with previously untreated advanced gastric cancer (EXPAND): A randomised, open-label phase 3 trial
    • F. Lordick, Y.-K. Kang, H.-C. Chung et al. , "Capecitabine and cisplatin with or without cetuximab for patients with previously untreated advanced gastric cancer (EXPAND): a randomised, open-label phase 3 trial, " The Lancet Oncology, vol. 14, no. 6, pp. 490-499, 2013.
    • (2013) The Lancet Oncology , vol.14 , Issue.6 , pp. 490-499
    • Lordick, F.1    Kang, Y.-K.2    Chung, H.-C.3
  • 25
    • 84876992498 scopus 로고    scopus 로고
    • Epirubicin, oxaliplatin, and capecitabine with or without panitumumab for patients with previously untreated advanced oesophagogastric cancer (REAL3): A randomised, open-label phase 3 trial
    • T. Waddell, I. Chau, D. Cunningham et al. , "Epirubicin, oxaliplatin, and capecitabine with or without panitumumab for patients with previously untreated advanced oesophagogastric cancer (REAL3): a randomised, open-label phase 3 trial, " The Lancet Oncology, vol. 14, no. 6, pp. 481-489, 2013.
    • (2013) The Lancet Oncology , vol.14 , Issue.6 , pp. 481-489
    • Waddell, T.1    Chau, I.2    Cunningham, D.3
  • 26
    • 84905566147 scopus 로고    scopus 로고
    • Lapatinib plus paclitaxel versus paclitaxel alone in the second-line treatment of HER2-amplified advanced gastric cancer in Asian populations: TyTAN-a randomized, phase III study
    • T. Satoh, R. H. Xu, H. C. Chung et al. , "Lapatinib plus paclitaxel versus paclitaxel alone in the second-line treatment of HER2-amplified advanced gastric cancer in Asian populations: TyTAN-a randomized, phase III study, " Journal of Clinical Oncology, vol. 32, pp. 2039-2049, 2014.
    • (2014) Journal of Clinical Oncology , vol.32 , pp. 2039-2049
    • Satoh, T.1    Xu, R.H.2    Chung, H.C.3
  • 27
    • 84891371392 scopus 로고    scopus 로고
    • Everolimus for previously treated advanced gastric cancer: Results of the randomized, double-blind, phase III GRANITE-1 study
    • A. Ohtsu, J. A. Ajani, Y.-X. Bai et al. , "Everolimus for previously treated advanced gastric cancer: results of the randomized, double-blind, phase III GRANITE-1 study, " Journal of Clinical Oncology, vol. 31, no. 31, pp. 3935-3943, 2013.
    • (2013) Journal of Clinical Oncology , vol.31 , Issue.31 , pp. 3935-3943
    • Ohtsu, A.1    Ajani, J.A.2    Bai, Y.-X.3
  • 28
    • 84880530647 scopus 로고    scopus 로고
    • Gastric cancer pathology and underlying molecular mechanisms
    • H. I. Grabsch and P. Tan, "Gastric cancer pathology and underlying molecular mechanisms, " Digestive Surgery, vol. 30, no. 2, pp. 150-158, 2013.
    • (2013) Digestive Surgery , vol.30 , Issue.2 , pp. 150-158
    • Grabsch, H.I.1    Tan, P.2
  • 29
    • 0026734665 scopus 로고
    • The APC gene, responsible for familial adenomatous polyposis, is mutated in human gastric cancer
    • A. Horii, S. Nakatsuru, Y. Miyoshi et al. , "The APC gene, responsible for familial adenomatous polyposis, is mutated in human gastric cancer, " Cancer Research, vol. 52, no. 11, pp. 3231-3233, 1992.
    • (1992) Cancer Research , vol.52 , Issue.11 , pp. 3231-3233
    • Horii, A.1    Nakatsuru, S.2    Miyoshi, Y.3
  • 30
    • 77952975814 scopus 로고    scopus 로고
    • Mutation analysis of tumor suppressor gene PTEN in patients with gastric carcinomas and its impact on PI3K/AKT pathway
    • Y.-G. Wen, Q. Wang, C.-Z. Zhou, G.-Q. Qiu, Z.-H. Peng, and H.-M. Tang, "Mutation analysis of tumor suppressor gene PTEN in patients with gastric carcinomas and its impact on PI3K/AKT pathway, " Oncology Reports, vol. 24, no. 1, pp. 89-95, 2010.
    • (2010) Oncology Reports , vol.24 , Issue.1 , pp. 89-95
    • Wen, Y.-G.1    Wang, Q.2    Zhou, C.-Z.3    Qiu, G.-Q.4    Peng, Z.-H.5    Tang, H.-M.6
  • 31
    • 84872203706 scopus 로고    scopus 로고
    • Recent progress in the study ofmethylated tumor suppressor genes in gastric cancer
    • X.-T. Hu and C. He, "Recent progress in the study ofmethylated tumor suppressor genes in gastric cancer, " Chinese Journal of Cancer, vol. 32, no. 1, pp. 31-41, 2013.
    • (2013) Chinese Journal of Cancer , vol.32 , Issue.1 , pp. 31-41
    • Hu, X.-T.1    He, C.2
  • 32
    • 84903398326 scopus 로고    scopus 로고
    • Role of p16 gene promoter methylation in gastric carcinogenesis: A metaanalysis
    • H.-L. Wang, P.-Y. Zhou, P. Liu, and Y. Zhang, "Role of p16 gene promoter methylation in gastric carcinogenesis: a metaanalysis, " Molecular Biology Reports, vol. 41, no. 7, pp. 4481-4492, 2014.
    • (2014) Molecular Biology Reports , vol.41 , Issue.7 , pp. 4481-4492
    • Wang, H.-L.1    Zhou, P.-Y.2    Liu, P.3    Zhang, Y.4
  • 33
    • 84871296892 scopus 로고    scopus 로고
    • Helicobacter pylori causes epigenetic dysregulation of FOXD3 to promote gastric carcinogenesis
    • A. S. L. Cheng, M. S. Li, W. Kang et al. , "Helicobacter pylori causes epigenetic dysregulation of FOXD3 to promote gastric carcinogenesis, " Gastroenterology, vol. 144, no. 1, pp. 122. e9-133. e9, 2013.
    • (2013) Gastroenterology , vol.144 , Issue.1 , pp. 122e9-133e9
    • Cheng, A.S.L.1    Li, M.S.2    Kang, W.3
  • 34
    • 84885585485 scopus 로고    scopus 로고
    • CagA mediates epigenetic regulation to attenuate let-7 expression in Helicobacter pylorirelated carcinogenesis
    • Y. Hayashi, M. Tsujii, J. Wang et al. , "CagA mediates epigenetic regulation to attenuate let-7 expression in Helicobacter pylorirelated carcinogenesis, " Gut, vol. 62, no. 11, pp. 1536-1546, 2013.
    • (2013) Gut , vol.62 , Issue.11 , pp. 1536-1546
    • Hayashi, Y.1    Tsujii, M.2    Wang, J.3
  • 35
    • 84866173068 scopus 로고    scopus 로고
    • Identification of gastric cancer risk markers that are informative in individualswith past H. Pylori infection
    • S. Nanjo, K. Asada, S. Yamashita et al. , "Identification of gastric cancer risk markers that are informative in individualswith past H. pylori infection, " Gastric Cancer, vol. 15, no. 4, pp. 382-388, 2012.
    • (2012) Gastric Cancer , vol.15 , Issue.4 , pp. 382-388
    • Nanjo, S.1    Asada, K.2    Yamashita, S.3
  • 36
    • 84877290069 scopus 로고    scopus 로고
    • Prevention of Helicobacter pylori-induced gastric cancers in gerbils by a DNA demethylating agent
    • T. Niwa, T. Toyoda, T. Tsukamoto, A. Mori, M. Tatematsu, and T. Ushijima, "Prevention of Helicobacter pylori-induced gastric cancers in gerbils by a DNA demethylating agent, " Cancer Prevention Research, vol. 6, no. 4, pp. 263-270, 2013.
    • (2013) Cancer Prevention Research , vol.6 , Issue.4 , pp. 263-270
    • Niwa, T.1    Toyoda, T.2    Tsukamoto, T.3    Mori, A.4    Tatematsu, M.5    Ushijima, T.6
  • 37
    • 84863897798 scopus 로고    scopus 로고
    • Bevacizumab in combination with chemotherapy as first-line therapy in advanced gastric cancer: A biomarker evaluation from the AVAGAST randomized phase III trial
    • E. van Cutsem, S. de Haas, Y.-K. Kang et al. , "Bevacizumab in combination with chemotherapy as first-line therapy in advanced gastric cancer: a biomarker evaluation from the AVAGAST randomized phase III trial, " Journal of Clinical Oncology, vol. 30, no. 17, pp. 2119-2127, 2012.
    • (2012) Journal of Clinical Oncology , vol.30 , Issue.17 , pp. 2119-2127
    • Van Cutsem, E.1    De Haas, S.2    Kang, Y.-K.3
  • 38
    • 84916196944 scopus 로고    scopus 로고
    • Bevacizumab plus capecitabine and cisplatin in Chinese patients with inoperable locally advanced or metastatic gastric or gastroesophageal junction cancer: Randomized, double-blind, phase III study (AVATAR study)
    • L. Shen, J. Li, J. Xu et al. , "Bevacizumab plus capecitabine and cisplatin in Chinese patients with inoperable locally advanced or metastatic gastric or gastroesophageal junction cancer: randomized, double-blind, phase III study (AVATAR study), " Gastric Cancer, 2014.
    • (2014) Gastric Cancer
    • Shen, L.1    Li, J.2    Xu, J.3
  • 39
    • 84892852372 scopus 로고    scopus 로고
    • Ramucirumab monotherapy for previously treated advanced gastric or gastrooesophageal junction adenocarcinoma (REGARD): An international, randomised, multicentre, placebo-controlled, phase 3 trial
    • C. S. Fuchs, J. Tomasek, C. J. Yong et al. , "Ramucirumab monotherapy for previously treated advanced gastric or gastrooesophageal junction adenocarcinoma (REGARD): an international, randomised, multicentre, placebo-controlled, phase 3 trial, " The Lancet, vol. 383, no. 9911, pp. 31-39, 2014.
    • (2014) The Lancet , vol.383 , Issue.9911 , pp. 31-39
    • Fuchs, C.S.1    Tomasek, J.2    Yong, C.J.3
  • 40
    • 84891373220 scopus 로고    scopus 로고
    • Apatinib for chemotherapy-refractory advanced metastatic gastric cancer: Results from a randomized, placebo-controlled, parallel-arm, phase II trial
    • J. Li, S. Qin, J. Xu et al. , "Apatinib for chemotherapy-refractory advanced metastatic gastric cancer: results from a randomized, placebo-controlled, parallel-arm, phase II trial, " Journal of Clinical Oncology, vol. 31, no. 26, pp. 3219-3225, 2013.
    • (2013) Journal of Clinical Oncology , vol.31 , Issue.26 , pp. 3219-3225
    • Li, J.1    Qin, S.2    Xu, J.3
  • 42
    • 84881104793 scopus 로고    scopus 로고
    • CD44 variant 9 expression in primary early gastric cancer as a predictivemarker for recurrence
    • K. Hirata, H. Suzuki, H. Imaeda et al. , "CD44 variant 9 expression in primary early gastric cancer as a predictivemarker for recurrence, " British Journal of Cancer, vol. 109, no. 2, pp. 379-386, 2013.
    • (2013) British Journal of Cancer , vol.109 , Issue.2 , pp. 379-386
    • Hirata, K.1    Suzuki, H.2    Imaeda, H.3
  • 43
    • 84862796154 scopus 로고    scopus 로고
    • Microribonucleic acids and gastric cancer
    • Y.-Y. Ma and H.-Q. Tao, "Microribonucleic acids and gastric cancer, " Cancer Science, vol. 103, no. 4, pp. 620-625, 2012.
    • (2012) Cancer Science , vol.103 , Issue.4 , pp. 620-625
    • Ma, Y.-Y.1    Tao, H.-Q.2
  • 44
    • 84867572582 scopus 로고    scopus 로고
    • H. Pylori eradication did not improve dysregulation of specific oncogenic miRNAs in intestinal metaplastic glands
    • A. Shiotani, N. Uedo, H. Iishi et al. , "H. pylori eradication did not improve dysregulation of specific oncogenic miRNAs in intestinal metaplastic glands, " Journal of Gastroenterology, vol. 47, no. 9, pp. 988-998, 2012.
    • (2012) Journal of Gastroenterology , vol.47 , Issue.9 , pp. 988-998
    • Shiotani, A.1    Uedo, N.2    Iishi, H.3
  • 45
    • 77952534868 scopus 로고    scopus 로고
    • H. Pylori-eradication therapy increases RUNX3 expression in the glandular epithelial cells in enlarged-fold gastritis
    • M. Suzuki, H. Suzuki, Y. Minegishi, K. Ito, T. Nishizawa, and T. Hibi, "H. pylori-eradication therapy increases RUNX3 expression in the glandular epithelial cells in enlarged-fold gastritis, " Journal of Clinical Biochemistry andNutrition, vol. 46, no. 3, pp. 259-264, 2010.
    • (2010) Journal of Clinical Biochemistry AndNutrition , vol.46 , Issue.3 , pp. 259-264
    • Suzuki, M.1    Suzuki, H.2    Minegishi, Y.3    Ito, K.4    Nishizawa, T.5    Hibi, T.6
  • 46
    • 77951666669 scopus 로고    scopus 로고
    • MicroRNA-130b regulates the tumour suppressor RUNX3 in gastric cancer
    • K. W. Lai, K. X. Koh, M. Loh et al. , "MicroRNA-130b regulates the tumour suppressor RUNX3 in gastric cancer, " European Journal of Cancer, vol. 46, no. 8, pp. 1456-1463, 2010.
    • (2010) European Journal of Cancer , vol.46 , Issue.8 , pp. 1456-1463
    • Lai, K.W.1    Koh, K.X.2    Loh, M.3
  • 47
    • 84877348831 scopus 로고    scopus 로고
    • Overexpressed miR-301a promotes cell proliferation and invasion by targeting RUNX3 in gastric cancer
    • M. Wang, C. Li, B. Yu et al. , "Overexpressed miR-301a promotes cell proliferation and invasion by targeting RUNX3 in gastric cancer, " Journal of Gastroenterology, vol. 48, no. 9, pp. 1023-1033, 2013.
    • (2013) Journal of Gastroenterology , vol.48 , Issue.9 , pp. 1023-1033
    • Wang, M.1    Li, C.2    Yu, B.3
  • 48
    • 84905379289 scopus 로고    scopus 로고
    • Aberrant methylation of microRNA-34b/c is a predictive marker of metachronous gastric cancer risk
    • R. Suzuki, E. Yamamoto, M. Nojima et al. , "Aberrant methylation of microRNA-34b/c is a predictive marker of metachronous gastric cancer risk, " Journal of Gastroenterology, vol. 49, no. 7, pp. 1135-1144, 2014.
    • (2014) Journal of Gastroenterology , vol.49 , Issue.7 , pp. 1135-1144
    • Suzuki, R.1    Yamamoto, E.2    Nojima, M.3
  • 49
    • 66149175569 scopus 로고    scopus 로고
    • Identification of gastric cancer stem cells using the cell surface marker CD44
    • S. Takaishi, T. Okumura, S. Tu et al. , "Identification of gastric cancer stem cells using the cell surface marker CD44, " Stem Cells, vol. 27, no. 5, pp. 1006-1020, 2009.
    • (2009) Stem Cells , vol.27 , Issue.5 , pp. 1006-1020
    • Takaishi, S.1    Okumura, T.2    Tu, S.3
  • 50
    • 84855948607 scopus 로고    scopus 로고
    • Expression of cancer stem cell markers ALDH1, CD44 and CD133 in primary tumor and lymph node metastasis of gastric cancer
    • Y. Wakamatsu, N. Sakamoto, H. Z. Oo et al. , "Expression of cancer stem cell markers ALDH1, CD44 and CD133 in primary tumor and lymph node metastasis of gastric cancer, " Pathology International, vol. 62, no. 2, pp. 112-119, 2012.
    • (2012) Pathology International , vol.62 , Issue.2 , pp. 112-119
    • Wakamatsu, Y.1    Sakamoto, N.2    Oo, H.Z.3
  • 51
    • 84655172846 scopus 로고    scopus 로고
    • Helicobacter pylori infection recruits bone marrow-derived cells that participate in gastric preneoplasia in mice
    • C. Varon, P. Dubus, F. Mazurier et al. , "Helicobacter pylori infection recruits bone marrow-derived cells that participate in gastric preneoplasia in mice, " Gastroenterology, vol. 142, no. 2, pp. 281-291, 2012.
    • (2012) Gastroenterology , vol.142 , Issue.2 , pp. 281-291
    • Varon, C.1    Dubus, P.2    Mazurier, F.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.