Age-associated increase in BMP signaling inhibits hippocampal neurogenesis

Stem Cells

Volumn 33, Issue 5, 2015, Pages 1577-1588

  Yousef, Hanadie ^a,c,d   Morgenthaler, Adam ^b   Schlesinger, Christina ^b   Bugaj, Lukasz ^b   Conboy, Irina M ^b   Schaffer, David V ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b University of California at Berkeley   (United States)

^c STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d VA PALO ALTO HEALTH CARE SYSTEM   (United States)

Author keywords

Adult stem cells; Aging; BMP signaling; Neural stem cell; Neurogenesis; Proliferation; Stem cell microenvironment interactions

Indexed keywords

BONE MORPHOGENETIC PROTEIN; BONE MORPHOGENETIC PROTEIN 2; BONE MORPHOGENETIC PROTEIN 4; BONE MORPHOGENETIC PROTEIN 6; LENTIVIRUS VECTOR; RNA; SHORT HAIRPIN RNA; CRE RECOMBINASE; INTEGRASE; SMAD PROTEIN;

AGE; AGED; ANIMAL CELL; ANIMAL CELL CULTURE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; HIPPOCAMPAL NEUROGENESIS; HIPPOCAMPUS; IMMUNOCYTOCHEMISTRY; IMMUNOFLUORESCENCE; IN VITRO STUDY; IN VIVO STUDY; MALE; MOUSE; NERVOUS SYSTEM DEVELOPMENT; NEURAL STEM CELL; NONHUMAN; PROTEIN ANALYSIS; PROTEIN EXPRESSION; RAT; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA ANALYSIS; RNA EXTRACTION; TISSUE SECTION; WESTERN BLOTTING; AGING; ANIMAL; C57BL MOUSE; CYTOLOGY; ENDOTHELIUM CELL; METABOLISM; MICROGLIA; PHOSPHORYLATION; PROTEIN TRANSPORT; SIGNAL TRANSDUCTION; TRANSGENIC MOUSE;

MURINAE; MUS;

AGING; ANIMALS; BONE MORPHOGENETIC PROTEINS; CELL PROLIFERATION; ENDOTHELIAL CELLS; HIPPOCAMPUS; INTEGRASES; MALE; MICE, INBRED C57BL; MICE, TRANSGENIC; MICROGLIA; NEURAL STEM CELLS; NEUROGENESIS; PHOSPHORYLATION; PROTEIN TRANSPORT; SIGNAL TRANSDUCTION; SMAD PROTEINS;

EID: 84928556888     PISSN: 10665099     EISSN: 15494918     Source Type: Journal    
DOI: 10.1002/stem.1943     Document Type: Article

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