Macrophages and regulation of erythropoiesis

Current Opinion in Hematology

Volumn 22, Issue 3, 2015, Pages 212-219

  Jacobsen, Rebecca N ^a   Perkins, Andrew C ^a,b   Levesque, Jean Pierre ^a  

^a UNIVERSITY OF QUEENSLAND   (Australia)

^b PRINCESS ALEXANDRA HOSPITAL   (Australia)

Author keywords

anemia; erythroblastic island; erythropoiesis; macrophage; red blood cell

Indexed keywords

CYTOKINE; GRANULOCYTE COLONY STIMULATING FACTOR; KRUPPEL LIKE FACTOR; TRANSCRIPTION FACTOR; TYROSINE KINASE RECEPTOR;

ANEMIA; BETA THALASSEMIA; BONE MARROW; CELL ADHESION; CELL MATURATION; CELL NUCLEUS; DIGESTION; ERYTHROBLAST; ERYTHROCYTE COUNT; ERYTHROID CELL; ERYTHROPOIESIS; GENETIC MODEL; HUMAN; IN VIVO STUDY; MACROPHAGE; MOLECULAR INTERACTION; MOLECULE; NONHUMAN; PHENOTYPE; POLYCYTHEMIA VERA; PRIORITY JOURNAL; REVIEW; THALASSEMIA; ANIMAL; BLOOD CELL COUNT; MOUSE; PHYSIOLOGY; PROSPECTIVE STUDY;

ANEMIA; ANIMALS; BLOOD CELL COUNT; ERYTHROBLASTS; ERYTHROPOIESIS; HUMANS; MACROPHAGES; MICE; PROSPECTIVE STUDIES;

EID: 84928503086     PISSN: 10656251     EISSN: 15317048     Source Type: Journal    
DOI: 10.1097/MOH.0000000000000131     Document Type: Review

References (42)

1. Bessis M. Lilot erythroblastique, unite fonctionelle de la moelle osseuse. Rev Hematol 1958; 13:8-11.
2. Chasis JA, Mohandas N. Erythroblastic islands: niches for erythropoiesis. Blood 2008; 112:470-478.
3. Sawada K, Krantz SB, Dessypris EN, et al. Human colony-forming unitserythroid do not require accessory cells, but do require direct interaction with insulin-like growth factor I and/or insulin for erythroid development. J Clin Invest 1989; 83:1701-1709.
4. Manwani D, Bieker JJ. The erythroblastic island. Curr Top Dev Biol 2008; 82:23-53.
5. Bessis MC, Breton-Gorius J. Iron metabolism in the bone marrow as seen by electron microscopy: a critical review. Blood 1962; 19:635-663.
6. Leimberg MJ, Prus E, Konijn AM, et al. Macrophages function as a ferritin iron source for cultured human erythroid precursors. J Cell Biochem 2008; 103:1211-1218.
7. Skutelsky E, Danon D. On the expulsion of the erythroid nucleus and its phagocytosis. Anat Rec 1972; 173:123-126.
8. Soni S, Bala S, Gwynn B, et al. Absence of erythroblast macrophage protein (Emp) leads to failure of erythroblast nuclear extrusion. J Biol Chem 2006; 281:20181-20189.
9. Crocker P, Werb Z, Gordon S, et al. Ultrastructural localization of a macrophage-restricted sialic acid binding hemagglutinin, SER, in macrophagehematopoietic cell clusters. Blood 1990; 76:1131-1138.
10. Hanspal M, Hanspal JS. The association of erythroblasts with macrophages promotes erythroid proliferation and maturation: a 30-kD heparin-binding protein is involved in this contact. Blood 1994; 84:3494-3504.
11. Hanspal M, Smockova Y, Uong Q. Molecular identification and functional characterization of a novel protein that mediates the attachment of erythroblasts to macrophages. Blood 1998; 92:2940-2950.
12. Sadahira Y, Yoshino T, Monobe Y. Very late activation antigen 4-vascular cell adhesion molecule 1 interaction is involved in the formation of erythroblastic islands. J Exp Med 1995; 181:411-415.
13. Lee G, Lo A, Short SA, et al. Targeted gene deletion demonstrates that the cell adhesion molecule ICAM-4 is critical for erythroblastic island formation. Blood 2006; 108:2064-2071.
14. de Jong JP, Voerman JS, van der Sluijs-Gelling AJ, et al. A monoclonal antibody (ER-HR3) against murine macrophages. I. Ontogeny, distribution and enzyme histochemical characterization of ER-HR3-positive cells. Cell Tissue Res 1994; 275:567-576.
15. Sonoda Y, Sasaki K. Hepatic extramedullary hematopoiesis and macrophages in the adult mouse: histometrical and immunohistochemical studies. Cells Tissues Organs 2012; 196:555-564.
16. Jacobsen RN, Forristal CE, Raggatt LJ, et al. Mobilization with granulocyte colony-stimulating factor blocks medullar erythropoiesis by depleting F4/ 80+VCAM1+CD169+ER-HR3+Ly6G+ erythroid island macrophages in the mouse. Exp Hematol 2014; 42:547-561; e544.
17. Chow A, Huggins M, Ahmed J, et al. CD169+ macrophages provide a niche promoting erythropoiesis under homeostasis and stress. Nat Med 2013; 19:429-436.
18. Ramos P, Casu C, Gardenghi S, et al. Macrophages support pathological erythropoiesis in polycythemia vera and [b]-thalassemia. Nat Med 2013; 19:437-445.
19. Mullally A, Lane SW, Ball B, et al. Physiological Jak2V617F expression causes a lethal myeloproliferative neoplasm with differential effects on hematopoietic stem and progenitor cells. Cancer Cell 2010; 17:584-596.
20. Bader BL, Rayburn H, Crowley D, et al. Extensive vasculogenesis, angiogenesis, and organogenesis precede lethality in mice lacking all av integrins. Cell 1998; 95:507-519.
21. Wang Z, Vogel O, Kuhn G, et al. Decreased stability of erythroblastic islands in integrin b3-deficient mice. Physiol Rep 2013; 1:e00018.
22. Spring FA, Griffiths RE, Mankelow TJ, et al. Tetraspanins CD81 and CD82 facilitate a4b1-mediated adhesion of human erythroblasts to vascular cell adhesion molecule-1. PLoS One 2013; 8:e62654.
23. Scott LM, Priestley GV, Papayannopoulou T. Deletion of {a}4 integrins from adult hematopoietic cells reveals roles in homeostasis, regeneration, and homing. Mol Cell Biol 2003; 23:9349-9360.
24. Ulyanova T, Scott LM, Priestley GV, et al. VCAM-1 expression in adult hematopoietic and nonhematopoietic cells is controlled by tissue-inductive signals and reflects their developmental origin. Blood 2005; 106:86-94.
25. Ulyanova T, Jiang Y, Padilla S, et al. Combinatorial and distinct roles of a5 and a4 integrins in stress erythropoiesis in mice. Blood 2011; 117:975-985.
26. Ulyanova T, Padilla SM, Papayannopoulou T. Stage specific functional roles of integrins in erythropoiesis. Exp Hematol 2014; 42:404-409.
27. Robier C, Amouzadeh-Ghadikolai O, Bregant C, et al. The anti-VLA-4 antibody natalizumab induces erythroblastaemia in the majority of the treated patients with multiple sclerosis. Mult Scler 2014; 20:1269-1272.
28. Papayannopoulou T, Nakamoto B. Peripheralization of hemopoietic progenitors in primates treated with anti-VLA4 integrin. Proc Natl Acad Sci USA 1993; 90:9374-9378.
29. Mao X, Shi X, Liu F, et al. Evaluation of erythroblast macrophage protein related to erythroblastic islands in patients with hematopoietic stem cell transplantation. Eur J Med Res 2013; 18:9.
30. Sui Z, Nowak RB, Bacconi A, et al. Tropomodulin3-null mice are embryonic lethal with anemia due to impaired erythroid terminal differentiation in the fetal liver. Blood 2014; 123:758-767.
31. Toda S, Segawa K, Nagata S. MerTK-mediated engulfment of pyrenocytes by central macrophages in erythroblastic islands. Blood 2014; 123:3963-3971.
32. McGrath KE. Red cell island dances: switching hands. Blood 2014; 123:3847-3848.
33. Tang H, Chen S, Wang H, et al. TAM receptors and the regulation of erythropoiesis in mice. Haematologica 2009; 94:326-334.
34. Perkins AC, Sharpe AH, Orkin SH. Lethal [b]-thalassaemia in mice lacking the erythroid CACCC-transcription factor EKLF. Nature 1995; 375:318-322.
35. Tallack MR, Perkins AC. KLF1 directly coordinates almost all aspects of terminal erythroid differentiation. IUBMB Life 2010; 62:886-890.
36. Siatecka M, Bieker JJ. The multifunctional role of EKLF/KLF1 during erythropoiesis. Blood 2011; 118:2044-2054.
37. Tallack MR, Magor GW, Dartigues B, et al. Novel roles for KLF1 in erythropoiesis revealed by mRNA-seq. Genome Res 2012; 22:2385-2398.
38. Porcu S, Manchinu MF, Marongiu MF, et al. Klf1 affectsDNase II-a expression in the central macrophage of a fetal liver erythroblastic island: a non-cell-autonomous role in definitive erythropoiesis. Mol Cell Biol 2011; 31:4144-4154.
39. Xue L, Galdass M, Gnanapragasam MN, et al. Extrinsic and intrinsic control by EKLF (KLF1) within a specialized erythroid niche. Development 2014; 141:2245-2254.
40. Xue L, Chen X, Chang Y, et al. Regulatory elements of the EKLF gene that direct erythroid cell-specific expression during mammalian development. Blood 2004; 103:4078-4083.
41. Perkins A. Erythroid Kruppel like factor: from fishing expedition to gourmet meal. Int J Biochem Cell Biol 1999; 31:1175-1192.
42. Kawane K, Fukuyama H, Kondoh G, et al. Requirement of DNase II for definitive erythropoiesis in the mouse fetal liver. Science 2001; 292:1546-1549.