Antibodies generated against streptococci protect in a mouse model of disseminated aspergillosis

Journal of Immunology

Volumn 194, Issue 9, 2015, Pages 4387-4396

  Wharton, Rebekah E ^a,b   Stefanov, Emily K ^a   King, R Glenn ^a   Kearney, John F ^a  

^a University of Alabama at Birmingham   (United States)

^b University of Alabama at Birmingham   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY SMB19; UNCLASSIFIED DRUG; BACTERIUM ANTIBODY; CALCIUM; OLIGOSACCHARIDE; PROTEIN BINDING;

ACTIVE IMMUNIZATION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY SPECIFICITY; ARTICLE; ASPERGILLUS FUMIGATUS; CONIDIUM; CONTROLLED STUDY; DRUG EFFICACY; DRUG RESEARCH; DRUG SCREENING; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; FUNGUS HYPHAE; GENE EXPRESSION; IN VIVO STUDY; INVASIVE ASPERGILLOSIS; MOUSE; MOUSE MODEL; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PASSIVE IMMUNIZATION; PATHOGEN CLEARANCE; PATHOGEN LOAD; PRIORITY JOURNAL; PROTECTION; STREPTOCOCCUS AGALACTIAE; SURVIVAL RATE; TRANSGENE; ANIMAL; ASPERGILLOSIS; ASPERGILLUS; BRAIN; CLASSIFICATION; DISEASE MODEL; GENETICS; IMMUNIZATION; IMMUNOLOGY; KIDNEY; METABOLISM; MORTALITY; PATHOLOGY; STREPTOCOCCUS; TRANSGENIC MOUSE;

ANIMALS; ANTIBODIES, BACTERIAL; ANTIBODIES, MONOCLONAL; ANTIBODY SPECIFICITY; ASPERGILLOSIS; ASPERGILLUS; BRAIN; CALCIUM; DISEASE MODELS, ANIMAL; IMMUNIZATION; KIDNEY; MICE; MICE, TRANSGENIC; NEUTROPHIL INFILTRATION; OLIGOSACCHARIDES; PROTEIN BINDING; STREPTOCOCCUS;

EID: 84928501304     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1401940     Document Type: Article

References (21)

1. Hohl, T. M., and M. Feldmesser. 2007. Aspergillus fumigatus: principles of pathogenesis and host defense. Eukaryot. Cell 6: 1953-1963.
2. Cutler, J. E., G. S. Deepe, Jr., and B. S. Klein. 2007. Advances in combating fungal diseases: vaccines on the threshold. Nat. Rev. Microbiol. 5: 13-28.
3. Montagnoli, C., F. Fallarino, R. Gaziano, S. Bozza, S. Bellocchio, T. Zelante, W. P. Kurup, L. Pitzurra, P. Puccetti, and L. Romani. 2006. Immunity and tolerance to Aspergillus involve functionally distinct regulatory T cells and tryptophan catabolism. J. Immunol. 176: 1712-1723.
4. Fontaine, T., A. Delangle, C. Simenel, B. Coddeville, S. J. van Vliet, Y. van Kooyk, S. Bozza, S. Moretti, F. Schwarz, C. Trichot, et al. 2011. Galactosaminogalactan, a new immunosuppressive polysaccharide of Aspergillus fumigatus. PLoS Pathog. 7: e1002372.
5. Latgé, J. P., H. Kobayashi, J. P. Debeaupuis, M. Diaquin, J. Sarfati, J. M. Wieruszeski, E. Parra, J. P. Bouchara, and B. Fournet. 1994. Chemical and immunological characterization of the extracellular galactomannan of Aspergillus fumigatus. Infect. Immun. 62: 5424-5433.
6. Montagnoli, C., S. Bozza, A. Bacci, R. Gaziano, P. Mosci, J. Morschhäuser, L. Pitzurra, M. Kopf, J. Cutler, and L. Romani. 2003. A role for antibodies in the generation of memory antifungal immunity. Eur. J. Immunol. 33: 1193-1204.
7. Torosantucci, A., P. Chiani, C. Bromuro, F. De Bernardis, A. S. Palma, Y. Liu, G. Mignogna, B. Maras, M. Colone, A. Stringaro, et al. 2009. Protection by anti-β-glucan antibodies is associated with restricted β-1,3 glucan binding specificity and inhibition of fungal growth and adherence. PLoS ONE 4: e5392.
8. Rachini, A., D. Pietrella, P. Lupo, A. Torosantucci, P. Chiani, C. Bromuro, C. Proietti, F. Bistoni, A. Cassone, and A. Vecchiarelli. 2007. An anti-β-glucan monoclonal antibody inhibits growth and capsule formation of Cryptococcus neoformans in vitro and exerts therapeutic, anticryptococcal activity in vivo. Infect. Immun. 75: 5085-5094.
9. Chaturvedi, A. K., A. Kavishwar, G. B. Shiva Keshava, and P. K. Shukla. 2005. Monoclonal immunoglobulin G1 directed against Aspergillus fumigatus cell wall glycoprotein protects against experimental murine aspergillosis. Clin. Diagn. Lab. Immunol. 12: 1063-1068.
10. Blanco, J. L., and M. E. Garcia. 2008. Immune response to fungal infections. Vet. Immunol. Immunopathol. 125: 47-70.
11. Baker, C. J., M. A. Rench, M. Fernandez, L. C. Paoletti, D. L. Kasper, and M. S. Edwards. 2003. Safety and immunogenicity of a bivalent group B streptococcal conjugate vaccine for serotypes II and III. J. Infect. Dis. 188: 66-73.
12. Foote, J. B., and J. F. Kearney. 2009. Generation of B cell memory to the bacterial polysaccharide α-1,3 dextran. J. Immunol. 183: 6359-6368.
13. Pritchard, D. G., B. M. Gray, and M. L. Egan. 1992. Murine monoclonal antibodies to type Ib polysaccharide of group B streptococci bind to human milk oligosaccharides. Infect. Immun. 60: 1598-1602.
14. Chen, X., F. Martin, K. A. Forbush, R. M. Perlmutter, and J. F. Kearney. 1997. Evidence for selection of a population of multi-reactive B cells into the splenic marginal zone. Int. Immunol. 9: 27-41.
15. Kin, N. W., E. K. Stefanov, B. L. Dizon, and J. F. Kearney. 2012. Antibodies generated against conserved antigens expressed by bacteria and allergen-bearing fungi suppress airway disease. J. Immunol. 189: 2246-2256.
16. Kearney, J. F., R. Barletta, Z. S. Quan, and J. Quintáns. 1981. Monoclonal vs. heterogeneous anti-H-8 antibodies in the analysis of the anti-phosphorylcholine response in BALB/c mice. Eur. J. Immunol. 11: 877-883.
17. Bowman, J. C., G. K. Abruzzo, J. W. Anderson, A. M. Flattery, C. J. Gill, V. B. Pikounis, D. M. Schmatz, P. A. Liberator, and C. M. Douglas. 2001. Quantitative PCR assay to measure Aspergillus fumigatus burden in a murine model of disseminated aspergillosis: demonstration of efficacy of caspofungin acetate. Antimicrob. Agents Chemother. 45: 3474-3481.
18. Jackson, S. L., and I. B. Heath. 1993. Roles of calcium ions in hyphal tip growth. Microbiol. Rev. 57: 367-382.
19. Hector, R. F., E. Yee, and M. S. Collins. 1990. Use of DBA/2N mice in models of systemic candidiasis and pulmonary and systemic aspergillosis. Infect. Immun. 58: 1476-1478.
20. Alviano, C. S., L. R. Travassos, and R. Schauer. 1999. Sialic acids in fungi: a minireview. Glycoconj. J. 16: 545-554.
21. Casadevall, A., and L. A. Pirofski. 2007. Antibody-mediated protection through cross-reactivity introduces a fungal heresy into immunological dogma. Infect. Immun. 75: 5074-5078.