Discovery of potent inhibitors of Schistosoma mansoni NAD+ catabolizing enzyme

Journal of Medicinal Chemistry

Volumn 58, Issue 8, 2015, Pages 3582-3592

  Jacques, Sylvain A ^a   Kuhn, Isabelle ^a   Koniev, Oleksandr ^a   Schuber, Francis ^a   Lund, Frances E ^b   Wagner, Alain ^a   Muller Steffner, HéleÌne ^a   Kellenberger, Esther ^a  

^a UNIVERSITÉ DE STRASBOURG   (France)

^b University of Alabama at Birmingham   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 METHYLFURAN 3 CARBOHYDRAZIDE; 2 METHYLFURAN 3 CARBOXYLIC ACID; 4 CHLORO 2 [5 (2 METHYLFURAN 3 YL) 1,3,4 OXADIAZOL 2 YL]PHENOL; ANTISCHISTOSOMAL AGENT; ENZYME INHIBITOR; N (2 METHOXYPHENETHYL) 2 METHYLFURAN 3 CARBOXAMIDE; N' (2 HYDROXY 3 METHYLBENZOYL) 2 METHYLFURAN 3 CARBOHYDRAZIDE; N' (2 HYDROXY 3 METHYLBENZYLIDENE) 2 METHYLFURAN 3 CARBOHYDRAZIDE; N' (2 HYDROXY 4 METHOXYBENZOYL) 2 METHYLFURAN 3 CARBOHYDRAZIDE; N' (2 HYDROXY 4 METHOXYBENZYLIDENE) 2 METHYLFURAN 3 CARBOHYDRAZIDE; N' (2 HYDROXY 4,6 DIMETHOXYBENZYLIDENE) 2 METHYLFURAN 3 CARBOHYDRAZIDE; N' (2 HYDROXY 5 METHOXYBENZYLIDENE) 2 METHYLFURAN 3 CARBOHYDRAZIDE; N' (2 HYDROXYBENZOYL) 2 METHYLFURAN 3 CARBOHYDRAZIDE; N' (2 HYDROXYBENZYL) 2 METHYLFURAN 3 CARBOHYDRAZIDE; N' (2 HYDROXYBENZYLIDENE) 2 METHYLFURAN 3 CARBOHYDRAZIDE; N' (2 HYDROXYBENZYLIDENE) N,2 DIMETHYLFURAN 3 CARBOHYDRAZIDE; N' (2 METHOXYBENZYL) 2 METHYLFURAN 3 CARBOHYDRAZIDE; N' (2 METHOXYBENZYLIDENE) 2 METHYLFURAN 3 CARBOHYDRAZIDE; N' (2 METHOXYBENZYLIDENE) N,2 DIMETHYLFURAN 3 CARBOHYDRAZIDE; N' (2,3 DIHYDROXYBENZYLIDENE) 2 METHYLFURAN 3 CARBOHYDRAZIDE; N' (2,4 DICHLORO 6 HYDROXYBENZYLIDENE) 2 METHYLFURAN 3 CARBOHYDRAZIDE; N' (3 CHLORO 2 HYDROXYBENZYLIDENE) 2 METHYLFURAN 3 CARBOHYDRAZIDE; N' (3,4 DIHYDROXYBENZYLIDENE) 2 METHYLFURAN 3 CARBOHYDRAZIDE; N' (5 CHLORO 2 HYDROXYBENZOYL) 2 METHYLFURAN 3 CARBOHYDRAZIDE; N' [3 (TERT-BUTYL) 2 HYDROXYBENZYLIDENE] 2 METHYLFURAN 3 CARBOHYDRAZIDE; N'[1 (2 HYDROXYPHENYL)ETHYLIDENE] 2 METHYLFURAN 3 CARBOHYDRAZIDE; N(2 HYDROXYPHENETHYL) 2 METHYLFURAN 3 CARBOXAMIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE CATABOLIZING ENZYME INHIBITOR; UNCLASSIFIED DRUG; UNINDEXED DRUG; ANTIPARASITIC AGENT; CD38 ANTIGEN; HELMINTH PROTEIN;

ADAPTIVE IMMUNITY; ADULT; ARTICLE; CATALYSIS; COMPETITIVE INHIBITION; DRUG DETERMINATION; DRUG POTENCY; DRUG SCREENING; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME DEGRADATION; HUMAN; IMMUNE EVASION; IN VITRO STUDY; MOLECULAR DOCKING; NEMATODE LIFE CYCLE STAGE; NONHUMAN; SCHISTOSOMA MANSONI; SCHISTOSOMIASIS; STRUCTURE ACTIVITY RELATION; WORM TEGUMENT; ANIMAL; ANTAGONISTS AND INHIBITORS; CHEMISTRY; DRUG EFFECTS; ENZYMOLOGY; METABOLISM; PARASITOLOGY; SCHISTOSOMIASIS MANSONI;

ANIMALS; ANTIGENS, CD38; ANTIPARASITIC AGENTS; ENZYME INHIBITORS; HELMINTH PROTEINS; HUMANS; MOLECULAR DOCKING SIMULATION; NAD; SCHISTOSOMA MANSONI; SCHISTOSOMIASIS MANSONI; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84928494315     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/acs.jmedchem.5b00203     Document Type: Article

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