Synthesis and antifungal activity of some new 1,2,4-triazole and furan containing compounds

Saudi Pharmaceutical Journal

Volumn 11, Issue 3, 2003, Pages 87-96

  Shehata, Ihsan A ^a  

^a KING SAUD UNIVERSITY   (Saudi Arabia)

Author keywords

1,2,4 triazole analogs; Antifungal activity; Substituted furans; Synthesis

Indexed keywords

1,2,4 TRIAZOLE DERIVATIVE; 3 (1 METHYL 2 PYRROLYLMETHYL) 4 PHENYL 5 (4 CHLOROPHENYLCARBAMOYLMETHYLTHIO) 1,2,4 TRIAZOLE; 5,6 DIHYDRO 4 OXO 5 PHENYL 4H FURO[2,3 C]PYRROLE; BUTOCONAZOLE; CHLORMIDAZOLE; FLUCONAZOLE; FURAN DERIVATIVE; UNCLASSIFIED DRUG;

ANTIFUNGAL ACTIVITY; ARTICLE; CANDIDA ALBICANS; CONTROLLED STUDY; DRUG ACTIVITY; DRUG SCREENING; DRUG SYNTHESIS; INFRARED SPECTROSCOPY; MELTING POINT; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; SACCHAROMYCES CEREVISIAE; ULTRAVIOLET SPECTROSCOPY;

EID: 0042129968     PISSN: 13190164     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (24)

1. th ed, eds. Lippincott Williams and Wikins, New York 2002; Chapter 36: 895.
2. Leyden J., Pharmacokinetics and Pharmacology of Terbinafine and Itraconazole, J. Am. Acad. Dermatol. 1999; 40: 282-7.
3. Gruz, M.C., Goldstein, A.L., Blankenship JR, Del Poeta M., Davis D., Cardenas M.E., Perfect J.R., McRusker, J.H., Heitman, J., Calcineurin is essential for survival during membrane stress in Candida albicans, EMBO J. 2002; 21: 546-59.
4. Itoh, H., Tanaka, H., Ohta, H., Takeshiba, H., Synthesis and fungicidal activities of silicon containing derivatives of 2-aryl-3-(1H-1,2,4-triazol-1-yl) propane nitriles, Chem. Pharm. Bull. (Tokyo) 2001; 49: 909-11.
5. Amoldi, A., Carzaniga, R., Morini, G., Merlini, L., Farina, G., Synthesis, Fungicidal activity and QSAR of a series of 2-dichlorophenyl-3-triazolylpropyl ethers, J. Agric. Food Chem. 2000; 48: 2457-55.
6. Srivastava, M.K., Khare, R.K., Singh, H., Synthesis and fungicidal activity of some 5-(2-aminoalkanoyl)-8-aryl-4(5H)-oxo-1,2,4-triazolo(4,3-b)- 1,4,2,6-dithiadiazine 6,6-dioxide derivatives, Boll. Chim. Farm. 1999; 138: 511-5.
7. Etran, R., Ayhan, G., Yulug, N., Rolland Y., Synthesis and antifungal activities of some new triazolyl acetophenone derivatives, Arzneim. Forsch. 1995; 45: 620-3.
8. Invidiata, F.P., Furno, G., Simoni, D., Lampront, I., Muru, C., Milia, C., Scintu, F., LaColla, P., 3,6-Disubstituted 1,2,4-triazolo[3,4-b]-1,3,4-thiadiazoles: Synthesis and evaluation for antimicrobial and antiviral activity, Farmaco 1997; 52: 259-61.
9. Pedini, M., Alunni, B.G., De Meo, G., Ricci, A., Bastianini, L., Sposini, T., Jacquignon, P. New heterocyclic derivatives of benzimidazole with germicidal activity. V. Synthesis and activity of new derivatives of di-2-benzimidazolyl-2,5-furan. Farmaco (Sci) 1988; 43: 935-42.
10. Stephens, C.E., Tanious, F., Kim, S., Wilson, W.D., Schell, W.A., Perfect, J.R., Franzblau, S.G., Boykin, D.W. Diguanidino and reversed diamidino 2,5-diarylfurans as antimicrobial agents, J. Med. Chem. 2001; 44: 1741-8.
11. El-Kerdawy, M.M., Yousif, M.Y., Shehata, I.A., Goda, F.E. Synthesis of certain pyrones and fused pyridines as potential antibacterial agents, Alex. J. Pharm. Sci. III 1989; 2: 204-12.
12. El-Kerdawy, M.M., Yousif, M.Y., Shehata, I.A., Goda F.E. Pyridones: Synthesis and antibacterial testing of certain chelidamic acid derivatives, Chin. Pharm. J. 1990; 42: 57-66.
13. Moustafa, M.A., Mashaly M.M., Shehata, I.A., Synthesis, metabolic behavior and antibacterial activity of new sulfanilamide pyrazoles, Chin. Pharm. J. 1991; 43: 69-80.
14. Shehata, I.A., Nasr, M., El-Subbagh, H.I., Gineinah, M.M., Kheira, S.M. Synthesis and biological testing of certain 1,3,5-oxadiazole and 1,2,4-triazole derivatives as potential antimicrobial agents. Sci. Pharm. 1996; 64: 133-43.
15. Abdelal, A.M., Moustafa, M.A., Shehata, I.A., El-Emam, A.A., Synthesis of certain N′-[4-aryl-6(2-benzofuryl)-2-pyrimidinyl]sulfanilamides as potential antibacterial agents, Sci. Pharm. 1992; 8: 304-10.
16. Shafiee, A., Naimi, E., Mansobi, P., Foroumadi, A., Shehari, M., Syntheses of substituted-oxazolo-1,3,4-thiadiazoles, 1,3,4-oxadiazoles and 1,2,4-triazoles, J. Heterocycl. Chem. 1995; 32: 1235-39.
17. th ed. Churchill Livingstone, London, UK.
18. El-Sherbeny, M.A., Badria, F.A., Kheira, S.A., Synthesis of some new thiazolo[4,5-d]-pyrimidine derivatives and evaluation of their antifungal, antiviral and cytotoxic activities, Med. Chem. Res, 1996; 6: 28-39.
19. , El-Subbagh, H.I., Nasr, M.A., Abdelal, A.M., Gineinah, M.M., El-Kashef H,A., Synthesis and anticonvulsant activity of some 1-substituted-2-oxopyrrolidine derivatives, Med. Chem. Res. 1994; 4: 335-345.
20. El-Subbagh, H.I., El-Naggar, W.A., Badria, F.A., Synthesis and biological testing of 2,4-disubstituted thiazole derivatives as potential antitumor antibiotics, Med. chem.. Res. 1994; 3: 503-516.
21. El-Subbagh, H.I., Al-Obaid, A.M., 2,4-Disubstituted thiazoles II. A novel class of antitumor agents, Synthesis and biological evaluation, Eur. J. Med. Chem. 1996; 31: 1017-1021.
22. Mitagawa, M., Mimura, T., Tanaka, M., Aryloxy acetic acid diuretics with uricosuric activity, Chem Pharm. Bull. 1991, 39: 2400-7.
23. Ismaiel, A.M., Yousif, Y., Metwally, M.A., El-Kerdawy, M., Syntheses of 1-substituted 4-arylhydrazono-3-methyl-2-pyrazoline-5-ones. 1-Substituted-4-arylazo-3,5-dimethylpyrazoles as potential anti-inflammatory agents, Indian J. Chem. 1986; 25B: 1238-42.
24. Czollner, L., Szilagyi, G., Lango, J., Janaky, J., Synthesis of new 1,5-diphenyl-3-1H-1,2,4-triazoles substituted with H-, alkyl, or carboxyl groups at C-3, Arch. Pharm. (Weinheim) 1990; 323: 225-7.