Iron accumulation is not homogenous among patients with Parkinson's disease

Parkinson's Disease

Volumn 2015, Issue , 2015, Pages

  Dashtipour, Khashayar ^a   Liu, Manju ^b   Kani, Camellia ^a   Dalaie, Pejman ^a   Obenaus, Andre ^a   Simmons, Daniel ^a   Gatto, Nicole M ^c   Zarifi, Mehran ^a  

^a LOMA LINDA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c LOMA LINDA UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

IRON;

AGED; ARTICLE; BRAIN REGION; CAUDATE NUCLEUS; CLINICAL ARTICLE; CONTROLLED STUDY; DENTATE NUCLEUS; FEMALE; GLOBUS PALLIDUS; GRAY MATTER; HUMAN; MALE; MOTOR CORTEX; NEUROIMAGING; PARKINSON DISEASE; PRIORITY JOURNAL; PUTAMEN; RED NUCLEUS; SUBSTANTIA NIGRA; SUSCEPTIBILITY WEIGHTED IMAGING; THALAMUS; WHITE MATTER;

EID: 84928471444     PISSN: None     EISSN: 20420080     Source Type: Journal    
DOI: 10.1155/2015/324843     Document Type: Article

References (27)

1. J. Lhermitte, W. M. Kraus, and M. A. Mc Alpine, "On the occurrence of abnormal deposits of iron in the brain in Parkinsonism with special reference to its localization, " The Journal of Neurology and Psychopathology, vol. 5, no. 19, pp. 195-208, 1924.
2. E. Sofic, W. Paulus, K. Jellinger, P. Riederer, and M. B. H. Youdim, "Selective increase of iron in substantia nigra zona compacta of Parkinsonian brains, " Journal of Neurochemistry, vol. 56, no. 3, pp. 978-982, 1991.
3. K. Jellinger, W. Paulus, I. Grundke-Iqbal, P. Riederer, and M. B. H. Youdim, "Brain iron and ferritin in Parkinson's and Alzheimer's diseases, " Journal of Neural Transmission: Parkinson's Disease and Dementia Section, vol. 2, no. 4, pp. 327-340, 1990.
4. D. T. Dexter, F. R. Wells, A. J. Lees et al., "Increased nigral iron content and alterations in other metal ions occurring in brain in Parkinson's disease, " Journal of Neurochemistry, vol. 52, no. 6, pp. 1830-1836, 1989.
5. E. Sofic, P. Riederer, H. Heinsen et al., "Increased iron (III) and total iron content in post mortem substantia nigra of parkinsonian brain, " Journal of Neural Transmission, vol. 74, no. 3, pp. 199-205, 1988.
6. B. P. Drayer, P. Burger, R. Darwin, S. Riederer, R. Herfkens, and G. A. Johnson, "Magnetic resonance imaging of brain iron, " The American Journal of Neuroradiology, vol. 7, no. 3, pp. 373-380, 1986.
7. M. B. H. Youdim and D. Ben-Shachar, "The neurotoxic component in Parkinson's disease may involve iron-melanin interaction and lipid peroxidation in the substantia nigra, " in Early Markers in Parkinson's and Alzheimer's Diseases, P. Dostert, P. Riederer, M. Strolin-Benedetti, and R. Roncucci, Eds., vol. 1 of New Vistas in Drug Research, pp. 111-122, Springer, Vienna, Austria, 1990.
8. D. Ben-Shachar, G. Eshel, J. P. M. Finberg, and M. B. H. Youdim, "The iron chelator desferrioxamine (Desferal) retards 6-hydroxydopamine-induced degeneration of nigrostriatal dopamine neurons, " Journal of Neurochemistry, vol. 56, no. 4, pp. 1441-1444, 1991.
9. D. Ben-Shachar and M. B. H. Youdim, "Intranigral iron injection induces behavioral and biochemical 'Parkinsonism' in rats, " Journal of Neurochemistry, vol. 57, no. 6, pp. 2133-2135, 1991.
10. M. B. H. Youdim, D. Ben-Shachar, and P. Riederer, "The possible role of iron in the etiopathology of Parkinson's disease, " Movement Disorders, vol. 8, no. 1, pp. 1-12, 1993.
11. A. Friedman, J. Galazka-Friedman, and D. Koziorowski, "Iron as a cause of Parkinson disease-a myth or a well established hypothesis?" Parkinsonism and Related Disorders, vol. 15, no. 3, pp. S212-S214, 2009.
12. P. Ryvlin, E. Broussolle, H. Piollet, F. Viallet, Y. Khalfallah, and G. Chazot, "Magnetic resonance imaging evidence of decreased putamenal iron content in idiopathic Parkinson's disease, " Archives of Neurology, vol. 52, no. 6, pp. 583-588, 1995.
13. G. Bartzokis, J. L. Cummings, C. H. Markham et al., "MRI evaluation of brain iron in earlier-and later-onset Parkinson's disease and normal subjects, " Magnetic Resonance Imaging, vol. 17, no. 2, pp. 213-222, 1999.
14. S. Baudrexel, L. Nürnberger, U. Rüb et al., "Quantitative mapping of T1 and T2 discloses nigral and brainstempathology in early Parkinson's disease, " NeuroImage, vol. 51, no. 2, pp. 512-520, 2010.
15. J. M. Gorell, R. J. Ordidge, G. G. Brown, J.-C. Deniau, N. M. Buderer, and J. A. Helpern, "Increased iron-related MRI contrast in the substantia nigra in Parkinson's disease, " Neurology, vol. 45, no. 6, pp. 1138-1143, 1995.
16. W. R. W. Martin, M. Wieler, and M. Gee, "Midbrain iron content in early Parkinson disease: a potential biomarker of disease status, " Neurology, vol. 70, no. 16, part 2, pp. 1411-1417, 2008.
17. S. Michaeli, G. Öz, D. J. Sorce et al., "Assessment of brain iron and neuronal integrity in patients with Parkinson's disease using novel MRI contrasts, " Movement Disorders, vol. 22, no. 3, pp. 334-340, 2007.
18. P. Péran, A. Cherubini, F. Assogna et al., "Magnetic resonance imaging markers of Parkinson's disease nigrostriatal signature, " Brain, vol. 133, no. 11, pp. 3423-3433, 2010.
19. G. Du, M. M. Lewis, M. Styner et al., "Combined R2∗ and diffusion tensor imaging changes in the substantia nigra in Parkinson's disease, " Movement Disorders, vol. 26, no. 9, pp. 1627-1632, 2011.
20. W. Zhang, S.-G. Sun, Y.-H. Jiang, X. Qiao, X. Sun, and Y. Wu, "Determination of brain iron content in patients with Parkinson's disease using magnetic susceptibility imaging, " Neuroscience Bulletin, vol. 25, no. 6, pp. 353-360, 2009.
21. J. Zhang, Y. Zhang, J. Wang et al., "Characterizing iron deposition in Parkinson's disease using susceptibility-weighted imaging: an in vivoMRstudy, " Brain Research, vol. 1330, pp. 124-130, 2010.
22. M. Rossi, H. Ruottinen, I. Elovaara et al., "Brain iron deposition and sequence characteristics in parkinsonism: comparison of SWI, T∗ 2 maps, T2-weighted-, and FLAIR-SPACE, " Investigative Radiology, vol. 45, no. 12, pp. 795-802, 2010.
23. M. E. Rossi, H. Ruottinen, T. Saunamäki, I. Elovaara, and P. Dastidar, "Imaging brain iron and diffusion patterns: a followup study of Parkinson's disease in the initial stages, " Academic Radiology, vol. 21, no. 1, pp. 64-71, 2014.
24. S. Haller, S. Badoud, D. Nguyen et al., "Differentiation between Parkinson disease and other forms of Parkinsonism using support vector machine analysis of susceptibility-weighted imaging (SWI): initial results, " European Radiology, vol. 23, no. 1, pp. 12-19, 2013.
25. S. Ayton and P. Lei, "Nigral iron elevation is an invariable feature of Parkinson's disease and is a sufficient cause of neurodegeneration, " BioMed Research International, vol. 2014, Article ID 581256, 9 pages, 2014.
26. A. J. Hughes, S. E. Daniel, L. Kilford, and A. J. Lees, "Accuracy of clinical diagnosis of idiopathic Parkinson's disease: a clinicopathological study of 100 cases, " Journal of Neurology, Neurosurgery and Psychiatry, vol. 55, no. 3, pp. 181-184, 1992.
27. J. Talairach and P. Tournoux, Co-Planar Stereotaxic Atlas of the Human Brain: 3-Dimensional Proportional System: an Approach to Cerebral Imaging, ThiemeMedical Publishers, New York, NY, USA, 1988.