Vitamin supplementation on the risk of venous thrombosis: Results from the MEGA case-control study

American Journal of Clinical Nutrition

Volumn 101, Issue 3, 2015, Pages 606-612

  Vučković, Biljana A ^a   Van Rein, Nienke ^b   Cannegieter, Suzanne C ^b   Rosendaal, Frits R ^b   Lijfering, Willem M ^b  

^a UNIVERSITY OF NOVI SAD   (Serbia)

^b LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Cardiovascular diseases; Epidemiology; Public health; Risk; Venous thrombosis

Indexed keywords

ALPHA TOCOPHEROL; ASCORBIC ACID; CYANOCOBALAMIN; FOLIC ACID; MULTIVITAMIN; PYRIDOXINE; RETINOL; VITAMIN; VITAMIN D;

ADULT; AGED; ARTICLE; CARDIOVASCULAR RISK; CONTROLLED STUDY; DEEP VEIN THROMBOSIS; FEMALE; HOSPITAL BASED CASE CONTROL STUDY; HUMAN; LUNG EMBOLISM; MAJOR CLINICAL STUDY; MALE; VEIN THROMBOSIS; VITAMIN SUPPLEMENTATION; ADOLESCENT; CASE CONTROL STUDY; CLINICAL TRIAL; DIET SUPPLEMENTATION; EPIDEMIOLOGY; MIDDLE AGED; MULTICENTER STUDY; NETHERLANDS; PULMONARY EMBOLISM; REPRODUCIBILITY; RISK FACTOR; STATISTICAL MODEL; VENOUS THROMBOSIS; YOUNG ADULT;

ADOLESCENT; ADULT; AGED; CASE-CONTROL STUDIES; CONFOUNDING FACTORS (EPIDEMIOLOGY); DIETARY SUPPLEMENTS; FEMALE; HUMANS; LOGISTIC MODELS; MALE; MIDDLE AGED; NETHERLANDS; PULMONARY EMBOLISM; REPRODUCIBILITY OF RESULTS; RISK FACTORS; VENOUS THROMBOSIS; VITAMINS; YOUNG ADULT;

EID: 84928432697     PISSN: 00029165     EISSN: 19383207     Source Type: Journal    
DOI: 10.3945/ajcn.114.095398     Document Type: Article

References (33)

1. Næss IA, Christiansen SC, Romundstad P, Cannegieter SC, Rosendaal FR, Hammerstrøm J. Incidence and mortality of venous thrombosis: a population-based study. J Thromb Haemost 2007;5:692-9.
2. Veeger NJGM, Piersma-Wichers M, Tijssen JGP, Hillege HL, van der Meer J. Individual time within target range in patients treated with vitamin K antagonists: main determinant of quality of anticoagulation and predictor of clinical outcome. A retrospective study of 2300 consecutive patients with venous thromboembolism. Br J Haematol 2005; 128:513-9.
3. McCully KS. Vascular pathology of homocysteinemia: implications for the pathogenesis of arteriosclerosis. Am J Pathol 1969;56:111-28.
4. Lijfering WM, Rosendaal FR, Cannegieter SC. Risk factors for venous thrombosis-current understanding from an epidemiological point of view. Br J Haematol 2010;149:824-33.
5. Das UN. Folic acid says no to vascular diseases. Nutrition 2003;19: 686-92.
6. 12 deficiency, hyperhomocysteinemia and thrombosis: a case and control study. Int J Hematol 2011;93:458-64.
7. den Heijer M, Willems HP, Blom HJ, Gerrits WB, Cattaneo M, Eichinger S, Rosendaal FR, Bos GMJ. Homocysteine lowering by B vitamins and the secondary prevention of deep vein thrombosis and pulmonary embolism: a randomized, placebo-controlled, double-blind trial. Blood 2007;109:139-44.
8. Ray JG, Kearon C, Yi Q, Sheridan P, Lonn E; Heart Outcomes Prevention Evaluation 2 (HOPE-2) Investigators. Homocysteine-lowering therapy and risk for venous thromboembolism: a randomized trial. Ann Intern Med 2007;146:761-7.
9. Loscalzo J. Homocysteine trials-clear outcomes for complex reasons. N Engl J Med 2006;354:1629-32.
10. Bhupathiraju SN, Tucker KL. Coronary heart disease prevention: nutrients, foods, and dietary patterns. Clin Chim Acta 2011;412:1493-514.
11. Lock K, Pomerleau J, Causer L, Altmann DR, McKee M. The global burden of disease attributable to low consumption of fruit and vegetables: implications for the global strategy on diet. Bull World Health Organ 2005;83:100-8.
12. Myung SK, Ju W, Cho B, Oh SW, Park SM, Koo BW, Park BJ. Efficacy of vitamin and antioxidant supplements in prevention of cardiovascular disease: systemic review and meta-analysis of randomized controlled trials. BMJ 2013;346:f10.
13. Brøndum-Jacobsen P, Benn M, Tybjaerg-Hansen A, Nordestgaard BG. 25-Hydroxyvitamin D concentrations and risk of venous thromboembolism in the general population with 18.791 participants. J Thromb Haemost 2013;11:423-31.
14. Glynn RJ, Ridker PM, Goldhaber SZ, Zee RYL, Buring JE. Effects of random allocation to vitamin E supplementation on the occurrence of venous thromboembolism. Circulation 2007;116:1497-503.
15. Brodin E, Lerstad G, Grimnes G, Brækkan SK, Vik A, Brox J, Svartberg J, Jorde R, Hansen JB. Serum levels of vitamin D are not associated with future risk of venous thromboembolism. Thromb Haemost 2013;109:885-90.
16. Pomp ER, van Stralen KJ, Le Cessie S, Vandenbroucke JP, Rosendaal FR, Doggen CJ. Experience with multiple control groups in a large population-based case-control study on genetic and environmental risk factors. Eur J Epidemiol 2010;25:459-66.
17. Ocak G, Vossen CY, Verdujin M, Dekker FW, Rosendaal FR, Cannegieter SC, Lijfering WM. Risk of venous thrombosis in patients with major illnesses: results from the MEGA study. J Thromb Haemost 2013;11:116-23.
18. Pomp ER, Rosendaal FR, Doggen CJ. Smoking increases the risk of venous thrombosis and acts synergistically with oral contraceptive use. Am J Hematol 2008;83:97-102.
19. Van Allen MI, Fraser FC, Dallaire L, Allanson J, McLeod DR, Andermann E, Friedman JM. Recommendations on the use of folic acid supplementation to prevent the recurrence of neural tube defects. Clinical Teratology Committee, Canadian College of Medical Geneticists. CMAJ 1993;149:1239-43.
20. Vasankari T, Ahotupa M, Viiakri J, Nuotio I, Strandberg T, Vanhanen H, Gylling H, Miettinen T, Tikkanen MJ. Effect of 12-month statin therapy on antioxidant potential of LDL and serum antioxidant vitamin concentrations. Ann Med 2004;36:618-22.
21. 12 in women using oral contraceptives to non-users. Thromb Res 2003;112:37-41.
22. Scragg R, Camargo CA Jr. Frequency of leisure-time physical activity and serum 25-hydroxyvitamin D levels in the US population: results from the Third National Health and Nutrition Examination Survey. Am J Epidemiol 2008;168:577-86.
23. Cannegieter SC. Thrombosis after travel: reply to a perspective. PLoS Med 2009;3:e307.
24. Rothman KJ. Thrombosis after travel. PLoS Med 2006;3:e300.
25. Breslow NE, Day NE. Statistical methods in cancer research. Lyon (France): International Agency for Research on Cancer; 1980.
26. Rothman KJ, Greenland S. Modern epidemiology. Philadelphia (PA): Lippincott Williams & Wilkins; 1988.
27. Messerer M, Johansson SE, Wolk A. Use of dietary supplements and natural remedies increased dramatically during the 1990s. J Intern Med 2001;250:160-6.
28. Spence JD, Stampfer MJ. Understanding the complexity of homocysteine lowering with vitamins: the potential role of subgroup analyses. JAMA 2011;306:2610-1.
29. Lonn E, Yusuf S, Arnold MJ, Sheridan P, Pogue J, Micks M, McQueen MJ, Probstfield J, Fodor G, Held C, et al. Homocysteine lowering with folic acid and B vitamins in vascular disease. N Engl J Med 2006;354: 1567-77.
30. Antoniades C, Tousoulis D, Tentolouris C, Toutouzo M, Marinou K, Goumas G, Tsioufis C, Toutouzas P, Stefanadis C. Effects of antioxidant vitamins C and E on endothelial function and thrombosis/fibrinolysis system in smokers. Thromb Haemost 2003;89:990-5.
31. Miller ER, Juraschek S, Pastor-Barviuso R, Bazzano LA, Appel LJ, Guallar E. Meta-analysis of folic acid supplementation trials on risk of cardiovascular disease and risk interaction with baseline homocysteine levels. Am J Cardiol 2010;106:517-27.
32. Figueiredo JC, Grau MV, Haile RW, Sandler RS, Summers RW, Bresalier RS. Folic acid and risk of prostate cancer: results from a randomized clinical trial. J Natl Cancer Inst 2009;101:432-5.
33. Bjelakovic G, Nikolova D, Gluud LL, Simonetti RG, Gluud C. Antioxidant supplements for prevention of mortality in healthy participants and patients with various diseases. Cochrane Database Syst Rev 2012; 3:CD007176.