Pre-clinical evaluation of an adult extracorporeal carbon dioxide removal system with active mixing for pediatric respiratory support

International Journal of Artificial Organs

Volumn 37, Issue 12, 2014, Pages 888-899

  Jeffries, R Garrett ^a,b   Mussin, Yerbol ^c   Bulanin, Denis S ^c   Lund, Laura W ^d   Kocyildirim, Ergin ^b,e,f   Zhumadilov, Zhaksybay Zh ^c   Olzhayev, Farkhad S ^c   Federspiel, William J ^a,b,f   Wearden, Peter D ^b,e,f  

^a UNIVERSITY OF PITTSBURGH   (United States)

^b MCGOWAN INSTITUTE FOR REGENERATIVE MEDICINE   (United States)

^c NAZARBAYEV UNIVERSITY   (Kazakhstan)

^d A Subsidiary of Neurolign Technologies Inc   (United States)

^e CHILDREN S HOSPITAL OF PITTSBURGH   (United States)

^f UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

Author keywords

Extracorporeal carbon dioxide removal (ECCO2R); Gas exchange; Hemolung; In vitro characterization; Pediatric extracorporeal membrane oxygenation (ECMO); Pump oxygenator

Indexed keywords

CARBON DIOXIDE; MIXING; OXYGENATION; PEDIATRICS; RESPIRATORY THERAPY;

CARBON DIOXIDE REMOVAL; EXTRACORPOREAL CARBON DIOXIDE REMOVAL (ECCO2R); EXTRACORPOREAL MEMBRANE OXYGENATION; GAS EXCHANGE; HEMOLUNG; IN VITRO CHARACTERIZATION; IN-VITRO; PEDIATRIC EXTRACORPOREAL MEMBRANE OXYGENATION; PUMP-OXYGENATOR; VITRO CHARACTERIZATION;

PUMPS;

CARBON DIOXIDE; ARTIFICIAL MEMBRANE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASSISTED VENTILATION; AUTOPSY; BLOOD FLOW; BLOOD GAS ANALYSIS; BLOOD OXYGEN TENSION; BLOOD PUMP; BREATHING CIRCUIT; CONTROLLED STUDY; EXTRACORPOREAL OXYGENATION; GAS EXCHANGE; HEART OUTPUT; MEAN ARTERIAL PRESSURE; NONHUMAN; OXYGEN SATURATION; PEDIATRICS; SHEEP; ADULT; ADVERSE EFFECTS; AGE; ANIMAL; ARTIFICIAL MEMBRANE; BLOOD; BLOOD FLOW VELOCITY; BODY WEIGHT; CHILD; DEVICES; EQUIPMENT DESIGN; EVALUATION STUDY; FEASIBILITY STUDY; HEMOFILTRATION; HUMAN; LUNG GAS EXCHANGE; MATERIALS TESTING; SURFACE PROPERTY; TIME;

ADULT; AGE FACTORS; ANIMALS; BLOOD FLOW VELOCITY; BODY WEIGHT; CARBON DIOXIDE; CHILD; EQUIPMENT DESIGN; EXTRACORPOREAL MEMBRANE OXYGENATION; FEASIBILITY STUDIES; HEMOFILTRATION; HUMANS; MATERIALS TESTING; MEMBRANES, ARTIFICIAL; MODELS, ANIMAL; PULMONARY GAS EXCHANGE; SHEEP; SURFACE PROPERTIES; TIME FACTORS;

EID: 84928407497     PISSN: 03913988     EISSN: 17246040     Source Type: Journal    
DOI: 10.5301/ijao.5000372     Document Type: Article

References (19)

1. Bahrami KR, Van Meurs KR ECMO for neonatal respiratory failure. Semin Perinatol. 2005;29(1):15-23.
2. Stolar CJH, Snedecor SM, Bartlett RH. Extracorporeal membrane oxygenation and neonatal respiratory failure: experience from the extracorporeal life support organization. J Pediatr Surg. 1991; 26(5):563-571.
3. Burki NK, Mani RK, Schmidt W, et al. A novel extracorporeal C02 removal system: Results of a Pilot Study of Hyper-capnic Respiratory Failure in Patients With COPD. Chest. 2013;143(3):678-686.
4. Pranikoff T, Hines M. Vascular Access for Extracorporeal Support. In: ECMO Extracorporeal Cardiopulmonary Support in Critical Care. 4th ed. Ann Arbor, Ml: Extracorporeal Life Support Organization: 2012:133-147.
5. Leverett LB, Heliums JD, Alfrey CP, Lynch EC. Red blood cell damage by shear stress. Biophys J. 1972;12(3): 257-273.
6. ANSI/AAMI. ISO 7199:2009-Cardiovascular implants and artificial organs-Blood-gas exchangers (oxygenators). 2009. Available at: www.aami.org.
7. Zhang T, Cheng G, Koert A, et al. Functional and biocompatibility performances of an integrated Maglev pump-oxygenator. Artif Organs. 2009;33(1):36-45.
8. De Villota ED, Ruiz Carmona MT, Rubio JJ, de Andrés S. Equality of the in vivo and in vitro oxygen-binding capacity of haemoglobin in patients with severe respiratory disease. Br J Anaesth. 1981; 53(12):1325-1328.
9. Costeff H. A simple empirical formula for calculating approximate surface area in children. Arch Dis Child. 1966; 41(220):681-683.
10. Furqan M, Haque A. Surface area in children: a simple formula. Indian Pediatr. 2009;46(12):1085-1087.
11. Wu ZJ, Gellman B, Zhang T, Taskin ME, Dasse KA, Griffith BP. Computational Fluid Dynamics and Experimental Characterization of the Pediatric Pump-Lung. Cardiovasc Eng Technol. 2011;2(4):276-287.
12. Wearden PD, Federspiel WJ, Morley SW, et al. Respiratory dialysis with an active-mixing extracorporeal carbon dioxide removal system in a chronic sheep study. Intensive Care Med. 2012;38(10):1705-1711.
13. Annich G, Lynch W, MacLaren G, Wilson J. Bartlett Reds, eds. ECMO: Extracorporeal Cardiopulmonary Support in Critical Care. 4th ed. Ann Arbor, Ml: Extracorporeal Life Support Organization; 2012.
14. Pantalos GM, Abel DE, Ravisankar A, et al. In Vitro Pumping Performance Evaluation of the Ension Pediatric Cardiopulmonary Assist System for Venoarterial and Venovenous ECMO. Cardiovasc Eng Technol. 2012;3(3):250-262.
15. Arens J, Schnoering H, Pfennig M, et al. The Aachen Mini-HLM-a miniaturized heart-lung machine for neonates with an integrated rotary blood pump. Artif Organs. 2010;34(9): 707-713.
16. Borchardt R, Schlanstein P, Mager I, Arens J, Schmitz-Rode T, Steinseifer U. In vitro performance testing of a pediatric oxygenator with an integrated pulsatile pump. ASAIO J. 2012; 58(4):420-425.
17. Kopp R, Bensberg R, Arens J, et al. A miniaturized extracorporeal membrane oxygenator with integrated rotary blood pump: preclinical in vivo testing. ASAIO J. 2011; 57(3):158-163.
18. Arens J, Schoberer M, Lohr A, et al. NeonatOx: a pumμless extracorporeal lung support for premature neonates. Artif Organs. 2011;35(11):997-1001.
19. OSU Department of Animal Sciences-Special Circular 156: Animal Sciences Research and Reviews. The Ohio State Bulletin. http://ohioline.osu.edu/sc156/sc156_47.html. Accessed November 24, 2014.