A miniaturized extracorporeal membrane oxygenator with integrated rotary blood pump: Preclinical in vivo testing

ASAIO Journal

Volumn 57, Issue 3, 2011, Pages 158-163

  Kopp, Ruedger ^a   Bensberg, Ralf ^a   Arens, Jutta ^b   Steinseifer, Ulrich ^b   Schmitz Rode, Thomas ^b   Rossaint, Rolf ^a   Henzler, Dietrich ^c  

^a UNIVERSITY HOSPITAL RWTH AACHEN   (Germany)

^b RWTH AACHEN UNIVERSITY   (Germany)

^c DALHOUSIE UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ACUTE RESPIRATORY DISTRESS SYNDROME; BLOOD FLOW; CARDIAC OUTPUT; DESIGN MODIFICATIONS; EXTRACORPOREAL MEMBRANE OXYGENATION; EXTRACORPOREAL MEMBRANES; FURTHER DEVELOPMENT; GAS EXCHANGE; HEMODYNAMIC INSTABILITY; HIGHLY INTEGRATED; HYPOXEMIA; IN-VIVO; OXYGEN SATURATION; OXYGEN TRANSFER; PROOF OF CONCEPT; ROTARY BLOOD PUMPS;

ANIMALS; BLOOD; COAGULATION; HEMODYNAMICS; HYDRODYNAMICS; INTEGRATION; OXYGEN; OXYGENATION; PUMPS; RESPIRATORY THERAPY;

OXYGENATORS;

CARBON DIOXIDE; OXYGEN;

ADULT RESPIRATORY DISTRESS SYNDROME; ANIMAL; ANOXIA; ARTICLE; ASSISTED CIRCULATION; BIOMEDICAL ENGINEERING; BLOOD; BLOOD CELL COUNT; BREATHING; DISEASE MODEL; ELECTRONICS; EQUIPMENT; EQUIPMENT DESIGN; EVALUATION; EXTRACORPOREAL OXYGENATION; FEMALE; HEMODYNAMICS; HUMAN; INSTRUMENTATION; LUNG GAS EXCHANGE; OXYGENATOR; PATHOPHYSIOLOGY; SWINE;

ANIMALS; ANOXIA; ASSISTED CIRCULATION; BIOMEDICAL ENGINEERING; BLOOD CELL COUNT; CARBON DIOXIDE; DISEASE MODELS, ANIMAL; EQUIPMENT DESIGN; EQUIPMENT FAILURE; EXTRACORPOREAL MEMBRANE OXYGENATION; FEMALE; HEMODYNAMICS; HUMANS; MINIATURIZATION; OXYGEN; OXYGENATORS, MEMBRANE; PULMONARY GAS EXCHANGE; RESPIRATION; RESPIRATORY DISTRESS SYNDROME, ADULT; SWINE;

EID: 79955584247     PISSN: 10582916     EISSN: None     Source Type: Journal    
DOI: 10.1097/MAT.0b013e31820bffa9     Document Type: Article

References (25)

1. Kopp R, Dembinski R, Kuhlen R: Role of extracorporeal lung assist in the treatment of acute respiratory failure. Minerva Anestesiol 72:587-595, 2006.
2. Peek GJ, Mugford M, Tiruvoipati R, et al: Efficacy and economic assessment of conventional ventilatory support versus extracorporeal membrane oxygenation for severe adult respiratory failure (CESAR): A multicentre randomised controlled trial. Lancet 374:1351-1363, 2009.
3. Brogan TV, Thiagarajan RR, Rycus PT, et al: Extracorporeal membrane oxygenation in adults with severe respiratory failure: A multi-center database. Intensive Care Med 35:2105-2114, 2009.
4. Wendel HP, Ziemer G: Coating-techniques to improve the hemocompatibility of artificial devices used for extracorporeal circulation. Eur J Cardiothorac Surg 16:342-350, 1999. (Pubitemid 29443972)
5. Mehlhorn U, Brieske M, Fischer UM, et al: LIFEBRIDGE: A portable, modular, rapidly available "plug-and-play" mechanical circulatory support system. Ann Thorac Surg 80:1887-1892, 2005. (Pubitemid 41464319)
6. Dembinski R, Kopp R, Henzler D, et al: Extracorporeal gas exchange with the DeltaStream rotary blood pump in experimental lung injury. Artif Organs 27:530-536, 2003. (Pubitemid 36683653)
7. Arlt M, Philipp A, Zimmermann M, et al: First experiences with a new miniaturised life support system for mobile percutaneous cardiopulmonary bypass. Resuscitation 77:345-350, 2008.
8. Rossaint R, Pappert D, Gerlach H, et al: Extracorporeal membrane oxygenation for transport of hypoxaemic patients with severe ARDS. Br J Anaesth 78:241-246, 1997. (Pubitemid 27099910)
9. Clement KC, Fiser RT, Fiser WP, et al: Single-institution experience with interhospital extracorporeal membrane oxygenation transport: A descriptive study. Pediatr Crit Care Med 11:509-513, 2010.
10. Prodhan P, Fiser RT, Cenac S, et al: Intrahospital transport of children on extracorporeal membrane oxygenation: Indications, process, interventions, and effectiveness. Pediatr Crit Care Med 11:227-233, 2010.
11. Cattaneo G, Strauss A, Reul H: Compact intra-and extracorporeal oxygenator developments. Perfusion 19:251-255, 2004. (Pubitemid 39173457)
12. Kopp R, Bensberg R, Henzler D, et al: Hemocompatibility of a miniaturized extracorporeal membrane oxygenation and a pumpless interventional lung assist in experimental lung injury. Artif Organs 34:13-21, 2010.
13. Strauss A, Cattaneo G, Henzler D, Reul H. Int J Artif Organs 27:634, 2004 (abstract).
14. Richterich R (ed): Klinische Chemie: Theorie und Praxis. Basel, Switzerland, Karger, 1968.
15. Ravanat C, Freund M, Dol F, et al: Cross-reactivity of human molecular markers for detection of prethrombotic states in various animal species. Blood Coagul Fibrinolysis 6:446-455, 1995.
16. Livigni S, Maio M, Ferretti E, et al: Efficacy and safety of a low-flow veno-venous carbon dioxide removal device: Results of an experimental study in adult sheep. Crit Care 10: R151, 2006.
17. Svitek RG, Frankowski BJ, Federspiel WJ: Evaluation of a pumping assist lung that uses a rotating fiber bundle. ASAIO J 51:773-780, 2005. (Pubitemid 44366143)
18. Bein T, Weber F, Philipp A, et al: A new pumpless extracorporeal interventional lung assist in critical hypoxemia/hypercapnia. Crit Care Med 34:1372-1377, 2006.
19. Kopp R, Mottaghy K, Kirschfink M: Mechanism of complement activation during extracorporeal blood-biomaterial interaction: Effects of heparin coated and uncoated surfaces. ASAIO J 48:598-605, 2002. (Pubitemid 35285511)
20. Dembinski R, Max M, Bensberg R, et al: High-frequency oscillatory ventilation in experimental lung injury: Effects on gas exchange. Intensive Care Med 28:768-774, 2002. (Pubitemid 34639492)
21. Fries M, Bickenbach J, Henzler D, et al: S-100 protein and neurohistopathologic changes in a porcine model of acute lung injury. Anesthesiology 102:761-767, 2005. (Pubitemid 40462855)
22. Muller T, Philipp A, Luchner A, et al: A new miniaturized system for extracorporeal membrane oxygenation in adult respiratory failure. Crit Care 13: R205, 2009.
23. Arlt M, Philipp A, Voelkel S, et al: Extracorporeal membrane oxygenation in severe trauma patients with bleeding shock. Resuscitation 2010;81:804-809.
24. Zwischenberger JB, Tao W, Bidani A: Intravascular membrane oxygenator and carbon dioxide removal devices: A review of performance and improvements. ASAIO J 45:41-46, 1999. (Pubitemid 30428359)
25. Budilarto SG, Frankowski BJ, Hattler BG, Federspiel WJ: Flow visualization study of a novel respiratory assist catheter. Artif Organs 33:411-418, 2009.