The aachen MiniHLM - A miniaturized heart-lung machine for neonates with an integrated rotary blood pump

Artificial Organs

Volumn 34, Issue 9, 2010, Pages 707-713

  Arens, Jutta ^a   Schnoering, Heike ^b   Pfennig, Michael ^a   Mager, Ilona ^a   Vázquez Jiménez, Jaime F ^b   Schmitz Rode, Thomas ^a   Steinseifer, Ulrich ^a  

^a RWTH AACHEN UNIVERSITY   (Germany)

^b UNIVERSITY HOSPITAL RWTH AACHEN   (Germany)

Author keywords

Heart Lung machine; Neonates; Oxygenation; Perfusion; Priming volume; Rotary blood pump

Indexed keywords

ARTIFICIAL HEART; BIOLOGICAL ORGANS; BLOOD; HEART; PUMPS; TUBING; VALVES (MECHANICAL);

% REDUCTIONS; BLOOD CONTACT; CONGENITAL HEART DEFECTS; CONTACT SURFACE; HEMODILUTION; HIGH VOLUMES; NEONATE; PERFUSION; PRIMING VOLUME; ROTARY BLOOD PUMPS;

OXYGENATION;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD PUMP; CAPILLARY LEAK SYNDROME; CARDIOPULMONARY BYPASS; CONTROLLED STUDY; FEMALE; FILTER; HEART LUNG MACHINE; HEAT EXCHANGE; HUMAN; IN VITRO STUDY; IN VIVO STUDY; INFLAMMATION; NEWBORN; NONHUMAN; OXYGENATOR; PERICARDIOTOMY; PRIORITY JOURNAL; RABBIT; VALIDATION STUDY;

EID: 77957269711     PISSN: 0160564X     EISSN: 15251594     Source Type: Journal    
DOI: 10.1111/j.1525-1594.2010.01082.x     Document Type: Article

References (13)

1. Seghaye MC, Engelhardt W, Grabitz RG, et al. Multiple system organ failure after open heart surgery in infants and children. Thorac Cardiovasc Surg 1993 41 : 49 53. (Pubitemid 23090270)
2. Seghaye MC, Grabitz RG, Duchateau J, et al. Inflammatory reaction and capillary leak syndrome related to cardiopulmonary bypass in neonates undergoing cardiac operations. J Thorac Cardiovasc Surg 1996 112 : 687 97. (Pubitemid 26347024)
3. Hall TS. The pathophysiology of cardiopulmonary bypass. The risks and benefits of hemodilution. Chest 1995 107 : 1125 133.
4. Hickey E, Karamlou T, You J, Ungerleider RM. Effects of circuit miniaturization in reducing inflammatory response to infant cardiopulmonary bypass by elimination of allogeneic blood products. Ann Thorac Surg 2006 81 : S2367 72. (Pubitemid 43775526)
5. Cattaneo G, Strauss A, Reul H. Compact intra- and extracorporeal oxygenator developments. Perfusion 2004 19 : 251 5. (Pubitemid 39173457)
6. Arens J, Schnöring H, Reisch F, Vázquez-Jiménez JF, Schmitz-Rode T, Steinseifer U. Development of a miniaturized heart-lung machine for neonates with congenital heart defect. ASAIO J 2008 54 : 509 13.
7. ISO 7199:2009. Cardiovascular implants and artificial organs - blood-gas exchangers (oxygenators). International Organization for Standardization, Nov 2009.
8. DIN EN 12022:1999. Blutgasaustauscher. DIN Deutsches Institut für Normung e.V., Mar 1999.
9. Guidance for Cardiopulmonary Bypass Oxygenators 510(k) Submissions; Final Guidance for Industry and FDA Staff. Rockville, MD: Food and Drug Administration. Available at: http://www.fda.gov/MedicalDevices/. Accessed July 22, 2010.
10. Klaus S, Körfer S, Mottaghy K, Reul H, Glasmacher B. In vitro blood damage by high shear flow: human versus porcine blood. Int J Artif Organs 2002 25 : 306 12. (Pubitemid 34618598)
11. Jikuya T, Tsutsui T, Shigeta O, Sankai Y, Mitsui T. Species differences in erythrocyte mechanical fragility: comparison of human, bovine, and ovine cells. ASAIO J 1998 44 : M452 5. (Pubitemid 28468875)
12. Schnoering H, Arens J, Sachweh JS, et al. The Aachen miniaturized heart-lung machine - first results in a small animal model. Artif Organs 2009 33 : 935 40.
13. Willcox TW. Vacuum-assisted venous drainage: to air or not to air, that is the question. Has the bubble burst? J Extra Corpor Technol 2002 34 : 24 8.