Improved endothelial function and decreased levels of endothelium-derived microparticles after transcatheter aortic valve implantation

EuroIntervention

Volumn 10, Issue 12, 2015, Pages 1456-1463

  Horn, Patrick ^a   Stern, Daniel ^a   Veulemans, Verena ^a   Heiss, Christian ^a   Zeus, Tobias ^a   Merx, Marc W ^a   Kelm, Malte ^a   Westenfeld, Ralf ^a  

^a HEINRICH HEINE UNIVERSITY   (Germany)

Author keywords

Aortic valve stenosis; Endothelial function; Endothelial integrity; Microparticles; Transcatheter aortic valve implantation

Indexed keywords

ACETYLSALICYLIC ACID; ANGIOTENSIN RECEPTOR ANTAGONIST; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CD31 ANTIGEN; CD62E ANTIGEN; CELL ANTIGEN; CLOPIDOGREL; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; FIBRINOGEN RECEPTOR; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; NITRATE; UNCLASSIFIED DRUG; VASCULAR ENDOTHELIAL CADHERIN; WARFARIN; CADHERIN; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; GLYCOPROTEIN IIB; LEUKOCYTE ANTIGEN;

AGED; ANALYTICAL EQUIPMENT; ANTIGEN EXPRESSION; AORTA VALVE STENOSIS; ARTERY WALL; ARTICLE; BLOOD VESSEL FUNCTION; CELL SUBPOPULATION; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CORONARY ARTERY BLOOD FLOW; CORONARY ARTERY DILATATION; DISEASE ASSOCIATION; DISEASE SEVERITY; ECHOGRAPH; ECHOGRAPHY; ENDOTHELIAL DYSFUNCTION; ENDOTHELIAL MICROPARTICLE; FEMALE; FLOW CYTOMETRY; HUMAN; HUMAN CELL; HYPERLIPIDEMIA; HYPERTENSION; MAJOR CLINICAL STUDY; MALE; OBSERVATIONAL STUDY; OUTCOME ASSESSMENT; PREDICTION; PROSPECTIVE STUDY; SHEAR STRESS; SYMPTOM; TRANSCATHETER AORTIC VALVE IMPLANTATION; TREATMENT RESPONSE; VASCULAR ENDOTHELIUM; AORTIC VALVE STENOSIS; ENDOTHELIUM CELL; MEMBRANE MICROPARTICLE; METABOLISM; PATHOPHYSIOLOGY; PHYSIOLOGY; TREATMENT OUTCOME; VASODILATATION; VERY ELDERLY;

AGED; AGED, 80 AND OVER; ANTIGENS, CD; ANTIGENS, CD31; AORTIC VALVE STENOSIS; CADHERINS; CELL-DERIVED MICROPARTICLES; E-SELECTIN; ENDOTHELIAL CELLS; ENDOTHELIUM, VASCULAR; FEMALE; HUMANS; MALE; PLATELET MEMBRANE GLYCOPROTEIN IIB; PROSPECTIVE STUDIES; TRANSCATHETER AORTIC VALVE REPLACEMENT; TREATMENT OUTCOME; VASODILATION;

EID: 84928400188     PISSN: 1774024X     EISSN: 19696213     Source Type: Journal    
DOI: 10.4244/EIJY14M10_02     Document Type: Article

References (30)

1. Nkomo VT, Gardin JM, Skelton T.N., Gottdiener JS, Scott CG, Enriquez-Sarano M. Burden of valvular heart diseases: a population-based study. Lancet. 2006; 368:1005-11.
2. Otto CM, Lind BK, Kitzman D.W., Gersh BJ, Siscovick DS. Association of aortic-valve sclerosis with cardiovascular mortality and morbidity in the elderly. N Engl J Med. 1999; 341:142-7.
3. Wierzbicki A, Shetty C. Aortic stenosis: an atherosclerotic disease? J Heart Valve Dis. 1999; 8:416-23.
4. Gimbrone MA Jr., Topper JN, Nagel T, Anderson K.R., Garcia-Cardena G. Endothelial dysfunction, hemodynamic forces, and atherogenesis. Ann N Y Acad Sci. 2000; 902:230-9; discussion 239-40
5. Joannides R, Haefeli WE, Linder L, Richard V., Bakkali EH, Thuillez C, Luscher TF. Nitric oxide is responsible for flow-dependent dilatation of human peripheral conduit arteries in vivo. Circulation. 1995; 91:1314-9.
6. Okahara K, Sun B, Kambayashi J. Upregulation of prostacyclin synthesis-related gene expression by shear stress in vascular endothelial cells. Arterioscler Thromb Vasc Biol. 1998; 18:1922-6.
7. Irace C, Gnasso A, Cirillo F., Leonardo G, Ciamei M, Crivaro A., Renzulli A, Cotrufo M. Arterial remodeling of the common carotid artery after aortic valve replacement in patients with aortic stenosis. Stroke. 2002; 33:2446-50.
8. Poggianti E, Venneri L, Chubuchny V., Jambrik Z, Baroncini LA, Picano E. Aortic valve sclerosis is associated with systemic endothelial dysfunction. J Am Coll Cardiol. 2003; 41:136-41.
9. Schumm J, Luetzkendorf S, Rademacher W., Franz M, Schmidt-Winter C, Kiehntopf M, Figulla H.R., Brehm BR. In patients with aortic stenosis increased flow-mediated dilation is independently associated with higher peak jet velocity and lower asymmetric dimethylarginine levels. Am Heart J. 2011; 161:893-9.
10. Diehl P, Nagy F, Sossong V., Helbing T, Beyersdorf F, Olschewski M., Bode C, Moser M. Increased levels of circulating microparticles in patients with severe aortic valve stenosis. Thromb Haemost. 2008; 99:711-9.
11. Rautou PE, Vion AC, Amabile N, Chironi G., Simon A, Tedgui A, Boulanger CM Mcroparticles, vascular function, and atherothrombosis. Circ Res. 2011; 109:593-606.
12. Dignat-George F., Boulanger CM The many faces of endothelial microparticles. Arterioscler Thromb Vasc Biol. 2011; 31:27-33.
13. Werner N, Wassmann S, Ahlers P., Kosiol S, Nickenig G. Circulating CD31+/annexin V+ apoptotic microparticles correlate with coronary endothelial function in patients with coronary artery disease. Arterioscler Thromb Vasc Biol. 2006; 26:112-6.
14. Sinning JM, Losch J, Walenta K., Bohm M, Nickenig G, Werner N. Circulating CD31+/Annexin V+ microparticles correlate with cardiovascular outcomes. Eur Heart J. 2011; 32:2034-41.
15. Amabile N, Guerin AP, Tedgui A, Boulanger C.M., London GM. Predictive value of circulating endothelial microparticles for cardiovascular mortality in end-stage renal failure: a pilot study. Nephrol Dial Transplant. 2012; 27:1873-80.
16. Joint Task Force on the Management of Valvular Heart Disease of the European Society of Cardiology (ESC), European Association for Cardio-Thoracic Surgery (EACTS), Vahanian A, Alfieri O, Andreotti F, Antunes MJ, Baron-Esquivias G, Baumgartner H, Borger MA, Carrel TP, De Bonis M, Evangelista A, Falk V, Iung B, Lancellotti P, Pierard L, Price S, Schafers HJ, Schuler G, Stepinska J, Swedberg K, Takkenberg J, Von Oppell UO, Windecker S, Zamorano JL, Zembala M. Guidelines on the management of valvular heart disease (version 2012). Eur Heart J. 2012; 33:2451-96.
17. Pyke KE, Tschakovsky ME The relationship between shear stress and flow-mediated dilatation: implications for the assessment of endothelial function. J Physiol. 2005; 568:357-69.
18. Balzer J, Boos M, Rassaf T., Heiss C, Preik M, Matern S., Schoebel F, Kelm M, Lauer T. "One-stop-shop" ultrasound diagnosis of functional, structural and physicomechanical properties of the brachial artery. Vasa. 2007; 36:100-6.
19. Horn P, Cortese-Krott MM, Amabile N., Hundsdorfer C, Kroncke KD, Kelm M, Heiss C. Circulating microparticles carry a functional endothelial nitric oxide synthase that is decreased in patients with endothelial dysfunction. J Am Heart Assoc. 2012; 2:e003764.
20. Chenevard R, Bechir M, Hurlimann D., Ruschitzka F, Turina J, Luscher T.F., Noll G. Persistent endothelial dysfunction in calcified aortic stenosis beyond valve replacement surgery. Heart. 2006; 92: 1862-3.
21. Nemes A, Galema TW, Geleijnse M.L., Soliman OI, Yap SC, Anwar AM, ten Cate FJ. Aortic valve replacement for aortic stenosis is associated with improved aortic distensibility at long-term follow-up. Am Heart J. 2007; 153:147-51.
22. Tricot O, Mallat Z, Heymes C., Belmin J, Leseche G, Tedgui A. Relation between endothelial cell apoptosis and blood flow direction in human atherosclerotic plaques. Circulation. 2000; 101:2450-3.
23. Boulanger CM, Amabile N, Guerin A.P., Pannier B., Leroyer AS, Mallat CN, Tedgui A, London GM In vivo shear stress determines circulating levels of endothelial microparticles in end-stage renal disease. Hypertension. 2007; 49:902-8.
24. Vion AC, Ramkhelawon B, Loyer X., Chironi G, Devue C, Loirand G., Tedgui A, Lehoux S, Boulanger CM Shear stress regulates endothelial microparticle release. Circ Res. 2013; 112:1323-33.
25. Makkar RR, Fontana GP, Jilaihawi H, Kapadia S., Pichard AD, Douglas PS, Thourani VH, Babaliaros V.C., Webb JG, Herrmann HC, Bavaria JE, Kodali S, Brown D.L., Bowers B., Dewey TM, Svensson LG, Tuzcu M, Moses J.W., Williams MR, Siegel RJ, Akin JJ, Anderson W.N., Pocock S., Smith CR, Leon MB; PARTNER Trial Investigators. Transcatheter aortic-valve replacement for inoperable severe aortic stenosis. N Engl J Med. 2012; 366:1696-704.
26. Ryu JH, Kim SJ Clopidogrel effectively suppresses endothelial microparticle generation induced by indoxyl sulfate via inhibition of the p38 mitogen-activated protein kinase pathway. Blood Purif. 2011; 32:186-94.
27. Warnholtz A, Ostad MA, Velich N, Trautmann C., Schinzel R, Walter U, Munzel T. A single loading dose of clopidogrel causes dose-dependent improvement of endothelial dysfunction in patients with stable coronary artery disease: results of a double-blind, randomized study. Atherosclerosis. 2008; 196:689-95.
28. Hamilos M, Muller O, Ntalianis A., Trana C, Bartunek J, Sarno G., Mangiacapra F, Dierickx K, Meeus P., Cuisset T, De Bruyne B, Wijns W, Barbato E. Relationship between peripheral arterial reactive hyperemia and residual platelet reactivity after 600 mg clopidogrel. J Thromb Thrombolysis. 2011; 32:64-71.
29. Franca CN, Pinheiro LF, Izar M.C., Brunialti MK, Salomao R, Bianco HT, Kasmas S.H., Barbosa SP, de Nucci G, Fonseca FA. Endothelial progenitor cell mobilization and platelet microparticle release are influenced by clopidogrel plasma levels in stable coronary artery disease. Circ J. 2012; 76:729-36.
30. Ostad MA, Nick E, Paixao-Gatinho V, Schnorbus B., Schiewe R, Tschentscher P, Munzel T., Warnholtz A. Lack of evidence for pleiotropic effects of clopidogrel on endothelial function and inflammation in patients with stable coronary artery disease: results of the double-blind, randomized CASSANDRA study. Clin Res Cardiol. 2011; 100:29-36.