-
1
-
-
0025996983
-
Nonnucleoside reverse transcriptase inhibitors that potently and specifically block human immunodeficiency virus type 1 replication
-
Romero DL, Busso M, Tan CK et al. Nonnucleoside reverse transcriptase inhibitors that potently and specifically block human immunodeficiency virus type 1 replication. Proc Natl Acad Sci USA 1991;88:8806-8810.
-
(1991)
Proc Natl Acad Sci USA
, vol.88
, pp. 8806-8810
-
-
Romero, D.L.1
Busso, M.2
Tan, C.K.3
-
2
-
-
0026806436
-
Prevention of the spread of HIV-1 infection with nonnucleoside reverse transcriptase inhibitors
-
Vasudevachari MB, Battista C, Lane HC, et al. Prevention of the spread of HIV-1 infection with nonnucleoside reverse transcriptase inhibitors Virology 1992;190:269-277.
-
(1992)
Virology
, vol.190
, pp. 269-277
-
-
Vasudevachari, M.B.1
Battista, C.2
Lane, H.C.3
-
3
-
-
0026592957
-
The binding of a novel bisheteroarylpiperazine mediates inhibition of HIV-1 reverse transcnptase
-
Dueweke TJ, Kezdy FJ, Waszak GA, et al. The binding of a novel bisheteroarylpiperazine mediates inhibition of HIV-1 reverse transcnptase. J Biol Chem 1993;267:27-30.
-
(1993)
J Biol Chem
, vol.267
, pp. 27-30
-
-
Dueweke, T.J.1
Kezdy, F.J.2
Waszak, G.A.3
-
4
-
-
0027278282
-
Bis(heleroaryl)piperazme (BHAP) reverse transcriptase inhibitors: Structure-activity relationships of novel substituted indole analogues and identification of U90152S, a second generation clinical candidate
-
Romero DL, Morge RA, Genin MJ et al. Bis(heleroaryl)piperazme (BHAP) reverse transcriptase inhibitors: Structure-activity relationships of novel substituted indole analogues and identification of U90152S, a second generation clinical candidate. J Med Chem 1993,36:1505-1508.
-
(1993)
J Med Chem
, vol.36
, pp. 1505-1508
-
-
Romero, D.L.1
Morge, R.A.2
Genin, M.J.3
-
5
-
-
0027178052
-
U-90152S, a potent inhibitor of human deficiency virus type 1 replication
-
Dueweke TJ, Poppe SM, Romero DL et al. U-90152S, a potent inhibitor of human deficiency virus type 1 replication. Antimicrob Agents Chemother 1993;37:1127-1131.
-
(1993)
Antimicrob Agents Chemother
, vol.37
, pp. 1127-1131
-
-
Dueweke, T.J.1
Poppe, S.M.2
Romero, D.L.3
-
6
-
-
0028357222
-
Kinetic studies with the non-nucleoside human immunodeficiency virus type-1 reverse transcriptase inhibitor U-90152E
-
Althaus IW, Chou JJ, Gonzales AJ, et al. Kinetic studies with the non-nucleoside human immunodeficiency virus type-1 reverse transcriptase inhibitor U-90152E. Biochem Pharmacol 1994;47:2017-2028.
-
(1994)
Biochem Pharmacol
, vol.47
, pp. 2017-2028
-
-
Althaus, I.W.1
Chou, J.J.2
Gonzales, A.J.3
-
7
-
-
3042975058
-
Phenotypic and genotypic characterization of HIV-1 viral isolates from patients treated with combined AZT and delavirdine mesylate (DLV) therapy
-
Kauai, Hawaii, August 2-5
-
Wathen LK, Freimuth WW, Batts DH et al. Phenotypic and genotypic characterization of HIV-1 viral isolates from patients treated with combined AZT and delavirdine mesylate (DLV) therapy. Third International Workshop on HIV and Drug Resistance. Kauai, Hawaii, August 2-5, 1994, page 42.
-
(1994)
Third International Workshop on HIV and Drug Resistance
, pp. 42
-
-
Wathen, L.K.1
Freimuth, W.W.2
Batts, D.H.3
-
8
-
-
0011726686
-
Phase II clinical trials of delavirdine mesylate combination therapy
-
Abstract 512 B, Yokohama, Japan, August 7-12
-
Freimuth B, Davey R, Batts D, et al. Phase II clinical trials of delavirdine mesylate combination therapy Abstract 512 B, Vol. 2, Page 59. Tenth International Conference on AIDS, Yokohama, Japan, August 7-12, 1994.
-
(1994)
Tenth International Conference on AIDS
, vol.2
, pp. 59
-
-
Freimuth, B.1
Davey, R.2
Batts, D.3
-
10
-
-
9244244493
-
Knocking-out concentrations of HIV-1 specific inhibitors completely suppress HIV-1 infection and prevent the emergence of drug-resistant virus
-
Balzarini J, Karlsson A, Perez-Perez MJ et al. Knocking-out concentrations of HIV-1 specific inhibitors completely suppress HIV-1 infection and prevent the emergence of drug-resistant virus. Virology 1993;19:6576-585.
-
(1993)
Virology
, vol.19
, pp. 6576-6585
-
-
Balzarini, J.1
Karlsson, A.2
Perez-Perez, M.J.3
-
11
-
-
0028044916
-
Bisheteroarylpiperazine reverse transcriptase inhibitor in combination with 3′-azido-3′-deoxythymidine or 2′, 3′ -dideoxyctidine synergistically inhibits human immunodeficiency virus type 1 replication in vitro
-
Chong KT, Pagano PJ, Hinshaw RR. Bisheteroarylpiperazine reverse transcriptase inhibitor in combination with 3′-azido-3′-deoxythymidine or 2′, 3′ -dideoxyctidine synergistically inhibits human immunodeficiency virus type 1 replication in vitro. Antimicrob Agents Chemother 1994;38:288-293.
-
(1994)
Antimicrob Agents Chemother
, vol.38
, pp. 288-293
-
-
Chong, K.T.1
Pagano, P.J.2
Hinshaw, R.R.3
-
12
-
-
9244232583
-
Antiviral effect of convergent vs divergent drug combination on HIV-1 spread in vitro
-
Abstract PA0314, Yokohama, Japan, August 7-12
-
Chong KT and Pagano PJ. Antiviral effect of convergent vs divergent drug combination on HIV-1 spread in vitro. Abstract PA0314, Vol 2, Page 108. Tenth International Conference on AIDS, Yokohama, Japan, August 7-12, 1994.
-
(1994)
Tenth International Conference on AIDS
, vol.2
, pp. 108
-
-
Chong, K.T.1
Pagano, P.J.2
-
13
-
-
0028795712
-
In vitro inhibition of human immunodeficiency virus type 1 by combination of delavirdine with protease inhibitor U-75875 or alpha interferon
-
Pagano PJ and Chong KT. In vitro inhibition of human immunodeficiency virus type 1 by combination of delavirdine with protease inhibitor U-75875 or alpha interferon. J Infect Dis 1995;171:61-67.
-
(1995)
J Infect Dis
, vol.171
, pp. 61-67
-
-
Pagano, P.J.1
Chong, K.T.2
-
14
-
-
9244248922
-
Synergistic inhibition of human immunodeficiency virus in vitro by U-90152 (bisheteroarylpiperazine) and protease inhibitor, U-75875
-
Berlin, Germany, June 7-11
-
Chong KT, Pagano PJ, and Hinshaw RR. Synergistic inhibition of human immunodeficiency virus in vitro by U-90152 (bisheteroarylpiperazine) and protease inhibitor, U-75875. IXth International Conference on AIDS Berlin, Germany, June 7-11, 1993.
-
(1993)
IXth International Conference on AIDS
-
-
Chong, K.T.1
Pagano, P.J.2
Hinshaw, R.R.3
-
15
-
-
0027231438
-
A mutation in reverse transcriptase of bisheteroaryl piperazine-resistant human immunodeficiency virus type 1 that confers increased sensitivity to other nonnucleoside inhibitors
-
Dueweke TJ, Pushkarskaya T, Poppe SM et al. A mutation in reverse transcriptase of bisheteroaryl piperazine-resistant human immunodeficiency virus type 1 that confers increased sensitivity to other nonnucleoside inhibitors. Proc Natl Acad Sci USA 1993;90:4713-4717.
-
(1993)
Proc Natl Acad Sci USA
, vol.90
, pp. 4713-4717
-
-
Dueweke, T.J.1
Pushkarskaya, T.2
Poppe, S.M.3
-
16
-
-
0027209906
-
Comprehensive mutant enzyme and viral variant assessment of human immunodeficiency virus type 1 reverse transcriptase resistance to nonnucleoside inhibitors
-
Byrnes VW, Sardana VV, Schleif WA et al. Comprehensive mutant enzyme and viral variant assessment of human immunodeficiency virus type 1 reverse transcriptase resistance to nonnucleoside inhibitors Antimicrob Agents Chemother 1993;37:1576-1579.
-
(1993)
Antimicrob Agents Chemother
, vol.37
, pp. 1576-1579
-
-
Byrnes, V.W.1
Sardana, V.V.2
Schleif, W.A.3
-
17
-
-
0028323494
-
Interactions between drug resistance mutations in human immunodeficiency virus type 1 reverse transcriptase
-
Larder BA. Interactions between drug resistance mutations in human immunodeficiency virus type 1 reverse transcriptase. J Gen Virol 1994;75:951-957.
-
(1994)
J Gen Virol
, vol.75
, pp. 951-957
-
-
Larder, B.A.1
-
18
-
-
0028120730
-
HIV resistance to reverse transcriptase inhibitors
-
De ClercQ E. HIV resistance to reverse transcriptase inhibitors Biochem Pharmacol 1994;47:155-169.
-
(1994)
Biochem Pharmacol
, vol.47
, pp. 155-169
-
-
De ClercQ, E.1
-
19
-
-
9244221373
-
Probing the mechanism for the in vitro drug resistance-sensitization mediated by the proline to leucine change at 236 of HIV-1 reverse transcriptase
-
Kauai, Hawaii, August 2-5
-
Sharma SK, Fan N, Evan DB et al. Probing the mechanism for the in vitro drug resistance-sensitization mediated by the proline to leucine change at 236 of HIV-1 reverse transcriptase. Third International Workshop on HIV Drug Resistance, Kauai, Hawaii, page 41, August 2-5, 1994.
-
(1994)
Third International Workshop on HIV Drug Resistance
, pp. 41
-
-
Sharma, S.K.1
Fan, N.2
Evan, D.B.3
-
20
-
-
0028271687
-
Structure of the binding site for nonnucleoside inhibitors of the reverse transcriptase of human immunodeficiency virus type 1
-
Smerdon SJ, Jager J, Kohlstaedt LA et al. Structure of the binding site for nonnucleoside inhibitors of the reverse transcriptase of human immunodeficiency virus type 1. Proc Natl Acad Sci 1994;91:3911-3915.
-
(1994)
Proc Natl Acad Sci
, vol.91
, pp. 3911-3915
-
-
Smerdon, S.J.1
Jager, J.2
Kohlstaedt, L.A.3
-
21
-
-
0028925773
-
Mechanism of inhibition of HIV-1 reverse transcriptase inhibitors
-
Spence RA, Kati WM, Anderson KS et al. Mechanism of inhibition of HIV-1 reverse transcriptase inhibitors Science 1995;267:988-993.
-
(1995)
Science
, vol.267
, pp. 988-993
-
-
Spence, R.A.1
Kati, W.M.2
Anderson, K.S.3
-
22
-
-
0027214433
-
Treatment of human immunodeficiency virus type-1 (HIV-1)-infected cells with combinations of HIV-1 specific inhibitors results in a different resistance pattern than does treatment with single-drug therapy
-
Balzarini J, Karlsson A, Perez-Perez MJ et al. Treatment of human immunodeficiency virus type-1 (HIV-1)-infected cells with combinations of HIV-1 specific inhibitors results in a different resistance pattern than does treatment with single-drug therapy. J Virol 1993;67(9):5353-5359.
-
(1993)
J Virol
, vol.67
, Issue.9
, pp. 5353-5359
-
-
Balzarini, J.1
Karlsson, A.2
Perez-Perez, M.J.3
-
23
-
-
0343883273
-
Escalating single and multiple dose safety, tolerance and pharmacokinetics (PK) of delavirdine mesylate (DLV, U-90152S) in normal volunteers
-
Abstact No. 562, Washington DC, December 12-16
-
Cox SR, Batts DH, Ward P, et al. Escalating single and multiple dose safety, tolerance and pharmacokinetics (PK) of delavirdine mesylate (DLV, U-90152S) in normal volunteers. First National Conference on Human Retroviruses and Related Infections. Abstact No. 562, Washington DC, December 12-16, 1993.
-
(1993)
First National Conference on Human Retroviruses and Related Infections
-
-
Cox, S.R.1
Batts, D.H.2
Ward, P.3
-
24
-
-
3042869429
-
Open-label escalating multiple-dose study of the safety, tolerance and pharmacokinetics of oral U-90152S (delavirdine, DLV) in HIV-1 infected males and females who are maintained on a stable dose of AZT
-
Abstract No. 564, Washington DC, December 12-16
-
Batts DH, Freimuth WW, Cox SR et al. Open-label escalating multiple-dose study of the safety, tolerance and pharmacokinetics of oral U-90152S (delavirdine, DLV) in HIV-1 infected males and females who are maintained on a stable dose of AZT. First National Conference on Human Retroviruses and Related Infections. Abstract No. 564, Washington DC, December 12-16, 1993.
-
(1993)
First National Conference on Human Retroviruses and Related Infections
-
-
Batts, D.H.1
Freimuth, W.W.2
Cox, S.R.3
-
25
-
-
0342397927
-
Mechanism-based inactivation of rat and human cytochrome P450 3A by delavirdine
-
Abstract, Zurich, Switzerland, July 23-27
-
Voorman RL, Maio SM and Wang X. Mechanism-based inactivation of rat and human cytochrome P450 3A by delavirdine. 9th International Conference on Cytochrome P450. Abstract, Zurich, Switzerland, July 23-27, 1995.
-
(1995)
9th International Conference on Cytochrome P450
-
-
Voorman, R.L.1
Maio, S.M.2
Wang, X.3
-
26
-
-
8944227462
-
+ patients
-
Abstract No A52, Orlando, FL, October 4-7
-
+ patients. 34th Interscience Conf. on Antimicrobial Agents and Chemotherapy, Abstract No A52, p. 82, Orlando, FL, October 4-7, 1994.
-
(1994)
34th Interscience Conf. on Antimicrobial Agents and Chemotherapy
, pp. 82
-
-
Morse, G.D.1
Fischl, M.A.2
Cox, S.R.3
-
27
-
-
0001810666
-
Single-dose pharmacokinetic (PK) studies with delavirdine (DLV) mesylate: Dose proportionality and effects of food and antacid
-
Abstract No. A54, Orlando, FL, October 4-7
-
Cox SR, Della-Colletta AA and Freimuth WW. Single-dose pharmacokinetic (PK) studies with delavirdine (DLV) mesylate: Dose proportionality and effects of food and antacid. 34th Interscience Conf. on Antimicrobial Agents and Chemotherapy, Abstract No. A54, p. 82, Orlando, FL, October 4-7, 1994.
-
(1994)
34th Interscience Conf. on Antimicrobial Agents and Chemotherapy
, pp. 82
-
-
Cox, S.R.1
Della-Colletta, A.A.2
Freimuth, W.W.3
-
28
-
-
0003342395
-
+ patients
-
Abstract, San Francisco, CA, September 17-20
-
+ patients. 35th Interscience Conf. on Antimicrobial Agents and Chemotherapy, Abstract, San Francisco, CA, September 17-20, 1995.
-
(1995)
35th Interscience Conf. on Antimicrobial Agents and Chemotherapy
-
-
Morse, G.D.1
Fischl, M.A.2
Cox, S.R.3
-
29
-
-
0003250969
-
+ patients
-
Abstract, San Francisco, CA, September 17-20
-
+ patients. 35th Interscience Conf on Antimicrobial Agents and Chemotherapy, Abstract, San Francisco, CA, September 17-20, 1995.
-
(1995)
35th Interscience Conf on Antimicrobial Agents and Chemotherapy
-
-
Cox, S.R.1
Cohn, S.E.2
Greisberger, C.3
-
30
-
-
0006623241
-
ZDV (ZDV) pharmacokinetics during an escalating multiple-dose study of delavirdine (DLV) mesylate
-
Abstract No. 1156, Orlando, FL, October 4-7
-
Morse GD, Cox SR, DeRemer MF et al. ZDV (ZDV) pharmacokinetics during an escalating multiple-dose study of delavirdine (DLV) mesylate. 34th Interscience Conf. on Antimicrobial Agents and Chemotherapy, Abstract No. 1156, p.132, Orlando, FL, October 4-7, 1994.
-
(1994)
34th Interscience Conf. on Antimicrobial Agents and Chemotherapy
, pp. 132
-
-
Morse, G.D.1
Cox, S.R.2
DeRemer, M.F.3
-
31
-
-
9244234097
-
Effect of fluconazole (FLU) on the clinical pharmacokinetics of delavirdine (DLV)
-
Abstract PB0284, Yokohama, Japan, August 7-12
-
Cox SR, Anderson RD, Driver M et al. Effect of fluconazole (FLU) on the clinical pharmacokinetics of delavirdine (DLV) Abstract PB0284, Vol 1, Page 214. Tenth International Conference on AIDS Yokohama, Japan, August 7-12, 1994.
-
(1994)
Tenth International Conference on AIDS
, vol.1
, pp. 214
-
-
Cox, S.R.1
Anderson, R.D.2
Driver, M.3
-
32
-
-
9244225947
-
Effect of clarithromycin (CLAR) on the steady-state pharmacokinetics (PK) of delavirdine (DLV) in HIV-1 patients
-
Abstract No 487, Washington DC, January 31 - February 3
-
Cox SR, Borin MT, Driver MR et al. Effect of clarithromycin (CLAR) on the steady-state pharmacokinetics (PK) of delavirdine (DLV) in HIV-1 patients. Second National Conference on Human Retroviruses and Related Infections. Abstract No 487, Washington DC, January 31 - February 3,1995.
-
(1995)
Second National Conference on Human Retroviruses and Related Infections
-
-
Cox, S.R.1
Borin, M.T.2
Driver, M.R.3
-
33
-
-
0342728994
-
+ patients
-
Abstract No A48, Orlando, FL, October 4-7
-
+ patients. 34th Interscience Conf. on Antimicrobial Agents and Chemotherapy, Abstract No A48, p. 81, Orlando, FL, October 4-7, 1994.
-
(1994)
34th Interscience Conf. on Antimicrobial Agents and Chemotherapy
, pp. 81
-
-
Borin, M.T.1
Cox, S.R.2
Driver, M.R.3
-
34
-
-
0342728994
-
+ patients
-
Abstract No A50, Orlando, FL, October 4-7
-
+ patients. 34th Interscience Conf on Antimicrobial Agents and Chemotherapy, Abstract No A50, p 82, Orlando, FL, October 4-7, 1994.
-
(1994)
34th Interscience Conf on Antimicrobial Agents and Chemotherapy
, pp. 82
-
-
Borin, M.T.1
Cox, S.R.2
Chambers, J.H.3
-
35
-
-
3042935797
-
A randomized phase I/II trial of delavirdine (U-90152S) compared to combination nucleoside therapy in HIV-1 infection
-
Washington, D.C., January 29 - February 2, Abstract No 267
-
Davey RT, Chaitt DG, Freimuth WW et al. A randomized phase I/II trial of delavirdine (U-90152S) compared to combination nucleoside therapy in HIV-1 infection. Second National Conference on Human Retroviruses and Relation Infections, Washington, D.C., January 29 - February 2, 1995. Abstract No 267.
-
(1995)
Second National Conference on Human Retroviruses and Relation Infections
-
-
Davey, R.T.1
Chaitt, D.G.2
Freimuth, W.W.3
-
36
-
-
0028152948
-
Application of branched DNA signal amplification to monitor human immunodeficiency virus type 1 burden in human plasma
-
Dewar RL, Highbarger HC, Sarmiento MD et al. Application of branched DNA signal amplification to monitor human immunodeficiency virus type 1 burden in human plasma. J Infect Dis 1994;170:1172-1179.
-
(1994)
J Infect Dis
, vol.170
, pp. 1172-1179
-
-
Dewar, R.L.1
Highbarger, H.C.2
Sarmiento, M.D.3
-
37
-
-
0028816484
-
Phase I study of atevirdine, a nonnucleoside reverse transcriptase inhibitor, in combination with zidovudine for human immunodeficiency virus type 1 infection
-
Reichman RC, Morse GD, Demeter LM et al. Phase I study of atevirdine, a nonnucleoside reverse transcriptase inhibitor, in combination with zidovudine for human immunodeficiency virus type 1 infection. J Infect Dis 1995;171:297-304.
-
(1995)
J Infect Dis
, vol.171
, pp. 297-304
-
-
Reichman, R.C.1
Morse, G.D.2
Demeter, L.M.3
-
38
-
-
0027957791
-
Nevirapine resistance mutations of human immunodeficiency virus type 1 selected during therapy
-
Richman DD, Havlir D, Corbeil J et al. Nevirapine resistance mutations of human immunodeficiency virus type 1 selected during therapy. J Virol 1994;68:1660-1666.
-
(1994)
J Virol
, vol.68
, pp. 1660-1666
-
-
Richman, D.D.1
Havlir, D.2
Corbeil, J.3
-
39
-
-
0028307861
-
Alternating nevirapine and zidovudine treatment of human immunodeficiency virus type 1-infected persons does not prolong nevirapine activity
-
De Jong MD, Loewenthal M, Boucher CAB et al. Alternating nevirapine and zidovudine treatment of human immunodeficiency virus type 1-infected persons does not prolong nevirapine activity. J Infect Dis 1994;169:1346-1350.
-
(1994)
J Infect Dis
, vol.169
, pp. 1346-1350
-
-
De Jong, M.D.1
Loewenthal, M.2
Boucher, C.A.B.3
-
40
-
-
0028930117
-
High-dose nevirapine: Safety, pharmacokinetics, and antiviral effect in patients with human immunodeficiency virus infection
-
Havlir D, Cheeseman SH, Mc Laughlin M et al. High-dose nevirapine: safety, pharmacokinetics, and antiviral effect in patients with human immunodeficiency virus infection. J Infect Dis 1995,171:537-545.
-
(1995)
J Infect Dis
, vol.171
, pp. 537-545
-
-
Havlir, D.1
Cheeseman, S.H.2
Mc Laughlin, M.3
-
41
-
-
0027374758
-
A short-term clinical evaluation of L-697,661, a non-nucleoside inhibitor of HIV-1 reverse transcriptase
-
Saag M, Emmi EA, Laskin OL et al. A short-term clinical evaluation of L-697,661, a non-nucleoside inhibitor of HIV-1 reverse transcriptase. N Eng J Med 1993;329:1065-1072.
-
(1993)
N Eng J Med
, vol.329
, pp. 1065-1072
-
-
Saag, M.1
Emmi, E.A.2
Laskin, O.L.3
-
42
-
-
0028898824
-
Combination therapy with zidovudine prevents selection of human immunodeficiency virus type I variants expressing high-level resistance to a nonnucleoside reverse transcriptase inhibitor
-
Combination therapy with zidovudine prevents selection of human immunodeficiency virus type I variants expressing high-level resistance to a nonnucleoside reverse transcriptase inhibitor. J Infect Dis 1995;171:1159-1165.
-
(1995)
J Infect Dis
, vol.171
, pp. 1159-1165
-
-
|