Accelerated bone loss and increased post-fracture mortality in elderly women and men

Osteoporosis International

Volumn 26, Issue 4, 2015, Pages 1331-1339

  Bliuc, D ^a   Nguyen, N D ^a   Alarkawi, D ^a   Nguyen, T V ^a,c   Eisman, J A ^a,b,c,d   Center, J R ^a,b,c  

^a GARVAN INSTITUTE OF MEDICAL RESEARCH   (Australia)

^b ST VINCENT S HOSPITAL   (Australia)

^c UNIVERSITY OF NEW SOUTH WALES   (Australia)

^d UNIVERSITY OF NOTRE DAME   (Australia)

Author keywords

BMD measurements; Bone loss; Mortality risk; Osteoporosis; Population

Indexed keywords

AGED; ARTICLE; CONTROLLED STUDY; FEMALE; FRAGILITY FRACTURE; HIP FRACTURE; HUMAN; MAJOR CLINICAL STUDY; MALE; MORTALITY; OSTEOLYSIS; PRIORITY JOURNAL; SPINE FRACTURE; SURVIVAL RATE; BONE DENSITY; COMORBIDITY; DISEASE COURSE; EPIDEMIOLOGY; FOLLOW UP; KAPLAN MEIER METHOD; MIDDLE AGED; NEW SOUTH WALES; OSTEOPOROSIS; PATHOPHYSIOLOGY; PHYSIOLOGY; POSTMENOPAUSE OSTEOPOROSIS; RISK FACTOR; SEX DIFFERENCE; VERY ELDERLY;

AGED; AGED, 80 AND OVER; BONE DENSITY; COMORBIDITY; DISEASE PROGRESSION; FEMALE; FOLLOW-UP STUDIES; HIP FRACTURES; HUMANS; KAPLAN-MEIER ESTIMATE; MALE; MIDDLE AGED; NEW SOUTH WALES; OSTEOPOROSIS; OSTEOPOROSIS, POSTMENOPAUSAL; OSTEOPOROTIC FRACTURES; RISK FACTORS; SEX FACTORS; SPINAL FRACTURES;

EID: 84928340902     PISSN: 0937941X     EISSN: 14332965     Source Type: Journal    
DOI: 10.1007/s00198-014-3014-9     Document Type: Article

References (27)

1. Bliuc D et al (2009) Mortality risk associated with low-trauma osteoporotic fracture and subsequent fracture in men and women. JAMA 301(5):513–21
2. Center JR et al (1999) Mortality after all major types of osteoporotic fracture in men and women: an observational study. Lancet 353(9156):878–82
3. Huntjens K et al (2010) Risk of subsequent fracture and mortality within 5 years after a non-vertebral fracture. Osteoporos Int
4. Empana JP, Dargent-Molina P, Breart G (2004) Effect of hip fracture on mortality in elderly women: the EPIDOS prospective study. J Am Geriatr Soc 52(5):685–90
5. Kado DM et al (2003) Incident vertebral fractures and mortality in older women: a prospective study. Osteoporos Int 14(7):589–94
6. Shortt NL, Robinson CM (2005) Mortality after low-energy fractures in patients aged at least 45 years old. J Orthop Trauma 19(6):396–400
7. Johnell O et al (2004) Mortality after osteoporotic fractures. Osteoporos Int 15(1):38–42
8. Kannegaard PN et al (2010) Excess mortality in men compared with women following a hip fracture. National analysis of comedications, comorbidity and survival. Age Ageing 39(2):203–9
9. Alegre-Lopez J et al (2005) Factors associated with mortality and functional disability after hip fracture: an inception cohort study. Osteoporos Int 16(7):729–36
10. Tosteson AN et al (2007) Excess mortality following hip fracture: the role of underlying health status. Osteoporos Int 18(11):1463–72
11. Vestergaard P, Rejnmark L, Mosekilde L (2007) Increased mortality in patients with a hip fracture-effect of pre-morbid conditions and post-fracture complications. Osteoporos Int 18(12):1583–93
12. Browner WS et al (1993) Association between low bone density and stroke in elderly women. The study of osteoporotic fractures. Stroke 24(7):940–6
13. Kado DM et al (2000) Rate of bone loss is associated with mortality in older women: a prospective study. J Bone Miner Res 15(10):1974–80
14. Nguyen ND et al (2007) Bone loss, weight loss, and weight fluctuation predict mortality risk in elderly men and women. J Bone Miner Res 22(8):1147–54
15. Center JR et al (2007) Risk of subsequent fracture after low-trauma fracture in men and women. JAMA 297(4):387–94
16. Simons LA et al (1990) The Dubbo study: an Australian prospective community study of the health of elderly. Aust N Z J Med 20(6):783–9
17. (2006) Base SAS: 9.1.3 Procedures Guide. 2nd ed Cary, NC: SAS Publishing
18. Ensrud KE et al (2007) Frailty and risk of falls, fracture, and mortality in older women: the study of osteoporotic fractures. J Gerontol A Biol Sci Med Sci 62(7):744–51
19. Ensrud KE et al (2009) A comparison of frailty indexes for the prediction of falls, disability, fractures, and mortality in older men. J Am Geriatr Soc 57(3):492–8
20. Ershler WB, Keller ET (2000) Age-associated increased interleukin-6 gene expression, late-life diseases, and frailty. Annu Rev Med 51:245–70
21. Redlich K, Smolen JS (2012) Inflammatory bone loss: pathogenesis and therapeutic intervention. Nat Rev Drug Discov 11(3):234–50
22. Jones KG et al (2001) Interleukin-6 (IL-6) and the prognosis of abdominal aortic aneurysms. Circulation 103(18):2260–5
23. Selim G et al (2006) Inflammation predicts all-cause and cardiovascular mortality in haemodialysis patients. Prilozi 27(1):133–44
24. Gulson B et al (2002) Skeletal lead release during bone resorption: effect of bisphosphonate treatment in a pilot study. Environ Health Perspect 110(10):1017–23
25. Gulson BL et al (1998) Mobilization of lead from the skeleton during the postnatal period is larger than during pregnancy. J Lab Clin Med 131(4):324–9
26. Silbergeld EK, Schwartz J, Mahaffey K (1988) Lead and osteoporosis: mobilization of lead from bone in postmenopausal women. Environ Res 47(1):79–94
27. Khalil N et al (2009) Association of blood lead concentrations with mortality in older women: a prospective cohort study. Environ Health 8:15