Do little embryos make big decisions? How maternal dietary protein restriction can permanently change an embryo's potential, affecting adult health

Reproduction, Fertility and Development

Volumn 27, Issue 4, 2015, Pages 684-692

  Fleming, Tom P ^a   Watkins, Adam J ^a,e   Sun, Congshan ^a,c   Velazquez, Miguel A ^a,d   Smyth, Neil R ^a   Eckert, Judith J ^b  

^a UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

^b UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

^c KING'S COLLEGE LONDON   (United Kingdom)

^d NEWCASTLE UNIVERSITY   (United Kingdom)

^e ASTON UNIVERSITY   (United Kingdom)

Author keywords

blastocyst; cardiometabolic disease; endocytosis; mammalian target of rapamycin complex signalling; primitive endoderm; trophectoderm

Indexed keywords

BRANCHED CHAIN AMINO ACID; INSULIN; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; PROTEIN INTAKE;

ADULT; ADULT DISEASE; ARTICLE; BLASTOCYST; CELL LINEAGE; CELL MOTILITY; CELL PROLIFERATION; CELL STIMULATION; DIET RESTRICTION; DIETARY INTAKE; ECTODERM; EMBRYO DEVELOPMENT; ENDOCYTOSIS; ENDODERM; EPIGENETICS; FETUS GROWTH; GENETIC REGULATION; LOW PROTEIN INTAKE DURING PREIMPLANTATION EMBRYO DEVELOPMENT; MATERNAL NUTRITION; MATERNAL SERUM; MATERNAL WELFARE; MICROENVIRONMENT; NONHUMAN; PHENOTYPE; PREIMPLANTATION EMBRYO; PRIMITIVE ENDODERM; PROTEIN INTAKE; PROTEIN RESTRICTION; RAT; SENSITIVITY ANALYSIS; SIGNAL TRANSDUCTION; TROPHECTODERM; UTERUS FLUID; ANIMAL; FEMALE; FETUS DEVELOPMENT; METABOLISM; MOUSE; PHYSIOLOGY; PREGNANCY;

MAMMALIA; RODENTIA;

ANIMALS; BLASTOCYST; DIET, PROTEIN-RESTRICTED; DIETARY PROTEINS; EMBRYONIC DEVELOPMENT; FEMALE; FETAL DEVELOPMENT; MATERNAL NUTRITIONAL PHYSIOLOGICAL PHENOMENA; MICE; PREGNANCY;

EID: 84928315377     PISSN: 10313613     EISSN: 14485990     Source Type: Journal    
DOI: 10.1071/RD14455     Document Type: Article

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