The changes in clot microstructure in patients with ischaemic stroke and the effects of therapeutic intervention: A prospective observational study

BMC Neurology

Volumn 15, Issue 1, 2015, Pages

  Stanford, Sophia N ^a,b   Sabra, Ahmed ^a,b   D'Silva, Lindsay ^a,b   Lawrence, Matthew ^a,b   Morris, Roger H K ^c   Storton, Sharon ^b   Brown, Martyn Rowan ^d   Evans, Vanessa ^b   Hawkins, Karl ^a   Williams, Phylip Rhodri ^d   Davidson, Simon J ^e   Wani, Mushtaq ^b   Potter, John F ^f   Evans, Phillip A ^a,b  

^a SWANSEA UNIVERSITY   (United Kingdom)

^b MORRISTON HOSPITAL   (United Kingdom)

^c CARDIFF METROPOLITAN UNIVERSITY   (United Kingdom)

^d SWANSEA UNIVERSITY   (United Kingdom)

^e ROYAL BROMPTON AND HAREFIELD NHS FOUNDATION TRUST   (United Kingdom)

^f UNIVERSITY OF EAST ANGLIA   (United Kingdom)

Author keywords

Aspirin; Biomarker; Clot microstructure; Fractal dimension; Ischaemic stroke; Thrombolysis

Indexed keywords

ACETYLSALICYLIC ACID; ALTEPLASE; BIOLOGICAL MARKER; CLOPIDOGREL; FIBRINOGEN; FIBRINOLYTIC AGENT; TISSUE PLASMINOGEN ACTIVATOR;

AGED; ARTICLE; BLOOD CLOT LYSIS; BRAIN ISCHEMIA; CLOT MICROSTRUCTURE; COHORT ANALYSIS; CONTROLLED STUDY; DRUG EFFECT; FEMALE; FLOW MEASUREMENT; HUMAN; MAJOR CLINICAL STUDY; MALE; NERVOUS SYSTEM PARAMETERS; OBSERVATIONAL STUDY; PARTIAL THROMBOPLASTIN TIME; PROSPECTIVE STUDY; BLOOD; BLOOD CLOTTING TIME; CASE CONTROL STUDY; ELASTICITY; FRACTAL ANALYSIS; METABOLISM; MIDDLE AGED; STROKE; THROMBOSIS; VERY ELDERLY;

AGED; AGED, 80 AND OVER; ASPIRIN; CASE-CONTROL STUDIES; COHORT STUDIES; ELASTICITY; FEMALE; FIBRINOGEN; FIBRINOLYTIC AGENTS; FRACTALS; HUMANS; MALE; MIDDLE AGED; PROSPECTIVE STUDIES; STROKE; THROMBOSIS; TISSUE PLASMINOGEN ACTIVATOR; WHOLE BLOOD COAGULATION TIME;

EID: 84928266911     PISSN: None     EISSN: 14712377     Source Type: Journal    
DOI: 10.1186/s12883-015-0289-1     Document Type: Article

References (43)

1. WHO. The top ten causes of death (2012). http://www.who.int/mediacentre/factsheets/fs310/en/Accessed March 3 2014
2. Undas A, Podolec P, Zawilska K, Pieculewicz M, Jedlinski I, Stepien E, et al. Altered fibrin clot structure/function in patients with cryptogenic ischemic stroke. Stroke. 2009;40:1499-501
3. Pera J, Undas A, Topor-Madry R, Jagiella J, Klimkowicz-Mrowiec A, Slowik A. Fibrin Clot Properties in Acute Stroke: What Differs Cerebral Hemorrhage From Cerebral Ischemia? Stroke. 2012;43:1412-14
4. Scott EM, Ariens RA, Grant PJ. Genetic and environmental determinants of fibrin structure and function: Relevance to clinical disease. Arterioscler Thromb Vasc Biol. 2004;24:1558-66
5. Collet JP, Allali Y, Lesty C, Tanguy ML, Silvain J, Ankri A, et al. Altered fibrin architecture is associated with hypofibrinolysis and premature coronary atherothrombosis. Arterioscler Thromb Vasc Biol. 2006;26:2567-73
6. Chung I, Lip GY. Virchow's triad revisited: Blood constituents. Pathophysiol Haemost Thromb. 2003;33:449-54
7. Curry ANG, Pierce JMT. Conventional and near-patient tests of coagulation. Continuing Education in Anaesthesia, Critical Care & Pain. 2007;7:45-50
8. Favaloro EJ, Lippi G. Coagulation update: What's new in hemostasis testing? Thromb Res. 2011;127 Suppl 2:S13-16
9. Antovic A. Screening haemostasis-looking for global assays: The overall haemostasis potential (ohp) method-a possible tool for laboratory investigation of global haemostasis in both hypo-and hypercoagulable conditions. Curr Vasc Pharmacol. 2008;6:173-85
10. Rooth E, Wallen NH, Blomback M, He S. Decreased fibrin network permeability and impaired fibrinolysis in the acute and convalescent phase of ischemic stroke. Thromb Res. 2011;127:51-6
11. Takahashi A, Kita R, Shinozaki T, Kubota K. Real space observation of 3-d network structure of hydrated fibrin gel. Colloid Polym Sci. 2003;28:832-8
12. Weisel JW. The mechanical properties of fibrin for basic scientists and clinicians. Biophys Chem. 2004;112:267-76
13. Lawrence MJ, Sabra A, Mills G, Pillai SG, Abdullah W, Hawkins K, Morris RHK, Davidson SJ, D'Silva L, Curtis DJ, Brown MR, Weisel JW, Williams PR, Evans PA. A new biomarker quantifies differences in clot microstructure in patients with venous thromboembolism. Br J Haematol. 2014. doi:10.1111/bjh.13173
14. Lawrence MJ, Kumar S, Hawkins K, Boden S, Rutt H, Mills G, et al. A new structural biomarker that quantifies and predicts changes in clot strength and quality in a model of progressive haemodilution. Thromb Res. 2014;134(2):488-94
15. Evans PA, Hawkins K, Morris RHK, Thirumalai N, Munro R, Wakeman L, et al. Gel point and fractal microstructure of incipient blood clots are significant new markers of hemostasis for healthy and anticoagulated blood. Blood. 2010;116:3341-6
16. Evans PA, Lawrence M, Morris RHK, Thirumalai N, Munro R, Wakeman L, et al. Fractal analysis of viscoelastic data with automated gel point location and its potential application in the investigation of therapeutically modified blood coagulation. Rheol Acta. 2010;49:901-8
17. Winter HH, Chambon F. Analysis of linear viscoelasticity of a crosslinking polymer at the gel point. J Rheol. 1986;30:367-82
18. Yoon WB, Kim BY, Park JW. Rheological characteristics of fibrinogen-thrombin solution and its effects on surimi gels. J Food Sci. 1999;64:291-4
19. Hatano S. Experience from a multicentre stroke register: A preliminary report. Bull World Health Organ. 1976;54:541-53
20. Curtis DJ, Brown MR, Hawkins K, Evans PA, Lawrence MJ, Rees P, et al. Rheometrical and molecular dynamics simulation studies of incipient clot formation in fibrin-thrombin gels: An activation limited aggregation approach. J Non-Newtonian Fluid Mech. 2011;166:932-8
21. Undas A, Slowik A, Wolkow P, Szczudlik A, Tracz W. Fibrin clot properties in acute ischemic stroke: Relation to neurological deficit. Thromb Res. 2010;125:357-61
22. Brown MR, Curtis DJ, Rees P, Summers HD, Hawkins K, Evans PA, et al. Fractal discrimination of random fractal aggregates and its application in biomarker analysis for blood coagulation. Chaos, Solitons Fractals. 2012;45:1025-32
23. Curtis DJ, Williams PR, Badiei N, Campbell AI, Hawkins K, Evans PA, et al. A study of microstructural templating in fibrin-thrombin gel networks by spectral and viscoelastic analysis. Soft Matter. 2013;9:4883-9
24. Simak J, Gelderman MP. Cell membrane microparticles in blood and blood products: potentially pathogenic agents and diagnostic markers. Transfus Med Rev. 2006;20(1):1-26
25. Wilhelmsen L, Svardsudd K, Korsan-Bengtsen K, Larsson B, Welin L, Tibblin G. Fibrinogen as a risk factor for stroke and myocardial infarction. N Engl J Med. 1984;311:501-5
26. Di Napoli M, Singh P. Is plasma fibrinogen useful in evaluating ischemic stroke patients?: Why, how, and when. Stroke. 2009;40:1549-52
27. He S, Blomback M, Yoo G, Sinha R, Henschen-Edman AH. Modified clotting properties of fibrinogen in the presence of acetylsalicylic acid in a purified system. Ann N Y Acad Sci. 2001;936:531-5
28. Undas A, Sydor WJ, Brummel K, Musial J, Mann KG, Szczeklik A. Aspirin alters the cardioprotective effects of the factor xiii val34leu polymorphism. Circulation. 2003;107:17-20
29. Bjornsson TD, Schneider DE, Berger H. Aspirin acetylates fibrinogen and enhances fibrinolysis. Fibrinolytic effect is independent of changes in plasminogen activator levels. J Pharmacol Exp Ther. 1989;250:154-61
30. Ceulemans AG, Zgavc T, Kooijman R, Hachimi-Idrissi S, Sarre S, Michotte Y. The dual role of the neuroinflammatory response after ischemic stroke: Modulatory effects of hypothermia. J Neuroinflammation. 2010;7:74
31. Sughrue ME, Mehra A, Connolly Jr ES, D'Ambrosio AL. Anti-adhesion molecule strategies as potential neuroprotective agents in cerebral ischemia: A critical review of the literature. Inflamm Res. 2004;53:497-508
32. Bode C, Runge MS, Haber E. Future directions in plasminogen activator therapy. Clin Cardiol. 1990;13:375-81
33. Tanswell P, Seifried E, Su PC, Feuerer W, Rijken DC. Pharmacokinetics and systemic effects of tissue-type plasminogen activator in normal subjects. Clin Pharmacol Ther. 1989;46:155-62
34. Noman A, Egred M, Bagnall A, Spyridopoulos I, Jamieson S, Ahmed J. Impact of thrombus aspiration during primary percutaneous coronary intervention on mortality in st-segment elevation myocardial infarction. Eur Heart J. 2012;33:3054-61
35. Fokkema ML, Wieringa WG, van der Horst IC, Boersma E, Zijlstra F, de Smet BJ. Quantitative analysis of the impact of total ischemic time on myocardial perfusion and clinical outcome in patients with st-elevation myocardial infarction. Am J Cardiol. 2011;108:1536-41
36. De Luca G, Suryapranata H, Ottervanger JP, Antman EM. Time delay to treatment and mortality in primary angioplasty for acute myocardial infarction: Every minute of delay counts. Circulation. 2004;109:1223-5
37. Kramer MC, van der Wal AC, Koch KT, Ploegmakers JP, van der Schaaf RJ, Henriques JP, et al. Presence of older thrombus is an independent predictor of long-term mortality in patients with st-elevation myocardial infarction treated with thrombus aspiration during primary percutaneous coronary intervention. Circulation. 2008;118:1810-16
38. Silvain J, Collet JP, Nagaswami C, Beygui F, Edmondson KE, Bellemain-Appaix A, et al. Composition of coronary thrombus in acute myocardial infarction. J Am Coll Cardiol. 2011;57:1359-67
39. Pretorius E, Oberholzer HM, van der Spuy WJ, Meiring JH. Smoking and coagulation: The sticky fibrin phenomenon. Ultrastruct Pathol. 2010;34:236-9
40. Sowers MR, Matthews KA, Jannausch M, Randolph JF, McConnell D, Sutton-Tyrrell K, et al. Hemostatic factors and estrogen during the menopausal transition. J Clin Endocrinol Metab. 2005;90:5942-8
41. Lip GYH. Using the CHADS2 and CHA2DS2-VASc Scores for stroke risk prediction as well as the identification of stroke outcomes and cardiac complications in patients with and without atrial fibrillation. Cerebrovasc Dis. 2013;36:281-2
42. Holzer K, Feurer R, Sadikovic S, Esposito L, Bockelbrink A, Sander D, et al. Prognostic value of the ABCD2 score beyond short-term follow-up after transient ischemic attack (TIA)-a cohort study. BMC Neurol. 2010;10:50
43. Prabhakaran S, Jovin TG, Tayal AH, Hussain MS, Nguyen TN, Sheth KN, et al. Posttreatment variables improve outcome prediction after intra-arterial therapy for acute ischemic stroke. Cerebrovasc Dis. 2014;37:356-63