A new biomarker quantifies differences in clot microstructure in patients with venous thromboembolism

British Journal of Haematology

Volumn 168, Issue 4, 2015, Pages 571-575

  Lawrence, Matthew J ^a,b   Sabra, Ahmed ^a,b   Mills, Gavin ^a   Pillai, Suresh G ^a   Abdullah, Wendy ^a   Hawkins, Karl ^a,b   Morris, Roger H K ^a,c   Davidson, Simon J ^d   D'Silva, Lindsay A ^a,b   Curtis, Daniel J ^e   Brown, Martin R ^e   Weisel, John W ^f   Williams, Phylip R ^a,e   Evans, Phillip A ^a,b  

^a MORRISTON HOSPITAL   (United Kingdom)

^b SWANSEA UNIVERSITY   (United Kingdom)

^c CARDIFF METROPOLITAN UNIVERSITY   (United Kingdom)

^d ROYAL BROMPTON AND HAREFIELD NHS FOUNDATION TRUST   (United Kingdom)

^e SWANSEA UNIVERSITY   (United Kingdom)

^f UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Anticoagulation; Blood coagulation; Haemostasis; Venous thrombosis; Warfarin

Indexed keywords

WARFARIN; ANTICOAGULANT AGENT; BIOLOGICAL MARKER; FIBRIN; GEL; VISCOELASTIC SUBSTANCE;

ADULT; ANTICOAGULANT THERAPY; ARTICLE; BLOOD ANALYSIS; BLOOD CLOTTING; CLOT FORMATION TIME; CLOT MICROSTRUCTURE; CONTROLLED STUDY; DISEASE MARKER; FEMALE; FUNCTIONS OF THE HEMIC, LYMPHATIC AND RETICULOENDOTHELIAL SYSTEMS; HUMAN; MAJOR CLINICAL STUDY; MALE; PARTIAL THROMBOPLASTIN TIME; PROTHROMBIN TIME; RISK ASSESSMENT; TREATMENT RESPONSE; VENOUS THROMBOEMBOLISM; AGED; BLOOD; BLOOD CLOTTING TEST; BLOOD RHEOLOGY; COMPARATIVE STUDY; ELASTOGRAPHY; FIBRINOLYSIS; GEL; MIDDLE AGED; TIME;

AGED; ANTICOAGULANTS; BIOLOGICAL MARKERS; BLOOD COAGULATION TESTS; ELASTICITY IMAGING TECHNIQUES; FEMALE; FIBRIN; FIBRINOLYSIS; GELS; HEMORHEOLOGY; HUMANS; MALE; MIDDLE AGED; TIME FACTORS; VENOUS THROMBOEMBOLISM; VISCOELASTIC SUBSTANCES; WARFARIN;

EID: 84923094213     PISSN: 00071048     EISSN: 13652141     Source Type: Journal    
DOI: 10.1111/bjh.13173     Document Type: Article

References (14)

1. Collet, J.P., Park, D., Lesty, C., Soria, J., Soria, C., Montalescot, G. & Weisel, J.W. (2000) Influence of fibrin network conformation and fibrin fiber diameter on fibrinolysis speed: dynamic and structural approaches by confocal microscopy. Arteriosclerosis, Thrombosis and Vascular Biology, 20, 1354-1361.
2. Curtis, D.J., Brown, M.R., Hawkins, K., Evans, P.A., Lawrence, M.J., Rees, P. & Williams, P.R. (2011) Rheometrical and molecular dynamics simulation studies of incipient clot formation in fibrin-thrombin gels: an activation limited aggregation approach. Journal of Non-Newtonian Fluid Mechanics, 166, 932-938.
3. Curtis, D.J., Williams, P.R., Badiei, N., Campbell, A.I., Hawkins, K., Evans, P.A. & Brown, M.R. (2013) A study of microstructural templating in fibrin-thrombin gel networks by spectral and viscoelastic analysis. Soft Matter, 9, 4883-4889.
4. Evans, P.A., Hawkins, K., Morris, R.H.K., Thirumalai, N., Munro, R., Wakeman, L., Lawrence, M.J. & Williams, P.R. (2010) Gel point and fractal microstructure of incipient clots are significant new markers of hemostasis for healthy and anticoagulated blood. Blood, 116, 3341-3344.
5. Heit, J., Petterson, T., Farmer, S., Bailey, K. & Melton, L. (2006) Trends in Incidence of deep vein thrombosis and pulmonary embolism: a 35-year population-based study. Blood, 108, 430.
6. Kearon, C., Julian, J.A., Kovacs, M.J., Anderson, D.R., Wells, P., MacKinnon, B., Weitz, J.I., Crowther, M.A., Dolan, S., Turpie, A.G., Geerts, W., Solymoss, S., van Nguyen, P., Demers, C., Kahn, S.R., Kassis, J., Rodger, M., Hambleton, J., Gent, M. & Ginsberg, J.S. (2008) Influence of thrombophilia on risk of recurrent venous thromboembolism while on warfarin: results from a randomized trial. Blood, 112, 4432-4436.
7. Lawrence, M.J., Kumar, S., Hawkins, K., Boden, S., Rutt, H., Mills, G., Sabra, A., Morris, R.H.K., Davidson, S.J., Badiei, N., Brown, M.R., Williams, P.R. & Evans, P.A. (2014) A new structural biomarker that quantifies and predicts changes in clot strength and quality in a model of progressive haemodilution. Thrombosis Research, 134, 488-494.
8. Martinez, M.R., Cuker, A., Mills, A.M., Crichlow, A., Lightfoot, R.T., Chernysh, I.N., Nagaswami, C., Weisel, J.W. & Ischiropoulos, H. (2014) Enhanced lysis and accelerated establishment of viscoelastic properties of fibrin clots are associated with pulmonary embolism. American Journal of Physiology - Lung Cellular and Molecular Physiology, 306, L397-L404.
9. Mills, J.D., Ariëns, R.A.S., Mansfield, M.W. & Gran, P.J. (2002) Altered fibrin clot structure in the healthy relatives of patients with premature coronary artery disease. Circulation, 106, 1938-1942.
10. Rosendaal, F.R., Cannegieter, S.C., van der Meer, F.J. & Briët, E. (1993) A method to determine the optimal intensity of oral anticoagulant therapy. Thrombosis and Haemostasis, 69, 236-239.
11. Silverstein, M., Heit, J., Mohr, D., Petterson, T., O'Fallon, W. & Melton, L. (1998) Trends in the incidence of deep vein thrombosis and pulmonary embolism: a 25-year population-based, cohort study. Archives of Internal Medicine, 158, 585-593.
12. Thachil, J. (2012) Recurrent venous thromboembolism while on anticoagulant therapy. Blood Reviews, 26, 175-181.
13. Undas, A., Zawilska, K., Ciesla-Dul, M., Lehmann-Kopydlowska, A., Skubiszak, A., Ciepluch, K. & Tracz, W. (2009) Altered fibrin clot structure/function in patients with idiopathic venous thromboembolism and in their relatives. Blood, 114, 4272-4278.
14. Weisel, J.W. & Litvinov, R.I. (2013) Mechanisms of fibrin polymerization and clinical implications. Blood, 121, 1712-1719.