메뉴 건너뛰기




Volumn 6, Issue 3, 2015, Pages 288-295

Expression of p63 and CK5/6 in early-stage lung squamous cell carcinoma is not only an early diagnostic indicator but also correlates with a good prognosis

Author keywords

Immunohistochemistry; Lung squamous cell carcinoma; Non small cell lung cancer; Prognosis

Indexed keywords

CYTOKERATIN 5; CYTOKERATIN 6; PROTEIN P40; PROTEIN P63;

EID: 84928258611     PISSN: 17597706     EISSN: 17597714     Source Type: Journal    
DOI: 10.1111/1759-7714.12181     Document Type: Article
Times cited : (36)

References (25)
  • 1
    • 52749099497 scopus 로고    scopus 로고
    • Assessment of somatic k-RAS mutations as a mechanism associated with resistance to EGFR-targeted agents: a systematic review and meta-analysis of studies in advanced non-small-cell lung cancer and metastatic colorectal cancer
    • Linardou H, Dahabreh IJ, Kanaloupiti D etal. Assessment of somatic k-RAS mutations as a mechanism associated with resistance to EGFR-targeted agents: a systematic review and meta-analysis of studies in advanced non-small-cell lung cancer and metastatic colorectal cancer. Lancet Oncol 2008; 9: 962-972.
    • (2008) Lancet Oncol , vol.9 , pp. 962-972
    • Linardou, H.1    Dahabreh, I.J.2    Kanaloupiti, D.3
  • 2
    • 35548962203 scopus 로고    scopus 로고
    • Mutations of the epidermal growth factor receptor gene and related genes as determinants of epidermal growth factor receptor tyrosine kinase inhibitors sensitivity in lung cancer
    • Mitsudomi T, Yatabe Y. Mutations of the epidermal growth factor receptor gene and related genes as determinants of epidermal growth factor receptor tyrosine kinase inhibitors sensitivity in lung cancer. Cancer Sci 2007; 98: 1817-1824.
    • (2007) Cancer Sci , vol.98 , pp. 1817-1824
    • Mitsudomi, T.1    Yatabe, Y.2
  • 3
    • 34547638047 scopus 로고    scopus 로고
    • Identification of the transforming EML4-ALK fusion gene in non-small-cell lung cancer
    • Soda M, Choi YL, Enomoto M etal. Identification of the transforming EML4-ALK fusion gene in non-small-cell lung cancer. Nature 2007; 448: 561-566.
    • (2007) Nature , vol.448 , pp. 561-566
    • Soda, M.1    Choi, Y.L.2    Enomoto, M.3
  • 4
    • 77952246629 scopus 로고    scopus 로고
    • The classification of lung carcinoma: time to change the morphology-based approach?
    • Pelosi G, Sonzogni A, Viale G. The classification of lung carcinoma: time to change the morphology-based approach? Int J Surg Pathol 2010; 18: 161-172.
    • (2010) Int J Surg Pathol , vol.18 , pp. 161-172
    • Pelosi, G.1    Sonzogni, A.2    Viale, G.3
  • 5
    • 79551563284 scopus 로고    scopus 로고
    • International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society international multidisciplinary classification of lung adenocarcinoma
    • Travis WD, Brambilla E, Noguchi M etal. International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society international multidisciplinary classification of lung adenocarcinoma. J Thorac Oncol 2011; 6: 244-285.
    • (2011) J Thorac Oncol , vol.6 , pp. 244-285
    • Travis, W.D.1    Brambilla, E.2    Noguchi, M.3
  • 6
    • 77954695549 scopus 로고    scopus 로고
    • Nrf2 and Keap1 abnormalities in non-small cell lung carcinoma and association with clinicopathologic features
    • Solis LM, Behrens C, Dong W etal. Nrf2 and Keap1 abnormalities in non-small cell lung carcinoma and association with clinicopathologic features. Clin Cancer Res 2010; 16: 3743-3753.
    • (2010) Clin Cancer Res , vol.16 , pp. 3743-3753
    • Solis, L.M.1    Behrens, C.2    Dong, W.3
  • 7
    • 0942266422 scopus 로고    scopus 로고
    • Prognostic significance of thyroid transcription factor-1 expression in both early-stage conventional adenocarcinoma and bronchioloalveolar carcinoma of the lung
    • Saad RS, Liu YL, Han H, Landreneau RJ, Silverman JF. Prognostic significance of thyroid transcription factor-1 expression in both early-stage conventional adenocarcinoma and bronchioloalveolar carcinoma of the lung. Hum Pathol 2004; 35: 3-7.
    • (2004) Hum Pathol , vol.35 , pp. 3-7
    • Saad, R.S.1    Liu, Y.L.2    Han, H.3    Landreneau, R.J.4    Silverman, J.F.5
  • 8
    • 77949894769 scopus 로고    scopus 로고
    • p63 in epithelial survival, germ cell surveillance, and neoplasia
    • Crum CP, McKeon FD. p63 in epithelial survival, germ cell surveillance, and neoplasia. Annu Rev Pathol 2010; 5: 349-371.
    • (2010) Annu Rev Pathol , vol.5 , pp. 349-371
    • Crum, C.P.1    McKeon, F.D.2
  • 9
    • 84870362699 scopus 로고    scopus 로고
    • p40: a p63 isoform useful for lung cancer diagnosis - a review of the physiological and pathological role of p63
    • Nobre AR, Albergaria A, Schmitt F. p40: a p63 isoform useful for lung cancer diagnosis - a review of the physiological and pathological role of p63. Acta Cytol 2013; 57: 1-8.
    • (2013) Acta Cytol , vol.57 , pp. 1-8
    • Nobre, A.R.1    Albergaria, A.2    Schmitt, F.3
  • 10
    • 78650862148 scopus 로고    scopus 로고
    • Subclassification of non-small cell lung carcinomas lacking morphologic differentiation on biopsy specimens: utility of an immunohistochemical panel containing TTF-1, napsin A, p63, and CK5/6
    • Mukhopadhyay S, Katzenstein AL. Subclassification of non-small cell lung carcinomas lacking morphologic differentiation on biopsy specimens: utility of an immunohistochemical panel containing TTF-1, napsin A, p63, and CK5/6. Am J Surg Pathol 2011; 35: 15-25.
    • (2011) Am J Surg Pathol , vol.35 , pp. 15-25
    • Mukhopadhyay, S.1    Katzenstein, A.L.2
  • 11
    • 84856669500 scopus 로고    scopus 로고
    • Evaluation of napsin A, cytokeratin 5/6, p63, and thyroid transcription factor 1 in adenocarcinoma versus squamous cell carcinoma of the lung
    • Whithaus K, Fukuoka J, Prihoda TJ, Jagirdar J. Evaluation of napsin A, cytokeratin 5/6, p63, and thyroid transcription factor 1 in adenocarcinoma versus squamous cell carcinoma of the lung. Arch Pathol Lab Med 2012; 136: 155-162.
    • (2012) Arch Pathol Lab Med , vol.136 , pp. 155-162
    • Whithaus, K.1    Fukuoka, J.2    Prihoda, T.J.3    Jagirdar, J.4
  • 12
    • 78049425319 scopus 로고    scopus 로고
    • Anaplastic lymphoma kinase inhibition in non-small-cell lung cancer
    • Kwak EL, Bang YJ, Camidge DR. Anaplastic lymphoma kinase inhibition in non-small-cell lung cancer. N Engl J Med 2010; 363: 1693-1703.
    • (2010) N Engl J Med , vol.363 , pp. 1693-1703
    • Kwak, E.L.1    Bang, Y.J.2    Camidge, D.R.3
  • 13
    • 79955467025 scopus 로고    scopus 로고
    • Frequent ALK rearrangement and TTF-1/p63 co-expression in lung adenocarcinoma with signet-ring cell component
    • Yoshida A, Tsuta K, Watanabe S. Frequent ALK rearrangement and TTF-1/p63 co-expression in lung adenocarcinoma with signet-ring cell component. Lung Cancer 2011; 72: 309-315.
    • (2011) Lung Cancer , vol.72 , pp. 309-315
    • Yoshida, A.1    Tsuta, K.2    Watanabe, S.3
  • 15
    • 84861231326 scopus 로고    scopus 로고
    • A study of DeltaNp63 expression in lung non-small cell carcinomas
    • Nonaka D. A study of DeltaNp63 expression in lung non-small cell carcinomas. Am J Surg Pathol 2012; 36: 895-899.
    • (2012) Am J Surg Pathol , vol.36 , pp. 895-899
    • Nonaka, D.1
  • 17
    • 0022033592 scopus 로고
    • Classification of human epithelia and their neoplasms using monoclonal antibodies to keratins: strategies, applications, and limitations
    • Cooper D, Schermer A, Sun TT. Classification of human epithelia and their neoplasms using monoclonal antibodies to keratins: strategies, applications, and limitations. Lab Invest 1985; 52: 243-256.
    • (1985) Lab Invest , vol.52 , pp. 243-256
    • Cooper, D.1    Schermer, A.2    Sun, T.T.3
  • 18
    • 0027509891 scopus 로고
    • Keratin immunohistochemistry: update of applications and pitfalls
    • Miettinen M. Keratin immunohistochemistry: update of applications and pitfalls. Pathol Annu 1993; 28 (Pt 2): 113-143.
    • (1993) Pathol Annu , vol.28 , pp. 113-143
    • Miettinen, M.1
  • 19
    • 0035184548 scopus 로고    scopus 로고
    • Value of p63 and cytokeratin 5/6 as immunohistochemical markers for the differential diagnosis of poorly differentiated and undifferentiated carcinomas
    • Kaufmann O, Fietze E, Mengs J, Dietel M. Value of p63 and cytokeratin 5/6 as immunohistochemical markers for the differential diagnosis of poorly differentiated and undifferentiated carcinomas. Am J Clin Pathol 2001; 116: 823-830.
    • (2001) Am J Clin Pathol , vol.116 , pp. 823-830
    • Kaufmann, O.1    Fietze, E.2    Mengs, J.3    Dietel, M.4
  • 20
    • 0035196801 scopus 로고    scopus 로고
    • Immunohistochemical panels for differentiating epithelial malignant mesothelioma from lung adenocarcinoma: a study with logistic regression analysis
    • Carella R, Deleonardi G, D'Errico A etal. Immunohistochemical panels for differentiating epithelial malignant mesothelioma from lung adenocarcinoma: a study with logistic regression analysis. Am J Surg Pathol 2001; 25: 43-50.
    • (2001) Am J Surg Pathol , vol.25 , pp. 43-50
    • Carella, R.1    Deleonardi, G.2    D'Errico, A.3
  • 21
    • 49649087950 scopus 로고    scopus 로고
    • If it's not CK5/6 positive, TTF-1 negative it's not a squamous cell carcinoma of lung
    • Downey P, Cummins R, Moran M, Gulmann C. If it's not CK5/6 positive, TTF-1 negative it's not a squamous cell carcinoma of lung. APMIS 2008; 116: 526-529.
    • (2008) APMIS , vol.116 , pp. 526-529
    • Downey, P.1    Cummins, R.2    Moran, M.3    Gulmann, C.4
  • 22
    • 37349100847 scopus 로고    scopus 로고
    • The diagnostic value of TTF-1, CK 5/6, and p63 immunostaining in classification of lung carcinomas
    • Kargi A, Gurel D, Tuna B. The diagnostic value of TTF-1, CK 5/6, and p63 immunostaining in classification of lung carcinomas. Appl Immunohistochem Mol Morphol 2007; 15: 415-420.
    • (2007) Appl Immunohistochem Mol Morphol , vol.15 , pp. 415-420
    • Kargi, A.1    Gurel, D.2    Tuna, B.3
  • 23
    • 67649396222 scopus 로고    scopus 로고
    • BCL-2 expression is prognostic for improved survival in non-small cell lung cancer
    • Renouf DJ, Wood-Baker R, Ionescu DN etal. BCL-2 expression is prognostic for improved survival in non-small cell lung cancer. J Thorac Oncol 2009; 4: 486-491.
    • (2009) J Thorac Oncol , vol.4 , pp. 486-491
    • Renouf, D.J.1    Wood-Baker, R.2    Ionescu, D.N.3
  • 24
    • 4544264923 scopus 로고    scopus 로고
    • Evaluation of immunohistochemical markers in non-small cell lung cancer by unsupervised hierarchical clustering analysis: a tissue microarray study of 284 cases and 18 markers
    • Au NH, Cheang M, Huntsman DG etal. Evaluation of immunohistochemical markers in non-small cell lung cancer by unsupervised hierarchical clustering analysis: a tissue microarray study of 284 cases and 18 markers. J Pathol 2004; 204: 101-109.
    • (2004) J Pathol , vol.204 , pp. 101-109
    • Au, N.H.1    Cheang, M.2    Huntsman, D.G.3
  • 25
    • 24744452608 scopus 로고    scopus 로고
    • A lack of prognostic significance regarding DeltaNp63 immunoreactivity in lung cancer
    • Iwata T, Uramoto H, Sugio K etal. A lack of prognostic significance regarding DeltaNp63 immunoreactivity in lung cancer. Lung Cancer 2005; 50: 67-73.
    • (2005) Lung Cancer , vol.50 , pp. 67-73
    • Iwata, T.1    Uramoto, H.2    Sugio, K.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.