Hepatocyte buds derived from progenitor cells repopulate regions of parenchymal extinction in human cirrhosis

Hepatology

Volumn 61, Issue 5, 2015, Pages 1696-1707

  Stueck, Ashley E ^a   Wanless, Ian R ^a  

^a QUEEN ELIZABETH II HEALTH SCIENCES CENTRE   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; CD34 ANTIGEN; EPITHELIAL CELL ADHESION MOLECULE; GLUTAMATE AMMONIA LIGASE; K19 PROTEIN; KI 67 ANTIGEN; UNCLASSIFIED DRUG;

ARTICLE; BILIARY TRACT DISEASE; CELL BUDDING; CELL MATURATION; CELL POPULATION; CELL STRUCTURE; DISEASE ASSOCIATION; HUMAN; HUMAN CELL; HUMAN TISSUE; LIVER CELL; LIVER CIRRHOSIS; LIVER RESECTION; LIVER VEIN; PRIORITY JOURNAL; PROGENY; QUANTITATIVE ANALYSIS; STEM CELL; TISSUE SECTION; CELL PROLIFERATION; CYTOLOGY; LIVER; PATHOLOGY;

CELL PROLIFERATION; HEPATOCYTES; HUMANS; LIVER; LIVER CIRRHOSIS; STEM CELLS;

EID: 84928205579     PISSN: 02709139     EISSN: 15273350     Source Type: Journal    
DOI: 10.1002/hep.27706     Document Type: Article

References (31)

1. Wanless IR, Huang W-Y. Vascular disorders. In: Burt AD, Portmann BC, Ferrell L, eds. MacSween's Pathology of the Liver. 6th ed. Edinburgh: Churchill-Livingstone-Elsevier; 2012:601-643.
2. Wanless IR, Nakashima E, Sherman M. Regression of human cirrhosis: morphologic features and the genesis of incomplete septal cirrhosis. Arch Pathol Lab Med 2000;124:1599-1607.
3. Sohrabpour AA, Mohamadnejad M, Malekzadeh R. Review article: the reversibility of cirrhosis. Aliment Pharmacol Ther 2012;36:824-832.
4. Grisham JW. A morphologic study of deoxyribonucleic acid synthesis and cell proliferation in regenerating rat liver; autoradiography with thymidine-H3. Cancer Res 1962;22:842-849.
5. Fausto N, Campbell JS, Riehle KJ. Liver regeneration. Hepatology 2006;43:S45-S53.
6. Itoh T, Miyajima A. Liver regeneration by stem/progenitor cells. Hepatology 2014;59:1617-1626.
7. Theise ND, Saxena R, Portmann BC, Thung SN, Yee H, Chiriboga L, et al. The canals of Hering and hepatic stem cells in humans. Hepatology 1999;30:1425-1433.
8. Roskams TA, Theise ND, Balabaud C, Bhagat G, Bhathal PS, Bioulac-Sage P, et al. Nomenclature of the finer branches of the biliary tree: canals, ductules, and ductular reactions in human livers. Hepatology 2004;39:1739-1745.
9. Lin WR, Lim SN, McDonald SA, Graham T, Wright VL, Peplow CL, et al. The histogenesis of regenerative nodules in human liver cirrhosis. Hepatology 2010;51:1017-1026.
10. Yoon SM, Gerasimidou D, Kuwahara R, Hytiroglou P, Yoo JE, Park YN, et al. Epithelial cell adhesion molecule (EpCAM) marks hepatocytes newly derived from stem/progenitor cells in humans. Hepatology 2011;53:964-973.
11. Español-Suñer R, Carpentier R, Van Hul N, Legry V, Achouri Y, Cordi S, et al. Liver progenitor cells yield functional hepatocytes in response to chronic liver injury in mice. Gastroenterology 2012;143:1564-1575.
12. Rodrigo-Torres D, Affò S, Coll M, Morales-Ibanez O, Millán C, Blaya D, et al. The biliary epithelium gives rise to liver progenitor cells. Hepatology 2014;60:1367-1377.
13. Wanless IR, Wong F, Blendis LM, Greig P, Heathcote EJ, Levy G. Hepatic and portal vein thrombosis in cirrhosis: possible role in development of parenchymal extinction and portal hypertension. Hepatology 1995;21:1238-1247.
14. Falkowski O, An HJ, Ianus IA, Chiriboga L, Yee H, West AB, et al. Regeneration of hepatocyte "buds" in cirrhosis from intrabiliary stem cells. J Hepatol 2003;39:357-364.
15. Wanless IR, Sweeney G, Dhillon AP, Guido M, Piga A, Galanello R, et al. Lack of progressive hepatic fibrosis during long-term therapy with deferiprone in subjects with transfusion-dependent beta-thalassemia. Blood 2002;100:1566-1569.
16. Kim SU, Oh HJ, Wanless IR, Lee S, Han KH, Park YN. The Laennec staging system for histological sub-classification of cirrhosis is useful for stratification of prognosis in patients with liver cirrhosis. J Hepatol 2012;57:556-563.
17. Kuwahara R, Kofman AV, Landis CS, Swenson ES, Barendswaard E, Theise ND. The hepatic stem cell niche: identification by label-retaining cell assay. Hepatology 2008;47:1994-2002.
18. Fleming K, Wanless IR. Glutamine synthetase expression in activated hepatocyte progenitor cells and loss of hepatocellular expression in congestion and cirrhosis. Liver Int 2013;33:525-534.
19. Bioulac-Sage P, Laumonier H, Cubel G, Saric J, Balabaud C. Over-expression of glutamine synthase in focal nodular hyperplasia (part 1): early stages in the formation support the hypothesis of a focal hyper-arterialisation with venous (portal and hepatic) and biliary damage. Comp Hepatol 2008;7(2):1-28.
20. Arnason T, Fleming K, Wanless IR. Peritumoural hyperplasia of the liver: a response to portal vein invasion by hypervascular neoplasms. Histopathology 2013;62:458-464.
21. D'Ambrosio R, Aghemo A, Rumi MG, Ronchi G, Donato MF, Paradis V, et al. A morphometric and immunohistochemical study to assess the benefit of a sustained virological response in hepatitis C virus patients with cirrhosis. Hepatology 2012;56:532-543.
22. Bioulac-Sage P, Rebouissou S, Thomas C, Blanc JF, Saric J, Sa Cunha A, et al. Hepatocellular adenoma subtype classification using molecular markers and immunohistochemistry. Hepatology 2007;46:740-748.
23. Theise ND, Dollé L, Kuwahara R. Low hepatocyte repopulation from stem cells: a matter of hepatobiliary linkage not massive production. Gastroenterology 2013;145:253-254.
24. Libbrecht L, Desmet V, Van Damme B, Roskams T. Deep intralobular extension of human hepatic "progenitor cells" correlates with parenchymal inflammation in chronic viral hepatitis: can "progenitor cells" migrate? J Pathol 2000;192:373-378.
25. Brunt EM, Blomenkamp K, Ahmed M, Ali F, Marcus N, Teckman J. Hepatic progenitor cell proliferation and liver injury in alpha-1-antitrypsin deficiency. J Pediatr Gastroenterol Nutr 2010;51:626-630.
26. Richardson MM, Jonsson JR, Powell EE, Brunt EM, Neuschwander-Tetri BA, Bhathal PS, et al. Progressive fibrosis in nonalcoholic steatohepatitis: association with altered regeneration and a ductular reaction. Gastroenterology 2007;133:80-90.
27. 1 arrest, impaired hepatic regeneration, and fibrosis in chronic hepatitis C virus infection. Gastroenterology 2005;128:33-42.
28. Delladetsima J, Alexandrou P, Giaslakiotis K, Psichogiou M, Hatzis G, Sypsa V, et al. Hepatic progenitor cells in chronic hepatitis C: a phenomenon of older age and advanced liver disease. Virchows Arch 2010;457:457-466.
29. Wood MJ, Gadd VL, Powell LW, Ramm GA, Clouston AD. Ductular reaction in hereditary hemochromatosis: the link between hepatocyte senescence and fibrosis progression. Hepatology 2014;59:848-857.
30. Sasaki M, Ikeda H, Yamaguchi J, Nakada S, Nakanuma Y. Telomere shortening in the damaged small bile ducts in primary biliary cirrhosis reflects ongoing cellular senescence. Hepatology 2008;48:186-195.
31. Tabibian JH, O'Hara SP, Splinter PL, Trussoni CE, LaRusso NF. Cholangiocyte senescence by way of N-ras activation is a characteristic of primary sclerosing cholangitis. Hepatology 2014;59:2263-2275.