Ductular reaction in hereditary hemochromatosis: The link between hepatocyte senescence and fibrosis progression

Hepatology

Volumn 59, Issue 3, 2014, Pages 848-857

  Wood, Marnie J ^a,b,c   Gadd, Victoria L ^b   Powell, Lawrie W ^b,d   Ramm, Grant A ^a,b   Clouston, Andrew D ^b,e  

^a QIMR BERGHOFER MEDICAL RESEARCH INSTITUTE   (Australia)

^b UNIVERSITY OF QUEENSLAND   (Australia)

^c ROYAL BRISBANE AND WOMEN'S HOSPITAL   (Australia)

^d UNIVERSITY OF QUEENSLAND   (Australia)

^e Envoi Specialist Pathologists   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; FERRITIN; GELATINASE B; IRON; PROTEIN P21;

ADULT; ALCOHOL CONSUMPTION; ARTICLE; CELL AGING; CELL PROLIFERATION; DISEASE COURSE; DUCTULAR REACTION; FATTY LIVER; FEMALE; FERRITIN BLOOD LEVEL; FIBROGENESIS; HEMOCHROMATOSIS; HISTOPATHOLOGY; HOMOZYGOSITY; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; INFLAMMATION; INFLAMMATORY INFILTRATE; KUPFFER CELL; LIVER BIOPSY; LIVER CELL; LIVER FIBROSIS; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; OXIDATIVE STRESS; PHLEBOTOMY; PRIORITY JOURNAL; SENESCENCE;

ADULT; BILE DUCTS, INTRAHEPATIC; BIOPSY; CELL AGING; DISEASE PROGRESSION; FATTY LIVER; FEMALE; HEMOCHROMATOSIS; HEPATOCYTES; HUMANS; KUPFFER CELLS; LIVER; LIVER CIRRHOSIS; MALE; MIDDLE AGED;

EID: 84896720729     PISSN: 02709139     EISSN: 15273350     Source Type: Journal    
DOI: 10.1002/hep.26706     Document Type: Article

References (29)

1. Adams PC. Is there a threshold of hepatic iron concentration that leads to cirrhosis in C282Y hemochromatosis? Am J Gastroenterol 2001;96:567-569.
2. Powell LW, Dixon JL, Ramm GA, Purdie DM, Lincoln DJ, Anderson GJ, et al. Screening for hemochromatosis in asymptomatic subjects with or without a family history. Arch Intern Med 2006;166:294-301.
3. Wood MJ, Powell LW, Ramm GA. Environmental and genetic modifiers of the progression to fibrosis and cirrhosis in hemochromatosis. Blood 2008;111:4456-4462.
4. Powell EE, Ali A, Clouston AD, Dixon JL, Lincoln DJ, Purdie DM, et al. Steatosis is a cofactor in liver injury in hemochromatosis. Gastroenterology 2005;129:1937-1943.
5. Deugnier YM, Loreal O, Turlin B, Guyader D, Jouanolle H, Moirand R, et al. Liver pathology in genetic hemochromatosis: a review of 135 homozygous cases and their bioclinical correlations. Gastroenterology 1992;102:2050-2059.
6. Roskams TA, Theise ND, Balabaud C, Bhagat G, Bhathal PS, Bioulac-Sage P, et al. Nomenclature of the finer branches of the biliary tree: canals, ductules, and ductular reactions in human livers. Hepatology 2004;39:1739-1745.
7. Gouw ASH, Clouston AD, Theise ND. Ductular reactions in human liver: diversity at the interface. Hepatology 2011;54:1853-1863.
8. Richardson MM, Jonsson JR, Powell EE, Brunt EM, Neuschwander-Tetri BA, Bhathal PS, et al. Progressive fibrosis in nonalcoholic steatohepatitis: association with altered regeneration and a ductular reaction. Gastroenterology 2007;133:80-90.
9. Brunt EM, Blomenkamp K, Ahmed M, Ali F, Marcus N, Teckman J. Hepatic progenitor cell proliferation and liver injury in alpha1-antitrypsin deficiency. J Pediatr Gastroenterol Nutr 2010;51:626-630.
10. Clouston AD, Powell EE, Walsh MJ, Richardson MM, Demetris AJ, Jonsson JR. Fibrosis correlates with a ductular reaction in hepatitis C: roles of impaired replication, progenitor cells and steatosis. Hepatology 2005;41:809-818.
11. Fletcher LM, Dixon JL, Purdie DM, Powell LW, Crawford DHG. Excess alcohol greatly increases the prevalence of cirrhosis in hereditary hemochromatosis. Gastroenterology 2002;122:281-289.
12. Bedossa P. Intraobserver and interobserver variations in liver biopsy interpretation in patients with chronic hepatitis C. Hepatology 1994;20:15-20.
13. Scheuer PJ, Williams R, Muir A. Hepatic pathology in relatives of patients with hemochromatosis. J Pathol Bacteriol 1962;84:53-64.
14. Ishak K, Baptista A, Bianchi L, Callea F, De Groote J, Gudat F, et al. Histological grading and staging of chronic hepatitis. J Hepatol 1995;22:696-699.
15. Gadd VL, Melino M, Roy S, Horsfall L, O'Rourke P, Williams MR, et al. Portal, but not lobular, macrophages express matrix metalloproteinase-9: association with the ductular reaction and fibrosis in chronic hepatitis C. Liver Int 2013;33:569-579.
16. Ramm GA, Crawford DHG, Powell LW, Walker NI, Fletcher LM, Halliday JW. Hepatic stellate cell activation in genetic hemochromatosis: lobular distribution, effect of increasing hepatic iron and response to phlebotomy. J Hepatol 1997;26:584-592.
17. Svegliati-Baroni G, Faraci G, Fabris L, Saccomanno S, Cadamuro M, Pierantonelli I, et al. Insulin resistance and necroinflammation drives ductular reaction and epithelial-mesenchymal transition in chronic hepatitis C. Gut 2011;60:108-115.
18. Van Hul NKM, Abarca-Quinones J, Sempoux C, Horsmans Y, Leclercq IA. Relation between liver progenitor cell expansion and extracellular matrix deposition in a CDE-induced murine model of chronic liver injury. Hepatology 2009;49:1625-1635.
19. Lorenzini S, Bird TG, Boulter L, Bellamy C, Samuel K, Aucott R, et al. Characterisation of a stereotypical cellular and extracellular adult liver progenitor cell niche in rodents and diseased human liver. Gut 2010;59:645-654.
20. Zhou H, Rogler LE, Teperman L, Morgan G, Rogler CE. Identification of hepatocytic and bile ductular cell lineages and candidate stem cells in bipolar ductular reactions in cirrhotic human liver. Hepatology 2007;45:716-724.
21. Boulter L, Govaere O, Bird TG, Radulescu S, Ramachandran P, Pellicoro A, et al. Macrophage-derived Wnt opposes Notch signaling to specify hepatic progenitor cell fate in chronic liver disease. Nat Med 2012;18:572-579.
22. Chobert M-N, Couchie D, Fourcot A, Zafrani E-S, Laperche Y, Mavier P, et al. Liver precursor cells increase hepatic fibrosis induced by chronic carbon tetrachloride intoxication in rats. Lab Invest 2012;92:135-150.
23. Kuramitsu K, Sverdlov DY, Liu SB, Csizmadia E, Burkly L, Schuppan D, et al. failure of fibrotic liver regeneration in mice is linked to a severe fibrogenic response driven by hepatic progenitor cell activation. Am J Pathol 2013;183:182-194.
24. Lemoinne S, Cadoret A, El Mourabit H, Thabut D, Housset C. Origins and functions of liver myofibroblasts. Biochim Biophys Acta Mol Basis Dis 2013;1832:948-954.
25. Stål P, Broomé U, Scheynius A, Befrits R, Hultcrantz R. Kupffer cell iron overload induces intercellular adhesion molecule-1 expression on hepatocytes in genetic hemochromatosis. Hepatology 1995;21:1308-1316.
26. Bridle KR, Crawford DHG, Fletcher LM, Smith JL, Powell LW, Ramm GA. Evidence for a sub-morphological inflammatory process in the liver in hemochromatosis. J Hepatol 2003;38:426-433.
27. Melino M, Gadd VL, Walker GV, Skoien R, Barrie HD, Jothimani D, et al. Macrophage secretory products induce an inflammatory phenotype in hepatocytes. World J Gastroenterol 2012;18:1732-1744.
28. Powell LW, Kerr JFR. The pathology of the liver in hemochromatosis. Pathobiol Annu 1975;5:317-337.
29. Majhail NS, Lazarus HM, Burns LJ. Iron overload in hematopoietic cell transplantation. Bone Marrow Transplant 2008;41:997-1003.